TY  - JOUR
AU  - Stojić, Vanja
AU  - Glišić, Branislav
AU  - Đukić, Ljiljana
AU  - Prokić, Bogomir
AU  - Janović, Aleksa
AU  - Stamenković, Zorana
AU  - Milutinović-Smiljanić, Sanja
AU  - Danilović, Vesna
AU  - Brković, Božidar
AU  - Roganović, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2512
AB  - Objective: We aimed to investigate alteration in cellular signaling mediated by vascular endothelial growth factor (VEGF) and parameters of oxidative stress/nitric oxide generation, superoxide dismutase (SOD) and neuronal nitric oxide synthase (nNOS), underlying altered functional mechanical loading of TMJ (temporomandibular joint) during lateral mandibular deviation. Design: Thirty-eight 5-week-old male Wistar rats were divided into experimental group, which received acrylic resin appliance that shifted mandible to the left during closure, and control group. Computed tomography and histomorphometry were used for condyle analyses, while samples of condyle, synovial membrane and m. masseter were analyzed with enzyme-linked immunosorbent assay and spectrophotometry to determine VEGF and nNOS protein concentrations, and SOD activity. Results: Experimental group of rats developed smaller and asymmetrical mandibles. Less of new bone and cartilage formation and larger bone marrow cavities area were found in the experimental group. Higher VEGF expression in condyle and m. masseter as well as higher nNOS expression in m. masseter and synovial membrane were found in the experimental compared to the control group. Alteration of SOD activity was found in m. masseter and synovial membrane in the experimental group. Conclusions: Lateral mandibular deviation induces mandibular and condylar morphological changes as well as significant cellular signaling alterations in condyle, synovial membrane and masticatory muscle. Cellular VEGF protein overexpression and oxidative stress/nitric oxide disbalance could be the mechanisms underlying unbalanced functional TMJ loading due to mandibular deviation.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Archives of Oral Biology
T1  - Mandibular lateral deviation induces alteration in vascular endothelial growth factor expression and oxidative stress/nitric oxide generation in rat condyle, synovial membrane and masseter muscle
VL  - 110
DO  - 10.1016/j.archoralbio.2019.104599
ER  - 

@article{
author = "Stojić, Vanja and Glišić, Branislav and Đukić, Ljiljana and Prokić, Bogomir and Janović, Aleksa and Stamenković, Zorana and Milutinović-Smiljanić, Sanja and Danilović, Vesna and Brković, Božidar and Roganović, Jelena",
year = "2020",
abstract = "Objective: We aimed to investigate alteration in cellular signaling mediated by vascular endothelial growth factor (VEGF) and parameters of oxidative stress/nitric oxide generation, superoxide dismutase (SOD) and neuronal nitric oxide synthase (nNOS), underlying altered functional mechanical loading of TMJ (temporomandibular joint) during lateral mandibular deviation. Design: Thirty-eight 5-week-old male Wistar rats were divided into experimental group, which received acrylic resin appliance that shifted mandible to the left during closure, and control group. Computed tomography and histomorphometry were used for condyle analyses, while samples of condyle, synovial membrane and m. masseter were analyzed with enzyme-linked immunosorbent assay and spectrophotometry to determine VEGF and nNOS protein concentrations, and SOD activity. Results: Experimental group of rats developed smaller and asymmetrical mandibles. Less of new bone and cartilage formation and larger bone marrow cavities area were found in the experimental group. Higher VEGF expression in condyle and m. masseter as well as higher nNOS expression in m. masseter and synovial membrane were found in the experimental compared to the control group. Alteration of SOD activity was found in m. masseter and synovial membrane in the experimental group. Conclusions: Lateral mandibular deviation induces mandibular and condylar morphological changes as well as significant cellular signaling alterations in condyle, synovial membrane and masticatory muscle. Cellular VEGF protein overexpression and oxidative stress/nitric oxide disbalance could be the mechanisms underlying unbalanced functional TMJ loading due to mandibular deviation.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Archives of Oral Biology",
title = "Mandibular lateral deviation induces alteration in vascular endothelial growth factor expression and oxidative stress/nitric oxide generation in rat condyle, synovial membrane and masseter muscle",
volume = "110",
doi = "10.1016/j.archoralbio.2019.104599"
}

Stojić, V., Glišić, B., Đukić, L., Prokić, B., Janović, A., Stamenković, Z., Milutinović-Smiljanić, S., Danilović, V., Brković, B.,& Roganović, J.. (2020). Mandibular lateral deviation induces alteration in vascular endothelial growth factor expression and oxidative stress/nitric oxide generation in rat condyle, synovial membrane and masseter muscle. in Archives of Oral Biology
Pergamon-Elsevier Science Ltd, Oxford., 110.
https://doi.org/10.1016/j.archoralbio.2019.104599

Stojić V, Glišić B, Đukić L, Prokić B, Janović A, Stamenković Z, Milutinović-Smiljanić S, Danilović V, Brković B, Roganović J. Mandibular lateral deviation induces alteration in vascular endothelial growth factor expression and oxidative stress/nitric oxide generation in rat condyle, synovial membrane and masseter muscle. in Archives of Oral Biology. 2020;110.
doi:10.1016/j.archoralbio.2019.104599 .

Stojić, Vanja, Glišić, Branislav, Đukić, Ljiljana, Prokić, Bogomir, Janović, Aleksa, Stamenković, Zorana, Milutinović-Smiljanić, Sanja, Danilović, Vesna, Brković, Božidar, Roganović, Jelena, "Mandibular lateral deviation induces alteration in vascular endothelial growth factor expression and oxidative stress/nitric oxide generation in rat condyle, synovial membrane and masseter muscle" in Archives of Oral Biology, 110 (2020),
https://doi.org/10.1016/j.archoralbio.2019.104599 . .

