TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Jaćimović, Jelena
AU  - Pavlović, Ognjan
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2570
AB  - Introduction
 This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.
 
 Methods
 An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.
 
 Results
 Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.
 
 Conclusions
 There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.
PB  - Elsevier Inc.
T2  - Journal of Endodontics
T1  - Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020
VL  - 46
IS  - 10
SP  - 1371
EP  - 1386.e8
DO  - 10.1016/j.joen.2020.07.007
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Jaćimović, Jelena and Pavlović, Ognjan and Miličić, Biljana and Beljić-Ivanović, Katarina and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Introduction
 This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.
 
 Methods
 An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.
 
 Results
 Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.
 
 Conclusions
 There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.",
publisher = "Elsevier Inc.",
journal = "Journal of Endodontics",
title = "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020",
volume = "46",
number = "10",
pages = "1371-1386.e8",
doi = "10.1016/j.joen.2020.07.007"
}

Jakovljević, A., Nikolić, N., Jaćimović, J., Pavlović, O., Miličić, B., Beljić-Ivanović, K., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics
Elsevier Inc.., 46(10), 1371-1386.e8.
https://doi.org/10.1016/j.joen.2020.07.007

Jakovljević A, Nikolić N, Jaćimović J, Pavlović O, Miličić B, Beljić-Ivanović K, Miletić M, Andrić M, Milašin J. Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics. 2020;46(10):1371-1386.e8.
doi:10.1016/j.joen.2020.07.007 .

Jakovljević, Aleksandar, Nikolić, Nadja, Jaćimović, Jelena, Pavlović, Ognjan, Miličić, Biljana, Beljić-Ivanović, Katarina, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020" in Journal of Endodontics, 46, no. 10 (2020):1371-1386.e8,
https://doi.org/10.1016/j.joen.2020.07.007 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Jaćimović, Jelena
AU  - Pavlović, Ognjan
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2531
AB  - Introduction
This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.

Methods
An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.

Results
Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.

Conclusions
There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.
PB  - Elsevier Inc.
T2  - Journal of Endodontics
T1  - Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020
VL  - 46
IS  - 10
SP  - 1371
EP  - 1386
DO  - 10.1016/j.joen.2020.07.007
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Jaćimović, Jelena and Pavlović, Ognjan and Miličić, Biljana and Beljić-Ivanović, Katarina and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Introduction
This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.

Methods
An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.

Results
Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.

Conclusions
There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.",
publisher = "Elsevier Inc.",
journal = "Journal of Endodontics",
title = "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020",
volume = "46",
number = "10",
pages = "1371-1386",
doi = "10.1016/j.joen.2020.07.007"
}

Jakovljević, A., Nikolić, N., Jaćimović, J., Pavlović, O., Miličić, B., Beljić-Ivanović, K., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics
Elsevier Inc.., 46(10), 1371-1386.
https://doi.org/10.1016/j.joen.2020.07.007

Jakovljević A, Nikolić N, Jaćimović J, Pavlović O, Miličić B, Beljić-Ivanović K, Miletić M, Andrić M, Milašin J. Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics. 2020;46(10):1371-1386.
doi:10.1016/j.joen.2020.07.007 .

Jakovljević, Aleksandar, Nikolić, Nadja, Jaćimović, Jelena, Pavlović, Ognjan, Miličić, Biljana, Beljić-Ivanović, Katarina, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020" in Journal of Endodontics, 46, no. 10 (2020):1371-1386,
https://doi.org/10.1016/j.joen.2020.07.007 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Andrić, Miroslav
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Jovanović, Tanja
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2493
AB  - Objectives: This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator of nuclear factor kappa-? ligand (RANKL) and osteoprotegerin (OPG)), and proinflammatory cytokines (tumour necrosis factor-alpha (TNF-?), interleukin-1 beta (IL-1?) and IL-6) compared to EBV negative lesions. Additionally, the potential correlation between investigated molecules in periapical lesions was analyzed. Materials and methods: Sixty-four apical periodontitis lesions were obtained subsequent to standard apicoectomy procedure. The presence of EBV was determined using nested PCR. Based on the presence of EBV all periapical lesions were divided into two groups, 29 EBV positive and 35 EBV negative lesions. A reverse transcriptase real-time PCR was used to determine mRNA levels of Notch2, Jagged1, RANKL, OPG, TNF-?, IL-1? and IL-6. Results: Significantly higher mRNA levels of Notch2, Jagged1, RANKL and IL-1? were observed in EBV positive compared to EBV negative lesions. Significant positive correlation was present between Notch2 and Jagged1, Jagged1 and RANKL, and IL-? and TNF-? in EBV positive periapical lesions. Conclusions: Notch signalling pathway may be involved in alveolar bone resorption in apical periodontitis lesions infected by EBV.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Acta Odontologica Scandinavica
T1  - Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis
VL  - 78
IS  - 2
SP  - 126
EP  - 131
DO  - 10.1080/00016357.2019.1658896
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Čarkić, Jelena and Andrić, Miroslav and Miletić, Maja and Beljić-Ivanović, Katarina and Jovanović, Tanja and Milašin, Jelena",
year = "2020",
abstract = "Objectives: This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator of nuclear factor kappa-? ligand (RANKL) and osteoprotegerin (OPG)), and proinflammatory cytokines (tumour necrosis factor-alpha (TNF-?), interleukin-1 beta (IL-1?) and IL-6) compared to EBV negative lesions. Additionally, the potential correlation between investigated molecules in periapical lesions was analyzed. Materials and methods: Sixty-four apical periodontitis lesions were obtained subsequent to standard apicoectomy procedure. The presence of EBV was determined using nested PCR. Based on the presence of EBV all periapical lesions were divided into two groups, 29 EBV positive and 35 EBV negative lesions. A reverse transcriptase real-time PCR was used to determine mRNA levels of Notch2, Jagged1, RANKL, OPG, TNF-?, IL-1? and IL-6. Results: Significantly higher mRNA levels of Notch2, Jagged1, RANKL and IL-1? were observed in EBV positive compared to EBV negative lesions. Significant positive correlation was present between Notch2 and Jagged1, Jagged1 and RANKL, and IL-? and TNF-? in EBV positive periapical lesions. Conclusions: Notch signalling pathway may be involved in alveolar bone resorption in apical periodontitis lesions infected by EBV.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Acta Odontologica Scandinavica",
title = "Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis",
volume = "78",
number = "2",
pages = "126-131",
doi = "10.1080/00016357.2019.1658896"
}

Jakovljević, A., Nikolić, N., Čarkić, J., Andrić, M., Miletić, M., Beljić-Ivanović, K., Jovanović, T.,& Milašin, J.. (2020). Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis. in Acta Odontologica Scandinavica
Taylor & Francis Ltd, Abingdon., 78(2), 126-131.
https://doi.org/10.1080/00016357.2019.1658896

Jakovljević A, Nikolić N, Čarkić J, Andrić M, Miletić M, Beljić-Ivanović K, Jovanović T, Milašin J. Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis. in Acta Odontologica Scandinavica. 2020;78(2):126-131.
doi:10.1080/00016357.2019.1658896 .

