TY  - JOUR
AU  - Smiljković, Marija
AU  - Matsoukas, Minos-Timotheos
AU  - Kritsi, Eftichia
AU  - Zelenko, Urska
AU  - Golic-Grdadolnik, Simona
AU  - Calhelha, Ricardo C.
AU  - Ferreira, Isabel C. F. R.
AU  - Sanković-Babić, Snežana
AU  - Glamočlija, Jasmina
AU  - Fotopoulou, Theano
AU  - Koufaki, Maria
AU  - Zoumpoulakis, Panagiotis
AU  - Soković, Marina
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2357
AB  - Four heteroaromatic compounds bearing nitrate esters were selected using a virtual-screening procedure as putative sterol 14-demethylase (CYP51) Candida albicans inhibitors. Compounds were examined for their inhibition on C.albicans growth and biofilm formation as well as for their toxicity. NMR spectroscopy studies, insilico docking, and molecular dynamics simulations were used to investigate further the selectivity of these compounds to fungal CYP51. All compounds exhibited good antimicrobial properties, indicated with low minimal inhibitory concentrations and ability to inhibit formation of fungal biofilm. Moreover, all of the compounds had the ability to inhibit growth of C.albicans cells. N-(2-Nitrooxyethyl)-1-indole-2-carboxamide was the only compound with selectivity on C.albicans CYP51 that did not exhibit cytotoxic effect on cells isolated from liver and should be further investigated for selective application in new leads for the treatment of candidiasis.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemmedchem
T1  - Nitrate Esters of Heteroaromatic Compounds as Candida albicans CYP51 Enzyme Inhibitors
VL  - 13
IS  - 3
SP  - 251
EP  - 258
DO  - 10.1002/cmdc.201700602
ER  - 

@article{
author = "Smiljković, Marija and Matsoukas, Minos-Timotheos and Kritsi, Eftichia and Zelenko, Urska and Golic-Grdadolnik, Simona and Calhelha, Ricardo C. and Ferreira, Isabel C. F. R. and Sanković-Babić, Snežana and Glamočlija, Jasmina and Fotopoulou, Theano and Koufaki, Maria and Zoumpoulakis, Panagiotis and Soković, Marina",
year = "2018",
abstract = "Four heteroaromatic compounds bearing nitrate esters were selected using a virtual-screening procedure as putative sterol 14-demethylase (CYP51) Candida albicans inhibitors. Compounds were examined for their inhibition on C.albicans growth and biofilm formation as well as for their toxicity. NMR spectroscopy studies, insilico docking, and molecular dynamics simulations were used to investigate further the selectivity of these compounds to fungal CYP51. All compounds exhibited good antimicrobial properties, indicated with low minimal inhibitory concentrations and ability to inhibit formation of fungal biofilm. Moreover, all of the compounds had the ability to inhibit growth of C.albicans cells. N-(2-Nitrooxyethyl)-1-indole-2-carboxamide was the only compound with selectivity on C.albicans CYP51 that did not exhibit cytotoxic effect on cells isolated from liver and should be further investigated for selective application in new leads for the treatment of candidiasis.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemmedchem",
title = "Nitrate Esters of Heteroaromatic Compounds as Candida albicans CYP51 Enzyme Inhibitors",
volume = "13",
number = "3",
pages = "251-258",
doi = "10.1002/cmdc.201700602"
}

Smiljković, M., Matsoukas, M., Kritsi, E., Zelenko, U., Golic-Grdadolnik, S., Calhelha, R. C., Ferreira, I. C. F. R., Sanković-Babić, S., Glamočlija, J., Fotopoulou, T., Koufaki, M., Zoumpoulakis, P.,& Soković, M.. (2018). Nitrate Esters of Heteroaromatic Compounds as Candida albicans CYP51 Enzyme Inhibitors. in Chemmedchem
Wiley-V C H Verlag Gmbh, Weinheim., 13(3), 251-258.
https://doi.org/10.1002/cmdc.201700602

Smiljković M, Matsoukas M, Kritsi E, Zelenko U, Golic-Grdadolnik S, Calhelha RC, Ferreira ICFR, Sanković-Babić S, Glamočlija J, Fotopoulou T, Koufaki M, Zoumpoulakis P, Soković M. Nitrate Esters of Heteroaromatic Compounds as Candida albicans CYP51 Enzyme Inhibitors. in Chemmedchem. 2018;13(3):251-258.
doi:10.1002/cmdc.201700602 .