TY  - JOUR
AU  - Janović, Nataša
AU  - Cocić, Aleksandar
AU  - Stamenić, Mirjana
AU  - Janović, Aleksa
AU  - Đurić, Marija
PY  - 2020
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1050
AB  - Objectives The objective of this study was to investigate the relationship between side asymmetry in nasal resistance (NR) and severity of the nasal airway obstruction (NAO) in patients with different types of nasal septal deformity (NSD). Design Computational fluid dynamics (CFD) study. Setting The study was conducted in a tertiary medical centre. Participants The study included 232 patients, who were referred to the CT examination of the paranasal sinuses. Exclusion criteria were sinonasal and respiratory diseases that may interfere with the nasal obstruction. The presence and the type of NSD were recorded according to the Mladina's classification. Main outcome measures The presence and severity of NAO in each patient were assessed by NOSE questionnaire. Eight computational models of the nasal cavity were created from CT scans. Models represented seven Mladina's NSD types and a straight septum of a symptomless patient. CFD calculated airflow partitioning and NR for each nasal passage. Side differences in NR were calculated by the equation increment NR = NRleft - NRright. The relationship between NOSE scores, airflow partitioning and side differences in NR was explored using Spearman's correlation analysis. Results Mladina's types of NSD showed differences in airflow partitioning and the degree of side asymmetry in NR. A significant positive correlation was detected between side differences in NR and NOSE scores (R = .762, P = .028). A significant negative correlation was found between the per cent of unilateral airflow and NR (R = -.524, P = .037). Conclusions Our results demonstrated that side asymmetry in NR could explain differences in NAO severity related to the NSD type.
PB  - Wiley, Hoboken
T2  - Clinical Otolaryngology
T1  - Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study
VL  - 45
IS  - 5
SP  - 718
EP  - 724
DO  - 10.1111/coa.13563
ER  - 

@article{
author = "Janović, Nataša and Cocić, Aleksandar and Stamenić, Mirjana and Janović, Aleksa and Đurić, Marija",
year = "2020, 2020",
abstract = "Objectives The objective of this study was to investigate the relationship between side asymmetry in nasal resistance (NR) and severity of the nasal airway obstruction (NAO) in patients with different types of nasal septal deformity (NSD). Design Computational fluid dynamics (CFD) study. Setting The study was conducted in a tertiary medical centre. Participants The study included 232 patients, who were referred to the CT examination of the paranasal sinuses. Exclusion criteria were sinonasal and respiratory diseases that may interfere with the nasal obstruction. The presence and the type of NSD were recorded according to the Mladina's classification. Main outcome measures The presence and severity of NAO in each patient were assessed by NOSE questionnaire. Eight computational models of the nasal cavity were created from CT scans. Models represented seven Mladina's NSD types and a straight septum of a symptomless patient. CFD calculated airflow partitioning and NR for each nasal passage. Side differences in NR were calculated by the equation increment NR = NRleft - NRright. The relationship between NOSE scores, airflow partitioning and side differences in NR was explored using Spearman's correlation analysis. Results Mladina's types of NSD showed differences in airflow partitioning and the degree of side asymmetry in NR. A significant positive correlation was detected between side differences in NR and NOSE scores (R = .762, P = .028). A significant negative correlation was found between the per cent of unilateral airflow and NR (R = -.524, P = .037). Conclusions Our results demonstrated that side asymmetry in NR could explain differences in NAO severity related to the NSD type.",
publisher = "Wiley, Hoboken",
journal = "Clinical Otolaryngology",
title = "Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study",
volume = "45",
number = "5",
pages = "718-724",
doi = "10.1111/coa.13563"
}

Janović, N., Cocić, A., Stamenić, M., Janović, A.,& Đurić, M.. (2020). Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study. in Clinical Otolaryngology
Wiley, Hoboken., 45(5), 718-724.
https://doi.org/10.1111/coa.13563

Janović N, Cocić A, Stamenić M, Janović A, Đurić M. Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study. in Clinical Otolaryngology. 2020;45(5):718-724.
doi:10.1111/coa.13563 .

Janović, Nataša, Cocić, Aleksandar, Stamenić, Mirjana, Janović, Aleksa, Đurić, Marija, "Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study" in Clinical Otolaryngology, 45, no. 5 (2020):718-724,
https://doi.org/10.1111/coa.13563 . .

TY  - JOUR
AU  - Janović, Nataša
AU  - Cocić, Aleksandar
AU  - Stamenić, Mirjana
AU  - Janović, Aleksa
AU  - Đurić, Marija
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2527
AB  - Objectives The objective of this study was to investigate the relationship between side asymmetry in nasal resistance (NR) and severity of the nasal airway obstruction (NAO) in patients with different types of nasal septal deformity (NSD). Design Computational fluid dynamics (CFD) study. Setting The study was conducted in a tertiary medical centre. Participants The study included 232 patients, who were referred to the CT examination of the paranasal sinuses. Exclusion criteria were sinonasal and respiratory diseases that may interfere with the nasal obstruction. The presence and the type of NSD were recorded according to the Mladina's classification. Main outcome measures The presence and severity of NAO in each patient were assessed by NOSE questionnaire. Eight computational models of the nasal cavity were created from CT scans. Models represented seven Mladina's NSD types and a straight septum of a symptomless patient. CFD calculated airflow partitioning and NR for each nasal passage. Side differences in NR were calculated by the equation increment NR = NRleft - NRright. The relationship between NOSE scores, airflow partitioning and side differences in NR was explored using Spearman's correlation analysis. Results Mladina's types of NSD showed differences in airflow partitioning and the degree of side asymmetry in NR. A significant positive correlation was detected between side differences in NR and NOSE scores (R = .762, P = .028). A significant negative correlation was found between the per cent of unilateral airflow and NR (R = -.524, P = .037). Conclusions Our results demonstrated that side asymmetry in NR could explain differences in NAO severity related to the NSD type.
PB  - Wiley, Hoboken
T2  - Clinical Otolaryngology
T1  - Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study
VL  - 45
IS  - 5
SP  - 718
EP  - 724
DO  - 10.1111/coa.13563
ER  - 

