TY  - JOUR
AU  - Radović, Mina
AU  - Bojić, Suzana
AU  - Kotur-Stevuljević, Jelena
AU  - Ležaić, Višnja
AU  - Miličić, Biljana
AU  - Velinović, Miloš
AU  - Karan, Radmila
AU  - Simić-Ogrizović, Sanja
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2404
AB  - Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil GelatinaseAssociated Lipocalin (N G AL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary N G AL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as lowrisk for developing CSA-AKI. u NGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uN G A L and KIM-1 levels compared to patients without CSA-AKI. Unlike uN G A L and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration > 4 mmol/L carried dramatically higher risk for developing CSA-AKI (O R 6.3 [1.9-20.5]). Conclusions: Unlike uN G A L and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB.
AB  - Uvod: Akutno ostećenje bubrega nakon kardiohirurskih procedura (KH-AOB) nastaje često i kod bolesnika koji su ocenjeni kao niskorizični za nastanak KH-AOB. Neutrofilna želatinaza udružena sa lipokalinom (NGAL), bubrežni štetni molekul-1 (KIM-1) i laktat su novi biomarkeri KH-AOB ali do sada nisu ispitivani kod niskorizičnih bolesnika. Cilj: Ispitati urinarni NGAL (uNGAL), KIM-1 i laktat kao biomarkere KH-AOB kod bolesnika koji su ocenjeni kao niskorizični za nastanak KH-AOB. Metode: Ovom prospektivnom opservacionom studijom obuhvaćeno je 100 odraslih elektivnih kardiohirurških bolesnika koji su ocenjeni kao niskorizični za razvoj KH-AOB. UNGAL, KIM-1 i laktat su određivani preoperativno, na kraju kardiopulmonalnog bajpasa (KPB) kao i 3, 12, 24 i 48 sati kasnije. Rezultati: KH-AOB se razvilo kod 15 bolesnika. Bolesnici sa KH-AOB su imali značajno više vrednosti lakatata ali slične vrednosti uNGAL i KIM-1 u poređenju sa bolesnicima bez KH-AOB. Za razliku od uN GAL i KIM-1, vrednost lakatata posle operacije se pokazala kao pouzdan biomarker KH-AOB sa najvišim OR 2.7 [1,4-4,9] 24 sata nakon zavrsetka KPB. Vrednosti lakatata > 4 mmol/L su bile povezane sa dramatično povišenim rizikom za nastanak KH-AOB (O R 6,3 [1,9-20,5]). Zaključak: Za razliku od uN GAL i KIM-1, vrednosti lakata posle operacije su bile značajan nezavisni prediktor razvoja KH-AOB sa najboljom prediktivnom vrednošću 24 sata nakon završetka KPB.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients
T1  - Serumski laktat kao pouzdan biomarker akutnog oštećenja bubrega kod niskorizičnih kardiohirurških bolesnika
VL  - 38
IS  - 2
SP  - 118
EP  - 125
DO  - 10.2478/jomb-2018-0018
ER  - 

