Nikolić, Slobodan

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  • Nikolić, Slobodan (3)
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Author's Bibliography

Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis

Đonić, Danijela; Bracanović, Đurđa; Rakočević, Zoran; Ivović, Miomira; Nikolić, Slobodan; Živković, Vladimir; Đurić, Marija

(Routledge Journals, Taylor & Francis Ltd, Abingdon, 2016)

TY  - JOUR
AU  - Đonić, Danijela
AU  - Bracanović, Đurđa
AU  - Rakočević, Zoran
AU  - Ivović, Miomira
AU  - Nikolić, Slobodan
AU  - Živković, Vladimir
AU  - Đurić, Marija
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2119
AB  - To improve our understanding of hyperostosis frontalis interna (HFI), we investigated whether HFI was accompanied by changes in the postcranial skeleton. Based on head CT scan analyses, 103 postmenopausal women were divided into controls without HFI and those with HFI, in whom we measured the thickness of frontal, occipital, and parietal bones. Women in the study underwent dual energy x-ray absorptiometry to analyze the bone density of the hip and vertebral region and external geometry of the proximal femora. Additionally, all of the women completed a questionnaire about symptoms and conditions that could be related to HFI. Women with HFI had a significantly higher prevalence of headaches, neurological and psychiatric disorders, and a significantly lower prevalence of having given birth. Increased bone thickness and altered bone structure in women with HFI was localized only on the skull, particularly on the frontal bone, probably due to specific properties of its underlying dura. Bone loss in the postcranial skeleton showed the same pattern in postmenopausal women with HFI as in those without HFI. Recording of HFI in medical records can be helpful in distinguishing whether reported disorders occur as a consequence of HFI or are related to other diseases, but does not appear helpful in identifying women at risk of bone loss.
PB  - Routledge Journals, Taylor & Francis Ltd, Abingdon
T2  - Women & Health
T1  - Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis
VL  - 56
IS  - 8
SP  - 994
EP  - 1007
DO  - 10.1080/03630242.2016.1178685
ER  - 
@article{
author = "Đonić, Danijela and Bracanović, Đurđa and Rakočević, Zoran and Ivović, Miomira and Nikolić, Slobodan and Živković, Vladimir and Đurić, Marija",
year = "2016",
abstract = "To improve our understanding of hyperostosis frontalis interna (HFI), we investigated whether HFI was accompanied by changes in the postcranial skeleton. Based on head CT scan analyses, 103 postmenopausal women were divided into controls without HFI and those with HFI, in whom we measured the thickness of frontal, occipital, and parietal bones. Women in the study underwent dual energy x-ray absorptiometry to analyze the bone density of the hip and vertebral region and external geometry of the proximal femora. Additionally, all of the women completed a questionnaire about symptoms and conditions that could be related to HFI. Women with HFI had a significantly higher prevalence of headaches, neurological and psychiatric disorders, and a significantly lower prevalence of having given birth. Increased bone thickness and altered bone structure in women with HFI was localized only on the skull, particularly on the frontal bone, probably due to specific properties of its underlying dura. Bone loss in the postcranial skeleton showed the same pattern in postmenopausal women with HFI as in those without HFI. Recording of HFI in medical records can be helpful in distinguishing whether reported disorders occur as a consequence of HFI or are related to other diseases, but does not appear helpful in identifying women at risk of bone loss.",
publisher = "Routledge Journals, Taylor & Francis Ltd, Abingdon",
journal = "Women & Health",
title = "Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis",
volume = "56",
number = "8",
pages = "994-1007",
doi = "10.1080/03630242.2016.1178685"
}
Đonić, D., Bracanović, Đ., Rakočević, Z., Ivović, M., Nikolić, S., Živković, V.,& Đurić, M.. (2016). Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis. in Women & Health
Routledge Journals, Taylor & Francis Ltd, Abingdon., 56(8), 994-1007.
https://doi.org/10.1080/03630242.2016.1178685
Đonić D, Bracanović Đ, Rakočević Z, Ivović M, Nikolić S, Živković V, Đurić M. Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis. in Women & Health. 2016;56(8):994-1007.
doi:10.1080/03630242.2016.1178685 .
Đonić, Danijela, Bracanović, Đurđa, Rakočević, Zoran, Ivović, Miomira, Nikolić, Slobodan, Živković, Vladimir, Đurić, Marija, "Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis" in Women & Health, 56, no. 8 (2016):994-1007,
https://doi.org/10.1080/03630242.2016.1178685 . .
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3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women

Bracanović, Đurđa; Đonić, Danijela; Nikolić, Slobodan; Milovanović, Petar; Rakočević, Zoran; Živković, Vladimir; Đurić, Marija

(Wiley-Blackwell, Hoboken, 2016)

