TY  - JOUR
AU  - Oprić, D.
AU  - Stankovich, A.D.
AU  - Nenadović, A.
AU  - Kovačević, S.
AU  - Obradović, D.D.
AU  - de Luka, Silvio R.
AU  - Nešović-Ostojić, J.
AU  - Milašin, Jelena
AU  - Ilić, A.Ž.
AU  - Trbovich, Alexander M.
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2506
AB  - Objective: Inflammation is a biological response of tissue to harmful stimuli. A high-fat diet was linked to low-grade chronic liver inflammation, which can further lead to more severe health conditions. It is crucial to assess the intensity of inflammation and structural tissue changes to reduce the subjective judgment by the examiner. We propose fractal-based methods for early-stage low-degree liver inflammation grading. Methods: We have randomly divided 40 C57BL/6 female mice into four groups (control, linseed oil, palm oil, sunflower oil). After 100 days, animals were euthanized, and liver tissue collected for analyses. We performed calculations of fractal dimension, fractal lacunarity, multifractal spectra, local fractal dimension, and particle metrics, applicable to tissue segmentation and grading. Results: Pathohistological analysis of some liver tissue showed a low-grade inflammatory infiltrate around the portal vein of experimental groups subjected to different high-fat diets. Differences in fractal dimension and lacunarity of the inflamed tissue were, in most cases, statistically significant between the high-fat diet groups. Both the observed intensity and area of inflammation were lowest for the sunflower oil. The results of standard fractal analysis, local fractal analysis, and particle analysis were in an excellent agreement. Conclusions: This study demonstrated the efficiency of the fractal analysis based tools in the quantification of complexity and early-stage structural changes in inflamed liver tissue, which could potentially be used in the diagnostic workup of inflammation in the liver. The presented methods could be implemented within a wider scope computer-aided diagnostics system in a very straightforward manner.
PB  - Elsevier Ltd
T2  - Biomedical Signal Processing & Control
T1  - Fractal analysis tools for early assessment of liver inflammation induced by chronic consumption of linseed, palm and sunflower oils
VL  - 61
DO  - 10.1016/j.bspc.2020.101959
ER  - 

@article{
author = "Oprić, D. and Stankovich, A.D. and Nenadović, A. and Kovačević, S. and Obradović, D.D. and de Luka, Silvio R. and Nešović-Ostojić, J. and Milašin, Jelena and Ilić, A.Ž. and Trbovich, Alexander M.",
year = "2020",
abstract = "Objective: Inflammation is a biological response of tissue to harmful stimuli. A high-fat diet was linked to low-grade chronic liver inflammation, which can further lead to more severe health conditions. It is crucial to assess the intensity of inflammation and structural tissue changes to reduce the subjective judgment by the examiner. We propose fractal-based methods for early-stage low-degree liver inflammation grading. Methods: We have randomly divided 40 C57BL/6 female mice into four groups (control, linseed oil, palm oil, sunflower oil). After 100 days, animals were euthanized, and liver tissue collected for analyses. We performed calculations of fractal dimension, fractal lacunarity, multifractal spectra, local fractal dimension, and particle metrics, applicable to tissue segmentation and grading. Results: Pathohistological analysis of some liver tissue showed a low-grade inflammatory infiltrate around the portal vein of experimental groups subjected to different high-fat diets. Differences in fractal dimension and lacunarity of the inflamed tissue were, in most cases, statistically significant between the high-fat diet groups. Both the observed intensity and area of inflammation were lowest for the sunflower oil. The results of standard fractal analysis, local fractal analysis, and particle analysis were in an excellent agreement. Conclusions: This study demonstrated the efficiency of the fractal analysis based tools in the quantification of complexity and early-stage structural changes in inflamed liver tissue, which could potentially be used in the diagnostic workup of inflammation in the liver. The presented methods could be implemented within a wider scope computer-aided diagnostics system in a very straightforward manner.",
publisher = "Elsevier Ltd",
journal = "Biomedical Signal Processing & Control",
title = "Fractal analysis tools for early assessment of liver inflammation induced by chronic consumption of linseed, palm and sunflower oils",
volume = "61",
doi = "10.1016/j.bspc.2020.101959"
}