Jakovljević, Aleksandar, Nikolić, Nadja, Čarkić, Jelena, Andrić, Miroslav, Miletić, Maja, Beljić-Ivanović, Katarina, Jovanović, Tanja, Milašin, Jelena, "Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis" in Acta Odontologica Scandinavica, 78, no. 2 (2020):126-131,
https://doi.org/10.1080/00016357.2019.1658896 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Beljić-Ivanović, Katarina
AU  - Soldatović, Ivan
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1047
AB  - Aim To investigate the possible association between TNF alpha (-308 G/A) and IL-1 beta (-511 C/T) single nucleotide polymorphisms (SNPs) and GSTT and GSTM deletion polymorphisms and risk of apical periodontitis (AP) development, and determine the association of different genotypes with the presence of herpesviral infection in AP. Methodology The study included 120 periapical lesions and 200 control samples. Gene polymorphism analysis was performed using either polymerase chain reaction (PCR) or PCR/ restriction fragment length polymorphism (RFLP). Relative gene expression of TNF-alpha and IL-1 beta was analysed using reverse transcriptase - real-time PCR. The presence of Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by nested PCR. Chi-square and Fisher's exact tests and logistic regression analyses were done for polymorphisms, whilst Mann-Whitney U-test was performed for the expression analysis. The expected frequency of variants was analysed by the Hardy-Weinberg equilibrium test. Results TNF-alpha (-308 G/A) SNP increased AP susceptibility for heterozygous (odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.06-2.80, P = 0.027) and homozygous (OR = 8.55, 95% CI = 1.77-41.36, P  lt  0.001) carriers of the variant A allele. On the other hand, IL-1 beta (-511 C/T) polymorphism exerted a protective effect both in heterozygotes (OR = 0.540, 95% CI = 0.332-0.880, P = 0.013) and homozygotes (OR = 0.114, 95% CI = 0.026-0.501, P  lt  0.001). In addition, GSTM1 and GSTT1 null genotypes separately, as well as concomitantly, were associated with an increased risk for AP development (P  lt  0.001). The null GSTT1 genotype increased approximately twice the risk of Epstein-Barr infection (EBV) in AP (OR = 2.17, 95% CI = 1-4.71, P = 0.048), whilst TNF-alpha SNP decreased it, both in heterozygotes (OR = 0.20, 95% CI = 0.08-0.48, P  lt  0.001) and AA homozygotes (OR = 0.07, 95% CI = 0.01-0.37, P = 0.001). Conclusions GSTM and GSTT deletion polymorphisms, as well as TNF alpha (-308 G/A) SNP, are associated with increased risk, whereas IL-1 beta (-511 C/T) polymorphism decreases the risk of AP development. GSTT and TNF alpha polymorphisms also appear to modulate the risk of EBV infection in Serbian patients with AP.
PB  - Wiley, Hoboken
T2  - International Endodontic Journal
T1  - Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?
VL  - 53
IS  - 7
SP  - 895
EP  - 904
DO  - 10.1111/iej.13298
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Čarkić, Jelena and Beljić-Ivanović, Katarina and Soldatović, Ivan and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Aim To investigate the possible association between TNF alpha (-308 G/A) and IL-1 beta (-511 C/T) single nucleotide polymorphisms (SNPs) and GSTT and GSTM deletion polymorphisms and risk of apical periodontitis (AP) development, and determine the association of different genotypes with the presence of herpesviral infection in AP. Methodology The study included 120 periapical lesions and 200 control samples. Gene polymorphism analysis was performed using either polymerase chain reaction (PCR) or PCR/ restriction fragment length polymorphism (RFLP). Relative gene expression of TNF-alpha and IL-1 beta was analysed using reverse transcriptase - real-time PCR. The presence of Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by nested PCR. Chi-square and Fisher's exact tests and logistic regression analyses were done for polymorphisms, whilst Mann-Whitney U-test was performed for the expression analysis. The expected frequency of variants was analysed by the Hardy-Weinberg equilibrium test. Results TNF-alpha (-308 G/A) SNP increased AP susceptibility for heterozygous (odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.06-2.80, P = 0.027) and homozygous (OR = 8.55, 95% CI = 1.77-41.36, P  lt  0.001) carriers of the variant A allele. On the other hand, IL-1 beta (-511 C/T) polymorphism exerted a protective effect both in heterozygotes (OR = 0.540, 95% CI = 0.332-0.880, P = 0.013) and homozygotes (OR = 0.114, 95% CI = 0.026-0.501, P  lt  0.001). In addition, GSTM1 and GSTT1 null genotypes separately, as well as concomitantly, were associated with an increased risk for AP development (P  lt  0.001). The null GSTT1 genotype increased approximately twice the risk of Epstein-Barr infection (EBV) in AP (OR = 2.17, 95% CI = 1-4.71, P = 0.048), whilst TNF-alpha SNP decreased it, both in heterozygotes (OR = 0.20, 95% CI = 0.08-0.48, P  lt  0.001) and AA homozygotes (OR = 0.07, 95% CI = 0.01-0.37, P = 0.001). Conclusions GSTM and GSTT deletion polymorphisms, as well as TNF alpha (-308 G/A) SNP, are associated with increased risk, whereas IL-1 beta (-511 C/T) polymorphism decreases the risk of AP development. GSTT and TNF alpha polymorphisms also appear to modulate the risk of EBV infection in Serbian patients with AP.",
publisher = "Wiley, Hoboken",
journal = "International Endodontic Journal",
title = "Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?",
volume = "53",
number = "7",
pages = "895-904",
doi = "10.1111/iej.13298"
}

Jakovljević, A., Nikolić, N., Čarkić, J., Beljić-Ivanović, K., Soldatović, I., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?. in International Endodontic Journal
Wiley, Hoboken., 53(7), 895-904.
https://doi.org/10.1111/iej.13298

Jakovljević A, Nikolić N, Čarkić J, Beljić-Ivanović K, Soldatović I, Miletić M, Andrić M, Milašin J. Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?. in International Endodontic Journal. 2020;53(7):895-904.
doi:10.1111/iej.13298 .

Jakovljević, Aleksandar, Nikolić, Nadja, Čarkić, Jelena, Beljić-Ivanović, Katarina, Soldatović, Ivan, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?" in International Endodontic Journal, 53, no. 7 (2020):895-904,
https://doi.org/10.1111/iej.13298 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Miletić, Maja
AU  - Nikolić, Nadja
AU  - Beljić-Ivanović, Katarina
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2455
AB  - Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. In recent years its involvement in bone homeostasis has attracted a significant consideration. We hypothesized that Notch signaling pathway, which has a complex interplay with proinflammatory cytokines and bone resorption regulators, contributes to alveolar bone resorption via increased Notch receptors on immune cell surface and stimulates Notch receptor intracellular domain (NICD) translocation into the nucleus. The potential benefit of medications aimed to down-regulate these pathways in apical periodontitis treatment remains to be assessed.
PB  - Churchill Livingstone, Edinburgh
T2  - Medical Hypotheses
T1  - Notch signaling pathway mediates alveolar bone resorption in apical periodontitis
VL  - 124
SP  - 87
EP  - 90
DO  - 10.1016/j.mehy.2019.02.018
ER  - 

@article{
author = "Jakovljević, Aleksandar and Miletić, Maja and Nikolić, Nadja and Beljić-Ivanović, Katarina and Andrić, Miroslav and Milašin, Jelena",
year = "2019",
abstract = "Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. In recent years its involvement in bone homeostasis has attracted a significant consideration. We hypothesized that Notch signaling pathway, which has a complex interplay with proinflammatory cytokines and bone resorption regulators, contributes to alveolar bone resorption via increased Notch receptors on immune cell surface and stimulates Notch receptor intracellular domain (NICD) translocation into the nucleus. The potential benefit of medications aimed to down-regulate these pathways in apical periodontitis treatment remains to be assessed.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Medical Hypotheses",
title = "Notch signaling pathway mediates alveolar bone resorption in apical periodontitis",
volume = "124",
pages = "87-90",
doi = "10.1016/j.mehy.2019.02.018"
}

Jakovljević, A., Miletić, M., Nikolić, N., Beljić-Ivanović, K., Andrić, M.,& Milašin, J.. (2019). Notch signaling pathway mediates alveolar bone resorption in apical periodontitis. in Medical Hypotheses
Churchill Livingstone, Edinburgh., 124, 87-90.
https://doi.org/10.1016/j.mehy.2019.02.018

Jakovljević A, Miletić M, Nikolić N, Beljić-Ivanović K, Andrić M, Milašin J. Notch signaling pathway mediates alveolar bone resorption in apical periodontitis. in Medical Hypotheses. 2019;124:87-90.
doi:10.1016/j.mehy.2019.02.018 .