TY  - JOUR
AU  - Bracanović, Đurđa
AU  - Đonić, Danijela
AU  - Nikolić, Slobodan
AU  - Milovanović, Petar
AU  - Rakočević, Zoran
AU  - Živković, Vladimir
AU  - Đurić, Marija
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2105
AB  - Although seen frequently during dissections and autopsies, Hyperostosis frontalis interna (HFI) - a morphological pattern of the frontal bone thickening - is often ignored and its nature and development are not yet understood sufficiently. Current macroscopic classification defines four grades/stages of HFI based on the morphological appearance and size of the affected area; however, it is unclear if these stages also depict the successive phases in the HFI development. Here we assessed 3D-microarchitecture of the frontal bone in women with various degrees of HFI expression and in an age- and sex-matched control group, hypothesizing that the bone microarchitecture bears imprints of the pathogenesis of HFI and may clarify the phases of its development. Frontal bone samples were collected during routine autopsies from 20 women with HFI (age: 69.9 +/- 11.1years) and 14 women without HFI (age: 74.1 +/- 9.7years). We classified the HFI samples into four groups, each group demonstrating different macroscopic type or stage of HFI. All samples were scanned by micro-computed tomography to evaluate 3D bone microarchitecture in the following regions of interest: total sample, outer table, diploe and inner table. Our results revealed that, compared to the control group, the women with HFI showed a significantly increased bone volume fraction in the region of diploe, along with significantly thicker and more plate-like shaped trabeculae and reduced trabecular separation and connectivity density. Moreover, the inner table of the frontal bone in women with HFI displayed significantly increased total porosity and mean pore diameter compared to controls. Microstructural reorganization of the frontal bone in women with HFI was also reflected in significantly higher porosity and lower bone volume fraction in the inner vs. outer table due to an increased number of pores larger than 100m. The individual comparisons between the control group and different macroscopic stages of HFI revealed significant differences only between the control group and the morphologically most pronounced type of HFI. Our microarchitectural findings demonstrated clear differences between the HFI and the control group in the region of diploe and the inner table. Macroscopic grades of HFI could not be distinguished at the level of bone microarchitecture and their consecutive nature cannot be supported. Rather, our study suggests that only two different types of HFI (moderate and severe HFI) have microstructural justification and should be considered further. It is essential to record HFI systematically in human postmortem subjects to provide more data on the mechanisms of its development.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Anatomy
T1  - 3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women
VL  - 229
IS  - 5
SP  - 673
EP  - 680
DO  - 10.1111/joa.12506
ER  - 
@article{
author = "Bracanović, Đurđa and Đonić, Danijela and Nikolić, Slobodan and Milovanović, Petar and Rakočević, Zoran and Živković, Vladimir and Đurić, Marija",
year = "2016",
abstract = "Although seen frequently during dissections and autopsies, Hyperostosis frontalis interna (HFI) - a morphological pattern of the frontal bone thickening - is often ignored and its nature and development are not yet understood sufficiently. Current macroscopic classification defines four grades/stages of HFI based on the morphological appearance and size of the affected area; however, it is unclear if these stages also depict the successive phases in the HFI development. Here we assessed 3D-microarchitecture of the frontal bone in women with various degrees of HFI expression and in an age- and sex-matched control group, hypothesizing that the bone microarchitecture bears imprints of the pathogenesis of HFI and may clarify the phases of its development. Frontal bone samples were collected during routine autopsies from 20 women with HFI (age: 69.9 +/- 11.1years) and 14 women without HFI (age: 74.1 +/- 9.7years). We classified the HFI samples into four groups, each group demonstrating different macroscopic type or stage of HFI. All samples were scanned by micro-computed tomography to evaluate 3D bone microarchitecture in the following regions of interest: total sample, outer table, diploe and inner table. Our results revealed that, compared to the control group, the women with HFI showed a significantly increased bone volume fraction in the region of diploe, along with significantly thicker and more plate-like shaped trabeculae and reduced trabecular separation and connectivity density. Moreover, the inner table of the frontal bone in women with HFI displayed significantly increased total porosity and mean pore diameter compared to controls. Microstructural reorganization of the frontal bone in women with HFI was also reflected in significantly higher porosity and lower bone volume fraction in the inner vs. outer table due to an increased number of pores larger than 100m. The individual comparisons between the control group and different macroscopic stages of HFI revealed significant differences only between the control group and the morphologically most pronounced type of HFI. Our microarchitectural findings demonstrated clear differences between the HFI and the control group in the region of diploe and the inner table. Macroscopic grades of HFI could not be distinguished at the level of bone microarchitecture and their consecutive nature cannot be supported. Rather, our study suggests that only two different types of HFI (moderate and severe HFI) have microstructural justification and should be considered further. It is essential to record HFI systematically in human postmortem subjects to provide more data on the mechanisms of its development.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Anatomy",
title = "3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women",
volume = "229",
number = "5",
pages = "673-680",
doi = "10.1111/joa.12506"
}
Bracanović, Đ., Đonić, D., Nikolić, S., Milovanović, P., Rakočević, Z., Živković, V.,& Đurić, M.. (2016). 3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women. in Journal of Anatomy
Wiley-Blackwell, Hoboken., 229(5), 673-680.
https://doi.org/10.1111/joa.12506
Bracanović Đ, Đonić D, Nikolić S, Milovanović P, Rakočević Z, Živković V, Đurić M. 3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women. in Journal of Anatomy. 2016;229(5):673-680.
doi:10.1111/joa.12506 .
Bracanović, Đurđa, Đonić, Danijela, Nikolić, Slobodan, Milovanović, Petar, Rakočević, Zoran, Živković, Vladimir, Đurić, Marija, "3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women" in Journal of Anatomy, 229, no. 5 (2016):673-680,
https://doi.org/10.1111/joa.12506 . .
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Myocardial bridges: A prospective forensic autopsy study

