TY  - JOUR
AU  - Lončar, D.
AU  - Janković, Saša
AU  - Milovanović, D.
AU  - Milošević-Đorđević, Olivera
AU  - Stojadinović, M.
AU  - Lončar, S.
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1636
AB  - Congenital anomalies are the cause of 20.0-25.0% of cases of perinatal death, while 3.0% of children are born with malformations of varying size. We examined the predictive values and defined the credibility ratio of the combined test results. Sensitivity of the test is 94.0%, and specificity is 99.0%. The positive likelihood ratio [likelihood ratio test (LR+)] is 94.00; a negative likelihood ratio [likelihood ratio test (LR-)] is 0.06. The pretest probability that pregnant women carry a fetus with chromosomal abnormality is 1:250. Posttest odds after the combined test to discover this abnormality are 0.3760, and probability of the same case is 0.2732 if it happens that the test result is positive. The result of our study confirms the justification of combined test usage in routine clinical practice, since the posttest odds rate in the case of a positive screening increases several times over (almost 90 times); the probability of detecting a chromosomal abnormality was about 70 times.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Non-invasive screening: The probability of events
VL  - 63
IS  - 3
SP  - 609
EP  - 615
DO  - 10.2298/ABS1103609L
ER  - 

@article{
author = "Lončar, D. and Janković, Saša and Milovanović, D. and Milošević-Đorđević, Olivera and Stojadinović, M. and Lončar, S.",
year = "2011",
abstract = "Congenital anomalies are the cause of 20.0-25.0% of cases of perinatal death, while 3.0% of children are born with malformations of varying size. We examined the predictive values and defined the credibility ratio of the combined test results. Sensitivity of the test is 94.0%, and specificity is 99.0%. The positive likelihood ratio [likelihood ratio test (LR+)] is 94.00; a negative likelihood ratio [likelihood ratio test (LR-)] is 0.06. The pretest probability that pregnant women carry a fetus with chromosomal abnormality is 1:250. Posttest odds after the combined test to discover this abnormality are 0.3760, and probability of the same case is 0.2732 if it happens that the test result is positive. The result of our study confirms the justification of combined test usage in routine clinical practice, since the posttest odds rate in the case of a positive screening increases several times over (almost 90 times); the probability of detecting a chromosomal abnormality was about 70 times.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Non-invasive screening: The probability of events",
volume = "63",
number = "3",
pages = "609-615",
doi = "10.2298/ABS1103609L"
}

Lončar, D., Janković, S., Milovanović, D., Milošević-Đorđević, O., Stojadinović, M.,& Lončar, S.. (2011). Non-invasive screening: The probability of events. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 63(3), 609-615.
https://doi.org/10.2298/ABS1103609L

Lončar D, Janković S, Milovanović D, Milošević-Đorđević O, Stojadinović M, Lončar S. Non-invasive screening: The probability of events. in Archives of Biological Sciences. 2011;63(3):609-615.
doi:10.2298/ABS1103609L .

Lončar, D., Janković, Saša, Milovanović, D., Milošević-Đorđević, Olivera, Stojadinović, M., Lončar, S., "Non-invasive screening: The probability of events" in Archives of Biological Sciences, 63, no. 3 (2011):609-615,
https://doi.org/10.2298/ABS1103609L . .