Smiljković, Marija, Matsoukas, Minos-Timotheos, Kritsi, Eftichia, Zelenko, Urska, Golic-Grdadolnik, Simona, Calhelha, Ricardo C., Ferreira, Isabel C. F. R., Sanković-Babić, Snežana, Glamočlija, Jasmina, Fotopoulou, Theano, Koufaki, Maria, Zoumpoulakis, Panagiotis, Soković, Marina, "Nitrate Esters of Heteroaromatic Compounds as Candida albicans CYP51 Enzyme Inhibitors" in Chemmedchem, 13, no. 3 (2018):251-258,
https://doi.org/10.1002/cmdc.201700602 . .

TY  - JOUR
AU  - Smiljković, Marija
AU  - Stanisavljević, Danijela
AU  - Stojković, Dejan
AU  - Petrović, Isidora
AU  - Marjanović-Vicentić, Jelena
AU  - Popović, Jelena
AU  - Golic-Grdadolnik, Simona
AU  - Marković, Dejan
AU  - Sanković-Babić, Snežana
AU  - Glamočlija, Jasmina
AU  - Stevanović, Milena
AU  - Soković, Marina
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2225
AB  - Bioactive potential of apigenin derivative apigenin-7-O-glucoside related to its antifungal activity on Candida spp. and cytotoxic effect on colon cancer cells was studied and compared with bioactive potential of apigenin. Antifungal activity was tested on 14 different isolates of Candida spp. using membrane permeability assay, measuring inhibition of reactive oxidative species and inhibition of CYP51 C. albicans enzyme. Cytotoxic potential of apigenin- 7-O-glucoside was tested on colon cancer HCT116 cells by measuring cell viability, apoptosis rate and apoptosis- and colon cancer-related gene expression. Obtained results indicated considerable antifungal activity of apigenin-7-O-glucoside towards all Candida isolates. Breakdown of C. albicans plasma membrane was achieved upon treatment with apigenin-7-O-glucoside for shorter period of time then with apigenin. Reduction of intra-and extracellular reactive oxidative species was achieved with minimum inhibitory concentrations of both compounds, suggesting that reactive oxidative species inhibition could be a mechanism of antifungal action. None of the compounds exhibited binding affinity to C. albicans CYP51 protein. Besides, apigenin-7-O-glucoside was more effective compared to apigenin in reduction of cell's viability and induction of cell death of HCT116 cells. Treatment with both compounds resulted in chromatin condensation, apoptotic bodies formation and apoptotic genes expression in HCT116 cells, but the apigenin-7-O-glucoside required a lower concentration to achieve the same effect. Compounds apigenin-7-O-glucoside and apigenin displayed prominent antifungal potential and cytotoxic effect on HCT116 cells. However, our results showed that apigenin-7-O-glucoside has more potent activity compared to apigenin in all assays that we used.
PB  - Excli Journal Managing Office, Dortmund
T2  - EXCLI Journal
T1  - Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions
VL  - 16
SP  - 795
EP  - 807
DO  - 10.17179/excli2017-300
ER  - 