@article{
author = "Janović, Nataša and Cocić, Aleksandar and Stamenić, Mirjana and Janović, Aleksa and Đurić, Marija",
year = "2020",
abstract = "Objectives The objective of this study was to investigate the relationship between side asymmetry in nasal resistance (NR) and severity of the nasal airway obstruction (NAO) in patients with different types of nasal septal deformity (NSD). Design Computational fluid dynamics (CFD) study. Setting The study was conducted in a tertiary medical centre. Participants The study included 232 patients, who were referred to the CT examination of the paranasal sinuses. Exclusion criteria were sinonasal and respiratory diseases that may interfere with the nasal obstruction. The presence and the type of NSD were recorded according to the Mladina's classification. Main outcome measures The presence and severity of NAO in each patient were assessed by NOSE questionnaire. Eight computational models of the nasal cavity were created from CT scans. Models represented seven Mladina's NSD types and a straight septum of a symptomless patient. CFD calculated airflow partitioning and NR for each nasal passage. Side differences in NR were calculated by the equation increment NR = NRleft - NRright. The relationship between NOSE scores, airflow partitioning and side differences in NR was explored using Spearman's correlation analysis. Results Mladina's types of NSD showed differences in airflow partitioning and the degree of side asymmetry in NR. A significant positive correlation was detected between side differences in NR and NOSE scores (R = .762, P = .028). A significant negative correlation was found between the per cent of unilateral airflow and NR (R = -.524, P = .037). Conclusions Our results demonstrated that side asymmetry in NR could explain differences in NAO severity related to the NSD type.",
publisher = "Wiley, Hoboken",
journal = "Clinical Otolaryngology",
title = "Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study",
volume = "45",
number = "5",
pages = "718-724",
doi = "10.1111/coa.13563"
}

Janović, N., Cocić, A., Stamenić, M., Janović, A.,& Đurić, M.. (2020). Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study. in Clinical Otolaryngology
Wiley, Hoboken., 45(5), 718-724.
https://doi.org/10.1111/coa.13563

Janović N, Cocić A, Stamenić M, Janović A, Đurić M. Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study. in Clinical Otolaryngology. 2020;45(5):718-724.
doi:10.1111/coa.13563 .

Janović, Nataša, Cocić, Aleksandar, Stamenić, Mirjana, Janović, Aleksa, Đurić, Marija, "Side asymmetry in nasal resistance correlate with nasal obstruction severity in patients with septal deformities: Computational fluid dynamics study" in Clinical Otolaryngology, 45, no. 5 (2020):718-724,
https://doi.org/10.1111/coa.13563 . .

TY  - JOUR
AU  - Bracanović, Đurđa
AU  - Vuković, Vesna
AU  - Janović, Aleksa
AU  - Radosavljević, Davorin
AU  - Rakočević, Zoran
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2224
AB  - Background: Secondary tumours of the hyoid bone and thyroid cartilage are extremely rare. In this paper, we present a case of the hyoid bone and thyroid cartilage metastases in a patient treated for sigmoid colon adenocarcinoma. Case Report: Four years after sigmoid colon adenocarcinoma was diagnosed and treated with surgery and chemotherapy, the patient developed bone metastases in the left sacroiliac joint and right proximal humerus. Although the patient did not complain of any related symptoms, in a bone scintigraphy the accumulation of Technetium-99m was incidentally detected in the two sites of the anterior neck. On ultrasound examination there were two hyperechoic and heterogeneous masses with calcifications placed in front of the hyoid bone and thyroid cartilage. Computerized tomography demonstrated massive hyoid bone and thyroid cartilage destruction. Conclusion: In patients with progressive sigmoid colon adenocarcinoma, destruction of the hyoid bone and thyroid cartilage could be suspected for metastases.
PB  - Galenos Yayincilik, Findikzade
T2  - Balkan Medical Journal
T1  - Hyoid Bone and Thyroid Cartilage Metastases from Sigmoid Colon Adenocarcinoma: A Case Report
VL  - 34
IS  - 3
SP  - 278
EP  - 280
DO  - 10.4274/balkanmedj.2015.1817
ER  - 

@article{
author = "Bracanović, Đurđa and Vuković, Vesna and Janović, Aleksa and Radosavljević, Davorin and Rakočević, Zoran",
year = "2017",
abstract = "Background: Secondary tumours of the hyoid bone and thyroid cartilage are extremely rare. In this paper, we present a case of the hyoid bone and thyroid cartilage metastases in a patient treated for sigmoid colon adenocarcinoma. Case Report: Four years after sigmoid colon adenocarcinoma was diagnosed and treated with surgery and chemotherapy, the patient developed bone metastases in the left sacroiliac joint and right proximal humerus. Although the patient did not complain of any related symptoms, in a bone scintigraphy the accumulation of Technetium-99m was incidentally detected in the two sites of the anterior neck. On ultrasound examination there were two hyperechoic and heterogeneous masses with calcifications placed in front of the hyoid bone and thyroid cartilage. Computerized tomography demonstrated massive hyoid bone and thyroid cartilage destruction. Conclusion: In patients with progressive sigmoid colon adenocarcinoma, destruction of the hyoid bone and thyroid cartilage could be suspected for metastases.",
publisher = "Galenos Yayincilik, Findikzade",
journal = "Balkan Medical Journal",
title = "Hyoid Bone and Thyroid Cartilage Metastases from Sigmoid Colon Adenocarcinoma: A Case Report",
volume = "34",
number = "3",
pages = "278-280",
doi = "10.4274/balkanmedj.2015.1817"
}

