TY  - JOUR
AU  - Ćetković, Dejan
AU  - Milić, Marija
AU  - Biočanin, Vladimir
AU  - Brajić, Ivana
AU  - Ćalasan, Dejan
AU  - Radović, Katarina
AU  - Živković, Rade
AU  - Brković, Božidar
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2448
AB  - Bacground/Aim. The efficient dental anesthesia, which is related to the clinically adequate depth, duration and the width of anesthetic field, is an important prerequisite for successful dental treatment. The aim of this study was to investigate and compare the pulpal anesthesia and cardiovascular parameters after the anterior middle superior alveolar (AMSA) nerve block with 4% articaine with epinephrine administered by conventional cartridge-syringe and computer-controlled local anesthetic delivery system (CCLADS). Methods. This controlled double-blind cross-over randomized clinical study included 38 healthy volunteers. Efficacy of pulpal anesthesia after the AMSA nerve block was evaluated by measuring a success rate, onset and duration of pulpal anesthesia, using an electrical pulp tester. The parameters of cardiovascular function (systolic and diastolic blood pressure, heart rate) were monitored noninvasively. Results. Successful pulpal anesthesia of all tested teeth was obtained in 57.9% participants with CCLADS and in 44.7% participants with conventional syringe. The onset time was not significantly different between two investigated groups. The pulpal anesthesia duration was not significantly different neither within nor between investigated groups. The systolic and diastolic blood pressures were significantly decreased in both investigated groups, in comparison with the baseline values. Heart rate significantly decreased within CCLADS from 10th to 30th minute when compared to baseline. Conclusion. The efficacy of pulpal anesthesia and safety of cardiovascular profile of 0.6 mL of articaine with epinephrine (1:100.000) delivered with CCLADS were improved in comparison to the conventional syringe delivery. Significant changes of cardiovascular function were not observed.
AB  - Uvod/Cilj. Efikasna zubna anestezija u pogledu klinički adekvatne dubine, trajanja i širine anestetičkog polja je važan preduslov za uspešno zubno lečenje. Cilj rada bio je ispitivanje i upoređivanje parametra anestezije zubne pulpe i kardiovaskularnih parametra posle gornje prednje i srednje alveolarne (AMSA) sprovodne anestezije postignute 4% artikainom sa epinefrinom, primenom standardne karpulbrizgalice i kompjuterski kontrolisanog sistema za primenu anestetičkog rastvora (CCLADS). Metode. U ovom randomizovanom, prospektivnom, kontrolisanom, dvostruko slepom ukrštenom kliničkom istraživanju učestvovalo je 38 ispitanika. Kvalitet anestezije zubne pulpe posle AMSA anestezije praćen je na osnovu uspešnosti, latentnog perioda i trajanja anestezije zubne pulpe, primenom električnog pulp-testera. Parametri kardiovaskularne funkcije (sistolni i dijastolni krvni pritisak, srčana frekvencija) praćeni su neinvazivno, primenom aparata za monitoring. Rezultati. Uspešna anestezija zubne pulpe svih ispitivanih zuba bila je prisutna kod 57,9% ispitanika posle kod CCLADS i kod 44,7% ispitanika posle primene standardne karpul-brizgalice. Latentni period i trajanje anestezije zubne pulpe nisu se značajno razlikovali između ispitivanih grupa. Sistolni i dijastolni pritisak bili su značajno sniženi u praćenim vremenskim intervalima u odnosu na početne vrednosti. Srčana frekvencija je bila značajno snižena kod CCLADS grupe od 10 do 30 minuta u odnosu na početne vrednosti. Zaključak. Kontrolisanom kompjuterizovanom primenom (CCLADS) 0,6 mL 4% artikaina sa epinefrinom (1:100,000) za AMSA sprovodnu anesteziju, postignut je bolji kvalitet anestezije zubne pulpe u odnosu na primenu artikaina sa epinefrinom standardnom karpul brizgalicom. Nisu uočene bitne promene funkcija kardiovaskularnog sistema.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study
T1  - Efikasnost i sigurnost 4% artikaina sa epinefrinom za gornji prednji i srednji alveolarni nervni blok primenom kompjuterski kontrolisanog sistema i standardnog pristupa za primenu anestetičkog rastvora - prospektivna, randomizovana, kontrolisana, dvosturko slepa, ukrštena klinička studija
VL  - 76
IS  - 10
SP  - 1045
EP  - 1053
DO  - 10.2298/VSP170511013C
ER  - 

