TY  - JOUR
AU  - Ćetenović, Bojana
AU  - Čolović, Božana
AU  - Vasilijić, Saša
AU  - Prokić, Bogomir
AU  - Pašalić, Snežana
AU  - Jokanović, Vukoman
AU  - Tepavčević, Zvezdana
AU  - Marković, Dejan
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2275
AB  - The aim of this study was to investigate the biocompatibility of nanostructured materials based on highly active calcium silicates mixed with different radiocontrast agents in comparison to MTA(+) using in vitro and in vivo model. Morphology of materials' samples was analyzed using SEM while the phase compositions were identified by XRD. pH values of materials' suspensions were conducted by pH-meter. The cytotoxicity of materials' solutions was tested by MTT test (100, 50, 25 and 12.5mg/ml). LDH and H-3-thymidine assay were utilized for biocompatibility investigations of materials' eluates (24h, 7 day and 21 day). Eighteen Guinea pigs were used for intramuscular implantation, as teflon tubes with freshly prepared materials were placed into intramuscular pockets. All samples were composed of round and needle-like particles equally distributed with Ca/Si ratio 2.7 at%, with the presence of hydrated calcium silicate phases. The pH values of ALBO-MPCA(1) and ALBO-MPCA(2) were high alkaline, while in case of MTA(+) they were lower and continuously declined (p lt 0.05). Investigated materials didn't exhibit dose-dependent effect on metabolic activity of L929 cells (p>0.05). Significant differences in the percentage of cytotoxicity between diluted and undiluted extracts between all tested materials after 24h and 7 day were noticed (p lt 0.05). Increase in L929 cells proliferation was noticed in case of undiluted eluates of ALBO-MPCA(1) and ALBO-MPCA(2) after 7 day (p lt 0.05). There were no statistically significant differences in the intensity of inflammatory response between investigated materials and control group after 60 day (p>0.05). Evaluation of biocompatibility of both ALBO-MPCA(1) and ALBO-MPCA(2) indicate their potential clinical use. [GRAPHICS] .
PB  - Springer, Dordrecht
T2  - Journal of Materials Science-Materials in Medicine
T1  - Nanostructured endodontic materials mixed with different radiocontrast agentsbiocompatibility study
VL  - 29
IS  - 12
DO  - 10.1007/s10856-018-6200-z
ER  - 

@article{
author = "Ćetenović, Bojana and Čolović, Božana and Vasilijić, Saša and Prokić, Bogomir and Pašalić, Snežana and Jokanović, Vukoman and Tepavčević, Zvezdana and Marković, Dejan",
year = "2018",
abstract = "The aim of this study was to investigate the biocompatibility of nanostructured materials based on highly active calcium silicates mixed with different radiocontrast agents in comparison to MTA(+) using in vitro and in vivo model. Morphology of materials' samples was analyzed using SEM while the phase compositions were identified by XRD. pH values of materials' suspensions were conducted by pH-meter. The cytotoxicity of materials' solutions was tested by MTT test (100, 50, 25 and 12.5mg/ml). LDH and H-3-thymidine assay were utilized for biocompatibility investigations of materials' eluates (24h, 7 day and 21 day). Eighteen Guinea pigs were used for intramuscular implantation, as teflon tubes with freshly prepared materials were placed into intramuscular pockets. All samples were composed of round and needle-like particles equally distributed with Ca/Si ratio 2.7 at%, with the presence of hydrated calcium silicate phases. The pH values of ALBO-MPCA(1) and ALBO-MPCA(2) were high alkaline, while in case of MTA(+) they were lower and continuously declined (p lt 0.05). Investigated materials didn't exhibit dose-dependent effect on metabolic activity of L929 cells (p>0.05). Significant differences in the percentage of cytotoxicity between diluted and undiluted extracts between all tested materials after 24h and 7 day were noticed (p lt 0.05). Increase in L929 cells proliferation was noticed in case of undiluted eluates of ALBO-MPCA(1) and ALBO-MPCA(2) after 7 day (p lt 0.05). There were no statistically significant differences in the intensity of inflammatory response between investigated materials and control group after 60 day (p>0.05). Evaluation of biocompatibility of both ALBO-MPCA(1) and ALBO-MPCA(2) indicate their potential clinical use. [GRAPHICS] .",
publisher = "Springer, Dordrecht",
journal = "Journal of Materials Science-Materials in Medicine",
title = "Nanostructured endodontic materials mixed with different radiocontrast agentsbiocompatibility study",
volume = "29",
number = "12",
doi = "10.1007/s10856-018-6200-z"
}