Bracanović, Đ., Vuković, V., Janović, A., Radosavljević, D.,& Rakočević, Z.. (2017). Hyoid Bone and Thyroid Cartilage Metastases from Sigmoid Colon Adenocarcinoma: A Case Report. in Balkan Medical Journal
Galenos Yayincilik, Findikzade., 34(3), 278-280.
https://doi.org/10.4274/balkanmedj.2015.1817

Bracanović Đ, Vuković V, Janović A, Radosavljević D, Rakočević Z. Hyoid Bone and Thyroid Cartilage Metastases from Sigmoid Colon Adenocarcinoma: A Case Report. in Balkan Medical Journal. 2017;34(3):278-280.
doi:10.4274/balkanmedj.2015.1817 .

Bracanović, Đurđa, Vuković, Vesna, Janović, Aleksa, Radosavljević, Davorin, Rakočević, Zoran, "Hyoid Bone and Thyroid Cartilage Metastases from Sigmoid Colon Adenocarcinoma: A Case Report" in Balkan Medical Journal, 34, no. 3 (2017):278-280,
https://doi.org/10.4274/balkanmedj.2015.1817 . .

TY  - CONF
AU  - Barac, Aleksandra
AU  - Pekmezović, Marina
AU  - Rakočević, Zoran
AU  - Janović, Aleksa
AU  - Bracanović, Đurđa
AU  - Antić, Svetlana
AU  - Stevanović, G.
AU  - Tomić-Spirić, Vesna
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2221
PB  - Wiley, Hoboken
C3  - Allergy
T1  - Are there any specific signs of allergic fungal rhinosinusitis visible by computed tomography scan?
VL  - 72
SP  - 206
EP  - 206
UR  - https://hdl.handle.net/21.15107/rcub_smile_2221
ER  - 

@conference{
author = "Barac, Aleksandra and Pekmezović, Marina and Rakočević, Zoran and Janović, Aleksa and Bracanović, Đurđa and Antić, Svetlana and Stevanović, G. and Tomić-Spirić, Vesna",
year = "2017",
publisher = "Wiley, Hoboken",
journal = "Allergy",
title = "Are there any specific signs of allergic fungal rhinosinusitis visible by computed tomography scan?",
volume = "72",
pages = "206-206",
url = "https://hdl.handle.net/21.15107/rcub_smile_2221"
}

Barac, A., Pekmezović, M., Rakočević, Z., Janović, A., Bracanović, Đ., Antić, S., Stevanović, G.,& Tomić-Spirić, V.. (2017). Are there any specific signs of allergic fungal rhinosinusitis visible by computed tomography scan?. in Allergy
Wiley, Hoboken., 72, 206-206.
https://hdl.handle.net/21.15107/rcub_smile_2221

Barac A, Pekmezović M, Rakočević Z, Janović A, Bracanović Đ, Antić S, Stevanović G, Tomić-Spirić V. Are there any specific signs of allergic fungal rhinosinusitis visible by computed tomography scan?. in Allergy. 2017;72:206-206.
https://hdl.handle.net/21.15107/rcub_smile_2221 .

Barac, Aleksandra, Pekmezović, Marina, Rakočević, Zoran, Janović, Aleksa, Bracanović, Đurđa, Antić, Svetlana, Stevanović, G., Tomić-Spirić, Vesna, "Are there any specific signs of allergic fungal rhinosinusitis visible by computed tomography scan?" in Allergy, 72 (2017):206-206,
https://hdl.handle.net/21.15107/rcub_smile_2221 .

TY  - JOUR
AU  - Pajić, Srbislav
AU  - Antić, Svetlana
AU  - Vukicević, Arso M.
AU  - Đorđević, Nenad
AU  - Jovicić, Gordana
AU  - Savić, Živorad
AU  - Saveljić, Igor
AU  - Janović, Aleksa
AU  - Pešić, Zoran
AU  - Đurić, Marija
AU  - Filipović, Nenad
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2215
AB  - Anatomy of frontal sinuses varies individually, from differences in volume and shape to a rare case when the sinuses are absent. However, there are scarce data related to influence of these variations on impact generated fracture pattern. Therefore, the aim of this study was to analyse the influence of frontal sinus volume on the stress distribution and fracture pattern in the frontal region. The study included four representative Finite Element models of the skull. Reference model was built on the basis of computed tomography scans of a human head with normally developed frontal sinuses. By modifying the reference model, three additional models were generated: a model without sinuses, with hypoplasic, and with hyperplasic sinuses. A 7.7 kN force was applied perpendicularly to the forehead of each model, in order to simulate a frontal impact. The results demonstrated that the distribution of impact stress in frontal region depends on the frontal sinus volume. The anterior sinus wall showed the highest fragility in case with hyperplasic sinuses, whereas posterior wall/inner plate showed more fragility in cases with hypoplasic and undeveloped sinuses. Well-developed frontal sinusesmight, through absorption of the impact energy by anterior wall, protect the posterior wall and intracranial contents.
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Physiology
T1  - Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study
VL  - 8
DO  - 10.3389/fphys.2017.00493
ER  - 