@article{
author = "Ćetković, Dejan and Milić, Marija and Biočanin, Vladimir and Brajić, Ivana and Ćalasan, Dejan and Radović, Katarina and Živković, Rade and Brković, Božidar",
year = "2019",
abstract = "Bacground/Aim. The efficient dental anesthesia, which is related to the clinically adequate depth, duration and the width of anesthetic field, is an important prerequisite for successful dental treatment. The aim of this study was to investigate and compare the pulpal anesthesia and cardiovascular parameters after the anterior middle superior alveolar (AMSA) nerve block with 4% articaine with epinephrine administered by conventional cartridge-syringe and computer-controlled local anesthetic delivery system (CCLADS). Methods. This controlled double-blind cross-over randomized clinical study included 38 healthy volunteers. Efficacy of pulpal anesthesia after the AMSA nerve block was evaluated by measuring a success rate, onset and duration of pulpal anesthesia, using an electrical pulp tester. The parameters of cardiovascular function (systolic and diastolic blood pressure, heart rate) were monitored noninvasively. Results. Successful pulpal anesthesia of all tested teeth was obtained in 57.9% participants with CCLADS and in 44.7% participants with conventional syringe. The onset time was not significantly different between two investigated groups. The pulpal anesthesia duration was not significantly different neither within nor between investigated groups. The systolic and diastolic blood pressures were significantly decreased in both investigated groups, in comparison with the baseline values. Heart rate significantly decreased within CCLADS from 10th to 30th minute when compared to baseline. Conclusion. The efficacy of pulpal anesthesia and safety of cardiovascular profile of 0.6 mL of articaine with epinephrine (1:100.000) delivered with CCLADS were improved in comparison to the conventional syringe delivery. Significant changes of cardiovascular function were not observed., Uvod/Cilj. Efikasna zubna anestezija u pogledu klinički adekvatne dubine, trajanja i širine anestetičkog polja je važan preduslov za uspešno zubno lečenje. Cilj rada bio je ispitivanje i upoređivanje parametra anestezije zubne pulpe i kardiovaskularnih parametra posle gornje prednje i srednje alveolarne (AMSA) sprovodne anestezije postignute 4% artikainom sa epinefrinom, primenom standardne karpulbrizgalice i kompjuterski kontrolisanog sistema za primenu anestetičkog rastvora (CCLADS). Metode. U ovom randomizovanom, prospektivnom, kontrolisanom, dvostruko slepom ukrštenom kliničkom istraživanju učestvovalo je 38 ispitanika. Kvalitet anestezije zubne pulpe posle AMSA anestezije praćen je na osnovu uspešnosti, latentnog perioda i trajanja anestezije zubne pulpe, primenom električnog pulp-testera. Parametri kardiovaskularne funkcije (sistolni i dijastolni krvni pritisak, srčana frekvencija) praćeni su neinvazivno, primenom aparata za monitoring. Rezultati. Uspešna anestezija zubne pulpe svih ispitivanih zuba bila je prisutna kod 57,9% ispitanika posle kod CCLADS i kod 44,7% ispitanika posle primene standardne karpul-brizgalice. Latentni period i trajanje anestezije zubne pulpe nisu se značajno razlikovali između ispitivanih grupa. Sistolni i dijastolni pritisak bili su značajno sniženi u praćenim vremenskim intervalima u odnosu na početne vrednosti. Srčana frekvencija je bila značajno snižena kod CCLADS grupe od 10 do 30 minuta u odnosu na početne vrednosti. Zaključak. Kontrolisanom kompjuterizovanom primenom (CCLADS) 0,6 mL 4% artikaina sa epinefrinom (1:100,000) za AMSA sprovodnu anesteziju, postignut je bolji kvalitet anestezije zubne pulpe u odnosu na primenu artikaina sa epinefrinom standardnom karpul brizgalicom. Nisu uočene bitne promene funkcija kardiovaskularnog sistema.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study, Efikasnost i sigurnost 4% artikaina sa epinefrinom za gornji prednji i srednji alveolarni nervni blok primenom kompjuterski kontrolisanog sistema i standardnog pristupa za primenu anestetičkog rastvora - prospektivna, randomizovana, kontrolisana, dvosturko slepa, ukrštena klinička studija",
volume = "76",
number = "10",
pages = "1045-1053",
doi = "10.2298/VSP170511013C"
}