@article{
author = "Smiljković, Marija and Stanisavljević, Danijela and Stojković, Dejan and Petrović, Isidora and Marjanović-Vicentić, Jelena and Popović, Jelena and Golic-Grdadolnik, Simona and Marković, Dejan and Sanković-Babić, Snežana and Glamočlija, Jasmina and Stevanović, Milena and Soković, Marina",
year = "2017",
abstract = "Bioactive potential of apigenin derivative apigenin-7-O-glucoside related to its antifungal activity on Candida spp. and cytotoxic effect on colon cancer cells was studied and compared with bioactive potential of apigenin. Antifungal activity was tested on 14 different isolates of Candida spp. using membrane permeability assay, measuring inhibition of reactive oxidative species and inhibition of CYP51 C. albicans enzyme. Cytotoxic potential of apigenin- 7-O-glucoside was tested on colon cancer HCT116 cells by measuring cell viability, apoptosis rate and apoptosis- and colon cancer-related gene expression. Obtained results indicated considerable antifungal activity of apigenin-7-O-glucoside towards all Candida isolates. Breakdown of C. albicans plasma membrane was achieved upon treatment with apigenin-7-O-glucoside for shorter period of time then with apigenin. Reduction of intra-and extracellular reactive oxidative species was achieved with minimum inhibitory concentrations of both compounds, suggesting that reactive oxidative species inhibition could be a mechanism of antifungal action. None of the compounds exhibited binding affinity to C. albicans CYP51 protein. Besides, apigenin-7-O-glucoside was more effective compared to apigenin in reduction of cell's viability and induction of cell death of HCT116 cells. Treatment with both compounds resulted in chromatin condensation, apoptotic bodies formation and apoptotic genes expression in HCT116 cells, but the apigenin-7-O-glucoside required a lower concentration to achieve the same effect. Compounds apigenin-7-O-glucoside and apigenin displayed prominent antifungal potential and cytotoxic effect on HCT116 cells. However, our results showed that apigenin-7-O-glucoside has more potent activity compared to apigenin in all assays that we used.",
publisher = "Excli Journal Managing Office, Dortmund",
journal = "EXCLI Journal",
title = "Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions",
volume = "16",
pages = "795-807",
doi = "10.17179/excli2017-300"
}

Smiljković, M., Stanisavljević, D., Stojković, D., Petrović, I., Marjanović-Vicentić, J., Popović, J., Golic-Grdadolnik, S., Marković, D., Sanković-Babić, S., Glamočlija, J., Stevanović, M.,& Soković, M.. (2017). Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions. in EXCLI Journal
Excli Journal Managing Office, Dortmund., 16, 795-807.
https://doi.org/10.17179/excli2017-300

Smiljković M, Stanisavljević D, Stojković D, Petrović I, Marjanović-Vicentić J, Popović J, Golic-Grdadolnik S, Marković D, Sanković-Babić S, Glamočlija J, Stevanović M, Soković M. Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions. in EXCLI Journal. 2017;16:795-807.
doi:10.17179/excli2017-300 .

Smiljković, Marija, Stanisavljević, Danijela, Stojković, Dejan, Petrović, Isidora, Marjanović-Vicentić, Jelena, Popović, Jelena, Golic-Grdadolnik, Simona, Marković, Dejan, Sanković-Babić, Snežana, Glamočlija, Jasmina, Stevanović, Milena, Soković, Marina, "Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions" in EXCLI Journal, 16 (2017):795-807,
https://doi.org/10.17179/excli2017-300 . .

TY  - CONF
AU  - Smiljković, M. S.
AU  - Kostić, M. Z.
AU  - Sanković-Babić, Snežana
AU  - Stojković, D. S.
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2234
PB  - Wiley, Hoboken
C3  - Mycoses
T1  - Camphor and rutin, compounds of distinct origin combating Candida albicans
VL  - 60
SP  - 55
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_smile_2234
ER  - 

@conference{
author = "Smiljković, M. S. and Kostić, M. Z. and Sanković-Babić, Snežana and Stojković, D. S. and Glamočlija, Jasmina and Soković, Marina",
year = "2017",
publisher = "Wiley, Hoboken",
journal = "Mycoses",
title = "Camphor and rutin, compounds of distinct origin combating Candida albicans",
volume = "60",
pages = "55-56",
url = "https://hdl.handle.net/21.15107/rcub_smile_2234"
}

Smiljković, M. S., Kostić, M. Z., Sanković-Babić, S., Stojković, D. S., Glamočlija, J.,& Soković, M.. (2017). Camphor and rutin, compounds of distinct origin combating Candida albicans. in Mycoses
Wiley, Hoboken., 60, 55-56.
https://hdl.handle.net/21.15107/rcub_smile_2234

Smiljković MS, Kostić MZ, Sanković-Babić S, Stojković DS, Glamočlija J, Soković M. Camphor and rutin, compounds of distinct origin combating Candida albicans. in Mycoses. 2017;60:55-56.
https://hdl.handle.net/21.15107/rcub_smile_2234 .

Smiljković, M. S., Kostić, M. Z., Sanković-Babić, Snežana, Stojković, D. S., Glamočlija, Jasmina, Soković, Marina, "Camphor and rutin, compounds of distinct origin combating Candida albicans" in Mycoses, 60 (2017):55-56,
https://hdl.handle.net/21.15107/rcub_smile_2234 .

