TY  - JOUR
AU  - Vuković, Rade
AU  - Milenković, Tatjana
AU  - Mitrović, Katarina
AU  - Todorović, Slađana
AU  - Plavsić, Ljiljana
AU  - Vuković, Ana
AU  - Zdravković, Dragan
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2010
AB  - Available data on metabolically healthy obese (MHO) phenotype in children suggest that gender, puberty, waist circumference, insulin sensitivity, and other laboratory predictors have a role in distinguishing these children from metabolically unhealthy obese (MUO) youth. The goal of this study was to identify predictors of MHO phenotype and to analyze glucose and insulin metabolism during oral glucose tolerance test (OGTT) in MHO children. OGTT was performed in 244 obese children and adolescents aged 4.6-18.9 years. Subjects were classified as MHO in case of no fulfilled criterion of metabolic syndrome except anthropometry or as MUO (a parts per thousand yen2 fulfilled criteria). Among the subjects, 21.7 % had MHO phenotype, and they were more likely to be female, younger, and in earlier stages of pubertal development, with lower degree of abdominal obesity. Insulin resistance was the only independent laboratory predictor of MUO phenotype (OR 1.59, CI 1.13-2.25), with 82 % sensitivity and 60 % specificity for diagnosing MUO using HOMA-IR cutoff point of a parts per thousand yen2.85. Although no significant differences were observed in glucose regulation, MUO children had higher insulin demand throughout OGTT, with 1.53 times higher total insulin secretion. Conclusion: Further research is needed to investigate the possibility of targeted treatment of insulin resistance to minimize pubertal cross-over to MUO in obese children.
PB  - Springer, New York
T2  - European Journal of Pediatrics
T1  - Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents
VL  - 174
IS  - 12
SP  - 1649
EP  - 1655
DO  - 10.1007/s00431-015-2587-4
ER  - 

@article{
author = "Vuković, Rade and Milenković, Tatjana and Mitrović, Katarina and Todorović, Slađana and Plavsić, Ljiljana and Vuković, Ana and Zdravković, Dragan",
year = "2015",
abstract = "Available data on metabolically healthy obese (MHO) phenotype in children suggest that gender, puberty, waist circumference, insulin sensitivity, and other laboratory predictors have a role in distinguishing these children from metabolically unhealthy obese (MUO) youth. The goal of this study was to identify predictors of MHO phenotype and to analyze glucose and insulin metabolism during oral glucose tolerance test (OGTT) in MHO children. OGTT was performed in 244 obese children and adolescents aged 4.6-18.9 years. Subjects were classified as MHO in case of no fulfilled criterion of metabolic syndrome except anthropometry or as MUO (a parts per thousand yen2 fulfilled criteria). Among the subjects, 21.7 % had MHO phenotype, and they were more likely to be female, younger, and in earlier stages of pubertal development, with lower degree of abdominal obesity. Insulin resistance was the only independent laboratory predictor of MUO phenotype (OR 1.59, CI 1.13-2.25), with 82 % sensitivity and 60 % specificity for diagnosing MUO using HOMA-IR cutoff point of a parts per thousand yen2.85. Although no significant differences were observed in glucose regulation, MUO children had higher insulin demand throughout OGTT, with 1.53 times higher total insulin secretion. Conclusion: Further research is needed to investigate the possibility of targeted treatment of insulin resistance to minimize pubertal cross-over to MUO in obese children.",
publisher = "Springer, New York",
journal = "European Journal of Pediatrics",
title = "Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents",
volume = "174",
number = "12",
pages = "1649-1655",
doi = "10.1007/s00431-015-2587-4"
}

Vuković, R., Milenković, T., Mitrović, K., Todorović, S., Plavsić, L., Vuković, A.,& Zdravković, D.. (2015). Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents. in European Journal of Pediatrics
Springer, New York., 174(12), 1649-1655.
https://doi.org/10.1007/s00431-015-2587-4

Vuković R, Milenković T, Mitrović K, Todorović S, Plavsić L, Vuković A, Zdravković D. Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents. in European Journal of Pediatrics. 2015;174(12):1649-1655.
doi:10.1007/s00431-015-2587-4 .