Ćetković, D., Milić, M., Biočanin, V., Brajić, I., Ćalasan, D., Radović, K., Živković, R.,& Brković, B.. (2019). Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(10), 1045-1053.
https://doi.org/10.2298/VSP170511013C

Ćetković D, Milić M, Biočanin V, Brajić I, Ćalasan D, Radović K, Živković R, Brković B. Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study. in Vojnosanitetski pregled. 2019;76(10):1045-1053.
doi:10.2298/VSP170511013C .

Ćetković, Dejan, Milić, Marija, Biočanin, Vladimir, Brajić, Ivana, Ćalasan, Dejan, Radović, Katarina, Živković, Rade, Brković, Božidar, "Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study" in Vojnosanitetski pregled, 76, no. 10 (2019):1045-1053,
https://doi.org/10.2298/VSP170511013C . .

TY  - THES
AU  - Brajić, Ivana
PY  - 2017
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=6819
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:19911/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024369038
UR  - http://nardus.mpn.gov.rs/123456789/11247
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1019
AB  - Keratocistični odontogeni tumori (KCOT) su benigne intrakoštane lezije, lokalizovane u donjoj i gornjoj vilici. Ovi tumori su ranije definisani kao ciste vilica zbog svog makroskopskog izgleda. Međutim, njihova agresivna priroda i sklonost ka recidivima, kao i uloga genskih mehanizama u njihovom nastanku, doveli su do toga da se ove lezije svrstaju u tumore glave i vrata. Danas se smatra da su za njihov nastanak ključne mutacije PTCH gena, koje su odgovorne i za nastanak drugih tipova tumora, a detektovane su i u ovim lezijama, bez obzira da li su u pitanju sporadični ili KCOT udruženi sa Nevoid Basal Cell Carcinoma (NBCC) sindromom. Jedan od protoonkogena koji ima uticaj na razvoj brojnih tumora čoveka, a između ostalog i oralnih karcinoma, je H-RAS gen. Ovaj gen ima ulogu u ćelijskoj proliferaciji i diferencijaciji. Mutacije H-RAS gena najčešće su detektovane na poziciji 12. i 13. kodona. Pored mutacija i polimorfizam ovog gena na 81. kodonu (81T/C) se smatra faktorom rizika za nastanak brojnih tumora. Do sada prisustvo mutacija i polimorfizama H-RAS gena nije ispitivano u KCOT. Takođe, predmet dosadašnjih istraživanja nije bilo ni prisustvo i lokalizacija p21hras proteina u ovim lezijama. Uloga ovog proteina, produkta H-RAS gena, ogleda se u prenosu ćelijskog signala od membrane do unutrašnjosti ćelije u cilju kontrole proliferacije i diferencijacije ćelija. Prekomerna ekspresija ovog proteina je konstatovana u različitim humanim tumorima, ali i u normalnim tkivima kao što su i zubni zameci. Važnost povećanog prisustva ovog proteina leži u činjenici da se time može delimično objasniti povećana proliferacija epitela, a tako i agresivno ponašanje KCOT. Lečenje KCOT najčešće podrazumeva dvofaznu proceduru koja obuhvata dekompresiju i, u drugom hirurškom aktu, enukleaciju preostale lezije kombinovanu sa primenom Karnojevog rastvora. S obzirom da dekompresija dovodi do promena u veličini lezije, zadebljanja njenog zida, kao i hiperplazije epitela, interesantno je povezati ove efekte sa promenama na molekularnom nivou. U tom smislu, interesantno je analizirati uticaj dekompresije KCOT na ekspresiju proteina koji su odgovorni za regulaciju ćelijskog ciklusa i apoptoze, kao što su survivin, ciklin D1 i p21hras, što do sada nije ispitivano...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Analysis of status of H-RAS gene and expression of survivin and p21ras in keratocystic odontogenic tumors before and after decompression
T1  - Analiza statusa H-RAS gena i ekspresije survivina i p21ras u keratocističnim odontogenim tumorima pre i nakon dekompresije
UR  - https://hdl.handle.net/21.15107/rcub_nardus_11247
ER  - 