TY  - JOUR
AU  - Sanković-Babić, Snežana
AU  - Kosanović, Rade
AU  - Ivanković, Zoran
AU  - Babac, Snezana
AU  - Tatović, Milica
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1925
AB  - Introduction Over the last two decades the intratympanic perfusion of corticosteroids has been used as a minimally invasive surgical therapy of Meniere's disease. According to experimental studies the antiinflammatory, immunoprotective, antioxidant and neuroprotective role of the locally perfused corticosteroids was noticed in the inner ear structures. The recovery of action potentials in the cells of the Corti organ was confirmed as well as a decreased expression of aquaporine-1, a glycoprotein responsible for labyrinth hydrops and N and K ions derangement. Objective The study showed results of intratympanic perfusion therapy with dexamethasone in patients with retractable Meniere's disease who are resistant to conservative treatment. Methods Single doses of 4 mg/ml dexamethasone were given intratympanically in 19 patients with retractable Meniere's disease. Six single successive doses of dexamethasone were administered in the posteroinferior quadrant of the tympanic membrane. Follow-up of the patients was conducted by using a clinical questionnaire a month after completed perfusion series as well as on every third month up to one year. Results One month after completed first course of perfusions, in 78% of patients, vertigo problems completely ceased or were markedly reduced. The recovery of hearing function was recorded in 68% and marked tinnitus reduction in 84% of patients. After a year of follow-up, in 63% of patients the reduction of vertigo persisted, while hearing function was satisfactory in 52%. Tinitus reduction was present in 73% of patients. Conclusion Intratympanic perfusion of dexamethasone in patients with Meniere's disease is a minimally invasive therapeutic method that contributes to the reduction of the intensity of vertigo recurrent attacks, decrease of the intensity of tinnitus and improvement of the average hearing threshold. Patients with chronic diseases and Meniere's disease who are contraindicted for systemic administration of cortocosteroids (hypertension, diabetes, glaucoma, peptic ulcer, etc.) have an additional therapeutic option by dexamethasone intratympanic perfusion.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Intratympanic Corticosteroid Perfusion in the Therapy of Meniere's Disease
VL  - 142
IS  - 5-6
SP  - 291
EP  - 295
DO  - 10.2298/SARH1406291S
ER  - 

@article{
author = "Sanković-Babić, Snežana and Kosanović, Rade and Ivanković, Zoran and Babac, Snezana and Tatović, Milica",
year = "2014",
abstract = "Introduction Over the last two decades the intratympanic perfusion of corticosteroids has been used as a minimally invasive surgical therapy of Meniere's disease. According to experimental studies the antiinflammatory, immunoprotective, antioxidant and neuroprotective role of the locally perfused corticosteroids was noticed in the inner ear structures. The recovery of action potentials in the cells of the Corti organ was confirmed as well as a decreased expression of aquaporine-1, a glycoprotein responsible for labyrinth hydrops and N and K ions derangement. Objective The study showed results of intratympanic perfusion therapy with dexamethasone in patients with retractable Meniere's disease who are resistant to conservative treatment. Methods Single doses of 4 mg/ml dexamethasone were given intratympanically in 19 patients with retractable Meniere's disease. Six single successive doses of dexamethasone were administered in the posteroinferior quadrant of the tympanic membrane. Follow-up of the patients was conducted by using a clinical questionnaire a month after completed perfusion series as well as on every third month up to one year. Results One month after completed first course of perfusions, in 78% of patients, vertigo problems completely ceased or were markedly reduced. The recovery of hearing function was recorded in 68% and marked tinnitus reduction in 84% of patients. After a year of follow-up, in 63% of patients the reduction of vertigo persisted, while hearing function was satisfactory in 52%. Tinitus reduction was present in 73% of patients. Conclusion Intratympanic perfusion of dexamethasone in patients with Meniere's disease is a minimally invasive therapeutic method that contributes to the reduction of the intensity of vertigo recurrent attacks, decrease of the intensity of tinnitus and improvement of the average hearing threshold. Patients with chronic diseases and Meniere's disease who are contraindicted for systemic administration of cortocosteroids (hypertension, diabetes, glaucoma, peptic ulcer, etc.) have an additional therapeutic option by dexamethasone intratympanic perfusion.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Intratympanic Corticosteroid Perfusion in the Therapy of Meniere's Disease",
volume = "142",
number = "5-6",
pages = "291-295",
doi = "10.2298/SARH1406291S"
}