Oprić, D., Stankovich, A.D., Nenadović, A., Kovačević, S., Obradović, D.D., de Luka, S. R., Nešović-Ostojić, J., Milašin, J., Ilić, A.Ž.,& Trbovich, A. M.. (2020). Fractal analysis tools for early assessment of liver inflammation induced by chronic consumption of linseed, palm and sunflower oils. in Biomedical Signal Processing & Control
Elsevier Ltd., 61.
https://doi.org/10.1016/j.bspc.2020.101959

Oprić D, Stankovich A, Nenadović A, Kovačević S, Obradović D, de Luka SR, Nešović-Ostojić J, Milašin J, Ilić A, Trbovich AM. Fractal analysis tools for early assessment of liver inflammation induced by chronic consumption of linseed, palm and sunflower oils. in Biomedical Signal Processing & Control. 2020;61.
doi:10.1016/j.bspc.2020.101959 .

Oprić, D., Stankovich, A.D., Nenadović, A., Kovačević, S., Obradović, D.D., de Luka, Silvio R., Nešović-Ostojić, J., Milašin, Jelena, Ilić, A.Ž., Trbovich, Alexander M., "Fractal analysis tools for early assessment of liver inflammation induced by chronic consumption of linseed, palm and sunflower oils" in Biomedical Signal Processing & Control, 61 (2020),
https://doi.org/10.1016/j.bspc.2020.101959 . .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Radojević-Škodrić, Sanja
AU  - Brašanac, Dimitrije
AU  - Đuricić, S.
AU  - Milašin, Jelena
AU  - Bogdanović, L.
AU  - Oprić, D.
AU  - Savin, M.
AU  - Baralić, I.
AU  - Jovanović, M.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1747
AB  - Purpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Prognostic value of survivin expression in Wilms tumor
VL  - 17
IS  - 1
SP  - 168
EP  - 173
UR  - https://hdl.handle.net/21.15107/rcub_smile_1747
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Radojević-Škodrić, Sanja and Brašanac, Dimitrije and Đuricić, S. and Milašin, Jelena and Bogdanović, L. and Oprić, D. and Savin, M. and Baralić, I. and Jovanović, M.",
year = "2012",
abstract = "Purpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Prognostic value of survivin expression in Wilms tumor",
volume = "17",
number = "1",
pages = "168-173",
url = "https://hdl.handle.net/21.15107/rcub_smile_1747"
}

Basta-Jovanović, G., Radojević-Škodrić, S., Brašanac, D., Đuricić, S., Milašin, J., Bogdanović, L., Oprić, D., Savin, M., Baralić, I.,& Jovanović, M.. (2012). Prognostic value of survivin expression in Wilms tumor. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 17(1), 168-173.
https://hdl.handle.net/21.15107/rcub_smile_1747

Basta-Jovanović G, Radojević-Škodrić S, Brašanac D, Đuricić S, Milašin J, Bogdanović L, Oprić D, Savin M, Baralić I, Jovanović M. Prognostic value of survivin expression in Wilms tumor. in Journal of BUON. 2012;17(1):168-173.
https://hdl.handle.net/21.15107/rcub_smile_1747 .

Basta-Jovanović, Gordana, Radojević-Škodrić, Sanja, Brašanac, Dimitrije, Đuricić, S., Milašin, Jelena, Bogdanović, L., Oprić, D., Savin, M., Baralić, I., Jovanović, M., "Prognostic value of survivin expression in Wilms tumor" in Journal of BUON, 17, no. 1 (2012):168-173,
https://hdl.handle.net/21.15107/rcub_smile_1747 .