TY  - JOUR
AU  - Kovačević, Bojan
AU  - Ignjatović, Mile
AU  - Živaljević, Vladan
AU  - Ćuk, Vladimir
AU  - Scepanović, Milena
AU  - Petrović, Zaklina
AU  - Paunović, Ivan
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1710
AB  - The National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI (TM)) 2003 and Kidney Disease: Improving Global Outcomes (KDIGO) 2009 have established guidelines for the treatement of secondary hyperparathyroidism. This study evaluated the impact of parathyroidectomy to achieve recommended values for parathyroid hormone, calcium, phosphorus and CaxPO(4) product in dialysis patients with severe secondary hyperparathyroidism that is resistant to medical treatment. This study included 43 consecutive patients who underwent parathyroidectomy for a severe form of secondary hyperparathyroidism (SHPT) that is unresponsive to medical treatment. The serum iPTH, calcium and phosphorus levels were measured prior to surgery, every morning after surgery for 5 days and on the first, sixth and eighth postoperative months. Following parathyroidectomy, a significant decline in iPTH values was observed in all patients; however, after the 8-month study period, only one of these patients achieved a serum iPTH concentration within the K/DOQI recommended target range. Unlike iPTH, targeting for calcium, phosphorus and CaxPO(4) at the last follow-up were 55.8%, 60.5% and 93%, respectively. These values indicated a significant improvement in comparison to preoperative percentages. In regards to the KDIGO recommended guidelines, the iPTH levels did not significantly change at the end of our study compared to preoperative values; however, calcium levels significantly declined and phosphorus levels significantly improved compared to preoperative values. Although the majority of patients fail to reach recommended iPTH values, parathyroidectomy remains a valuable tool to attain these NKF-K/DOQI recommendations for serum calcium, phosphorus and CaxPO(4) in dialysis patients with secondary hyperparathyroidism resistant to medical therapy. Parathyroidectomy was shown to be an inadequate intervention for achieving KDIGO recommendations.
PB  - Springer, New York
T2  - Langenbecks Archives of Surgery
T1  - Parathyroidectomy for the attainment of NKF-K/DOQI (TM) and KDIGO recommended values for bone and mineral metabolism in dialysis patients with uncontrollable secondary hyperparathyroidism
VL  - 397
IS  - 3
SP  - 413
EP  - 420
DO  - 10.1007/s00423-011-0901-9
ER  - 

@article{
author = "Kovačević, Bojan and Ignjatović, Mile and Živaljević, Vladan and Ćuk, Vladimir and Scepanović, Milena and Petrović, Zaklina and Paunović, Ivan",
year = "2012",
abstract = "The National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI (TM)) 2003 and Kidney Disease: Improving Global Outcomes (KDIGO) 2009 have established guidelines for the treatement of secondary hyperparathyroidism. This study evaluated the impact of parathyroidectomy to achieve recommended values for parathyroid hormone, calcium, phosphorus and CaxPO(4) product in dialysis patients with severe secondary hyperparathyroidism that is resistant to medical treatment. This study included 43 consecutive patients who underwent parathyroidectomy for a severe form of secondary hyperparathyroidism (SHPT) that is unresponsive to medical treatment. The serum iPTH, calcium and phosphorus levels were measured prior to surgery, every morning after surgery for 5 days and on the first, sixth and eighth postoperative months. Following parathyroidectomy, a significant decline in iPTH values was observed in all patients; however, after the 8-month study period, only one of these patients achieved a serum iPTH concentration within the K/DOQI recommended target range. Unlike iPTH, targeting for calcium, phosphorus and CaxPO(4) at the last follow-up were 55.8%, 60.5% and 93%, respectively. These values indicated a significant improvement in comparison to preoperative percentages. In regards to the KDIGO recommended guidelines, the iPTH levels did not significantly change at the end of our study compared to preoperative values; however, calcium levels significantly declined and phosphorus levels significantly improved compared to preoperative values. Although the majority of patients fail to reach recommended iPTH values, parathyroidectomy remains a valuable tool to attain these NKF-K/DOQI recommendations for serum calcium, phosphorus and CaxPO(4) in dialysis patients with secondary hyperparathyroidism resistant to medical therapy. Parathyroidectomy was shown to be an inadequate intervention for achieving KDIGO recommendations.",
publisher = "Springer, New York",
journal = "Langenbecks Archives of Surgery",
title = "Parathyroidectomy for the attainment of NKF-K/DOQI (TM) and KDIGO recommended values for bone and mineral metabolism in dialysis patients with uncontrollable secondary hyperparathyroidism",
volume = "397",
number = "3",
pages = "413-420",
doi = "10.1007/s00423-011-0901-9"
}

Kovačević, B., Ignjatović, M., Živaljević, V., Ćuk, V., Scepanović, M., Petrović, Z.,& Paunović, I.. (2012). Parathyroidectomy for the attainment of NKF-K/DOQI (TM) and KDIGO recommended values for bone and mineral metabolism in dialysis patients with uncontrollable secondary hyperparathyroidism. in Langenbecks Archives of Surgery
Springer, New York., 397(3), 413-420.
https://doi.org/10.1007/s00423-011-0901-9

Kovačević B, Ignjatović M, Živaljević V, Ćuk V, Scepanović M, Petrović Z, Paunović I. Parathyroidectomy for the attainment of NKF-K/DOQI (TM) and KDIGO recommended values for bone and mineral metabolism in dialysis patients with uncontrollable secondary hyperparathyroidism. in Langenbecks Archives of Surgery. 2012;397(3):413-420.
doi:10.1007/s00423-011-0901-9 .

Kovačević, Bojan, Ignjatović, Mile, Živaljević, Vladan, Ćuk, Vladimir, Scepanović, Milena, Petrović, Zaklina, Paunović, Ivan, "Parathyroidectomy for the attainment of NKF-K/DOQI (TM) and KDIGO recommended values for bone and mineral metabolism in dialysis patients with uncontrollable secondary hyperparathyroidism" in Langenbecks Archives of Surgery, 397, no. 3 (2012):413-420,
https://doi.org/10.1007/s00423-011-0901-9 . .