Jakovljević, Aleksandar, Miletić, Maja, Nikolić, Nadja, Beljić-Ivanović, Katarina, Andrić, Miroslav, Milašin, Jelena, "Notch signaling pathway mediates alveolar bone resorption in apical periodontitis" in Medical Hypotheses, 124 (2019):87-90,
https://doi.org/10.1016/j.mehy.2019.02.018 . .

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Jakovljević, Aleksandar
AU  - Čarkić, Jelena
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Soldatović, Ivan
AU  - Andrić, Miroslav
AU  - Ivanović, Vladimir
AU  - Milašin, Jelena
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2390
AB  - Introduction: The exact mechanisms of periapical bone resorption have not been fully elucidated. This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-alpha], interleukin [IL]-1 beta, and IL-6) in human apical periodontitis lesions with different receptor activator of nuclear factor kappa B ligand (RANKL)/osteo-protegerin (OPG) ratios and determine their potential correlation. Methods: The study group consisted of 50 periapical lesions collected in conjunction with apicoectomy. The relative gene expression of the investigated molecules (Notch2, Jagged1, Hey1, RANKL, OPG, TNF-alpha, IL-1 beta, and IL-6) in all tissue samples was analyzed using reverse transcriptase real-time polymerase chain reaction. The Student t test, Mann-Whitney U test and Spearman correlation were used for statistical analysis. Results: Based on the RANKUOPG ratio, periapical lesions were either RANKL predominant (RANKL > OPG, n = 33) or OPG predominant (RANKL  lt  OPG, n = 17). Symptomatic lesions occurred more frequently in RANKL-predominant compared with OPG-predominant lesions (24 vs 7, P=.029). Notch2,Jagged1, Hey1, and TNF-alpha were significantly overexpressed in lesions with predominant RANKL compared with lesions with predominant OPG (P =.001, P =.001, P =.027, and P =.016, respectively). Significant correlations were observed between the investigated genes in periapical lesions. Conclusions: Notch signaling appeared to be activated in periapical inflammation. An increase in Notch2, Jagged1, Hey1, and TNF-alpha expression in RANKL-predominant periapical lesions corroborates their joined involvement in extensive periapical bone resorption.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines
VL  - 45
IS  - 2
SP  - 123
EP  - 128
DO  - 10.1016/j.joen.2018.10.015
ER  - 

@article{
author = "Nikolić, Nadja and Jakovljević, Aleksandar and Čarkić, Jelena and Beljić-Ivanović, Katarina and Miletić, Maja and Soldatović, Ivan and Andrić, Miroslav and Ivanović, Vladimir and Milašin, Jelena",
year = "2019",
abstract = "Introduction: The exact mechanisms of periapical bone resorption have not been fully elucidated. This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-alpha], interleukin [IL]-1 beta, and IL-6) in human apical periodontitis lesions with different receptor activator of nuclear factor kappa B ligand (RANKL)/osteo-protegerin (OPG) ratios and determine their potential correlation. Methods: The study group consisted of 50 periapical lesions collected in conjunction with apicoectomy. The relative gene expression of the investigated molecules (Notch2, Jagged1, Hey1, RANKL, OPG, TNF-alpha, IL-1 beta, and IL-6) in all tissue samples was analyzed using reverse transcriptase real-time polymerase chain reaction. The Student t test, Mann-Whitney U test and Spearman correlation were used for statistical analysis. Results: Based on the RANKUOPG ratio, periapical lesions were either RANKL predominant (RANKL > OPG, n = 33) or OPG predominant (RANKL  lt  OPG, n = 17). Symptomatic lesions occurred more frequently in RANKL-predominant compared with OPG-predominant lesions (24 vs 7, P=.029). Notch2,Jagged1, Hey1, and TNF-alpha were significantly overexpressed in lesions with predominant RANKL compared with lesions with predominant OPG (P =.001, P =.001, P =.027, and P =.016, respectively). Significant correlations were observed between the investigated genes in periapical lesions. Conclusions: Notch signaling appeared to be activated in periapical inflammation. An increase in Notch2, Jagged1, Hey1, and TNF-alpha expression in RANKL-predominant periapical lesions corroborates their joined involvement in extensive periapical bone resorption.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines",
volume = "45",
number = "2",
pages = "123-128",
doi = "10.1016/j.joen.2018.10.015"
}

Nikolić, N., Jakovljević, A., Čarkić, J., Beljić-Ivanović, K., Miletić, M., Soldatović, I., Andrić, M., Ivanović, V.,& Milašin, J.. (2019). Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines. in Journal of Endodontics
Elsevier Science Inc, New York., 45(2), 123-128.
https://doi.org/10.1016/j.joen.2018.10.015

Nikolić N, Jakovljević A, Čarkić J, Beljić-Ivanović K, Miletić M, Soldatović I, Andrić M, Ivanović V, Milašin J. Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines. in Journal of Endodontics. 2019;45(2):123-128.
doi:10.1016/j.joen.2018.10.015 .

Nikolić, Nadja, Jakovljević, Aleksandar, Čarkić, Jelena, Beljić-Ivanović, Katarina, Miletić, Maja, Soldatović, Ivan, Andrić, Miroslav, Ivanović, Vladimir, Milašin, Jelena, "Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines" in Journal of Endodontics, 45, no. 2 (2019):123-128,
https://doi.org/10.1016/j.joen.2018.10.015 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Milašin, Jelena
AU  - Sabeti, Mohammad
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2595
AB  - Purpose of Review
This review describes the most recent findings on herpesviral infections and offers current concepts of herpesviral role in the pathogenesis of periapical periodontitis.

Recent Findings
Thirty articles reported data on herpesviral infection in periapical periodontitis. Epstein-Barr virus and human cytomegalovirus are the most frequently detected herpesviruses in periapical samples. The main hypothesis postulates a bidirectional herpesviral-bacterial relationship in the etiopathogenesis of periapical periodontitis. A high heterogeneity of herpesviruses incidence was registered within the studies, in part, due to various methodological approaches used in laboratory testing, different inclusion criteria, study design, seroprevalence of herpesviruses, and sociodemographic characteristics of investigated populations.

Summary
Herpesviruses have been shown to potentially impair local host defense in periapical tissue. Although it has been demonstrated that endodontic pathogenic bacteria are able to reactivate herpesviruses, further, in vitro studies should provide more data on herpesviruses as a factor in the pathogenesis of the periapical pathoses. It is, therefore, necessary to investigate potential benefits of antiviral therapy in well-designed controlled longitudinal studies.
PB  - Springer
T2  - Current Oral Health Reports
T1  - Herpesviral Infection in Periapical Periodontitis
VL  - 5
IS  - 4
SP  - 255
EP  - 263
DO  - 10.1007/s40496-018-0198-7
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Miletić, Maja and Beljić-Ivanović, Katarina and Milašin, Jelena and Sabeti, Mohammad",
year = "2018",
abstract = "Purpose of Review
This review describes the most recent findings on herpesviral infections and offers current concepts of herpesviral role in the pathogenesis of periapical periodontitis.

Recent Findings
Thirty articles reported data on herpesviral infection in periapical periodontitis. Epstein-Barr virus and human cytomegalovirus are the most frequently detected herpesviruses in periapical samples. The main hypothesis postulates a bidirectional herpesviral-bacterial relationship in the etiopathogenesis of periapical periodontitis. A high heterogeneity of herpesviruses incidence was registered within the studies, in part, due to various methodological approaches used in laboratory testing, different inclusion criteria, study design, seroprevalence of herpesviruses, and sociodemographic characteristics of investigated populations.

