TY  - JOUR
AU  - Dželetović, Bojan
AU  - Aleksić, Nikola
AU  - Radak, Đorđe
AU  - Stratimirović, Đorđe
AU  - Đukić, Ljiljana
AU  - Stojić, Dragica
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2499
AB  - Introduction: Age-related changes of dental pulp tissue and atherosclerosis of carotid arteries as its feeding arteries could influence the functionality of pulpal circulation. The objective of our study was to evaluate the effect of aging (physiological process) and carotid bifurcation atherosclerosis (pathologic process) on the pulpal microcirculatory system using multifractal analysis of the laser Doppler flowmetry signal. Methods: Three groups of 10 subjects were enrolled in the study: the young group (healthy subjects, 20-25 years), the middle-aged group (healthy subjects, 50-60 years), and the clinical group (subjects with carotid bifurcation atherosclerosis, 50-60 years). Pulpal blood flow (PBF) signals recorded by laser Doppler flowmetry were assessed by multifractal analysis that estimates Holder exponents of the signal. PBF levels, the average mean values, and the range of Holder exponents were obtained. Results: PBF levels were significantly higher in the young group compared with the middle-aged and clinical groups, and the difference between the middle-aged and clinical groups was not statistically significant. The range of the Holder exponents was narrower in the middle-aged and clinical groups than in the young group and narrower in the clinical group than in the middle-aged group. The average mean value of Holder exponents was significantly higher in the young group than in the middle-aged and clinical groups, whereas there was no significant difference between the middle-aged and clinical groups. Conclusions: Our study investigating the multifractality of the PBF signal showed that the aging process and carotid atherosclerosis could affect the complex structure of PBF oscillations and contribute to a better understanding of pulpal hemodynamics.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - Effect of Aging and Carotid Atherosclerosis on Multifractality of Dental Pulp Blood Flow Oscillations
VL  - 46
IS  - 3
SP  - 358
EP  - 363
DO  - 10.1016/j.joen.2019.12.008
ER  - 

@article{
author = "Dželetović, Bojan and Aleksić, Nikola and Radak, Đorđe and Stratimirović, Đorđe and Đukić, Ljiljana and Stojić, Dragica",
year = "2020",
abstract = "Introduction: Age-related changes of dental pulp tissue and atherosclerosis of carotid arteries as its feeding arteries could influence the functionality of pulpal circulation. The objective of our study was to evaluate the effect of aging (physiological process) and carotid bifurcation atherosclerosis (pathologic process) on the pulpal microcirculatory system using multifractal analysis of the laser Doppler flowmetry signal. Methods: Three groups of 10 subjects were enrolled in the study: the young group (healthy subjects, 20-25 years), the middle-aged group (healthy subjects, 50-60 years), and the clinical group (subjects with carotid bifurcation atherosclerosis, 50-60 years). Pulpal blood flow (PBF) signals recorded by laser Doppler flowmetry were assessed by multifractal analysis that estimates Holder exponents of the signal. PBF levels, the average mean values, and the range of Holder exponents were obtained. Results: PBF levels were significantly higher in the young group compared with the middle-aged and clinical groups, and the difference between the middle-aged and clinical groups was not statistically significant. The range of the Holder exponents was narrower in the middle-aged and clinical groups than in the young group and narrower in the clinical group than in the middle-aged group. The average mean value of Holder exponents was significantly higher in the young group than in the middle-aged and clinical groups, whereas there was no significant difference between the middle-aged and clinical groups. Conclusions: Our study investigating the multifractality of the PBF signal showed that the aging process and carotid atherosclerosis could affect the complex structure of PBF oscillations and contribute to a better understanding of pulpal hemodynamics.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "Effect of Aging and Carotid Atherosclerosis on Multifractality of Dental Pulp Blood Flow Oscillations",
volume = "46",
number = "3",
pages = "358-363",
doi = "10.1016/j.joen.2019.12.008"
}

Dželetović, B., Aleksić, N., Radak, Đ., Stratimirović, Đ., Đukić, L.,& Stojić, D.. (2020). Effect of Aging and Carotid Atherosclerosis on Multifractality of Dental Pulp Blood Flow Oscillations. in Journal of Endodontics
Elsevier Science Inc, New York., 46(3), 358-363.
https://doi.org/10.1016/j.joen.2019.12.008

Dželetović B, Aleksić N, Radak Đ, Stratimirović Đ, Đukić L, Stojić D. Effect of Aging and Carotid Atherosclerosis on Multifractality of Dental Pulp Blood Flow Oscillations. in Journal of Endodontics. 2020;46(3):358-363.
doi:10.1016/j.joen.2019.12.008 .

