TY  - JOUR
AU  - Vuković, Rade
AU  - Milenković, Tatjana
AU  - Stojan, George
AU  - Vuković, Ana
AU  - Mitrović, Katarina
AU  - Todorović, Slađana
AU  - Soldatović, Ivan
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2258
AB  - Background The dichotomous nature of the current definition of metabolic syndrome (MS) in youth results in loss of information. On the other hand, the calculation of continuous MS scores using standardized residuals in linear regression (Z scores) or factor scores of principal component analysis (PCA) is highly impractical for clinical use. Recently, a novel, easily calculated continuous MS score called siMS score was developed based on the IDF MS criteria for the adult population. Objective To develop a Pediatric siMS score (PsiMS), a modified continuous MS score for use in the obese youth, based on the original siMS score, while keeping the score as simple as possible and retaining high correlation with more complex scores. Subjects and methods The database consisted of clinical data on 153 obese (BMI >= 95th percentile) children and adolescents. Continuous MS scores were calculated using Z scores and PCA, as well as the original siMS score. Four variants of PsiMS score were developed in accordance with IDF criteria for MS in youth and correlation of these scores with PCA and Z score derived MS continuous scores was assessed. Results PsiMS score calculated using formula: (2xWaist/Height) + (Glucose(mmol/l)/5.6) + (triglycerides( mmol/l)/1.7) + (Systolic BP/130)-(HDL(mmol/l)/1.02) showed the highest correlation with most of the complex continuous scores (0.792-0.901). The original siMS score also showed high correlation with continuous MS scores. Conclusion PsiMS score represents a practical and accurate score for the evaluation of MS in the obese youth. The original siMS score should be used when evaluating large cohorts consisting of both adults and children.
PB  - Public Library Science, San Francisco
T2  - PLoS One
T1  - Pediatric siMS score: A new, simple and accurate continuous metabolic syndrome score for everyday use in pediatrics
VL  - 12
IS  - 12
DO  - 10.1371/journal.pone.0189232
ER  - 

@article{
author = "Vuković, Rade and Milenković, Tatjana and Stojan, George and Vuković, Ana and Mitrović, Katarina and Todorović, Slađana and Soldatović, Ivan",
year = "2017",
abstract = "Background The dichotomous nature of the current definition of metabolic syndrome (MS) in youth results in loss of information. On the other hand, the calculation of continuous MS scores using standardized residuals in linear regression (Z scores) or factor scores of principal component analysis (PCA) is highly impractical for clinical use. Recently, a novel, easily calculated continuous MS score called siMS score was developed based on the IDF MS criteria for the adult population. Objective To develop a Pediatric siMS score (PsiMS), a modified continuous MS score for use in the obese youth, based on the original siMS score, while keeping the score as simple as possible and retaining high correlation with more complex scores. Subjects and methods The database consisted of clinical data on 153 obese (BMI >= 95th percentile) children and adolescents. Continuous MS scores were calculated using Z scores and PCA, as well as the original siMS score. Four variants of PsiMS score were developed in accordance with IDF criteria for MS in youth and correlation of these scores with PCA and Z score derived MS continuous scores was assessed. Results PsiMS score calculated using formula: (2xWaist/Height) + (Glucose(mmol/l)/5.6) + (triglycerides( mmol/l)/1.7) + (Systolic BP/130)-(HDL(mmol/l)/1.02) showed the highest correlation with most of the complex continuous scores (0.792-0.901). The original siMS score also showed high correlation with continuous MS scores. Conclusion PsiMS score represents a practical and accurate score for the evaluation of MS in the obese youth. The original siMS score should be used when evaluating large cohorts consisting of both adults and children.",
publisher = "Public Library Science, San Francisco",
journal = "PLoS One",
title = "Pediatric siMS score: A new, simple and accurate continuous metabolic syndrome score for everyday use in pediatrics",
volume = "12",
number = "12",
doi = "10.1371/journal.pone.0189232"
}

Vuković, R., Milenković, T., Stojan, G., Vuković, A., Mitrović, K., Todorović, S.,& Soldatović, I.. (2017). Pediatric siMS score: A new, simple and accurate continuous metabolic syndrome score for everyday use in pediatrics. in PLoS One
Public Library Science, San Francisco., 12(12).
https://doi.org/10.1371/journal.pone.0189232

Vuković R, Milenković T, Stojan G, Vuković A, Mitrović K, Todorović S, Soldatović I. Pediatric siMS score: A new, simple and accurate continuous metabolic syndrome score for everyday use in pediatrics. in PLoS One. 2017;12(12).
doi:10.1371/journal.pone.0189232 .