Summary
Herpesviruses have been shown to potentially impair local host defense in periapical tissue. Although it has been demonstrated that endodontic pathogenic bacteria are able to reactivate herpesviruses, further, in vitro studies should provide more data on herpesviruses as a factor in the pathogenesis of the periapical pathoses. It is, therefore, necessary to investigate potential benefits of antiviral therapy in well-designed controlled longitudinal studies.",
publisher = "Springer",
journal = "Current Oral Health Reports",
title = "Herpesviral Infection in Periapical Periodontitis",
volume = "5",
number = "4",
pages = "255-263",
doi = "10.1007/s40496-018-0198-7"
}

Jakovljević, A., Andrić, M., Knežević, A., Miletić, M., Beljić-Ivanović, K., Milašin, J.,& Sabeti, M.. (2018). Herpesviral Infection in Periapical Periodontitis. in Current Oral Health Reports
Springer., 5(4), 255-263.
https://doi.org/10.1007/s40496-018-0198-7

Jakovljević A, Andrić M, Knežević A, Miletić M, Beljić-Ivanović K, Milašin J, Sabeti M. Herpesviral Infection in Periapical Periodontitis. in Current Oral Health Reports. 2018;5(4):255-263.
doi:10.1007/s40496-018-0198-7 .

Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Miletić, Maja, Beljić-Ivanović, Katarina, Milašin, Jelena, Sabeti, Mohammad, "Herpesviral Infection in Periapical Periodontitis" in Current Oral Health Reports, 5, no. 4 (2018):255-263,
https://doi.org/10.1007/s40496-018-0198-7 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Nikolić, Nadja
AU  - Corić, V.
AU  - Krezović, S.
AU  - Čarkić, Jelena
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Pljesa-Ercegovac, M.
AU  - Miletić, Maja
AU  - Soldatović, Ivan
AU  - Radosavljević, T.
AU  - Jovanović, T.
AU  - Simić, T.
AU  - Ivanović, Vladimir
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2293
AB  - AimTo investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] and bone resorption regulators [receptor activator of nuclear factor (NF-B) ligand (RANKL) and osteoprotegerin (OPG)] compared to EBV-negative periapical lesions and healthy pulp tissues. MethodologyThe experimental group consisted of 30 EBV-positive and 30 EBV-negative periapical lesions collected in conjunction with apicoectomy. The pulp tissues of 20 impacted third molars were used as healthy controls. The qualitative and quantitative analysis of EBV was performed by nested and real-time polymerase chain reaction (PCR), respectively. The levels of RANKL and OPG were analysed by reverse transcriptase real-time PCR. The levels of 8-OHdG and GSSG were determined by enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U-test and Spearman's correlation were used for statistical analysis. ResultsThe levels of RANKL, OPG, 8-OHdG and GSSG were significantly higher in apical periodontitis lesions compared to healthy pulp controls (P=0.001, P lt 0.001, P lt 0.001 and P lt 0.05, respectively). RANKL and OPG mRNA expression was significantly higher in EBV-positive compared to EBV-negative periapical lesions (P lt 0.05). There was no significant correlation between EBV copy numbers and levels of RANKL, OPG, 8OH-dG and GSSG in apical periodontitis. ConclusionLevels of bone resorption regulators and oxidative stress biomarkers were increased in apical periodontitis compared to healthy pulp tissues. EBV-positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV-negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.
PB  - Wiley, Hoboken
T2  - International Endodontic Journal
T1  - Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus
VL  - 51
IS  - 6
SP  - 593
EP  - 604
DO  - 10.1111/iej.12886
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Nikolić, Nadja and Corić, V. and Krezović, S. and Čarkić, Jelena and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Pljesa-Ercegovac, M. and Miletić, Maja and Soldatović, Ivan and Radosavljević, T. and Jovanović, T. and Simić, T. and Ivanović, Vladimir and Milašin, Jelena",
year = "2018",
abstract = "AimTo investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] and bone resorption regulators [receptor activator of nuclear factor (NF-B) ligand (RANKL) and osteoprotegerin (OPG)] compared to EBV-negative periapical lesions and healthy pulp tissues. MethodologyThe experimental group consisted of 30 EBV-positive and 30 EBV-negative periapical lesions collected in conjunction with apicoectomy. The pulp tissues of 20 impacted third molars were used as healthy controls. The qualitative and quantitative analysis of EBV was performed by nested and real-time polymerase chain reaction (PCR), respectively. The levels of RANKL and OPG were analysed by reverse transcriptase real-time PCR. The levels of 8-OHdG and GSSG were determined by enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U-test and Spearman's correlation were used for statistical analysis. ResultsThe levels of RANKL, OPG, 8-OHdG and GSSG were significantly higher in apical periodontitis lesions compared to healthy pulp controls (P=0.001, P lt 0.001, P lt 0.001 and P lt 0.05, respectively). RANKL and OPG mRNA expression was significantly higher in EBV-positive compared to EBV-negative periapical lesions (P lt 0.05). There was no significant correlation between EBV copy numbers and levels of RANKL, OPG, 8OH-dG and GSSG in apical periodontitis. ConclusionLevels of bone resorption regulators and oxidative stress biomarkers were increased in apical periodontitis compared to healthy pulp tissues. EBV-positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV-negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.",
publisher = "Wiley, Hoboken",
journal = "International Endodontic Journal",
title = "Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus",
volume = "51",
number = "6",
pages = "593-604",
doi = "10.1111/iej.12886"
}

Jakovljević, A., Andrić, M., Nikolić, N., Corić, V., Krezović, S., Čarkić, J., Knežević, A., Beljić-Ivanović, K., Pljesa-Ercegovac, M., Miletić, M., Soldatović, I., Radosavljević, T., Jovanović, T., Simić, T., Ivanović, V.,& Milašin, J.. (2018). Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. in International Endodontic Journal
Wiley, Hoboken., 51(6), 593-604.
https://doi.org/10.1111/iej.12886

Jakovljević A, Andrić M, Nikolić N, Corić V, Krezović S, Čarkić J, Knežević A, Beljić-Ivanović K, Pljesa-Ercegovac M, Miletić M, Soldatović I, Radosavljević T, Jovanović T, Simić T, Ivanović V, Milašin J. Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. in International Endodontic Journal. 2018;51(6):593-604.
doi:10.1111/iej.12886 .

Jakovljević, Aleksandar, Andrić, Miroslav, Nikolić, Nadja, Corić, V., Krezović, S., Čarkić, Jelena, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Pljesa-Ercegovac, M., Miletić, Maja, Soldatović, Ivan, Radosavljević, T., Jovanović, T., Simić, T., Ivanović, Vladimir, Milašin, Jelena, "Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus" in International Endodontic Journal, 51, no. 6 (2018):593-604,
https://doi.org/10.1111/iej.12886 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Kuzmanović, Jovana
AU  - Dragan, Irina E.
AU  - Knežević, Aleksandra
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2223
AB  - Introduction: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies. Methods: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus. A qualitative critical appraisal of the included articles was performed. Results: The electronic database search. yielded 66 hits from PubMed, 73 hits from Web of Science, and 107 from Scopus: Seven case reports and 3 cross-sectional studies were included in the final review. When summarized, in 7 patients with a history of a previous HZ attack and with no other apparent cause, -23 teeth were diagnosed with apical periodontitis, 8 teeth with internal and 1 tooth with external root resorption. The cross-sectional studies investigated the presence of VZV DNA in samples of acute apical abscess. The VZV DNA was found only in 2 of 65 samples. Conclusions: All studies included in this systematic review.had a low level of evidence (4 and 5). Still, the potential role of VZV in the etiopathogenesis of periapical pathoses and root resorption cannot be ruled out. Future investigations should be directed toward the analysis of VZV pathologic effects on pulp blood vessels, which might cause local ischemia and tissue necrosis.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review
VL  - 43
IS  - 8
SP  - 1230
EP  - 1236
DO  - 10.1016/j.joen.2017.04.021
ER  - 

