TY  - JOUR
AU  - Nikolić, Miloš
AU  - Glamočlija, Jasmina
AU  - Ferreira, Isabel C. F. R.
AU  - Calhelha, Ricardo C.
AU  - Fernandes, Angela
AU  - Marković, Tatjana
AU  - Marković, Dejan
AU  - Giweli, Abdulhamed
AU  - Soković, Marina
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1949
AB  - Aromatic plant species of genus Thymus are important medicinal plants, highly recommended due to a range of therapeutic properties of their essential oils, commonly known as thyme oil: antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. The oil is also beneficial in boosting the immune system and helps to fight colds, flu, infectious diseases and chills. It is proved to be a urinary antiseptic, being very helpful for cystitis and urethritis. Scientific validation of traditional uses, and phytochemical and bioactivity evaluation of essential oils from Thymus serpyllum, Thymus algeriensis and Thymus vulgaris were performed. GC/MS analysis revealed thymol as a major component of T. algeriensis, T. vulgaris and T. serpyllum, with its contribution to the oil 56.0%, 48.9% and 38.5%, respectively. All three essential oils (EOs) exhibited a significant antimicrobial activity against all tested strains, the T. serpyllum oil being the most potent one (MIC 2.5-5 mu g/mL, MBC 5-10 mu g/mL; MIC 1-2 mu g/mL, MFC 2-4 mu g/mL). In addition, the T. serpyllum oil revealed the highest antioxidant activity in all conducted assays and it was the most effective one against all tested cell lines, presenting GI(50) values of 7.02-52.69 mu g/mL. Moreover, none of the EOs showed toxicity at tested concentrations (>400 mu g/mL) for porcine liver primary cell culture. In addition to their well-known traditional use in food and cosmetics, the great potential of tested Thymus essential oils for application in oral diseases and anticancer treatments, encourage further investigation.
PB  - Elsevier, Amsterdam
T2  - Industrial Crops & Products
T1  - Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils
VL  - 52
SP  - 183
EP  - 190
DO  - 10.1016/j.indcrop.2013.10.006
ER  - 

@article{
author = "Nikolić, Miloš and Glamočlija, Jasmina and Ferreira, Isabel C. F. R. and Calhelha, Ricardo C. and Fernandes, Angela and Marković, Tatjana and Marković, Dejan and Giweli, Abdulhamed and Soković, Marina",
year = "2014",
abstract = "Aromatic plant species of genus Thymus are important medicinal plants, highly recommended due to a range of therapeutic properties of their essential oils, commonly known as thyme oil: antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. The oil is also beneficial in boosting the immune system and helps to fight colds, flu, infectious diseases and chills. It is proved to be a urinary antiseptic, being very helpful for cystitis and urethritis. Scientific validation of traditional uses, and phytochemical and bioactivity evaluation of essential oils from Thymus serpyllum, Thymus algeriensis and Thymus vulgaris were performed. GC/MS analysis revealed thymol as a major component of T. algeriensis, T. vulgaris and T. serpyllum, with its contribution to the oil 56.0%, 48.9% and 38.5%, respectively. All three essential oils (EOs) exhibited a significant antimicrobial activity against all tested strains, the T. serpyllum oil being the most potent one (MIC 2.5-5 mu g/mL, MBC 5-10 mu g/mL; MIC 1-2 mu g/mL, MFC 2-4 mu g/mL). In addition, the T. serpyllum oil revealed the highest antioxidant activity in all conducted assays and it was the most effective one against all tested cell lines, presenting GI(50) values of 7.02-52.69 mu g/mL. Moreover, none of the EOs showed toxicity at tested concentrations (>400 mu g/mL) for porcine liver primary cell culture. In addition to their well-known traditional use in food and cosmetics, the great potential of tested Thymus essential oils for application in oral diseases and anticancer treatments, encourage further investigation.",
publisher = "Elsevier, Amsterdam",
journal = "Industrial Crops & Products",
title = "Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils",
volume = "52",
pages = "183-190",
doi = "10.1016/j.indcrop.2013.10.006"
}

Nikolić, M., Glamočlija, J., Ferreira, I. C. F. R., Calhelha, R. C., Fernandes, A., Marković, T., Marković, D., Giweli, A.,& Soković, M.. (2014). Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils. in Industrial Crops & Products
Elsevier, Amsterdam., 52, 183-190.
https://doi.org/10.1016/j.indcrop.2013.10.006

Nikolić M, Glamočlija J, Ferreira ICFR, Calhelha RC, Fernandes A, Marković T, Marković D, Giweli A, Soković M. Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils. in Industrial Crops & Products. 2014;52:183-190.
doi:10.1016/j.indcrop.2013.10.006 .

Nikolić, Miloš, Glamočlija, Jasmina, Ferreira, Isabel C. F. R., Calhelha, Ricardo C., Fernandes, Angela, Marković, Tatjana, Marković, Dejan, Giweli, Abdulhamed, Soković, Marina, "Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils" in Industrial Crops & Products, 52 (2014):183-190,
https://doi.org/10.1016/j.indcrop.2013.10.006 . .