Vuković, Rade, Milenković, Tatjana, Stojan, George, Vuković, Ana, Mitrović, Katarina, Todorović, Slađana, Soldatović, Ivan, "Pediatric siMS score: A new, simple and accurate continuous metabolic syndrome score for everyday use in pediatrics" in PLoS One, 12, no. 12 (2017),
https://doi.org/10.1371/journal.pone.0189232 . .

TY  - JOUR
AU  - Vuković, Rade
AU  - Milenković, Tatjana
AU  - Mitrović, Katarina
AU  - Todorović, Slađana
AU  - Plavsić, Ljiljana
AU  - Vuković, Ana
AU  - Zdravković, Dragan
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2010
AB  - Available data on metabolically healthy obese (MHO) phenotype in children suggest that gender, puberty, waist circumference, insulin sensitivity, and other laboratory predictors have a role in distinguishing these children from metabolically unhealthy obese (MUO) youth. The goal of this study was to identify predictors of MHO phenotype and to analyze glucose and insulin metabolism during oral glucose tolerance test (OGTT) in MHO children. OGTT was performed in 244 obese children and adolescents aged 4.6-18.9 years. Subjects were classified as MHO in case of no fulfilled criterion of metabolic syndrome except anthropometry or as MUO (a parts per thousand yen2 fulfilled criteria). Among the subjects, 21.7 % had MHO phenotype, and they were more likely to be female, younger, and in earlier stages of pubertal development, with lower degree of abdominal obesity. Insulin resistance was the only independent laboratory predictor of MUO phenotype (OR 1.59, CI 1.13-2.25), with 82 % sensitivity and 60 % specificity for diagnosing MUO using HOMA-IR cutoff point of a parts per thousand yen2.85. Although no significant differences were observed in glucose regulation, MUO children had higher insulin demand throughout OGTT, with 1.53 times higher total insulin secretion. Conclusion: Further research is needed to investigate the possibility of targeted treatment of insulin resistance to minimize pubertal cross-over to MUO in obese children.
PB  - Springer, New York
T2  - European Journal of Pediatrics
T1  - Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents
VL  - 174
IS  - 12
SP  - 1649
EP  - 1655
DO  - 10.1007/s00431-015-2587-4
ER  - 

@article{
author = "Vuković, Rade and Milenković, Tatjana and Mitrović, Katarina and Todorović, Slađana and Plavsić, Ljiljana and Vuković, Ana and Zdravković, Dragan",
year = "2015",
abstract = "Available data on metabolically healthy obese (MHO) phenotype in children suggest that gender, puberty, waist circumference, insulin sensitivity, and other laboratory predictors have a role in distinguishing these children from metabolically unhealthy obese (MUO) youth. The goal of this study was to identify predictors of MHO phenotype and to analyze glucose and insulin metabolism during oral glucose tolerance test (OGTT) in MHO children. OGTT was performed in 244 obese children and adolescents aged 4.6-18.9 years. Subjects were classified as MHO in case of no fulfilled criterion of metabolic syndrome except anthropometry or as MUO (a parts per thousand yen2 fulfilled criteria). Among the subjects, 21.7 % had MHO phenotype, and they were more likely to be female, younger, and in earlier stages of pubertal development, with lower degree of abdominal obesity. Insulin resistance was the only independent laboratory predictor of MUO phenotype (OR 1.59, CI 1.13-2.25), with 82 % sensitivity and 60 % specificity for diagnosing MUO using HOMA-IR cutoff point of a parts per thousand yen2.85. Although no significant differences were observed in glucose regulation, MUO children had higher insulin demand throughout OGTT, with 1.53 times higher total insulin secretion. Conclusion: Further research is needed to investigate the possibility of targeted treatment of insulin resistance to minimize pubertal cross-over to MUO in obese children.",
publisher = "Springer, New York",
journal = "European Journal of Pediatrics",
title = "Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents",
volume = "174",
number = "12",
pages = "1649-1655",
doi = "10.1007/s00431-015-2587-4"
}

Vuković, R., Milenković, T., Mitrović, K., Todorović, S., Plavsić, L., Vuković, A.,& Zdravković, D.. (2015). Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents. in European Journal of Pediatrics
Springer, New York., 174(12), 1649-1655.
https://doi.org/10.1007/s00431-015-2587-4

Vuković R, Milenković T, Mitrović K, Todorović S, Plavsić L, Vuković A, Zdravković D. Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents. in European Journal of Pediatrics. 2015;174(12):1649-1655.
doi:10.1007/s00431-015-2587-4 .