Vuković, Rade, Milenković, Tatjana, Mitrović, Katarina, Todorović, Slađana, Plavsić, Ljiljana, Vuković, Ana, Zdravković, Dragan, "Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents" in European Journal of Pediatrics, 174, no. 12 (2015):1649-1655,
https://doi.org/10.1007/s00431-015-2587-4 . .

TY  - JOUR
AU  - Vuković, Rade
AU  - Zdravković, Dragan
AU  - Mitrović, Katarina
AU  - Milenković, Tatjana
AU  - Todorović, Slađana
AU  - Vuković, Ana
AU  - Soldatović, Ivan
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1969
AB  - Objective: To assess the prevalence of metabolic syndrome (MS) in obese children and adolescents in Serbia. Subjects and methods: The study group consisted of 254 subjects (148 female and 106 male), aged 4.6-18.9 years with diet-induced obesity (body mass index >= 95th percentile). Presence of MS using the International Diabetes Federation definition was assessed in all subjects, as well as oral glucose tolerance test and insulin resistance indices. Results: Overall prevalence of MS in all subjects aged >= 10 years was 31.2%, namely, 28.7% in children aged 10 to  lt 16 years and 40.5% in adolescents >= 16 years. When adjusted for age, gender and pubertal development, higher degree of obesity was a strong predictor of MS. Multivariate analysis showed that taller subjects and those with higher degree of insulin resistance were at significantly higher risk of MS, independent of the degree of obesity. Conclusions: High prevalence of MS emphasizes the need for prevention and treatment of childhood obesity.
PB  - Walter De Gruyter Gmbh, Berlin
T2  - Journal of Pediatric Endocrinology & Metabolism
T1  - Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors
VL  - 28
IS  - 7-8
SP  - 903
EP  - 909
DO  - 10.1515/jpem-2014-0533
ER  - 

@article{
author = "Vuković, Rade and Zdravković, Dragan and Mitrović, Katarina and Milenković, Tatjana and Todorović, Slađana and Vuković, Ana and Soldatović, Ivan",
year = "2015",
abstract = "Objective: To assess the prevalence of metabolic syndrome (MS) in obese children and adolescents in Serbia. Subjects and methods: The study group consisted of 254 subjects (148 female and 106 male), aged 4.6-18.9 years with diet-induced obesity (body mass index >= 95th percentile). Presence of MS using the International Diabetes Federation definition was assessed in all subjects, as well as oral glucose tolerance test and insulin resistance indices. Results: Overall prevalence of MS in all subjects aged >= 10 years was 31.2%, namely, 28.7% in children aged 10 to  lt 16 years and 40.5% in adolescents >= 16 years. When adjusted for age, gender and pubertal development, higher degree of obesity was a strong predictor of MS. Multivariate analysis showed that taller subjects and those with higher degree of insulin resistance were at significantly higher risk of MS, independent of the degree of obesity. Conclusions: High prevalence of MS emphasizes the need for prevention and treatment of childhood obesity.",
publisher = "Walter De Gruyter Gmbh, Berlin",
journal = "Journal of Pediatric Endocrinology & Metabolism",
title = "Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors",
volume = "28",
number = "7-8",
pages = "903-909",
doi = "10.1515/jpem-2014-0533"
}

Vuković, R., Zdravković, D., Mitrović, K., Milenković, T., Todorović, S., Vuković, A.,& Soldatović, I.. (2015). Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors. in Journal of Pediatric Endocrinology & Metabolism
Walter De Gruyter Gmbh, Berlin., 28(7-8), 903-909.
https://doi.org/10.1515/jpem-2014-0533

Vuković R, Zdravković D, Mitrović K, Milenković T, Todorović S, Vuković A, Soldatović I. Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors. in Journal of Pediatric Endocrinology & Metabolism. 2015;28(7-8):903-909.
doi:10.1515/jpem-2014-0533 .

Vuković, Rade, Zdravković, Dragan, Mitrović, Katarina, Milenković, Tatjana, Todorović, Slađana, Vuković, Ana, Soldatović, Ivan, "Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors" in Journal of Pediatric Endocrinology & Metabolism, 28, no. 7-8 (2015):903-909,
https://doi.org/10.1515/jpem-2014-0533 . .