Ćetenović, B., Čolović, B., Vasilijić, S., Prokić, B., Pašalić, S., Jokanović, V., Tepavčević, Z.,& Marković, D.. (2018). Nanostructured endodontic materials mixed with different radiocontrast agentsbiocompatibility study. in Journal of Materials Science-Materials in Medicine
Springer, Dordrecht., 29(12).
https://doi.org/10.1007/s10856-018-6200-z

Ćetenović B, Čolović B, Vasilijić S, Prokić B, Pašalić S, Jokanović V, Tepavčević Z, Marković D. Nanostructured endodontic materials mixed with different radiocontrast agentsbiocompatibility study. in Journal of Materials Science-Materials in Medicine. 2018;29(12).
doi:10.1007/s10856-018-6200-z .

Ćetenović, Bojana, Čolović, Božana, Vasilijić, Saša, Prokić, Bogomir, Pašalić, Snežana, Jokanović, Vukoman, Tepavčević, Zvezdana, Marković, Dejan, "Nanostructured endodontic materials mixed with different radiocontrast agentsbiocompatibility study" in Journal of Materials Science-Materials in Medicine, 29, no. 12 (2018),
https://doi.org/10.1007/s10856-018-6200-z . .

TY  - JOUR
AU  - Ćetenović, Bojana
AU  - Čolović, Božana
AU  - Vasilijić, Saša
AU  - Pašalić, Snežana
AU  - Jokanović, Vukoman
AU  - Marković, Dejan
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2249
AB  - Background/Aim: Lately, fully innovative sol-gel method with high-temperature self-propagating reaction was used for the synthesis of new nanostructured endodontic materials, in combination with different radiopacifiers: bismuth (ALBO-MPCA1) and barium (ALBO-MPCA2). The aim of this study was to investigate the biocompatibility of nanostructured endodontic materials based on highly active calcium silicates and mixed with different radiopacifiers in comparison to MTA+ using human stem cells from the apical papilla- SCAP cells. Material and Methods: Morphology of the samples was studied by SEM. The tested materials were mixed with distilled water in a ratio 2:1 (m/m). Fifteen minutes after the preparation, samples were used in the experiment. The biocompatibility of fresh materials, after 3h and 7 days, was tested using 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide- MTT test. Results: Samples mostly consisted of spherical and rode-like. The relative viability of cells increased following the exposure time. Conclusion: The biocompatibility of synthesized materials is comparable to the control material MTA+, and therefore these materials can be recommended for further clinical studies.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Dental Medicine
T1  - In vitro biocompatibility of nanostructured endodontic materials using SCAP cells
VL  - 21
IS  - 3
SP  - 167
EP  - 170
DO  - 10.1515/bjdm-2017-0029
ER  - 

@article{
author = "Ćetenović, Bojana and Čolović, Božana and Vasilijić, Saša and Pašalić, Snežana and Jokanović, Vukoman and Marković, Dejan",
year = "2017",
abstract = "Background/Aim: Lately, fully innovative sol-gel method with high-temperature self-propagating reaction was used for the synthesis of new nanostructured endodontic materials, in combination with different radiopacifiers: bismuth (ALBO-MPCA1) and barium (ALBO-MPCA2). The aim of this study was to investigate the biocompatibility of nanostructured endodontic materials based on highly active calcium silicates and mixed with different radiopacifiers in comparison to MTA+ using human stem cells from the apical papilla- SCAP cells. Material and Methods: Morphology of the samples was studied by SEM. The tested materials were mixed with distilled water in a ratio 2:1 (m/m). Fifteen minutes after the preparation, samples were used in the experiment. The biocompatibility of fresh materials, after 3h and 7 days, was tested using 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide- MTT test. Results: Samples mostly consisted of spherical and rode-like. The relative viability of cells increased following the exposure time. Conclusion: The biocompatibility of synthesized materials is comparable to the control material MTA+, and therefore these materials can be recommended for further clinical studies.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Dental Medicine",
title = "In vitro biocompatibility of nanostructured endodontic materials using SCAP cells",
volume = "21",
number = "3",
pages = "167-170",
doi = "10.1515/bjdm-2017-0029"
}

Ćetenović, B., Čolović, B., Vasilijić, S., Pašalić, S., Jokanović, V.,& Marković, D.. (2017). In vitro biocompatibility of nanostructured endodontic materials using SCAP cells. in Balkan Journal of Dental Medicine
Udruženje stomatologa Balkana., 21(3), 167-170.
https://doi.org/10.1515/bjdm-2017-0029

Ćetenović B, Čolović B, Vasilijić S, Pašalić S, Jokanović V, Marković D. In vitro biocompatibility of nanostructured endodontic materials using SCAP cells. in Balkan Journal of Dental Medicine. 2017;21(3):167-170.
doi:10.1515/bjdm-2017-0029 .