@article{
author = "Pajić, Srbislav and Antić, Svetlana and Vukicević, Arso M. and Đorđević, Nenad and Jovicić, Gordana and Savić, Živorad and Saveljić, Igor and Janović, Aleksa and Pešić, Zoran and Đurić, Marija and Filipović, Nenad",
year = "2017",
abstract = "Anatomy of frontal sinuses varies individually, from differences in volume and shape to a rare case when the sinuses are absent. However, there are scarce data related to influence of these variations on impact generated fracture pattern. Therefore, the aim of this study was to analyse the influence of frontal sinus volume on the stress distribution and fracture pattern in the frontal region. The study included four representative Finite Element models of the skull. Reference model was built on the basis of computed tomography scans of a human head with normally developed frontal sinuses. By modifying the reference model, three additional models were generated: a model without sinuses, with hypoplasic, and with hyperplasic sinuses. A 7.7 kN force was applied perpendicularly to the forehead of each model, in order to simulate a frontal impact. The results demonstrated that the distribution of impact stress in frontal region depends on the frontal sinus volume. The anterior sinus wall showed the highest fragility in case with hyperplasic sinuses, whereas posterior wall/inner plate showed more fragility in cases with hypoplasic and undeveloped sinuses. Well-developed frontal sinusesmight, through absorption of the impact energy by anterior wall, protect the posterior wall and intracranial contents.",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Physiology",
title = "Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study",
volume = "8",
doi = "10.3389/fphys.2017.00493"
}

Pajić, S., Antić, S., Vukicević, A. M., Đorđević, N., Jovicić, G., Savić, Ž., Saveljić, I., Janović, A., Pešić, Z., Đurić, M.,& Filipović, N.. (2017). Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study. in Frontiers in Physiology
Frontiers Media Sa, Lausanne., 8.
https://doi.org/10.3389/fphys.2017.00493

Pajić S, Antić S, Vukicević AM, Đorđević N, Jovicić G, Savić Ž, Saveljić I, Janović A, Pešić Z, Đurić M, Filipović N. Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study. in Frontiers in Physiology. 2017;8.
doi:10.3389/fphys.2017.00493 .

Pajić, Srbislav, Antić, Svetlana, Vukicević, Arso M., Đorđević, Nenad, Jovicić, Gordana, Savić, Živorad, Saveljić, Igor, Janović, Aleksa, Pešić, Zoran, Đurić, Marija, Filipović, Nenad, "Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study" in Frontiers in Physiology, 8 (2017),
https://doi.org/10.3389/fphys.2017.00493 . .

TY  - JOUR
AU  - Janović, Aleksa
AU  - Milovanović, Petar
AU  - Hahn, Michael
AU  - Rakočević, Zoran
AU  - Amling, Michael
AU  - Busse, Bjoern
AU  - Dimitrijević, Milovan
AU  - Đurić, Marija
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2183
AB  - Background/AimLe Fort lines have traditionally been considered as zones of weakness in the mid-facial skeleton although the structural basis of increased bone fragility at these sites has not yet been investigated. Considering recent findings of occlusal loading-related regional heterogeneity in the mid-facial bone micro-architecture, the aim of this study was to explore whether such heterogeneity in cortical and cancellous bone micro-architecture may contribute to increased fragility at Le Fort fracture sites. Materials and MethodsTwenty-five cortical and thirteen cancellous bone specimens were harvested from a dry skull and analyzed by micro-CT. Specimens were classified into Le Fort or Non-Le Fort groups based on their location in the mid-facial skeleton. ResultsCortical bone along Le Fort lines showed tendencies toward lower thickness (1.50.63 vs 1.75 +/- 0.79; P=.39) and greater porosity (11.48 +/- 5.67 vs 10.28 +/- 5.28; P=.59). A significant difference was detected in the trabecular degree of anisotropy which was higher in cancellous bone from Le Fort fracture sites (2.14 +/- 0.69 vs 1.58 +/- 0.34; P=.02). ConclusionsRegional heterogeneity in cortical bone micro-architecture could not fully explain increased fragility of the mid-facial skeleton at the Le Fort lines. However, regional differences in trabecular bone anisotropy may contribute to increased bone fragility.
PB  - Wiley, Hoboken
T2  - Dental Traumatology
T1  - Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines
VL  - 33
IS  - 4
SP  - 300
EP  - 306
DO  - 10.1111/edt.12333
ER  - 

@article{
author = "Janović, Aleksa and Milovanović, Petar and Hahn, Michael and Rakočević, Zoran and Amling, Michael and Busse, Bjoern and Dimitrijević, Milovan and Đurić, Marija",
year = "2017",
abstract = "Background/AimLe Fort lines have traditionally been considered as zones of weakness in the mid-facial skeleton although the structural basis of increased bone fragility at these sites has not yet been investigated. Considering recent findings of occlusal loading-related regional heterogeneity in the mid-facial bone micro-architecture, the aim of this study was to explore whether such heterogeneity in cortical and cancellous bone micro-architecture may contribute to increased fragility at Le Fort fracture sites. Materials and MethodsTwenty-five cortical and thirteen cancellous bone specimens were harvested from a dry skull and analyzed by micro-CT. Specimens were classified into Le Fort or Non-Le Fort groups based on their location in the mid-facial skeleton. ResultsCortical bone along Le Fort lines showed tendencies toward lower thickness (1.50.63 vs 1.75 +/- 0.79; P=.39) and greater porosity (11.48 +/- 5.67 vs 10.28 +/- 5.28; P=.59). A significant difference was detected in the trabecular degree of anisotropy which was higher in cancellous bone from Le Fort fracture sites (2.14 +/- 0.69 vs 1.58 +/- 0.34; P=.02). ConclusionsRegional heterogeneity in cortical bone micro-architecture could not fully explain increased fragility of the mid-facial skeleton at the Le Fort lines. However, regional differences in trabecular bone anisotropy may contribute to increased bone fragility.",
publisher = "Wiley, Hoboken",
journal = "Dental Traumatology",
title = "Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines",
volume = "33",
number = "4",
pages = "300-306",
doi = "10.1111/edt.12333"
}

Janović, A., Milovanović, P., Hahn, M., Rakočević, Z., Amling, M., Busse, B., Dimitrijević, M.,& Đurić, M.. (2017). Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines. in Dental Traumatology
Wiley, Hoboken., 33(4), 300-306.
https://doi.org/10.1111/edt.12333

Janović A, Milovanović P, Hahn M, Rakočević Z, Amling M, Busse B, Dimitrijević M, Đurić M. Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines. in Dental Traumatology. 2017;33(4):300-306.
doi:10.1111/edt.12333 .