TY  - JOUR
AU  - Milenković, Ana
AU  - Marković, Dejan
AU  - Zdravković, Dragan
AU  - Perić, Tamara
AU  - Milenković, Tatjana
AU  - Vuković, Rade
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1569
AB  - Primary adrenal insufficiency is an endocrine disorder characterized by cortisol and aldosterone deficiency caused by destruction of the adrenal cortex. Adrenal crisis is a medical emergency with acute symptoms: nausea, vomiting, abdominal pain, fever, hypoglycemia, seizures, hypovolemic shock, and cardiovascular failure. It occurs in patients with chronic adrenal insufficiency who are exposed to additional stress, such as infection, trauma, or surgical procedures. Dental infection is a possible cause of adrenal crisis in patients with chronic adrenal insufficiency, so pediatric endocrinologists and pediatric dentists should be aware of this risk. The purpose of this report was to present a 6-year-old patient in whom Addison disease was diagnosed through adrenal crisis provoked by dental infection. The patient was treated with intravenous rehydration, intravenous hydrocortisone and antibiotics, and extraction of the infected primary tooth. Multidisciplinary approach and collaboration between the pediatric endocrinologist and the pediatric dentist are necessary to enable adequate medical and dental treatment in children with primary adrenal insufficiency. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:325-329)
PB  - Mosby-Elsevier, New York
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
T1  - Adrenal crisis provoked by dental infection: case report and review of the literature
VL  - 110
IS  - 3
SP  - 325
EP  - 329
DO  - 10.1016/j.tripleo.2010.04.025
ER  - 

@article{
author = "Milenković, Ana and Marković, Dejan and Zdravković, Dragan and Perić, Tamara and Milenković, Tatjana and Vuković, Rade",
year = "2010",
abstract = "Primary adrenal insufficiency is an endocrine disorder characterized by cortisol and aldosterone deficiency caused by destruction of the adrenal cortex. Adrenal crisis is a medical emergency with acute symptoms: nausea, vomiting, abdominal pain, fever, hypoglycemia, seizures, hypovolemic shock, and cardiovascular failure. It occurs in patients with chronic adrenal insufficiency who are exposed to additional stress, such as infection, trauma, or surgical procedures. Dental infection is a possible cause of adrenal crisis in patients with chronic adrenal insufficiency, so pediatric endocrinologists and pediatric dentists should be aware of this risk. The purpose of this report was to present a 6-year-old patient in whom Addison disease was diagnosed through adrenal crisis provoked by dental infection. The patient was treated with intravenous rehydration, intravenous hydrocortisone and antibiotics, and extraction of the infected primary tooth. Multidisciplinary approach and collaboration between the pediatric endocrinologist and the pediatric dentist are necessary to enable adequate medical and dental treatment in children with primary adrenal insufficiency. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:325-329)",
publisher = "Mosby-Elsevier, New York",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology",
title = "Adrenal crisis provoked by dental infection: case report and review of the literature",
volume = "110",
number = "3",
pages = "325-329",
doi = "10.1016/j.tripleo.2010.04.025"
}

Milenković, A., Marković, D., Zdravković, D., Perić, T., Milenković, T.,& Vuković, R.. (2010). Adrenal crisis provoked by dental infection: case report and review of the literature. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
Mosby-Elsevier, New York., 110(3), 325-329.
https://doi.org/10.1016/j.tripleo.2010.04.025

Milenković A, Marković D, Zdravković D, Perić T, Milenković T, Vuković R. Adrenal crisis provoked by dental infection: case report and review of the literature. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology. 2010;110(3):325-329.
doi:10.1016/j.tripleo.2010.04.025 .

Milenković, Ana, Marković, Dejan, Zdravković, Dragan, Perić, Tamara, Milenković, Tatjana, Vuković, Rade, "Adrenal crisis provoked by dental infection: case report and review of the literature" in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology, 110, no. 3 (2010):325-329,
https://doi.org/10.1016/j.tripleo.2010.04.025 . .