@article{
author = "Jakovljević, Aleksandar and Kuzmanović, Jovana and Dragan, Irina E. and Knežević, Aleksandra and Miletić, Maja and Beljić-Ivanović, Katarina and Milašin, Jelena and Andrić, Miroslav",
year = "2017",
abstract = "Introduction: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies. Methods: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus. A qualitative critical appraisal of the included articles was performed. Results: The electronic database search. yielded 66 hits from PubMed, 73 hits from Web of Science, and 107 from Scopus: Seven case reports and 3 cross-sectional studies were included in the final review. When summarized, in 7 patients with a history of a previous HZ attack and with no other apparent cause, -23 teeth were diagnosed with apical periodontitis, 8 teeth with internal and 1 tooth with external root resorption. The cross-sectional studies investigated the presence of VZV DNA in samples of acute apical abscess. The VZV DNA was found only in 2 of 65 samples. Conclusions: All studies included in this systematic review.had a low level of evidence (4 and 5). Still, the potential role of VZV in the etiopathogenesis of periapical pathoses and root resorption cannot be ruled out. Future investigations should be directed toward the analysis of VZV pathologic effects on pulp blood vessels, which might cause local ischemia and tissue necrosis.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review",
volume = "43",
number = "8",
pages = "1230-1236",
doi = "10.1016/j.joen.2017.04.021"
}

Jakovljević, A., Kuzmanović, J., Dragan, I. E., Knežević, A., Miletić, M., Beljić-Ivanović, K., Milašin, J.,& Andrić, M.. (2017). The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review. in Journal of Endodontics
Elsevier Science Inc, New York., 43(8), 1230-1236.
https://doi.org/10.1016/j.joen.2017.04.021

Jakovljević A, Kuzmanović J, Dragan IE, Knežević A, Miletić M, Beljić-Ivanović K, Milašin J, Andrić M. The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review. in Journal of Endodontics. 2017;43(8):1230-1236.
doi:10.1016/j.joen.2017.04.021 .

Jakovljević, Aleksandar, Kuzmanović, Jovana, Dragan, Irina E., Knežević, Aleksandra, Miletić, Maja, Beljić-Ivanović, Katarina, Milašin, Jelena, Andrić, Miroslav, "The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review" in Journal of Endodontics, 43, no. 8 (2017):1230-1236,
https://doi.org/10.1016/j.joen.2017.04.021 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Perunović, Neda
AU  - Nikolić, Nadja
AU  - Milašin, Jelena
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2189
AB  - The aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. Fifty samples obtained with paper points (30 from pericoronitis and 20 controls) were subjected to polymerase chain reaction (PCR) analysis. A single-stage and nested PCR assays were used to detect herpesviruses: human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) and six periodontopathic anaerobic bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Parvimonas micra, Treponema denticola, and Tannarella forsythia. Pericoronitis samples harbored HCMV and EBV at significantly higher rates than the control group (70 vs. 40 % and 46.7 vs. 15 %, P = 0.035, P = 0.021, respectively). P. micra and T. forsythia (66.7 vs. 0 %, and 40 vs. 10 %, P = 0.001, P = 0.021, respectively) were significantly more common in pericoronitis compared to the control group. Multivariate logistic regression analysis showed that the presence of T. forsythia was associated with pericoronitis development (OR 7.3, 95 % CI, 1.2-43.2, P = 0.028). The occurrence of HCVM and EBV extends our previous knowledge on microbiota in pericoronitis. These PCR-based findings demonstrated that bacterial and viral DNA occurred concomitantly in pericoronitis samples. T. forsythia appeared to be significantly associated with pericoronitis development in the examined sample. Herpesviral-bacterial co-infections might exacerbate the progression of pericoronitis.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Herpesviral-bacterial co-infection in mandibular third molar pericoronitis
VL  - 21
IS  - 5
SP  - 1639
EP  - 1646
DO  - 10.1007/s00784-016-1955-4
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Miličić, Biljana and Beljić-Ivanović, Katarina and Perunović, Neda and Nikolić, Nadja and Milašin, Jelena",
year = "2017",
abstract = "The aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. Fifty samples obtained with paper points (30 from pericoronitis and 20 controls) were subjected to polymerase chain reaction (PCR) analysis. A single-stage and nested PCR assays were used to detect herpesviruses: human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) and six periodontopathic anaerobic bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Parvimonas micra, Treponema denticola, and Tannarella forsythia. Pericoronitis samples harbored HCMV and EBV at significantly higher rates than the control group (70 vs. 40 % and 46.7 vs. 15 %, P = 0.035, P = 0.021, respectively). P. micra and T. forsythia (66.7 vs. 0 %, and 40 vs. 10 %, P = 0.001, P = 0.021, respectively) were significantly more common in pericoronitis compared to the control group. Multivariate logistic regression analysis showed that the presence of T. forsythia was associated with pericoronitis development (OR 7.3, 95 % CI, 1.2-43.2, P = 0.028). The occurrence of HCVM and EBV extends our previous knowledge on microbiota in pericoronitis. These PCR-based findings demonstrated that bacterial and viral DNA occurred concomitantly in pericoronitis samples. T. forsythia appeared to be significantly associated with pericoronitis development in the examined sample. Herpesviral-bacterial co-infections might exacerbate the progression of pericoronitis.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Herpesviral-bacterial co-infection in mandibular third molar pericoronitis",
volume = "21",
number = "5",
pages = "1639-1646",
doi = "10.1007/s00784-016-1955-4"
}

Jakovljević, A., Andrić, M., Knežević, A., Miličić, B., Beljić-Ivanović, K., Perunović, N., Nikolić, N.,& Milašin, J.. (2017). Herpesviral-bacterial co-infection in mandibular third molar pericoronitis. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 21(5), 1639-1646.
https://doi.org/10.1007/s00784-016-1955-4

Jakovljević A, Andrić M, Knežević A, Miličić B, Beljić-Ivanović K, Perunović N, Nikolić N, Milašin J. Herpesviral-bacterial co-infection in mandibular third molar pericoronitis. in Clinical Oral Investigations. 2017;21(5):1639-1646.
doi:10.1007/s00784-016-1955-4 .

Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Miličić, Biljana, Beljić-Ivanović, Katarina, Perunović, Neda, Nikolić, Nadja, Milašin, Jelena, "Herpesviral-bacterial co-infection in mandibular third molar pericoronitis" in Clinical Oral Investigations, 21, no. 5 (2017):1639-1646,
https://doi.org/10.1007/s00784-016-1955-4 . .

TY  - CHAP
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Jovanović, Tanja
AU  - Kesić, Ljiljana
AU  - Milasin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2597
AB  - Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.
PB  - Rijeka : InTech
T2  - Herpesviridae
T1  - Herpesviruses in Periapical Pathoses: An Updated Systematic Review
SP  - 31
EP  - 74
DO  - 10.5772/64004
ER  - 

@inbook{
editor = "Ongrádi, Joseph",
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Miletić, Maja and Jovanović, Tanja and Kesić, Ljiljana and Milasin, Jelena",
year = "2016",
abstract = "Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.",
publisher = "Rijeka : InTech",
journal = "Herpesviridae",
booktitle = "Herpesviruses in Periapical Pathoses: An Updated Systematic Review",
pages = "31-74",
doi = "10.5772/64004"
}

Ongrádi, J., Jakovljević, A., Andrić, M., Knežević, A., Beljić-Ivanović, K., Miletić, M., Jovanović, T., Kesić, L.,& Milasin, J.. (2016). Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae
Rijeka : InTech., 31-74.
https://doi.org/10.5772/64004

Ongrádi J, Jakovljević A, Andrić M, Knežević A, Beljić-Ivanović K, Miletić M, Jovanović T, Kesić L, Milasin J. Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae. 2016;:31-74.
doi:10.5772/64004 .