Dželetović, Bojan, Aleksić, Nikola, Radak, Đorđe, Stratimirović, Đorđe, Đukić, Ljiljana, Stojić, Dragica, "Effect of Aging and Carotid Atherosclerosis on Multifractality of Dental Pulp Blood Flow Oscillations" in Journal of Endodontics, 46, no. 3 (2020):358-363,
https://doi.org/10.1016/j.joen.2019.12.008 . .

TY  - JOUR
AU  - Dželetović, Bojan
AU  - Aleksić, Nikola
AU  - Grga, Đurica
AU  - Savić-Stanković, Tatjana
AU  - Milanović, Ivana
AU  - Radak, Đorđe
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2059
AB  - Introduction Vascular network of dental pulp is supplied through common and external carotid artery and terminal dental branches that supply each pulp tissue. Age related changes of pulp tissue influence pulpal vascularization as well. The aim of this study was to compare and correlate pulpal and common and external carotid artery blood flow in young and middle age individuals of general population. Material and Methods Two groups of 10 participants were included in the study, young (20-25 years) and middle age (50-55 years) group. Pulpal blood flow (PBF) measurements on intact right and left upper central incisors were performed using laser Doppler flowmetry (LDF) method. Carotid arteries blood flow was assessed using carotid ultrasonography. Results PBF levels were significantly higher in young (3.11±0.67 and 3.46±1.11, right and left upper central incisors, respectively) compared to middle age (1.93±0.47 and 2.30±0.64, right and left upper central incisors, respectively) participants (independent sample t test; p lt 0.05). There was no correlation between common and external carotid artery blood flow and upper central incisors PBF in young as well as middle age participants, for right or left side. Conclusion Absence of correlation between carotid arteries blood flow and PBF suggests that reduced PBF in middle age participants was probably not due to reduced blood supply from carotid arteries but it was result of age related changes at the level of pulpal blood vessels.
AB  - Uvod Vaskularna mreža zubne pulpe dobija dotok krvi preko zajedničke i spoljašnje karotidne arterije i završnih zubnih grana koje snabdevaju svaku pojedinačnu pulpu. Mala fleksibilnost okruženja zubne pulpe pojačava promene vezane za starenje koje utiču na vaskularizaciju pulpe. Cilj ovog rada je bio da se uporedi i utvrdi međusobna povezanost pulpnog i protoka krvi u zajedničkoj i spoljašnjoj karotidnoj arteriji kod mladih i osoba srednje životne dobi opšte populacije. Materijal i metode rada Dve grupe od po 10 ispitanika su učestvovale u studiji: mladi (20-25 godina) i ispitanici srednje životne dobi (50-55 godina). Merenja protoka krvi kroz zubnu pulpu (PBF) na intaktnim desnim i levim gornjim centralnim sekutićima izvedena su metodom laser Dopler floumetrije (LDF). Protok krvi kroz karotidne arterije je procenjivan ultrazvučnim pregledom. Rezultati Nivoi PBF bili su značajno viši kod mladih ispitanika (desni gornji centralni sekutići: 3,11±0,67; levi gornji centralni sekutići: 3,46±1,11) u odnosu na ispitanike srednje dobi (desni gornji centralni sekutići: 1,93±0,47; levi gornji centralni sekutići: 2,30±0,64) (Studentov t-test za nezavisne uzorke, p lt 0,05). Nije bilo korelacije između protoka krvi kroz zajedničke i spoljašnje karotidne arterije i PBF gornjih sekutića kod mladih, niti kod ispitanika srednje dobi, za desnu i levu stranu. Zaključak Nepostojanje veze između protoka krvi kroz karotidne arterije i PBF ukazuje na to da smanjenje PBF kod ispitanika srednje životne dobi verovatno nije posledica smanjenog dotoka krvi iz karotidnih arterija, već rezultat promena u vezi sa starenjem na nivou pulpnih krvnih sudova.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Correlation between pulpal and carotid arteries blood flow in two age groups
T1  - Nivo protoka krvi kroz zubnu pulpu i njegova korelacija s protokom krvi kroz karotidne arterije kod dve starosne grupe opšte populacije
VL  - 62
IS  - 3
SP  - 130
EP  - 136
DO  - 10.1515/sdj-2015-0014
ER  - 

