TY  - JOUR
AU  - Cvetković, Ana
AU  - Kalezić, Nevena
AU  - Miličić, Biljana
AU  - Nikolić, Srđan
AU  - Zegarac, Milan
AU  - Gavrilović, Dušica
AU  - Stojiljković, Dejan
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2322
AB  - Purpose: The purpose of this study was to compare two groups in postoperative recovery, whether there were any complications and whether the length of their hospital stay differed. One group received intraoperatively a combination of crystalloids and a small colloid dose, while the other group received only the crystalloids intraoperatively. Methods: This randomized prospective study included 80 patients with colorectal cancer prepared for major elective colorectal surgery. The patients were randomly assigned to either the control group (CG) which received only crystalloid solutions intraoperatively or to the research group (RG) which received a combination of colloid and crystalloid solutions. Regional and general endotracheal anesthesia techniques were combined in all patients. Goal-directed fluid therapy was administered to patients in both groups. After extubation, patients were transferred in the Intensive Care Unit (ICU). We measured the administered fluids, fluid balance, the volume of received red packed cells (RPC) and fresh frozen plasma (FFP). Recorded were the first bowel movement, the first flatus, the tolerance on oral food, complications by Clavian-Dindo classification, days of patient's recovery delay in the ICU, Surgery Department (SD) and the total length of hospital stay (LOS). Results: Statistically significant differences were present in all parameters of postoperative recovery. RG patients showed better results relative to the CG patients. RG patients were faster in restoring bowel movement and peristalsis, get the first postoperative stool and re-acquire oral food tolerance. According to the Clavian-Dindo classification of complications, no significant difference between these two groups was noted. Conclusions: Goal-directed colloid-crystalloid therapy significantly improved postoperative recovery.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - The impact of different infusion solutions on postoperative recovery following colorectal cancer surgery
VL  - 23
IS  - 5
SP  - 1369
EP  - 1379
UR  - https://hdl.handle.net/21.15107/rcub_smile_2322
ER  - 

@article{
author = "Cvetković, Ana and Kalezić, Nevena and Miličić, Biljana and Nikolić, Srđan and Zegarac, Milan and Gavrilović, Dušica and Stojiljković, Dejan",
year = "2018",
abstract = "Purpose: The purpose of this study was to compare two groups in postoperative recovery, whether there were any complications and whether the length of their hospital stay differed. One group received intraoperatively a combination of crystalloids and a small colloid dose, while the other group received only the crystalloids intraoperatively. Methods: This randomized prospective study included 80 patients with colorectal cancer prepared for major elective colorectal surgery. The patients were randomly assigned to either the control group (CG) which received only crystalloid solutions intraoperatively or to the research group (RG) which received a combination of colloid and crystalloid solutions. Regional and general endotracheal anesthesia techniques were combined in all patients. Goal-directed fluid therapy was administered to patients in both groups. After extubation, patients were transferred in the Intensive Care Unit (ICU). We measured the administered fluids, fluid balance, the volume of received red packed cells (RPC) and fresh frozen plasma (FFP). Recorded were the first bowel movement, the first flatus, the tolerance on oral food, complications by Clavian-Dindo classification, days of patient's recovery delay in the ICU, Surgery Department (SD) and the total length of hospital stay (LOS). Results: Statistically significant differences were present in all parameters of postoperative recovery. RG patients showed better results relative to the CG patients. RG patients were faster in restoring bowel movement and peristalsis, get the first postoperative stool and re-acquire oral food tolerance. According to the Clavian-Dindo classification of complications, no significant difference between these two groups was noted. Conclusions: Goal-directed colloid-crystalloid therapy significantly improved postoperative recovery.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "The impact of different infusion solutions on postoperative recovery following colorectal cancer surgery",
volume = "23",
number = "5",
pages = "1369-1379",
url = "https://hdl.handle.net/21.15107/rcub_smile_2322"
}

Cvetković, A., Kalezić, N., Miličić, B., Nikolić, S., Zegarac, M., Gavrilović, D.,& Stojiljković, D.. (2018). The impact of different infusion solutions on postoperative recovery following colorectal cancer surgery. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 23(5), 1369-1379.
https://hdl.handle.net/21.15107/rcub_smile_2322

Cvetković A, Kalezić N, Miličić B, Nikolić S, Zegarac M, Gavrilović D, Stojiljković D. The impact of different infusion solutions on postoperative recovery following colorectal cancer surgery. in Journal of BUON. 2018;23(5):1369-1379.
https://hdl.handle.net/21.15107/rcub_smile_2322 .