Vuković, Rade, Milenković, Tatjana, Mitrović, Katarina, Todorović, Slađana, Plavsić, Ljiljana, Vuković, Ana, Zdravković, Dragan, "Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents" in European Journal of Pediatrics, 174, no. 12 (2015):1649-1655,
https://doi.org/10.1007/s00431-015-2587-4 . .

TY  - JOUR
AU  - Vuković, Rade
AU  - Zdravković, Dragan
AU  - Mitrović, Katarina
AU  - Milenković, Tatjana
AU  - Todorović, Slađana
AU  - Vuković, Ana
AU  - Soldatović, Ivan
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1969
AB  - Objective: To assess the prevalence of metabolic syndrome (MS) in obese children and adolescents in Serbia. Subjects and methods: The study group consisted of 254 subjects (148 female and 106 male), aged 4.6-18.9 years with diet-induced obesity (body mass index >= 95th percentile). Presence of MS using the International Diabetes Federation definition was assessed in all subjects, as well as oral glucose tolerance test and insulin resistance indices. Results: Overall prevalence of MS in all subjects aged >= 10 years was 31.2%, namely, 28.7% in children aged 10 to  lt 16 years and 40.5% in adolescents >= 16 years. When adjusted for age, gender and pubertal development, higher degree of obesity was a strong predictor of MS. Multivariate analysis showed that taller subjects and those with higher degree of insulin resistance were at significantly higher risk of MS, independent of the degree of obesity. Conclusions: High prevalence of MS emphasizes the need for prevention and treatment of childhood obesity.
PB  - Walter De Gruyter Gmbh, Berlin
T2  - Journal of Pediatric Endocrinology & Metabolism
T1  - Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors
VL  - 28
IS  - 7-8
SP  - 903
EP  - 909
DO  - 10.1515/jpem-2014-0533
ER  - 

@article{
author = "Vuković, Rade and Zdravković, Dragan and Mitrović, Katarina and Milenković, Tatjana and Todorović, Slađana and Vuković, Ana and Soldatović, Ivan",
year = "2015",
abstract = "Objective: To assess the prevalence of metabolic syndrome (MS) in obese children and adolescents in Serbia. Subjects and methods: The study group consisted of 254 subjects (148 female and 106 male), aged 4.6-18.9 years with diet-induced obesity (body mass index >= 95th percentile). Presence of MS using the International Diabetes Federation definition was assessed in all subjects, as well as oral glucose tolerance test and insulin resistance indices. Results: Overall prevalence of MS in all subjects aged >= 10 years was 31.2%, namely, 28.7% in children aged 10 to  lt 16 years and 40.5% in adolescents >= 16 years. When adjusted for age, gender and pubertal development, higher degree of obesity was a strong predictor of MS. Multivariate analysis showed that taller subjects and those with higher degree of insulin resistance were at significantly higher risk of MS, independent of the degree of obesity. Conclusions: High prevalence of MS emphasizes the need for prevention and treatment of childhood obesity.",
publisher = "Walter De Gruyter Gmbh, Berlin",
journal = "Journal of Pediatric Endocrinology & Metabolism",
title = "Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors",
volume = "28",
number = "7-8",
pages = "903-909",
doi = "10.1515/jpem-2014-0533"
}

Vuković, R., Zdravković, D., Mitrović, K., Milenković, T., Todorović, S., Vuković, A.,& Soldatović, I.. (2015). Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors. in Journal of Pediatric Endocrinology & Metabolism
Walter De Gruyter Gmbh, Berlin., 28(7-8), 903-909.
https://doi.org/10.1515/jpem-2014-0533

Vuković R, Zdravković D, Mitrović K, Milenković T, Todorović S, Vuković A, Soldatović I. Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors. in Journal of Pediatric Endocrinology & Metabolism. 2015;28(7-8):903-909.
doi:10.1515/jpem-2014-0533 .

Vuković, Rade, Zdravković, Dragan, Mitrović, Katarina, Milenković, Tatjana, Todorović, Slađana, Vuković, Ana, Soldatović, Ivan, "Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors" in Journal of Pediatric Endocrinology & Metabolism, 28, no. 7-8 (2015):903-909,
https://doi.org/10.1515/jpem-2014-0533 . .