TY  - JOUR
AU  - Vasić, N.
AU  - Glumac, Sofija
AU  - Pejić, S.
AU  - Amidžić, L. J.
AU  - Tadić-Latinović, Ljiljana
AU  - Dožić, Branko
AU  - Hinić, S.
AU  - Maksimović, Z.
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2226
AB  - Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation.
PB  - Charles Univ Prague, First Faculty Medicine, Prague 6
T2  - Folia Biologica
T1  - Expression of Matrix Metalloproteinases and Endogenous Inhibitors in Abdominal Aortic Aneurysm and Aortoiliac Occlusive Disease (Syndrome Leriche)
VL  - 63
IS  - 5-6
SP  - 209
EP  - 216
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7676
ER  - 

@article{
author = "Vasić, N. and Glumac, Sofija and Pejić, S. and Amidžić, L. J. and Tadić-Latinović, Ljiljana and Dožić, Branko and Hinić, S. and Maksimović, Z.",
year = "2017",
abstract = "Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation.",
publisher = "Charles Univ Prague, First Faculty Medicine, Prague 6",
journal = "Folia Biologica",
title = "Expression of Matrix Metalloproteinases and Endogenous Inhibitors in Abdominal Aortic Aneurysm and Aortoiliac Occlusive Disease (Syndrome Leriche)",
volume = "63",
number = "5-6",
pages = "209-216",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7676"
}

Vasić, N., Glumac, S., Pejić, S., Amidžić, L. J., Tadić-Latinović, L., Dožić, B., Hinić, S.,& Maksimović, Z.. (2017). Expression of Matrix Metalloproteinases and Endogenous Inhibitors in Abdominal Aortic Aneurysm and Aortoiliac Occlusive Disease (Syndrome Leriche). in Folia Biologica
Charles Univ Prague, First Faculty Medicine, Prague 6., 63(5-6), 209-216.
https://hdl.handle.net/21.15107/rcub_vinar_7676

Vasić N, Glumac S, Pejić S, Amidžić LJ, Tadić-Latinović L, Dožić B, Hinić S, Maksimović Z. Expression of Matrix Metalloproteinases and Endogenous Inhibitors in Abdominal Aortic Aneurysm and Aortoiliac Occlusive Disease (Syndrome Leriche). in Folia Biologica. 2017;63(5-6):209-216.
https://hdl.handle.net/21.15107/rcub_vinar_7676 .

Vasić, N., Glumac, Sofija, Pejić, S., Amidžić, L. J., Tadić-Latinović, Ljiljana, Dožić, Branko, Hinić, S., Maksimović, Z., "Expression of Matrix Metalloproteinases and Endogenous Inhibitors in Abdominal Aortic Aneurysm and Aortoiliac Occlusive Disease (Syndrome Leriche)" in Folia Biologica, 63, no. 5-6 (2017):209-216,
https://hdl.handle.net/21.15107/rcub_vinar_7676 .