Sanković-Babić, S., Kosanović, R., Ivanković, Z., Babac, S.,& Tatović, M.. (2014). Intratympanic Corticosteroid Perfusion in the Therapy of Meniere's Disease. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(5-6), 291-295.
https://doi.org/10.2298/SARH1406291S

Sanković-Babić S, Kosanović R, Ivanković Z, Babac S, Tatović M. Intratympanic Corticosteroid Perfusion in the Therapy of Meniere's Disease. in Srpski arhiv za celokupno lekarstvo. 2014;142(5-6):291-295.
doi:10.2298/SARH1406291S .

Sanković-Babić, Snežana, Kosanović, Rade, Ivanković, Zoran, Babac, Snezana, Tatović, Milica, "Intratympanic Corticosteroid Perfusion in the Therapy of Meniere's Disease" in Srpski arhiv za celokupno lekarstvo, 142, no. 5-6 (2014):291-295,
https://doi.org/10.2298/SARH1406291S . .

TY  - CONF
AU  - Sanković-Babić, Snežana
AU  - Atanasković, M.
AU  - Kosanović, Rade
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1709
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Conservative therapy in children with allergic rhinitis and secretory otitis media
VL  - 67
SP  - 331
EP  - 331
UR  - https://hdl.handle.net/21.15107/rcub_smile_1709
ER  - 

@conference{
author = "Sanković-Babić, Snežana and Atanasković, M. and Kosanović, Rade",
year = "2012",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Conservative therapy in children with allergic rhinitis and secretory otitis media",
volume = "67",
pages = "331-331",
url = "https://hdl.handle.net/21.15107/rcub_smile_1709"
}

Sanković-Babić, S., Atanasković, M.,& Kosanović, R.. (2012). Conservative therapy in children with allergic rhinitis and secretory otitis media. in Allergy
Wiley-Blackwell, Hoboken., 67, 331-331.
https://hdl.handle.net/21.15107/rcub_smile_1709

Sanković-Babić S, Atanasković M, Kosanović R. Conservative therapy in children with allergic rhinitis and secretory otitis media. in Allergy. 2012;67:331-331.
https://hdl.handle.net/21.15107/rcub_smile_1709 .

Sanković-Babić, Snežana, Atanasković, M., Kosanović, Rade, "Conservative therapy in children with allergic rhinitis and secretory otitis media" in Allergy, 67 (2012):331-331,
https://hdl.handle.net/21.15107/rcub_smile_1709 .

TY  - CONF
AU  - Sanković-Babić, Snežana
AU  - Atanasković, M.
AU  - Kosanović, Rade
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1601
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Clinical benefit of the conservative therapy in children with allergic rhinitis and otitis media with effusion
VL  - 65
SP  - 685
EP  - 685
UR  - https://hdl.handle.net/21.15107/rcub_smile_1601
ER  - 

@conference{
author = "Sanković-Babić, Snežana and Atanasković, M. and Kosanović, Rade",
year = "2010",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Clinical benefit of the conservative therapy in children with allergic rhinitis and otitis media with effusion",
volume = "65",
pages = "685-685",
url = "https://hdl.handle.net/21.15107/rcub_smile_1601"
}

Sanković-Babić, S., Atanasković, M.,& Kosanović, R.. (2010). Clinical benefit of the conservative therapy in children with allergic rhinitis and otitis media with effusion. in Allergy
Wiley-Blackwell, Hoboken., 65, 685-685.
https://hdl.handle.net/21.15107/rcub_smile_1601

Sanković-Babić S, Atanasković M, Kosanović R. Clinical benefit of the conservative therapy in children with allergic rhinitis and otitis media with effusion. in Allergy. 2010;65:685-685.
https://hdl.handle.net/21.15107/rcub_smile_1601 .

Sanković-Babić, Snežana, Atanasković, M., Kosanović, Rade, "Clinical benefit of the conservative therapy in children with allergic rhinitis and otitis media with effusion" in Allergy, 65 (2010):685-685,
https://hdl.handle.net/21.15107/rcub_smile_1601 .

TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Zivanović, Mirjana
AU  - Gavrović-Jankulović, Marija
AU  - Ćirković-Veličković, Tanja
AU  - Đurić, Vojislav
AU  - Sanković-Babić, Snežana
AU  - Nestorović, Branimir
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1542
AB  - Introduction Ingestion is the principal route for food allergens to trigger allergic reaction in atopic persons. However, in some highly sensitive patients severe symptoms may develop upon skin contact and by inhalation. The clinical spectrum ranges from mild facial urticaria and angioedema to life-threatening anaphylactic reactions. Outline of Cases We describe cases of severe anaphylactic reactions by skin contact, induced by kissing in five children with prior history of severe anaphylaxis caused by food ingestion. These cases were found to have the medical history of IgE mediated food allergy, a very high total and specific serum IgE level and very strong family history of allergy. Conclusion The presence of tiny particles of food on the kisser's lips was sufficient to trigger an anaphylactic reaction in sensitized children with prior history of severe allergic reaction caused by ingestion of food. Allergic reaction provoked with food allergens by skin contact can be a risk factor for generalized reactions. Therefore, extreme care has to be taken in avoiding kissing allergic children after eating foods to which they are highly allergic. Considering that kissing can be a cause of severe danger for the food allergic patient, such persons should inform their partners about the risk factor for causing their food hypersensitivity.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Kiss-Induced Severe Anaphylactic Reactions
VL  - 138
IS  - 7-8
SP  - 498
EP  - 501
DO  - 10.2298/SARH1008498A
ER  - 

@article{
author = "Atanasković-Marković, Marina and Zivanović, Mirjana and Gavrović-Jankulović, Marija and Ćirković-Veličković, Tanja and Đurić, Vojislav and Sanković-Babić, Snežana and Nestorović, Branimir",
year = "2010",
abstract = "Introduction Ingestion is the principal route for food allergens to trigger allergic reaction in atopic persons. However, in some highly sensitive patients severe symptoms may develop upon skin contact and by inhalation. The clinical spectrum ranges from mild facial urticaria and angioedema to life-threatening anaphylactic reactions. Outline of Cases We describe cases of severe anaphylactic reactions by skin contact, induced by kissing in five children with prior history of severe anaphylaxis caused by food ingestion. These cases were found to have the medical history of IgE mediated food allergy, a very high total and specific serum IgE level and very strong family history of allergy. Conclusion The presence of tiny particles of food on the kisser's lips was sufficient to trigger an anaphylactic reaction in sensitized children with prior history of severe allergic reaction caused by ingestion of food. Allergic reaction provoked with food allergens by skin contact can be a risk factor for generalized reactions. Therefore, extreme care has to be taken in avoiding kissing allergic children after eating foods to which they are highly allergic. Considering that kissing can be a cause of severe danger for the food allergic patient, such persons should inform their partners about the risk factor for causing their food hypersensitivity.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Kiss-Induced Severe Anaphylactic Reactions",
volume = "138",
number = "7-8",
pages = "498-501",
doi = "10.2298/SARH1008498A"
}

Atanasković-Marković, M., Zivanović, M., Gavrović-Jankulović, M., Ćirković-Veličković, T., Đurić, V., Sanković-Babić, S.,& Nestorović, B.. (2010). Kiss-Induced Severe Anaphylactic Reactions. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 138(7-8), 498-501.
https://doi.org/10.2298/SARH1008498A

Atanasković-Marković M, Zivanović M, Gavrović-Jankulović M, Ćirković-Veličković T, Đurić V, Sanković-Babić S, Nestorović B. Kiss-Induced Severe Anaphylactic Reactions. in Srpski arhiv za celokupno lekarstvo. 2010;138(7-8):498-501.
doi:10.2298/SARH1008498A .

Atanasković-Marković, Marina, Zivanović, Mirjana, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Đurić, Vojislav, Sanković-Babić, Snežana, Nestorović, Branimir, "Kiss-Induced Severe Anaphylactic Reactions" in Srpski arhiv za celokupno lekarstvo, 138, no. 7-8 (2010):498-501,
https://doi.org/10.2298/SARH1008498A . .