Janović, Aleksa, Milovanović, Petar, Hahn, Michael, Rakočević, Zoran, Amling, Michael, Busse, Bjoern, Dimitrijević, Milovan, Đurić, Marija, "Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines" in Dental Traumatology, 33, no. 4 (2017):300-306,
https://doi.org/10.1111/edt.12333 . .

TY  - CONF
AU  - Barac, Aleksandra
AU  - Pekmezović, Marina
AU  - Rajković, Katarina
AU  - Rakočević, Zoran
AU  - Janović, Aleksa
AU  - Bracanović, Đurđa
AU  - Stošović, Rajica
AU  - Spirić, Tomić, V
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2085
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Mathematical modeling and image analysis: possible clinical application in practice as a predictor of fungal rhinosinusitis
VL  - 71
SP  - 426
EP  - 426
UR  - https://hdl.handle.net/21.15107/rcub_smile_2085
ER  - 

@conference{
author = "Barac, Aleksandra and Pekmezović, Marina and Rajković, Katarina and Rakočević, Zoran and Janović, Aleksa and Bracanović, Đurđa and Stošović, Rajica and Spirić, Tomić, V",
year = "2016",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Mathematical modeling and image analysis: possible clinical application in practice as a predictor of fungal rhinosinusitis",
volume = "71",
pages = "426-426",
url = "https://hdl.handle.net/21.15107/rcub_smile_2085"
}

Barac, A., Pekmezović, M., Rajković, K., Rakočević, Z., Janović, A., Bracanović, Đ., Stošović, R.,& Spirić, T. V.. (2016). Mathematical modeling and image analysis: possible clinical application in practice as a predictor of fungal rhinosinusitis. in Allergy
Wiley-Blackwell, Hoboken., 71, 426-426.
https://hdl.handle.net/21.15107/rcub_smile_2085

Barac A, Pekmezović M, Rajković K, Rakočević Z, Janović A, Bracanović Đ, Stošović R, Spirić TV. Mathematical modeling and image analysis: possible clinical application in practice as a predictor of fungal rhinosinusitis. in Allergy. 2016;71:426-426.
https://hdl.handle.net/21.15107/rcub_smile_2085 .

Barac, Aleksandra, Pekmezović, Marina, Rajković, Katarina, Rakočević, Zoran, Janović, Aleksa, Bracanović, Đurđa, Stošović, Rajica, Spirić, Tomić, V, "Mathematical modeling and image analysis: possible clinical application in practice as a predictor of fungal rhinosinusitis" in Allergy, 71 (2016):426-426,
https://hdl.handle.net/21.15107/rcub_smile_2085 .

TY  - JOUR
AU  - Janović, Aleksa
AU  - Saveljić, Igor
AU  - Vukicević, Arso M.
AU  - Nikolić, Dalibor
AU  - Rakočević, Zoran
AU  - Jovicić, Gordana
AU  - Filipović, Nenad
AU  - Đurić, Marija
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2050
AB  - Understanding of the occlusal load distribution through the mid-facial skeleton in natural dentition is essential because alterations in magnitude and/or direction of occlusal forces may cause remarkable changes in cortical and trabecular bone structure. Previous analyses by strain gauge technique, photoelastic and, more recently, finite element (FE) methods provided no direct evidence for occlusal load distribution through the cortical and trabecular bone compartments individually. Therefore, we developed an improved three-dimensional FE model of the human skull in order to clarify the distribution of occlusal forces through the cortical and trabecular bone during habitual masticatory activities. Particular focus was placed on the load transfer through the anterior and posterior maxilla. The results were presented in von Mises stress (VMS) and the maximum principal stress, and compared to the reported FE and strain gauge data. Our qualitative stress analysis indicates that occlusal forces distribute through the mid-facial skeleton along five vertical and two horizontal buttresses. We demonstrated that cortical bone has a priority in the transfer of occlusal load in the anterior maxilla, whereas both cortical and trabecular bone in the posterior maxilla are equally involved in performing this task Observed site dependence of the occlusal load distribution may help clinicians in creating strategies for implantology and orthodontic treatments. Additionally, the magnitude of VMS in our model was significantly lower in comparison to previous FE models composed only of cortical bone. This finding suggests that both cortical and trabecular bone should be modeled whenever stress will be quantitatively analyzed.
PB  - Elsevier Gmbh, Munich
T2  - Annals of Anatomy - Anatomischer Anzeiger
T1  - Occlusal load distribution through the cortical and trabecular bone of the human mid-facial skeleton in natural dentition: A three-dimensional finite element study
VL  - 197
SP  - 16
EP  - 23
DO  - 10.1016/j.aanat.2014.09.002
ER  - 