Ćetenović, Bojana, Čolović, Božana, Vasilijić, Saša, Pašalić, Snežana, Jokanović, Vukoman, Marković, Dejan, "In vitro biocompatibility of nanostructured endodontic materials using SCAP cells" in Balkan Journal of Dental Medicine, 21, no. 3 (2017):167-170,
https://doi.org/10.1515/bjdm-2017-0029 . .

TY  - JOUR
AU  - Jokanović, Vukoman
AU  - Jokanović, Bojan
AU  - Marković, Dejan
AU  - Živojinović, Vesna
AU  - Pašalić, Snežana
AU  - Izvonar, Dušan
AU  - Plasvić, M.
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1434
AB  - In this paper, the kinetics and sintering mechanism of hydro-thermally synthesized hydroxyapatite in the temperature range 900-1100 degrees C are presented. It was found that at 900 degrees C, the sintering process is very slow, whereas at 1000, 1050, and 1100 degrees C is much faster, caused by activated sintering with liquid phase/phase of solution on spots with concentrated material impurity and the formation of reaction/polyeutectic mixtures dominates. The activation energies of sintering were also determined. At all the investigated sintering temperatures, an approximate value of 90 kJ mol(-1) was found.
PB  - Elsevier Science Sa, Lausanne
T2  - Materials Chemistry & Physics
T1  - Kinetics and sintering mechanisms of hydro-thermally obtained hydroxyapatite
VL  - 111
IS  - 1
SP  - 180
EP  - 185
DO  - 10.1016/j.matchemphys.2008.04.005
ER  - 

@article{
author = "Jokanović, Vukoman and Jokanović, Bojan and Marković, Dejan and Živojinović, Vesna and Pašalić, Snežana and Izvonar, Dušan and Plasvić, M.",
year = "2008",
abstract = "In this paper, the kinetics and sintering mechanism of hydro-thermally synthesized hydroxyapatite in the temperature range 900-1100 degrees C are presented. It was found that at 900 degrees C, the sintering process is very slow, whereas at 1000, 1050, and 1100 degrees C is much faster, caused by activated sintering with liquid phase/phase of solution on spots with concentrated material impurity and the formation of reaction/polyeutectic mixtures dominates. The activation energies of sintering were also determined. At all the investigated sintering temperatures, an approximate value of 90 kJ mol(-1) was found.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Materials Chemistry & Physics",
title = "Kinetics and sintering mechanisms of hydro-thermally obtained hydroxyapatite",
volume = "111",
number = "1",
pages = "180-185",
doi = "10.1016/j.matchemphys.2008.04.005"
}

Jokanović, V., Jokanović, B., Marković, D., Živojinović, V., Pašalić, S., Izvonar, D.,& Plasvić, M.. (2008). Kinetics and sintering mechanisms of hydro-thermally obtained hydroxyapatite. in Materials Chemistry & Physics
Elsevier Science Sa, Lausanne., 111(1), 180-185.
https://doi.org/10.1016/j.matchemphys.2008.04.005

Jokanović V, Jokanović B, Marković D, Živojinović V, Pašalić S, Izvonar D, Plasvić M. Kinetics and sintering mechanisms of hydro-thermally obtained hydroxyapatite. in Materials Chemistry & Physics. 2008;111(1):180-185.
doi:10.1016/j.matchemphys.2008.04.005 .

Jokanović, Vukoman, Jokanović, Bojan, Marković, Dejan, Živojinović, Vesna, Pašalić, Snežana, Izvonar, Dušan, Plasvić, M., "Kinetics and sintering mechanisms of hydro-thermally obtained hydroxyapatite" in Materials Chemistry & Physics, 111, no. 1 (2008):180-185,
https://doi.org/10.1016/j.matchemphys.2008.04.005 . .