Cvetković, Ana, Kalezić, Nevena, Miličić, Biljana, Nikolić, Srđan, Zegarac, Milan, Gavrilović, Dušica, Stojiljković, Dejan, "The impact of different infusion solutions on postoperative recovery following colorectal cancer surgery" in Journal of BUON, 23, no. 5 (2018):1369-1379,
https://hdl.handle.net/21.15107/rcub_smile_2322 .

TY  - JOUR
AU  - Cvetković, Ana
AU  - Kalezić, Nevena
AU  - Miličić, Biljana
AU  - Nikolić, Srđan
AU  - Zegarac, Milan
AU  - Stojiljković, Dejan
AU  - Goran, Merima
AU  - Stojanović, Marina
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2285
AB  - Purpose: To determine whether there was a correlation between the type of administered infusion solutions intraoperatively with the quantity of administered infusion solutions, differences in values of cardiac output (CO) and cardiac index (CI) and need to use vasopressors and inotropes, between control and research groups. Methods: This randomized prospective study included 55 patients with colorectal cancer. Subjects in the control group received only crystalloid solutions intraoperatively and postoperatively. The patients in the research group received a combination of colloid in dosage of 10mg/kg and crystalloid solutions. Patients in both groups were given goal directed fluid therapy. Results: The control group received a significantly larger amount of crystalloid solution per kg of body weight during the entire surgical operation, in comparison with the volume of crystalloids in the research group (mean +/- SD 50.78 +/- 28.13 vs. 31.63 +/- 25.60 respectively, p=0.01). During the first hour of the surgery, the control group received a larger quantity of fluid in comparison with the research group (mean +/- SD 31.14 +/- 9.78 vs. 22.17 +/- 9.92 respectively, p=0.001). From the beginning of anesthesia until 6th postoperative hr the values of CI were significantly higher in the research group in comparison with the control group. Conclusions: Goal directed fluid therapy with colloids, followed by crystalloids during surgery, decreased the total intraoperative fluid volumes, and provided higher values of CI intraoperatively which were also maintained postoperatively.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Hemodynamic stability achievement by application of goal directed fluid therapy with different infusion solutions in colorectal surgery
VL  - 23
IS  - 2
SP  - 329
EP  - 339
UR  - https://hdl.handle.net/21.15107/rcub_smile_2285
ER  - 

@article{
author = "Cvetković, Ana and Kalezić, Nevena and Miličić, Biljana and Nikolić, Srđan and Zegarac, Milan and Stojiljković, Dejan and Goran, Merima and Stojanović, Marina",
year = "2018",
abstract = "Purpose: To determine whether there was a correlation between the type of administered infusion solutions intraoperatively with the quantity of administered infusion solutions, differences in values of cardiac output (CO) and cardiac index (CI) and need to use vasopressors and inotropes, between control and research groups. Methods: This randomized prospective study included 55 patients with colorectal cancer. Subjects in the control group received only crystalloid solutions intraoperatively and postoperatively. The patients in the research group received a combination of colloid in dosage of 10mg/kg and crystalloid solutions. Patients in both groups were given goal directed fluid therapy. Results: The control group received a significantly larger amount of crystalloid solution per kg of body weight during the entire surgical operation, in comparison with the volume of crystalloids in the research group (mean +/- SD 50.78 +/- 28.13 vs. 31.63 +/- 25.60 respectively, p=0.01). During the first hour of the surgery, the control group received a larger quantity of fluid in comparison with the research group (mean +/- SD 31.14 +/- 9.78 vs. 22.17 +/- 9.92 respectively, p=0.001). From the beginning of anesthesia until 6th postoperative hr the values of CI were significantly higher in the research group in comparison with the control group. Conclusions: Goal directed fluid therapy with colloids, followed by crystalloids during surgery, decreased the total intraoperative fluid volumes, and provided higher values of CI intraoperatively which were also maintained postoperatively.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Hemodynamic stability achievement by application of goal directed fluid therapy with different infusion solutions in colorectal surgery",
volume = "23",
number = "2",
pages = "329-339",
url = "https://hdl.handle.net/21.15107/rcub_smile_2285"
}