Ongrádi, Joseph, Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Miletić, Maja, Jovanović, Tanja, Kesić, Ljiljana, Milasin, Jelena, "Herpesviruses in Periapical Pathoses: An Updated Systematic Review" in Herpesviridae (2016):31-74,
https://doi.org/10.5772/64004 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Knežević, Aleksandra
AU  - Mojsilović, Slavko
AU  - Milašin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2147
AB  - Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.
PB  - Churchill Livingstone, Edinburgh
T2  - Medical Hypotheses
T1  - Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species
VL  - 94
SP  - 40
EP  - 42
DO  - 10.1016/j.mehy.2016.06.020
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Miletić, Maja and Beljić-Ivanović, Katarina and Knežević, Aleksandra and Mojsilović, Slavko and Milašin, Jelena",
year = "2016",
abstract = "Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Medical Hypotheses",
title = "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species",
volume = "94",
pages = "40-42",
doi = "10.1016/j.mehy.2016.06.020"
}

Jakovljević, A., Andrić, M., Miletić, M., Beljić-Ivanović, K., Knežević, A., Mojsilović, S.,& Milašin, J.. (2016). Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses
Churchill Livingstone, Edinburgh., 94, 40-42.
https://doi.org/10.1016/j.mehy.2016.06.020

Jakovljević A, Andrić M, Miletić M, Beljić-Ivanović K, Knežević A, Mojsilović S, Milašin J. Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses. 2016;94:40-42.
doi:10.1016/j.mehy.2016.06.020 .

Jakovljević, Aleksandar, Andrić, Miroslav, Miletić, Maja, Beljić-Ivanović, Katarina, Knežević, Aleksandra, Mojsilović, Slavko, Milašin, Jelena, "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species" in Medical Hypotheses, 94 (2016):40-42,
https://doi.org/10.1016/j.mehy.2016.06.020 . .

TY  - THES
AU  - Beljić-Ivanović, Katarina
PY  - 2015
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=2474
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:10502/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=47656975
UR  - http://nardus.mpn.gov.rs/123456789/4639
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/985
AB  - The idea for this study emerged from everyday problems that practitioners are faced in their clinical work during endodontic therapy of teeth with complex root canal anatomy, and due to a lack of information and sufficient data from the literature about influence of machine driven instrumentation techniques on the original anatomy of the root canal system of first maxillary molars. Crucial aim of this dissertation followed the idea of the study, and upon that fact the major tasks were given in order to choose relevant group of maxillary first molars: A) teeth with three distinctive roots and with canal configuration of Vertucci type IV in the mesiobuccal root, and B) teeth with fused roots. Detailed evaluation of several parameters that will define changes of anatomical details were conducted before and after root canal preparation with five machine driven instrumentation techniques: ProTaper Next, Revo-S, WaveOne, Tilos and Self Adjusting File (SAF). With the aid of Cone Beam Computed Tomography (CBCT), introduced in endodontics in the last decade, at the distance of 1.0 mm and 0.1 mm along each root canal the following measurements were conducted: canal walls thickness, dimensions of root canal diameters measured from two directions, and surface area of the root canal cross sections before and after mechanical preparation. The influence, mode of effects and differences of those effects between applied machine driven techniques on the original anatomy of root canals in first maxillary molars were analyzed using appropriate statistical methods. Results of the studies of the anatomical features of two groups of maxillary first molars showed that all dimensions of the tooth crown measured at the level of the pulp chamber floor were significantly greater in teeth with three distinctive roots than in those with fused roots. It was also shown that distances between centers of the canal orifices were significantly different between the two groups of maxillary first molars. These results are of great clinical importance, and with no similar findings in available endodontic literature. Changes in the root canal diameters after mechanical preparation were least in the apical third, and significantly greater at the orifice and in the coronal third of all root canals irrespective to the instrumentation technique. Degree of changes in dimensions of canal diameter was different between the group with three distinctive roots and group with fused roots...
AB  - Ideja za istraživanje proizašla je iz problematike sa kojom se susreću terapeuti u kliničkom radu tokom endodontske preparacije zuba sa komplikovanim kanalnim sistemima i nedostataka literaturinih podataka o uticaju mašinskih tehnika instrumentacije na originalnu anatomiju kanalnog sistema prvih maksilarnih molara. Osnovni cilj ove disertacije je pratio ideju istraživanja, na osnovu čega su postavljeni i konkretni zadaci, koji su rukovodili odabir relevantnih grupa prvih maksilarnih molara: I – zubi sa tri odvojena korena i morfološkim tipom Vertucci IV kanala u mezio-bukalnom korenu i II – zubi sa fuzionisanim korenovima. Na njima su sprovedena proučavanja parametara koji će definisati promene anatomskih detalja pre i posle instrumentacije kanala korena koristeći pet specifičnih sistema mašinske obrade: ProTaper Next, Revo-S, WaveOne, Tilos i Self Adjusting File (SAF). Koristeći kompjuterizovanu tomografiju konusnog zraka (CBCT), uvedenu u endodonciju pre nepune decenije, na rastojanju od 1,0 i 0,1 mm duž svakog kanala merene su: debljine zidova korenskih kanala, dimenzije prečnika kanala iz dva osnovna pravca i površine poprečnih preseka kanala pre i posle mašinske preparacije. Statističkim metodima analizirano je da li i na koji način primenjeni sistemi za mašinsku preparaciju utiču na originalnu anatomiju prvih maksilarnih molara i da li između njih postoje razlike. Rezultati antomskih karaktersitika dve grupe prvih maksilarnih molara pokazali su da su sve dimenzije krunice zuba na nivou dna krunične komore veće u grupi sa tri odvojena nego u grupi sa fuzionisanim korenovima. Takođe je pokazano da su rastojanja između cenatara ulaza u korenske kanale statistički zančajno različite između ove dve grupe prvih maksilarnih molara, što je od izuzetnog kliničkog značaja, a bez sličnih nalaza u dostupnoj literaturi. Promene dimenzije prečnika kanala posle preparacije su bile najmanje u njihovoj apeksnoj trećini, a statistički značajno veće na ulazu i u koronarnoj trećini kanala. Stepen promena dimenzija prečnika razlikovao se između grupe sa tri odvojena i grupe sa fuzionisanim korenovima. U obe grupe zuba su najizrazitije promene vrednosti prečnika kanala bile na njihovom ulazu, a najmanje u apeksnoj trećini, i to posle primene svih pet tehnika instrumentacije...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Effect of different machine driven instrumentation techniques on the original root canal anatomy of the first maxillary molars
T1  - Uticaj različitih tehnika mašinske preparacije na originalnu anatomiju kanala korenova prvih maksilarnih molara
UR  - https://hdl.handle.net/21.15107/rcub_nardus_4639
ER  - 

