TY  - JOUR
AU  - Japundžić-Žigon, Nina
AU  - Milutinović-Smiljanić, Sanja
AU  - Jovanović, A
PY  - 2004
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1220
AB  - Effects of V-1 (OPC-21268) and V-2 (OPC-31260) vasopressin antagonists on blood pressure (BP) short-term variability were investigated in adult spontaneously hypertensive rats (SHR) under basal conditions and after the stimulation of vasopressin release by hemorrhage. BP was recorded intra-arterially and sampled at 20 Hz to be analyzed on a personal computer. BP time spectra were calculated on 30 stationary overlapping 2048 point-time series. Spectral power was estimated in total (0.00976 - 3 Hz), very low frequency (VLF: 0.00976 - 0.195 Hz), low frequency (LF: 0.195 - 0.605 Hz), and high frequency (HF: 0. 8 - 3 Hz) regions. Under basal conditions a V, antagonist (5 mg/kg, i.v.) decreased BP without affecting BP variability, while combined (V-1 + V-2) blockade or V-2 blockade (1 mg/kg, i.v.) alone did not affect cardiovascular parameters. Mild hemorrhage (5 ml/kg per min) increased HF-BP variability, while moderate (10 ml/kg per min) and massive (15 ml/kg per min) hemorrhage did not affect it. In V-1, but not V-2, antagonist pre-treated SHR HF-BP increased significantly after moderate and massive hemorrhage. V-1 or V-2 antagonist pre-treatment also enhanced VLF-BP variability during massive hemorrhage. Moreover V-1 blockade prevented hemorrhage-induced bradycardia, while V-2 blockade potentiated it. It follows that in adult SHR, vasopressin buffers BP oscillations in HF and VLF frequency domains only in hypovolaemic conditions and that the modulation of the autonomic adjustment of the HR to hemorrhage by vasopressin is preserved.
PB  - Japanese Pharmacological Soc, Kyoto
T2  - Journal of Pharmacological Sciences
T1  - Effects of nonpeptide and selective V-1 and V-2 antagonists on blood pressure short-term variability in spontaneously hypertensive rats
VL  - 95
IS  - 1
SP  - 47
EP  - 55
DO  - 10.1254/jphs.95.47
ER  - 

@article{
author = "Japundžić-Žigon, Nina and Milutinović-Smiljanić, Sanja and Jovanović, A",
year = "2004",
abstract = "Effects of V-1 (OPC-21268) and V-2 (OPC-31260) vasopressin antagonists on blood pressure (BP) short-term variability were investigated in adult spontaneously hypertensive rats (SHR) under basal conditions and after the stimulation of vasopressin release by hemorrhage. BP was recorded intra-arterially and sampled at 20 Hz to be analyzed on a personal computer. BP time spectra were calculated on 30 stationary overlapping 2048 point-time series. Spectral power was estimated in total (0.00976 - 3 Hz), very low frequency (VLF: 0.00976 - 0.195 Hz), low frequency (LF: 0.195 - 0.605 Hz), and high frequency (HF: 0. 8 - 3 Hz) regions. Under basal conditions a V, antagonist (5 mg/kg, i.v.) decreased BP without affecting BP variability, while combined (V-1 + V-2) blockade or V-2 blockade (1 mg/kg, i.v.) alone did not affect cardiovascular parameters. Mild hemorrhage (5 ml/kg per min) increased HF-BP variability, while moderate (10 ml/kg per min) and massive (15 ml/kg per min) hemorrhage did not affect it. In V-1, but not V-2, antagonist pre-treated SHR HF-BP increased significantly after moderate and massive hemorrhage. V-1 or V-2 antagonist pre-treatment also enhanced VLF-BP variability during massive hemorrhage. Moreover V-1 blockade prevented hemorrhage-induced bradycardia, while V-2 blockade potentiated it. It follows that in adult SHR, vasopressin buffers BP oscillations in HF and VLF frequency domains only in hypovolaemic conditions and that the modulation of the autonomic adjustment of the HR to hemorrhage by vasopressin is preserved.",
publisher = "Japanese Pharmacological Soc, Kyoto",
journal = "Journal of Pharmacological Sciences",
title = "Effects of nonpeptide and selective V-1 and V-2 antagonists on blood pressure short-term variability in spontaneously hypertensive rats",
volume = "95",
number = "1",
pages = "47-55",
doi = "10.1254/jphs.95.47"
}

Japundžić-Žigon, N., Milutinović-Smiljanić, S.,& Jovanović, A.. (2004). Effects of nonpeptide and selective V-1 and V-2 antagonists on blood pressure short-term variability in spontaneously hypertensive rats. in Journal of Pharmacological Sciences
Japanese Pharmacological Soc, Kyoto., 95(1), 47-55.
https://doi.org/10.1254/jphs.95.47

Japundžić-Žigon N, Milutinović-Smiljanić S, Jovanović A. Effects of nonpeptide and selective V-1 and V-2 antagonists on blood pressure short-term variability in spontaneously hypertensive rats. in Journal of Pharmacological Sciences. 2004;95(1):47-55.
doi:10.1254/jphs.95.47 .

Japundžić-Žigon, Nina, Milutinović-Smiljanić, Sanja, Jovanović, A, "Effects of nonpeptide and selective V-1 and V-2 antagonists on blood pressure short-term variability in spontaneously hypertensive rats" in Journal of Pharmacological Sciences, 95, no. 1 (2004):47-55,
https://doi.org/10.1254/jphs.95.47 . .