@phdthesis{
author = "Brajić, Ivana",
year = "2017",
abstract = "Keratocistični odontogeni tumori (KCOT) su benigne intrakoštane lezije, lokalizovane u donjoj i gornjoj vilici. Ovi tumori su ranije definisani kao ciste vilica zbog svog makroskopskog izgleda. Međutim, njihova agresivna priroda i sklonost ka recidivima, kao i uloga genskih mehanizama u njihovom nastanku, doveli su do toga da se ove lezije svrstaju u tumore glave i vrata. Danas se smatra da su za njihov nastanak ključne mutacije PTCH gena, koje su odgovorne i za nastanak drugih tipova tumora, a detektovane su i u ovim lezijama, bez obzira da li su u pitanju sporadični ili KCOT udruženi sa Nevoid Basal Cell Carcinoma (NBCC) sindromom. Jedan od protoonkogena koji ima uticaj na razvoj brojnih tumora čoveka, a između ostalog i oralnih karcinoma, je H-RAS gen. Ovaj gen ima ulogu u ćelijskoj proliferaciji i diferencijaciji. Mutacije H-RAS gena najčešće su detektovane na poziciji 12. i 13. kodona. Pored mutacija i polimorfizam ovog gena na 81. kodonu (81T/C) se smatra faktorom rizika za nastanak brojnih tumora. Do sada prisustvo mutacija i polimorfizama H-RAS gena nije ispitivano u KCOT. Takođe, predmet dosadašnjih istraživanja nije bilo ni prisustvo i lokalizacija p21hras proteina u ovim lezijama. Uloga ovog proteina, produkta H-RAS gena, ogleda se u prenosu ćelijskog signala od membrane do unutrašnjosti ćelije u cilju kontrole proliferacije i diferencijacije ćelija. Prekomerna ekspresija ovog proteina je konstatovana u različitim humanim tumorima, ali i u normalnim tkivima kao što su i zubni zameci. Važnost povećanog prisustva ovog proteina leži u činjenici da se time može delimično objasniti povećana proliferacija epitela, a tako i agresivno ponašanje KCOT. Lečenje KCOT najčešće podrazumeva dvofaznu proceduru koja obuhvata dekompresiju i, u drugom hirurškom aktu, enukleaciju preostale lezije kombinovanu sa primenom Karnojevog rastvora. S obzirom da dekompresija dovodi do promena u veličini lezije, zadebljanja njenog zida, kao i hiperplazije epitela, interesantno je povezati ove efekte sa promenama na molekularnom nivou. U tom smislu, interesantno je analizirati uticaj dekompresije KCOT na ekspresiju proteina koji su odgovorni za regulaciju ćelijskog ciklusa i apoptoze, kao što su survivin, ciklin D1 i p21hras, što do sada nije ispitivano...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Analysis of status of H-RAS gene and expression of survivin and p21ras in keratocystic odontogenic tumors before and after decompression, Analiza statusa H-RAS gena i ekspresije survivina i p21ras u keratocističnim odontogenim tumorima pre i nakon dekompresije",
url = "https://hdl.handle.net/21.15107/rcub_nardus_11247"
}

Brajić, I.. (2017). Analysis of status of H-RAS gene and expression of survivin and p21ras in keratocystic odontogenic tumors before and after decompression. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_11247

Brajić I. Analysis of status of H-RAS gene and expression of survivin and p21ras in keratocystic odontogenic tumors before and after decompression. 2017;.
https://hdl.handle.net/21.15107/rcub_nardus_11247 .

Brajić, Ivana, "Analysis of status of H-RAS gene and expression of survivin and p21ras in keratocystic odontogenic tumors before and after decompression" (2017),
https://hdl.handle.net/21.15107/rcub_nardus_11247 .

