Vucinić, Nada

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  • Vucinić, Nada (1)
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Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population

Grubiša, Ivana; Otašević, Petar; Vucinić, Nada; Miličić, Biljana; Jozić, Tanja; Krstić, Slobodan; Milašin, Jelena

(Soc Brasil Genetica, Ribeirao Pret, 2018)

TY  - JOUR
AU  - Grubiša, Ivana
AU  - Otašević, Petar
AU  - Vucinić, Nada
AU  - Miličić, Biljana
AU  - Jozić, Tanja
AU  - Krstić, Slobodan
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2287
AB  - Oxidative stress (OS) plays an important role in atherogenesis and since glutathione S-transferases (GSTs) provide protection against OS, we have tested the hypothesis that deletion polymorphisms in two GSTs (GSTM1 and GSTT1) may affect the risk of developing atherosclerosis. A total of 382 individuals (200 patients with atherosclerosis and 182 healthy controls) were included in this association study. Genomic DNA was isolated from peripheral blood cells or from buccal epithelial cells and genotyping was performed using multiplex-PCR or real-time PCR methods. GSTM1 null genotype was significantly more frequent in atherosclerotic patients than in controls (52.0% vs 34.1%) and individuals with the GSTM1 null genotype had an approximately 2-fold increase in atherosclerosis risk (OR: 2.1, 95%CI=1.39-3.17, P=0.0004). GSTT1 null genotype alone did not show a statistically significant effect on atherosclerosis risk modulation, but the association approached significance (OR: 1.57, 95%CI=0.94-2.64, P=0.08). The combined analysis showed that the presence of both genes had a protective effect against atherosclerosis (OR=0.55, 95%CI=0.37-0.83, P=0.005) while double null genotypes led to a robust atherosclerosis risk increase (OR: 8.14, 95%CI=2.41-27.51, P  lt  0.0001). This study demonstrated that the GSTM1 null and combined GSTM1/GSTT1 null genotypes are susceptibility factors for development of atherosclerosis in a Serbian population.
PB  - Soc Brasil Genetica, Ribeirao Pret
T2  - Genetics & Molecular Biology
T1  - Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population
VL  - 41
IS  - 1
SP  - 35
EP  - 40
DO  - 10.1590/1678-4685-GMB-2017-0034
ER  - 
@article{
author = "Grubiša, Ivana and Otašević, Petar and Vucinić, Nada and Miličić, Biljana and Jozić, Tanja and Krstić, Slobodan and Milašin, Jelena",
year = "2018",
abstract = "Oxidative stress (OS) plays an important role in atherogenesis and since glutathione S-transferases (GSTs) provide protection against OS, we have tested the hypothesis that deletion polymorphisms in two GSTs (GSTM1 and GSTT1) may affect the risk of developing atherosclerosis. A total of 382 individuals (200 patients with atherosclerosis and 182 healthy controls) were included in this association study. Genomic DNA was isolated from peripheral blood cells or from buccal epithelial cells and genotyping was performed using multiplex-PCR or real-time PCR methods. GSTM1 null genotype was significantly more frequent in atherosclerotic patients than in controls (52.0% vs 34.1%) and individuals with the GSTM1 null genotype had an approximately 2-fold increase in atherosclerosis risk (OR: 2.1, 95%CI=1.39-3.17, P=0.0004). GSTT1 null genotype alone did not show a statistically significant effect on atherosclerosis risk modulation, but the association approached significance (OR: 1.57, 95%CI=0.94-2.64, P=0.08). The combined analysis showed that the presence of both genes had a protective effect against atherosclerosis (OR=0.55, 95%CI=0.37-0.83, P=0.005) while double null genotypes led to a robust atherosclerosis risk increase (OR: 8.14, 95%CI=2.41-27.51, P  lt  0.0001). This study demonstrated that the GSTM1 null and combined GSTM1/GSTT1 null genotypes are susceptibility factors for development of atherosclerosis in a Serbian population.",
publisher = "Soc Brasil Genetica, Ribeirao Pret",
journal = "Genetics & Molecular Biology",
title = "Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population",
volume = "41",
number = "1",
pages = "35-40",
doi = "10.1590/1678-4685-GMB-2017-0034"
}
Grubiša, I., Otašević, P., Vucinić, N., Miličić, B., Jozić, T., Krstić, S.,& Milašin, J.. (2018). Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population. in Genetics & Molecular Biology
Soc Brasil Genetica, Ribeirao Pret., 41(1), 35-40.
https://doi.org/10.1590/1678-4685-GMB-2017-0034
Grubiša I, Otašević P, Vucinić N, Miličić B, Jozić T, Krstić S, Milašin J. Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population. in Genetics & Molecular Biology. 2018;41(1):35-40.
doi:10.1590/1678-4685-GMB-2017-0034 .
Grubiša, Ivana, Otašević, Petar, Vucinić, Nada, Miličić, Biljana, Jozić, Tanja, Krstić, Slobodan, Milašin, Jelena, "Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population" in Genetics & Molecular Biology, 41, no. 1 (2018):35-40,
https://doi.org/10.1590/1678-4685-GMB-2017-0034 . .
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