Cvetković, A., Kalezić, N., Miličić, B., Nikolić, S., Zegarac, M., Stojiljković, D., Goran, M.,& Stojanović, M.. (2018). Hemodynamic stability achievement by application of goal directed fluid therapy with different infusion solutions in colorectal surgery. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 23(2), 329-339.
https://hdl.handle.net/21.15107/rcub_smile_2285

Cvetković A, Kalezić N, Miličić B, Nikolić S, Zegarac M, Stojiljković D, Goran M, Stojanović M. Hemodynamic stability achievement by application of goal directed fluid therapy with different infusion solutions in colorectal surgery. in Journal of BUON. 2018;23(2):329-339.
https://hdl.handle.net/21.15107/rcub_smile_2285 .

Cvetković, Ana, Kalezić, Nevena, Miličić, Biljana, Nikolić, Srđan, Zegarac, Milan, Stojiljković, Dejan, Goran, Merima, Stojanović, Marina, "Hemodynamic stability achievement by application of goal directed fluid therapy with different infusion solutions in colorectal surgery" in Journal of BUON, 23, no. 2 (2018):329-339,
https://hdl.handle.net/21.15107/rcub_smile_2285 .

TY  - JOUR
AU  - Latić, Dragana
AU  - Radojević-Škodrić, Sanja
AU  - Nikolić, Srđan
AU  - Prvanović, Mirjana
AU  - Lazić, Miodrag
AU  - Džamić, Zoran
AU  - Bogdanović, Ljiljana
AU  - Radunović, Milena
AU  - Vuković, Marina
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2206
AB  - Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma
VL  - 22
IS  - 5
SP  - 1322
EP  - 1327
UR  - https://hdl.handle.net/21.15107/rcub_smile_2206
ER  - 

@article{
author = "Latić, Dragana and Radojević-Škodrić, Sanja and Nikolić, Srđan and Prvanović, Mirjana and Lazić, Miodrag and Džamić, Zoran and Bogdanović, Ljiljana and Radunović, Milena and Vuković, Marina",
year = "2017",
abstract = "Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma",
volume = "22",
number = "5",
pages = "1322-1327",
url = "https://hdl.handle.net/21.15107/rcub_smile_2206"
}

Latić, D., Radojević-Škodrić, S., Nikolić, S., Prvanović, M., Lazić, M., Džamić, Z., Bogdanović, L., Radunović, M.,& Vuković, M.. (2017). Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 22(5), 1322-1327.
https://hdl.handle.net/21.15107/rcub_smile_2206

Latić D, Radojević-Škodrić S, Nikolić S, Prvanović M, Lazić M, Džamić Z, Bogdanović L, Radunović M, Vuković M. Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma. in Journal of BUON. 2017;22(5):1322-1327.
https://hdl.handle.net/21.15107/rcub_smile_2206 .

Latić, Dragana, Radojević-Škodrić, Sanja, Nikolić, Srđan, Prvanović, Mirjana, Lazić, Miodrag, Džamić, Zoran, Bogdanović, Ljiljana, Radunović, Milena, Vuković, Marina, "Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma" in Journal of BUON, 22, no. 5 (2017):1322-1327,
https://hdl.handle.net/21.15107/rcub_smile_2206 .