TY  - JOUR
AU  - Brajić, Ivana
AU  - Skodrić, Sanja
AU  - Milenković, S.
AU  - Tepavčević, Zvezdana
AU  - Soldatović, Ivan
AU  - Čolić, Snježana
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2140
AB  - ObjectivesThe aim of this study was to investigate survivin, cyclin D1, and p21hras expression in keratocystic odontogenic tumors before and after decompression, as well as in pericoronal follicles. A potential correlation between the expression levels of these proteins was also investigated. Materials and methodsWe analyzed eighteen keratocystic tumors treated by decompression and subsequent enucleation along with seven pericoronal follicles using immunohistochemistry. ResultsKeratocystic tumor samples, both before and after decompression, were positive for each of the investigated proteins. In pericoronal follicles, survivin exhibited cytoplasmic staining in contrast to nuclear staining in keratocystic tumors. Cyclin D1 expression was negative in pericoronal follicles, and p21hras expression was similar in both groups. Survivin showed significantly higher expression after decompression, while cyclin D1 and p21hras remained unchanged (P=0.039, P=0.255, P=0.913, respectively). There was no correlation between these proteins neither before nor after decompression. ConclusionsWithin the limits of the study, we can conclude that following decompression, keratocystic odontogenic tumors preserve distinct immunohistochemical profiles of cyclin D1 and p21hras expression, despite substantial reduction in size of the lesions. Significant increase of survivin expression after decompression might be attributed to higher level of epithelial proliferation caused by this procedure.
PB  - Wiley-Blackwell, Hoboken
T2  - Oral Diseases
T1  - Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression
VL  - 22
IS  - 3
SP  - 220
EP  - 225
DO  - 10.1111/odi.12414
ER  - 

@article{
author = "Brajić, Ivana and Skodrić, Sanja and Milenković, S. and Tepavčević, Zvezdana and Soldatović, Ivan and Čolić, Snježana and Milašin, Jelena and Andrić, Miroslav",
year = "2016",
abstract = "ObjectivesThe aim of this study was to investigate survivin, cyclin D1, and p21hras expression in keratocystic odontogenic tumors before and after decompression, as well as in pericoronal follicles. A potential correlation between the expression levels of these proteins was also investigated. Materials and methodsWe analyzed eighteen keratocystic tumors treated by decompression and subsequent enucleation along with seven pericoronal follicles using immunohistochemistry. ResultsKeratocystic tumor samples, both before and after decompression, were positive for each of the investigated proteins. In pericoronal follicles, survivin exhibited cytoplasmic staining in contrast to nuclear staining in keratocystic tumors. Cyclin D1 expression was negative in pericoronal follicles, and p21hras expression was similar in both groups. Survivin showed significantly higher expression after decompression, while cyclin D1 and p21hras remained unchanged (P=0.039, P=0.255, P=0.913, respectively). There was no correlation between these proteins neither before nor after decompression. ConclusionsWithin the limits of the study, we can conclude that following decompression, keratocystic odontogenic tumors preserve distinct immunohistochemical profiles of cyclin D1 and p21hras expression, despite substantial reduction in size of the lesions. Significant increase of survivin expression after decompression might be attributed to higher level of epithelial proliferation caused by this procedure.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Oral Diseases",
title = "Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression",
volume = "22",
number = "3",
pages = "220-225",
doi = "10.1111/odi.12414"
}

Brajić, I., Skodrić, S., Milenković, S., Tepavčević, Z., Soldatović, I., Čolić, S., Milašin, J.,& Andrić, M.. (2016). Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression. in Oral Diseases
Wiley-Blackwell, Hoboken., 22(3), 220-225.
https://doi.org/10.1111/odi.12414

Brajić I, Skodrić S, Milenković S, Tepavčević Z, Soldatović I, Čolić S, Milašin J, Andrić M. Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression. in Oral Diseases. 2016;22(3):220-225.
doi:10.1111/odi.12414 .

Brajić, Ivana, Skodrić, Sanja, Milenković, S., Tepavčević, Zvezdana, Soldatović, Ivan, Čolić, Snježana, Milašin, Jelena, Andrić, Miroslav, "Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression" in Oral Diseases, 22, no. 3 (2016):220-225,
https://doi.org/10.1111/odi.12414 . .