Micić-Labudović, Jelena; Atanasijević, Tatjana; Popović, Vesna; Mihailović, Zoran; Nikolić, Slobodan; Puzović, Dragana

(Srpsko lekarsko društvo, Beograd, 2015)

TY  - JOUR
AU  - Micić-Labudović, Jelena
AU  - Atanasijević, Tatjana
AU  - Popović, Vesna
AU  - Mihailović, Zoran
AU  - Nikolić, Slobodan
AU  - Puzović, Dragana
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2038
AB  - Introduction When the coronary artery, located subepicardially, submerges into the myocardium and appears again subepicardially after a short intramural course, it represents an embedded coronary artery, while the part of the myocardium above is a myocardial bridge. Objective We investigated the frequency of the embedded left coronary artery (LAD) in the autopsy material considering the descending branch of the LAD to be the most important one in the nourishment of the myocardium and myocardial bridges to be the most frequent in its area, as well as clinically important. Methods A prospective autopsy study of 975 cases was performed, including both, natural (21.33%) and violent (78.67%) deaths. The sample consisted of 74.56% males and 25.44% females. In order to discover myocardyal bridges and their characteristics, the hearts were examined by both transverse cuts and longitudinal openings of the LAD. Results Myocardial bridge was found in 78 cases (8.00%), more commonly in males (9.35%) than females (4.03%). The average length of the myocardial bridge was 21.85±16.10mm and thickness 3.744±1.48 mm. The common localization of the myocardial bridge was the proximal half of the LAD (89.74%). The upper part of the artery, proximal to the bridge, was a common site of atherosclerotic changes. Myocardial bridge was found in 12.50% of natural deaths, but in 13.38% out of all cases of sudden cardiac deaths. Conclusion Therefore, the presence of the myocardial bridge by itself is not predominant, but it is certainly a contributing factor to a sudden cardiac death.
AB  - Uvod 'Poniruća koronarna arterija' je pojam koji se odnosi na slučaj kada koronarna arterija - inače lokalizovana subepikardno - ponire u miokard i ponovo se pojavljuje subepikardno, posle kratkog puta kroz mišić, pri čemu se mišić iznad nje naziva 'miokardni most'. Cilj rada Istraživali smo učestalost poniruće descendentne grane leve koronarne arterije u autopsijskom materijalu imajući u vidu da je ona najvažnija u ishrani srčanog mišića, da najčešće ponire u srčani mišić i da je vrlo značajna i s kliničkog aspekta. Metode rada Urađena je prospektivna autopsijska studija 975 slučajeva prirodnih (21,33%) i nasilnih smrti (78,67%). Uzorak je obuhvatio 74,56% osoba muškog i 25,44% ženskog pola. Radi otkrivanja miokardnog mosta i analize njegovih osobenosti, nishodna grana leve koronarne arterije otvarana je uzdužnim i poprečnim obdukcionim rezovima. Rezultati Miokardni most je utvrđen u 78 slučajeva (8,00%), češće kod muškaraca (9,35%) nego kod žena (4,03%). Prosečna dužina miokardnog mosta bila je 21,85±16,10 mm, a debljina 3,744±1,48 mm. Najčešća lokalizacija miokardnog mosta bila je u predelu proksimalne polovine descendentne grane leve koronarne arterije (89,74%), a aterosklerotske promene su najčešće ustanovljene ushodno od miokardnog mosta. Miokardni most je postojao u 12,50% slučajeva prirodnih smrti, odnosno u 13,38% slučajeva tzv. naprasnih srčanih smrti. Zaključak Postojanje miokardnog mosta nije predominantni činilac za pojavu naprasne srčane smrti, ali je njegovo postojanje faktor rizika za njen nastanak.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Myocardial bridges: A prospective forensic autopsy study
T1  - Miokardni mostovi - prospektivna forenzička autopsijska studija
VL  - 143
IS  - 3-4
SP  - 153
EP  - 157
DO  - 10.2298/SARH1504153M
ER  - 
@article{
author = "Micić-Labudović, Jelena and Atanasijević, Tatjana and Popović, Vesna and Mihailović, Zoran and Nikolić, Slobodan and Puzović, Dragana",
year = "2015",