@phdthesis{
author = "Beljić-Ivanović, Katarina",
year = "2015",
abstract = "The idea for this study emerged from everyday problems that practitioners are faced in their clinical work during endodontic therapy of teeth with complex root canal anatomy, and due to a lack of information and sufficient data from the literature about influence of machine driven instrumentation techniques on the original anatomy of the root canal system of first maxillary molars. Crucial aim of this dissertation followed the idea of the study, and upon that fact the major tasks were given in order to choose relevant group of maxillary first molars: A) teeth with three distinctive roots and with canal configuration of Vertucci type IV in the mesiobuccal root, and B) teeth with fused roots. Detailed evaluation of several parameters that will define changes of anatomical details were conducted before and after root canal preparation with five machine driven instrumentation techniques: ProTaper Next, Revo-S, WaveOne, Tilos and Self Adjusting File (SAF). With the aid of Cone Beam Computed Tomography (CBCT), introduced in endodontics in the last decade, at the distance of 1.0 mm and 0.1 mm along each root canal the following measurements were conducted: canal walls thickness, dimensions of root canal diameters measured from two directions, and surface area of the root canal cross sections before and after mechanical preparation. The influence, mode of effects and differences of those effects between applied machine driven techniques on the original anatomy of root canals in first maxillary molars were analyzed using appropriate statistical methods. Results of the studies of the anatomical features of two groups of maxillary first molars showed that all dimensions of the tooth crown measured at the level of the pulp chamber floor were significantly greater in teeth with three distinctive roots than in those with fused roots. It was also shown that distances between centers of the canal orifices were significantly different between the two groups of maxillary first molars. These results are of great clinical importance, and with no similar findings in available endodontic literature. Changes in the root canal diameters after mechanical preparation were least in the apical third, and significantly greater at the orifice and in the coronal third of all root canals irrespective to the instrumentation technique. Degree of changes in dimensions of canal diameter was different between the group with three distinctive roots and group with fused roots..., Ideja za istraživanje proizašla je iz problematike sa kojom se susreću terapeuti u kliničkom radu tokom endodontske preparacije zuba sa komplikovanim kanalnim sistemima i nedostataka literaturinih podataka o uticaju mašinskih tehnika instrumentacije na originalnu anatomiju kanalnog sistema prvih maksilarnih molara. Osnovni cilj ove disertacije je pratio ideju istraživanja, na osnovu čega su postavljeni i konkretni zadaci, koji su rukovodili odabir relevantnih grupa prvih maksilarnih molara: I – zubi sa tri odvojena korena i morfološkim tipom Vertucci IV kanala u mezio-bukalnom korenu i II – zubi sa fuzionisanim korenovima. Na njima su sprovedena proučavanja parametara koji će definisati promene anatomskih detalja pre i posle instrumentacije kanala korena koristeći pet specifičnih sistema mašinske obrade: ProTaper Next, Revo-S, WaveOne, Tilos i Self Adjusting File (SAF). Koristeći kompjuterizovanu tomografiju konusnog zraka (CBCT), uvedenu u endodonciju pre nepune decenije, na rastojanju od 1,0 i 0,1 mm duž svakog kanala merene su: debljine zidova korenskih kanala, dimenzije prečnika kanala iz dva osnovna pravca i površine poprečnih preseka kanala pre i posle mašinske preparacije. Statističkim metodima analizirano je da li i na koji način primenjeni sistemi za mašinsku preparaciju utiču na originalnu anatomiju prvih maksilarnih molara i da li između njih postoje razlike. Rezultati antomskih karaktersitika dve grupe prvih maksilarnih molara pokazali su da su sve dimenzije krunice zuba na nivou dna krunične komore veće u grupi sa tri odvojena nego u grupi sa fuzionisanim korenovima. Takođe je pokazano da su rastojanja između cenatara ulaza u korenske kanale statistički zančajno različite između ove dve grupe prvih maksilarnih molara, što je od izuzetnog kliničkog značaja, a bez sličnih nalaza u dostupnoj literaturi. Promene dimenzije prečnika kanala posle preparacije su bile najmanje u njihovoj apeksnoj trećini, a statistički značajno veće na ulazu i u koronarnoj trećini kanala. Stepen promena dimenzija prečnika razlikovao se između grupe sa tri odvojena i grupe sa fuzionisanim korenovima. U obe grupe zuba su najizrazitije promene vrednosti prečnika kanala bile na njihovom ulazu, a najmanje u apeksnoj trećini, i to posle primene svih pet tehnika instrumentacije...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Effect of different machine driven instrumentation techniques on the original root canal anatomy of the first maxillary molars, Uticaj različitih tehnika mašinske preparacije na originalnu anatomiju kanala korenova prvih maksilarnih molara",
url = "https://hdl.handle.net/21.15107/rcub_nardus_4639"
}

Beljić-Ivanović, K.. (2015). Effect of different machine driven instrumentation techniques on the original root canal anatomy of the first maxillary molars. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_4639

Beljić-Ivanović K. Effect of different machine driven instrumentation techniques on the original root canal anatomy of the first maxillary molars. 2015;.
https://hdl.handle.net/21.15107/rcub_nardus_4639 .

Beljić-Ivanović, Katarina, "Effect of different machine driven instrumentation techniques on the original root canal anatomy of the first maxillary molars" (2015),
https://hdl.handle.net/21.15107/rcub_nardus_4639 .

TY  - JOUR
AU  - Ivanović, Vladimir
AU  - Savić-Stanković, Tatjana
AU  - Karadžić, Branislav
AU  - Ilić, Jugoslav
AU  - Santini, Ario
AU  - Beljić-Ivanović, Katarina
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1799
AB  - Introduction. Postoperative sensitivity in restorative dentistry can be related to preparation trauma, dentin adhesives' ability to seal open dentinal tubules, deformation of restorations under occlusal stresses and microleakage. Objective. The study assessed possible reduction in postoperative sensitivity with low shrinkage compared to conventional composites using different bonding agents and the influence of the operator skill on the incidence of postoperative sensitivity. Methods. Nine hundred and sixty permanent premolars and molars with primary carious lesions from patients 21 to 40 years old were used. Cavities 2 to 3 mm deep and with margins in enamel were prepared by four operators. Two operators had five years (A and B) and two had over 20 years (C and D) of clinical experience. Teeth were divided into eight groups each contained 120 restorations: (1) Els®+James-2 (original formula), (2) Els®+James-2 (new formula), (3) Els®+Excite, (4) InTenSe®+James-2 (original formula), (5) InTenSe®+James-2 (new formula), (6) InTenSe®+Excite, (7) Tetric Ceram®+Excite, and (8) Point 4®+OptiBond Solo Plus. At 14 days postoperatively, two independent operators, who did not take part in the clinical procedure, assessed postoperative teeth sensitivity using special questionnaires. Data were analyzed using non-parametric chi-square, Mann-Whitney and ANOVA tests. Results. Group 8 showed significantly higher score than the other groups. Less postoperative sensitivity was reported with two low-shrinkage composites (groups 2, 3, and 5) but with no significant difference. There was no statistical difference between groups 1, 2, 3, 4, 5, 6 and 7. Operator A had the highest postoperative sensitivity score compared to the other three. Conclusion. Conventional composite material Point 4® with its bonding agent caused significantly more postoperative sensitivity than low shrinkage composites combined with different adhesives. Operator skill influenced the incidence of postoperative sensitivity.
AB  - Uvod. Posle postavljanja kompozitnih ispuna može da se javi postoperaciona osetljivost izazvana preparacionom traumom, sposobnošću adhezivnog sistema da hermetički zatvori dentinske kanaliće, deformacijom pod okluzalnim opterećenjem ili prodorom bakterijskih toksina. Cilj rada. Cilj istraživanja je bio da se ispita da li je osetljivost zuba manja kod kompozita s malom kontrakcijom u poređenju s konvencionalnim kompozitima i odgovarajućim adhezivnim sistemima, kao i uticaj veštine stomatologa na incidenciju postoperacione osetljivosti zuba. Metode rada. Na 960 premolara i molara stalne denticije s primarnim karijesom, pacijenata starosti od 21 godine do 40 godina, preparisani su kaviteti dubine 2-3 mm s rubovima u gleđi. Čitavu proceduru su obavila četiri specijalista stomatologije, od kojih su dva imala pet (A i B), a druga dva više od 20 godina kliničkog iskustva (C i D). Zubi su svrstani u osam grupa od po 120 uzoraka prema korišćenom kompozitnom i adhezivnom sistemu: 1) Els®+James-2; 2) Els®+James-2 (nova formula); 3) Els®+Excite; 4) InTenSe®+James-2; 5) InTenSe®+James-2 (nova formula); 6) InTenSe®+Excite; 7) Tetric Ceram®+Excite; i 8) Point 4®+OptiBond Solo Plus. Dve nedelje posle intervencije dva nezavisna stomatologa (koja nisu učestvovala u kliničkoj proceduri) ocenjivala su posebnim upitnicima postoperacionu osetljivost zuba. Podaci su analizirani neparametrijskim c2, Man-Vitnijevim (Mann-Whitney) i ANOVA testom. Rezultati. U osmoj grupi utvrđena je statistički značajno češća postoperaciona osetljivost nego u ostalim grupama zuba. Nije bilo statistički značajne razlike između grupa 1, 2, 3, 4, 5, 6 i 7. Kompoziti sa nižom polimerizacionom kontrakcijom izazvali su manju postoperacionu ostetljivost, ali bez statističke značajnosti razlika (grupe 2, 3 i 5). Kod stomatologa A javljala se statistički značajno češće postoperaciona osetljivost nego kod ostala tri. Zaključak. Tip kompozitnog materijala s odgovarajućim adhezivnim sistemom i spretnost stomatologa utiču na učestalost pojave osetljivosti zuba posle restauracija srednje dubokih kaviteta II klase.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Postoperative sensitivity associated with low shrinkage versus conventional composites
T1  - Uticaj kompozita s malom kontrakcijom i konvencionalnih kompozita na postoperacionu osetljivost zuba
VL  - 141
IS  - 7-8
SP  - 447
EP  - 453
DO  - 10.2298/SARH1308447I
ER  - 