@article{
author = "Janović, Aleksa and Saveljić, Igor and Vukicević, Arso M. and Nikolić, Dalibor and Rakočević, Zoran and Jovicić, Gordana and Filipović, Nenad and Đurić, Marija",
year = "2015",
abstract = "Understanding of the occlusal load distribution through the mid-facial skeleton in natural dentition is essential because alterations in magnitude and/or direction of occlusal forces may cause remarkable changes in cortical and trabecular bone structure. Previous analyses by strain gauge technique, photoelastic and, more recently, finite element (FE) methods provided no direct evidence for occlusal load distribution through the cortical and trabecular bone compartments individually. Therefore, we developed an improved three-dimensional FE model of the human skull in order to clarify the distribution of occlusal forces through the cortical and trabecular bone during habitual masticatory activities. Particular focus was placed on the load transfer through the anterior and posterior maxilla. The results were presented in von Mises stress (VMS) and the maximum principal stress, and compared to the reported FE and strain gauge data. Our qualitative stress analysis indicates that occlusal forces distribute through the mid-facial skeleton along five vertical and two horizontal buttresses. We demonstrated that cortical bone has a priority in the transfer of occlusal load in the anterior maxilla, whereas both cortical and trabecular bone in the posterior maxilla are equally involved in performing this task Observed site dependence of the occlusal load distribution may help clinicians in creating strategies for implantology and orthodontic treatments. Additionally, the magnitude of VMS in our model was significantly lower in comparison to previous FE models composed only of cortical bone. This finding suggests that both cortical and trabecular bone should be modeled whenever stress will be quantitatively analyzed.",
publisher = "Elsevier Gmbh, Munich",
journal = "Annals of Anatomy - Anatomischer Anzeiger",
title = "Occlusal load distribution through the cortical and trabecular bone of the human mid-facial skeleton in natural dentition: A three-dimensional finite element study",
volume = "197",
pages = "16-23",
doi = "10.1016/j.aanat.2014.09.002"
}

Janović, A., Saveljić, I., Vukicević, A. M., Nikolić, D., Rakočević, Z., Jovicić, G., Filipović, N.,& Đurić, M.. (2015). Occlusal load distribution through the cortical and trabecular bone of the human mid-facial skeleton in natural dentition: A three-dimensional finite element study. in Annals of Anatomy - Anatomischer Anzeiger
Elsevier Gmbh, Munich., 197, 16-23.
https://doi.org/10.1016/j.aanat.2014.09.002

Janović A, Saveljić I, Vukicević AM, Nikolić D, Rakočević Z, Jovicić G, Filipović N, Đurić M. Occlusal load distribution through the cortical and trabecular bone of the human mid-facial skeleton in natural dentition: A three-dimensional finite element study. in Annals of Anatomy - Anatomischer Anzeiger. 2015;197:16-23.
doi:10.1016/j.aanat.2014.09.002 .

Janović, Aleksa, Saveljić, Igor, Vukicević, Arso M., Nikolić, Dalibor, Rakočević, Zoran, Jovicić, Gordana, Filipović, Nenad, Đurić, Marija, "Occlusal load distribution through the cortical and trabecular bone of the human mid-facial skeleton in natural dentition: A three-dimensional finite element study" in Annals of Anatomy - Anatomischer Anzeiger, 197 (2015):16-23,
https://doi.org/10.1016/j.aanat.2014.09.002 . .

TY  - JOUR
AU  - Janović, Aleksa
AU  - Milovanović, Petar
AU  - Saveljić, Igor
AU  - Nikolić, Dalibor
AU  - Hahn, Michael
AU  - Rakočević, Zoran
AU  - Filipović, Nenad
AU  - Amling, Michael
AU  - Busse, Bjoern
AU  - Đurić, Marija
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1881
AB  - Although the concept of the occlusal load transfer through the facial skeleton along the buttresses has been extensively studied, there has been no study to link microarchitecture of the mid-facial bones to the occlusal load distribution. The aim of this study was to analyze micro-structural properties of the mid-facial bones in relation to occlusal stress. The study was performed by combining the three-dimensional finite element analysis (3D FEA) and micro-computed tomography analysis (micro-CT). Clenching was simulated on the computer model of the adult male human skull which was also used as a source of bone specimens. After the PEA was run, stress was measured at the specific sites in cortical shell and trabecular bone of the model along and between the buttresses. From the corresponding sites on the skull, twenty-five cortical and thirteen cancellous bone specimens were harvested. The specimens were classified into high stress or low stress group based on the stress levels measured via the FEA. Micro-architecture of each specimen was assessed by micro-CT. In the high stress group, cortical bone showed a tendency toward greater thickness and density, lower porosity, and greater pore separation. Stress-related differences in microstructure between the groups were more pronounced in trabecular bone, which showed significantly greater bone volume fraction (BV/TV) and trabecular thickness (Tb.Th) in the high stress group. Our results suggest that the mid-facial bones in the adult dentate male skull exhibit regional variations in cortical and trabecular bone micro-architecture that could be a consequence of different occlusal
PB  - Elsevier Science Inc, New York
T2  - Bone
T1  - Microstructural properties of the mid-facial bones in relation to the distribution of occlusal loading
VL  - 68
SP  - 108
EP  - 114
DO  - 10.1016/j.bone.2014.07.032
ER  - 

@article{
author = "Janović, Aleksa and Milovanović, Petar and Saveljić, Igor and Nikolić, Dalibor and Hahn, Michael and Rakočević, Zoran and Filipović, Nenad and Amling, Michael and Busse, Bjoern and Đurić, Marija",
year = "2014",
abstract = "Although the concept of the occlusal load transfer through the facial skeleton along the buttresses has been extensively studied, there has been no study to link microarchitecture of the mid-facial bones to the occlusal load distribution. The aim of this study was to analyze micro-structural properties of the mid-facial bones in relation to occlusal stress. The study was performed by combining the three-dimensional finite element analysis (3D FEA) and micro-computed tomography analysis (micro-CT). Clenching was simulated on the computer model of the adult male human skull which was also used as a source of bone specimens. After the PEA was run, stress was measured at the specific sites in cortical shell and trabecular bone of the model along and between the buttresses. From the corresponding sites on the skull, twenty-five cortical and thirteen cancellous bone specimens were harvested. The specimens were classified into high stress or low stress group based on the stress levels measured via the FEA. Micro-architecture of each specimen was assessed by micro-CT. In the high stress group, cortical bone showed a tendency toward greater thickness and density, lower porosity, and greater pore separation. Stress-related differences in microstructure between the groups were more pronounced in trabecular bone, which showed significantly greater bone volume fraction (BV/TV) and trabecular thickness (Tb.Th) in the high stress group. Our results suggest that the mid-facial bones in the adult dentate male skull exhibit regional variations in cortical and trabecular bone micro-architecture that could be a consequence of different occlusal",
publisher = "Elsevier Science Inc, New York",
journal = "Bone",
title = "Microstructural properties of the mid-facial bones in relation to the distribution of occlusal loading",
volume = "68",
pages = "108-114",
doi = "10.1016/j.bone.2014.07.032"
}