@article{
author = "Dželetović, Bojan and Aleksić, Nikola and Grga, Đurica and Savić-Stanković, Tatjana and Milanović, Ivana and Radak, Đorđe",
year = "2015",
abstract = "Introduction Vascular network of dental pulp is supplied through common and external carotid artery and terminal dental branches that supply each pulp tissue. Age related changes of pulp tissue influence pulpal vascularization as well. The aim of this study was to compare and correlate pulpal and common and external carotid artery blood flow in young and middle age individuals of general population. Material and Methods Two groups of 10 participants were included in the study, young (20-25 years) and middle age (50-55 years) group. Pulpal blood flow (PBF) measurements on intact right and left upper central incisors were performed using laser Doppler flowmetry (LDF) method. Carotid arteries blood flow was assessed using carotid ultrasonography. Results PBF levels were significantly higher in young (3.11±0.67 and 3.46±1.11, right and left upper central incisors, respectively) compared to middle age (1.93±0.47 and 2.30±0.64, right and left upper central incisors, respectively) participants (independent sample t test; p lt 0.05). There was no correlation between common and external carotid artery blood flow and upper central incisors PBF in young as well as middle age participants, for right or left side. Conclusion Absence of correlation between carotid arteries blood flow and PBF suggests that reduced PBF in middle age participants was probably not due to reduced blood supply from carotid arteries but it was result of age related changes at the level of pulpal blood vessels., Uvod Vaskularna mreža zubne pulpe dobija dotok krvi preko zajedničke i spoljašnje karotidne arterije i završnih zubnih grana koje snabdevaju svaku pojedinačnu pulpu. Mala fleksibilnost okruženja zubne pulpe pojačava promene vezane za starenje koje utiču na vaskularizaciju pulpe. Cilj ovog rada je bio da se uporedi i utvrdi međusobna povezanost pulpnog i protoka krvi u zajedničkoj i spoljašnjoj karotidnoj arteriji kod mladih i osoba srednje životne dobi opšte populacije. Materijal i metode rada Dve grupe od po 10 ispitanika su učestvovale u studiji: mladi (20-25 godina) i ispitanici srednje životne dobi (50-55 godina). Merenja protoka krvi kroz zubnu pulpu (PBF) na intaktnim desnim i levim gornjim centralnim sekutićima izvedena su metodom laser Dopler floumetrije (LDF). Protok krvi kroz karotidne arterije je procenjivan ultrazvučnim pregledom. Rezultati Nivoi PBF bili su značajno viši kod mladih ispitanika (desni gornji centralni sekutići: 3,11±0,67; levi gornji centralni sekutići: 3,46±1,11) u odnosu na ispitanike srednje dobi (desni gornji centralni sekutići: 1,93±0,47; levi gornji centralni sekutići: 2,30±0,64) (Studentov t-test za nezavisne uzorke, p lt 0,05). Nije bilo korelacije između protoka krvi kroz zajedničke i spoljašnje karotidne arterije i PBF gornjih sekutića kod mladih, niti kod ispitanika srednje dobi, za desnu i levu stranu. Zaključak Nepostojanje veze između protoka krvi kroz karotidne arterije i PBF ukazuje na to da smanjenje PBF kod ispitanika srednje životne dobi verovatno nije posledica smanjenog dotoka krvi iz karotidnih arterija, već rezultat promena u vezi sa starenjem na nivou pulpnih krvnih sudova.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Correlation between pulpal and carotid arteries blood flow in two age groups, Nivo protoka krvi kroz zubnu pulpu i njegova korelacija s protokom krvi kroz karotidne arterije kod dve starosne grupe opšte populacije",
volume = "62",
number = "3",
pages = "130-136",
doi = "10.1515/sdj-2015-0014"
}

Dželetović, B., Aleksić, N., Grga, Đ., Savić-Stanković, T., Milanović, I.,& Radak, Đ.. (2015). Correlation between pulpal and carotid arteries blood flow in two age groups. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 62(3), 130-136.
https://doi.org/10.1515/sdj-2015-0014

Dželetović B, Aleksić N, Grga Đ, Savić-Stanković T, Milanović I, Radak Đ. Correlation between pulpal and carotid arteries blood flow in two age groups. in Stomatološki glasnik Srbije. 2015;62(3):130-136.
doi:10.1515/sdj-2015-0014 .

Dželetović, Bojan, Aleksić, Nikola, Grga, Đurica, Savić-Stanković, Tatjana, Milanović, Ivana, Radak, Đorđe, "Correlation between pulpal and carotid arteries blood flow in two age groups" in Stomatološki glasnik Srbije, 62, no. 3 (2015):130-136,
https://doi.org/10.1515/sdj-2015-0014 . .