abstract = "Introduction When the coronary artery, located subepicardially, submerges into the myocardium and appears again subepicardially after a short intramural course, it represents an embedded coronary artery, while the part of the myocardium above is a myocardial bridge. Objective We investigated the frequency of the embedded left coronary artery (LAD) in the autopsy material considering the descending branch of the LAD to be the most important one in the nourishment of the myocardium and myocardial bridges to be the most frequent in its area, as well as clinically important. Methods A prospective autopsy study of 975 cases was performed, including both, natural (21.33%) and violent (78.67%) deaths. The sample consisted of 74.56% males and 25.44% females. In order to discover myocardyal bridges and their characteristics, the hearts were examined by both transverse cuts and longitudinal openings of the LAD. Results Myocardial bridge was found in 78 cases (8.00%), more commonly in males (9.35%) than females (4.03%). The average length of the myocardial bridge was 21.85±16.10mm and thickness 3.744±1.48 mm. The common localization of the myocardial bridge was the proximal half of the LAD (89.74%). The upper part of the artery, proximal to the bridge, was a common site of atherosclerotic changes. Myocardial bridge was found in 12.50% of natural deaths, but in 13.38% out of all cases of sudden cardiac deaths. Conclusion Therefore, the presence of the myocardial bridge by itself is not predominant, but it is certainly a contributing factor to a sudden cardiac death., Uvod 'Poniruća koronarna arterija' je pojam koji se odnosi na slučaj kada koronarna arterija - inače lokalizovana subepikardno - ponire u miokard i ponovo se pojavljuje subepikardno, posle kratkog puta kroz mišić, pri čemu se mišić iznad nje naziva 'miokardni most'. Cilj rada Istraživali smo učestalost poniruće descendentne grane leve koronarne arterije u autopsijskom materijalu imajući u vidu da je ona najvažnija u ishrani srčanog mišića, da najčešće ponire u srčani mišić i da je vrlo značajna i s kliničkog aspekta. Metode rada Urađena je prospektivna autopsijska studija 975 slučajeva prirodnih (21,33%) i nasilnih smrti (78,67%). Uzorak je obuhvatio 74,56% osoba muškog i 25,44% ženskog pola. Radi otkrivanja miokardnog mosta i analize njegovih osobenosti, nishodna grana leve koronarne arterije otvarana je uzdužnim i poprečnim obdukcionim rezovima. Rezultati Miokardni most je utvrđen u 78 slučajeva (8,00%), češće kod muškaraca (9,35%) nego kod žena (4,03%). Prosečna dužina miokardnog mosta bila je 21,85±16,10 mm, a debljina 3,744±1,48 mm. Najčešća lokalizacija miokardnog mosta bila je u predelu proksimalne polovine descendentne grane leve koronarne arterije (89,74%), a aterosklerotske promene su najčešće ustanovljene ushodno od miokardnog mosta. Miokardni most je postojao u 12,50% slučajeva prirodnih smrti, odnosno u 13,38% slučajeva tzv. naprasnih srčanih smrti. Zaključak Postojanje miokardnog mosta nije predominantni činilac za pojavu naprasne srčane smrti, ali je njegovo postojanje faktor rizika za njen nastanak.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Myocardial bridges: A prospective forensic autopsy study, Miokardni mostovi - prospektivna forenzička autopsijska studija",
volume = "143",
number = "3-4",
pages = "153-157",
doi = "10.2298/SARH1504153M"
}
Micić-Labudović, J., Atanasijević, T., Popović, V., Mihailović, Z., Nikolić, S.,& Puzović, D.. (2015). Myocardial bridges: A prospective forensic autopsy study. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 143(3-4), 153-157.
https://doi.org/10.2298/SARH1504153M
Micić-Labudović J, Atanasijević T, Popović V, Mihailović Z, Nikolić S, Puzović D. Myocardial bridges: A prospective forensic autopsy study. in Srpski arhiv za celokupno lekarstvo. 2015;143(3-4):153-157.
doi:10.2298/SARH1504153M .
Micić-Labudović, Jelena, Atanasijević, Tatjana, Popović, Vesna, Mihailović, Zoran, Nikolić, Slobodan, Puzović, Dragana, "Myocardial bridges: A prospective forensic autopsy study" in Srpski arhiv za celokupno lekarstvo, 143, no. 3-4 (2015):153-157,
https://doi.org/10.2298/SARH1504153M . .
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