Janović, A., Milovanović, P., Saveljić, I., Nikolić, D., Hahn, M., Rakočević, Z., Filipović, N., Amling, M., Busse, B.,& Đurić, M.. (2014). Microstructural properties of the mid-facial bones in relation to the distribution of occlusal loading. in Bone
Elsevier Science Inc, New York., 68, 108-114.
https://doi.org/10.1016/j.bone.2014.07.032

Janović A, Milovanović P, Saveljić I, Nikolić D, Hahn M, Rakočević Z, Filipović N, Amling M, Busse B, Đurić M. Microstructural properties of the mid-facial bones in relation to the distribution of occlusal loading. in Bone. 2014;68:108-114.
doi:10.1016/j.bone.2014.07.032 .

Janović, Aleksa, Milovanović, Petar, Saveljić, Igor, Nikolić, Dalibor, Hahn, Michael, Rakočević, Zoran, Filipović, Nenad, Amling, Michael, Busse, Bjoern, Đurić, Marija, "Microstructural properties of the mid-facial bones in relation to the distribution of occlusal loading" in Bone, 68 (2014):108-114,
https://doi.org/10.1016/j.bone.2014.07.032 . .

TY  - JOUR
AU  - Janović, Aleksa
AU  - Antić, Svetlana
AU  - Rakočević, Zoran
AU  - Đurić, Marija
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1846
AB  - Background: Developmental disturbances of the paranasal sinuses are proposed as the cause of osteoma. We examined whether such disturbances may result in the frequent presence of anatomical variations of the paranasal sinuses in patients with osteoma. Methodology/Principal: The study was performed retrospectively on 2,820 patients subjected to CT examination during 2005 - 2011. Demographic and CT characteristics of osteoma, and associated pathological findings were evaluated for 104 patients with diagnosed osteoma. The presence of anatomical variations was assessed for 51 osteoma patients with a complete medical history, and for 1,233 patients from a control group. Results: The prevalence of osteomas was found to be 3.69%, with male to female ratio 1.08:1. The frontal sinus was most commonly affected, The presence of anatomical variations was more frequent in patients with osteoma than in controls, with significant differences confirmed for the sphenomaxillary plate, infraorbital cell, and crista galli pneumatization. Conclusions: The paranasal sinus osteoma is associated with higher prevalence of anatomical variations, This can be explained either by the stronger influence of genetic and/or environmental factors on the development of the paranasal sinuses in patients with osteoma, or by their higher susceptibility to abovementioned factors.
PB  - Int Rhinologic Soc, Utrecht
T2  - Rhinology
T1  - Paranasal sinus osteoma: is there any association with anatomical variations?
VL  - 51
IS  - 1
SP  - 54
EP  - 60
DO  - 10.4193/Rhin12.130
ER  - 

@article{
author = "Janović, Aleksa and Antić, Svetlana and Rakočević, Zoran and Đurić, Marija",
year = "2013",
abstract = "Background: Developmental disturbances of the paranasal sinuses are proposed as the cause of osteoma. We examined whether such disturbances may result in the frequent presence of anatomical variations of the paranasal sinuses in patients with osteoma. Methodology/Principal: The study was performed retrospectively on 2,820 patients subjected to CT examination during 2005 - 2011. Demographic and CT characteristics of osteoma, and associated pathological findings were evaluated for 104 patients with diagnosed osteoma. The presence of anatomical variations was assessed for 51 osteoma patients with a complete medical history, and for 1,233 patients from a control group. Results: The prevalence of osteomas was found to be 3.69%, with male to female ratio 1.08:1. The frontal sinus was most commonly affected, The presence of anatomical variations was more frequent in patients with osteoma than in controls, with significant differences confirmed for the sphenomaxillary plate, infraorbital cell, and crista galli pneumatization. Conclusions: The paranasal sinus osteoma is associated with higher prevalence of anatomical variations, This can be explained either by the stronger influence of genetic and/or environmental factors on the development of the paranasal sinuses in patients with osteoma, or by their higher susceptibility to abovementioned factors.",
publisher = "Int Rhinologic Soc, Utrecht",
journal = "Rhinology",
title = "Paranasal sinus osteoma: is there any association with anatomical variations?",
volume = "51",
number = "1",
pages = "54-60",
doi = "10.4193/Rhin12.130"
}

Janović, A., Antić, S., Rakočević, Z.,& Đurić, M.. (2013). Paranasal sinus osteoma: is there any association with anatomical variations?. in Rhinology
Int Rhinologic Soc, Utrecht., 51(1), 54-60.
https://doi.org/10.4193/Rhin12.130

Janović A, Antić S, Rakočević Z, Đurić M. Paranasal sinus osteoma: is there any association with anatomical variations?. in Rhinology. 2013;51(1):54-60.
doi:10.4193/Rhin12.130 .

Janović, Aleksa, Antić, Svetlana, Rakočević, Zoran, Đurić, Marija, "Paranasal sinus osteoma: is there any association with anatomical variations?" in Rhinology, 51, no. 1 (2013):54-60,
https://doi.org/10.4193/Rhin12.130 . .