TY  - JOUR
AU  - Grga, Đurica
AU  - Dželetović, Bojan
AU  - Aleksić, Nikola
AU  - Kršljak, Elena
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1551
AB  - Laser Doppler floumetar measure dynamic changes in blood flow to a non invasive way recording movement of blood cells in microcirculation. This method is based on the change in frequency of light with the refusal of blood cells in motion, a phenomenon known as the Doppler effect. Results obtained in orofacial region show that the laser Doppler is valid method for tooth pulp vitality testing, monitoring of tooth vitality after teeth or jaws trauma, monitoring reactions of oral tissues to locally and systemically applied drugs electrical or thermal stimulation as well as for monitoring the reaction of pulp to orthodontics and ortognatics procedures.
AB  - Laser dopler floumetrija meri dinamske promene u protoku krvi na ne invazivni način registrujući kretanje krvnih ćelija u mikrocirkulaciji. Ova metoda se zasniva na promeni frekvencije svetlosti pri odbijanju od krvnih ćelija u pokretu, fenomen poznat kao Doplerov efekat. Rezultati dobijeni istraživanjima u orofacijalnoj regiji pokazuju da je laser Dopler validna metoda za ispitivanje vitaliteta zubne pulpe, praćenje vitaliteta posle traume zuba ili vilica, praćenju reakcije oralnih tkiva na lokalno i sistemno primenjene lekove električnu ili termalnu stimulaciju kao i za praćenje reakcije pulpe na ortodontske i ortognatske procedure.
PB  - Univerzitet u Beogradu - Medicinski fakultet, Beograd
T2  - Medicinska istraživanja
T1  - Principles of the laser Doppler method for application in dentistry
T1  - Principi laser Dopler metode za primenu u stomatologiji
VL  - 44
IS  - 1
SP  - 16
EP  - 21
UR  - https://hdl.handle.net/21.15107/rcub_smile_1551
ER  - 

@article{
author = "Grga, Đurica and Dželetović, Bojan and Aleksić, Nikola and Kršljak, Elena",
year = "2010",
abstract = "Laser Doppler floumetar measure dynamic changes in blood flow to a non invasive way recording movement of blood cells in microcirculation. This method is based on the change in frequency of light with the refusal of blood cells in motion, a phenomenon known as the Doppler effect. Results obtained in orofacial region show that the laser Doppler is valid method for tooth pulp vitality testing, monitoring of tooth vitality after teeth or jaws trauma, monitoring reactions of oral tissues to locally and systemically applied drugs electrical or thermal stimulation as well as for monitoring the reaction of pulp to orthodontics and ortognatics procedures., Laser dopler floumetrija meri dinamske promene u protoku krvi na ne invazivni način registrujući kretanje krvnih ćelija u mikrocirkulaciji. Ova metoda se zasniva na promeni frekvencije svetlosti pri odbijanju od krvnih ćelija u pokretu, fenomen poznat kao Doplerov efekat. Rezultati dobijeni istraživanjima u orofacijalnoj regiji pokazuju da je laser Dopler validna metoda za ispitivanje vitaliteta zubne pulpe, praćenje vitaliteta posle traume zuba ili vilica, praćenju reakcije oralnih tkiva na lokalno i sistemno primenjene lekove električnu ili termalnu stimulaciju kao i za praćenje reakcije pulpe na ortodontske i ortognatske procedure.",
publisher = "Univerzitet u Beogradu - Medicinski fakultet, Beograd",
journal = "Medicinska istraživanja",
title = "Principles of the laser Doppler method for application in dentistry, Principi laser Dopler metode za primenu u stomatologiji",
volume = "44",
number = "1",
pages = "16-21",
url = "https://hdl.handle.net/21.15107/rcub_smile_1551"
}

Grga, Đ., Dželetović, B., Aleksić, N.,& Kršljak, E.. (2010). Principles of the laser Doppler method for application in dentistry. in Medicinska istraživanja
Univerzitet u Beogradu - Medicinski fakultet, Beograd., 44(1), 16-21.
https://hdl.handle.net/21.15107/rcub_smile_1551

Grga Đ, Dželetović B, Aleksić N, Kršljak E. Principles of the laser Doppler method for application in dentistry. in Medicinska istraživanja. 2010;44(1):16-21.
https://hdl.handle.net/21.15107/rcub_smile_1551 .

Grga, Đurica, Dželetović, Bojan, Aleksić, Nikola, Kršljak, Elena, "Principles of the laser Doppler method for application in dentistry" in Medicinska istraživanja, 44, no. 1 (2010):16-21,
https://hdl.handle.net/21.15107/rcub_smile_1551 .