@article{
author = "Radović, Mina and Bojić, Suzana and Kotur-Stevuljević, Jelena and Ležaić, Višnja and Miličić, Biljana and Velinović, Miloš and Karan, Radmila and Simić-Ogrizović, Sanja",
year = "2019",
abstract = "Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil GelatinaseAssociated Lipocalin (N G AL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary N G AL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as lowrisk for developing CSA-AKI. u NGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uN G A L and KIM-1 levels compared to patients without CSA-AKI. Unlike uN G A L and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration > 4 mmol/L carried dramatically higher risk for developing CSA-AKI (O R 6.3 [1.9-20.5]). Conclusions: Unlike uN G A L and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB., Uvod: Akutno ostećenje bubrega nakon kardiohirurskih procedura (KH-AOB) nastaje često i kod bolesnika koji su ocenjeni kao niskorizični za nastanak KH-AOB. Neutrofilna želatinaza udružena sa lipokalinom (NGAL), bubrežni štetni molekul-1 (KIM-1) i laktat su novi biomarkeri KH-AOB ali do sada nisu ispitivani kod niskorizičnih bolesnika. Cilj: Ispitati urinarni NGAL (uNGAL), KIM-1 i laktat kao biomarkere KH-AOB kod bolesnika koji su ocenjeni kao niskorizični za nastanak KH-AOB. Metode: Ovom prospektivnom opservacionom studijom obuhvaćeno je 100 odraslih elektivnih kardiohirurških bolesnika koji su ocenjeni kao niskorizični za razvoj KH-AOB. UNGAL, KIM-1 i laktat su određivani preoperativno, na kraju kardiopulmonalnog bajpasa (KPB) kao i 3, 12, 24 i 48 sati kasnije. Rezultati: KH-AOB se razvilo kod 15 bolesnika. Bolesnici sa KH-AOB su imali značajno više vrednosti lakatata ali slične vrednosti uNGAL i KIM-1 u poređenju sa bolesnicima bez KH-AOB. Za razliku od uN GAL i KIM-1, vrednost lakatata posle operacije se pokazala kao pouzdan biomarker KH-AOB sa najvišim OR 2.7 [1,4-4,9] 24 sata nakon zavrsetka KPB. Vrednosti lakatata > 4 mmol/L su bile povezane sa dramatično povišenim rizikom za nastanak KH-AOB (O R 6,3 [1,9-20,5]). Zaključak: Za razliku od uN GAL i KIM-1, vrednosti lakata posle operacije su bile značajan nezavisni prediktor razvoja KH-AOB sa najboljom prediktivnom vrednošću 24 sata nakon završetka KPB.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients, Serumski laktat kao pouzdan biomarker akutnog oštećenja bubrega kod niskorizičnih kardiohirurških bolesnika",
volume = "38",
number = "2",
pages = "118-125",
doi = "10.2478/jomb-2018-0018"
}

Radović, M., Bojić, S., Kotur-Stevuljević, J., Ležaić, V., Miličić, B., Velinović, M., Karan, R.,& Simić-Ogrizović, S.. (2019). Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(2), 118-125.
https://doi.org/10.2478/jomb-2018-0018

Radović M, Bojić S, Kotur-Stevuljević J, Ležaić V, Miličić B, Velinović M, Karan R, Simić-Ogrizović S. Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients. in Journal of Medical Biochemistry. 2019;38(2):118-125.
doi:10.2478/jomb-2018-0018 .

Radović, Mina, Bojić, Suzana, Kotur-Stevuljević, Jelena, Ležaić, Višnja, Miličić, Biljana, Velinović, Miloš, Karan, Radmila, Simić-Ogrizović, Sanja, "Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients" in Journal of Medical Biochemistry, 38, no. 2 (2019):118-125,
https://doi.org/10.2478/jomb-2018-0018 . .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Bogdanović, Ljiljana
AU  - Radunović, Milena
AU  - Prostran, Milica S.
AU  - Naumović, R.
AU  - Simić-Ogrizović, Sanja
AU  - Radojević-Škodrić, Sanja
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2094
AB  - Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Medicinal Chemistry
T1  - Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation
VL  - 23
IS  - 19
SP  - 2012
EP  - 2017
DO  - 10.2174/092986732319160719192019
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Bogdanović, Ljiljana and Radunović, Milena and Prostran, Milica S. and Naumović, R. and Simić-Ogrizović, Sanja and Radojević-Škodrić, Sanja",
year = "2016",
abstract = "Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Medicinal Chemistry",
title = "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation",
volume = "23",
number = "19",
pages = "2012-2017",
doi = "10.2174/092986732319160719192019"
}

Basta-Jovanović, G., Bogdanović, L., Radunović, M., Prostran, M. S., Naumović, R., Simić-Ogrizović, S.,& Radojević-Škodrić, S.. (2016). Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 23(19), 2012-2017.
https://doi.org/10.2174/092986732319160719192019

Basta-Jovanović G, Bogdanović L, Radunović M, Prostran MS, Naumović R, Simić-Ogrizović S, Radojević-Škodrić S. Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry. 2016;23(19):2012-2017.
doi:10.2174/092986732319160719192019 .

Basta-Jovanović, Gordana, Bogdanović, Ljiljana, Radunović, Milena, Prostran, Milica S., Naumović, R., Simić-Ogrizović, Sanja, Radojević-Škodrić, Sanja, "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation" in Current Medicinal Chemistry, 23, no. 19 (2016):2012-2017,
https://doi.org/10.2174/092986732319160719192019 . .