@article{
author = "Ivanović, Vladimir and Savić-Stanković, Tatjana and Karadžić, Branislav and Ilić, Jugoslav and Santini, Ario and Beljić-Ivanović, Katarina",
year = "2013",
abstract = "Introduction. Postoperative sensitivity in restorative dentistry can be related to preparation trauma, dentin adhesives' ability to seal open dentinal tubules, deformation of restorations under occlusal stresses and microleakage. Objective. The study assessed possible reduction in postoperative sensitivity with low shrinkage compared to conventional composites using different bonding agents and the influence of the operator skill on the incidence of postoperative sensitivity. Methods. Nine hundred and sixty permanent premolars and molars with primary carious lesions from patients 21 to 40 years old were used. Cavities 2 to 3 mm deep and with margins in enamel were prepared by four operators. Two operators had five years (A and B) and two had over 20 years (C and D) of clinical experience. Teeth were divided into eight groups each contained 120 restorations: (1) Els®+James-2 (original formula), (2) Els®+James-2 (new formula), (3) Els®+Excite, (4) InTenSe®+James-2 (original formula), (5) InTenSe®+James-2 (new formula), (6) InTenSe®+Excite, (7) Tetric Ceram®+Excite, and (8) Point 4®+OptiBond Solo Plus. At 14 days postoperatively, two independent operators, who did not take part in the clinical procedure, assessed postoperative teeth sensitivity using special questionnaires. Data were analyzed using non-parametric chi-square, Mann-Whitney and ANOVA tests. Results. Group 8 showed significantly higher score than the other groups. Less postoperative sensitivity was reported with two low-shrinkage composites (groups 2, 3, and 5) but with no significant difference. There was no statistical difference between groups 1, 2, 3, 4, 5, 6 and 7. Operator A had the highest postoperative sensitivity score compared to the other three. Conclusion. Conventional composite material Point 4® with its bonding agent caused significantly more postoperative sensitivity than low shrinkage composites combined with different adhesives. Operator skill influenced the incidence of postoperative sensitivity., Uvod. Posle postavljanja kompozitnih ispuna može da se javi postoperaciona osetljivost izazvana preparacionom traumom, sposobnošću adhezivnog sistema da hermetički zatvori dentinske kanaliće, deformacijom pod okluzalnim opterećenjem ili prodorom bakterijskih toksina. Cilj rada. Cilj istraživanja je bio da se ispita da li je osetljivost zuba manja kod kompozita s malom kontrakcijom u poređenju s konvencionalnim kompozitima i odgovarajućim adhezivnim sistemima, kao i uticaj veštine stomatologa na incidenciju postoperacione osetljivosti zuba. Metode rada. Na 960 premolara i molara stalne denticije s primarnim karijesom, pacijenata starosti od 21 godine do 40 godina, preparisani su kaviteti dubine 2-3 mm s rubovima u gleđi. Čitavu proceduru su obavila četiri specijalista stomatologije, od kojih su dva imala pet (A i B), a druga dva više od 20 godina kliničkog iskustva (C i D). Zubi su svrstani u osam grupa od po 120 uzoraka prema korišćenom kompozitnom i adhezivnom sistemu: 1) Els®+James-2; 2) Els®+James-2 (nova formula); 3) Els®+Excite; 4) InTenSe®+James-2; 5) InTenSe®+James-2 (nova formula); 6) InTenSe®+Excite; 7) Tetric Ceram®+Excite; i 8) Point 4®+OptiBond Solo Plus. Dve nedelje posle intervencije dva nezavisna stomatologa (koja nisu učestvovala u kliničkoj proceduri) ocenjivala su posebnim upitnicima postoperacionu osetljivost zuba. Podaci su analizirani neparametrijskim c2, Man-Vitnijevim (Mann-Whitney) i ANOVA testom. Rezultati. U osmoj grupi utvrđena je statistički značajno češća postoperaciona osetljivost nego u ostalim grupama zuba. Nije bilo statistički značajne razlike između grupa 1, 2, 3, 4, 5, 6 i 7. Kompoziti sa nižom polimerizacionom kontrakcijom izazvali su manju postoperacionu ostetljivost, ali bez statističke značajnosti razlika (grupe 2, 3 i 5). Kod stomatologa A javljala se statistički značajno češće postoperaciona osetljivost nego kod ostala tri. Zaključak. Tip kompozitnog materijala s odgovarajućim adhezivnim sistemom i spretnost stomatologa utiču na učestalost pojave osetljivosti zuba posle restauracija srednje dubokih kaviteta II klase.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Postoperative sensitivity associated with low shrinkage versus conventional composites, Uticaj kompozita s malom kontrakcijom i konvencionalnih kompozita na postoperacionu osetljivost zuba",
volume = "141",
number = "7-8",
pages = "447-453",
doi = "10.2298/SARH1308447I"
}

Ivanović, V., Savić-Stanković, T., Karadžić, B., Ilić, J., Santini, A.,& Beljić-Ivanović, K.. (2013). Postoperative sensitivity associated with low shrinkage versus conventional composites. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 141(7-8), 447-453.
https://doi.org/10.2298/SARH1308447I

Ivanović V, Savić-Stanković T, Karadžić B, Ilić J, Santini A, Beljić-Ivanović K. Postoperative sensitivity associated with low shrinkage versus conventional composites. in Srpski arhiv za celokupno lekarstvo. 2013;141(7-8):447-453.
doi:10.2298/SARH1308447I .

Ivanović, Vladimir, Savić-Stanković, Tatjana, Karadžić, Branislav, Ilić, Jugoslav, Santini, Ario, Beljić-Ivanović, Katarina, "Postoperative sensitivity associated with low shrinkage versus conventional composites" in Srpski arhiv za celokupno lekarstvo, 141, no. 7-8 (2013):447-453,
https://doi.org/10.2298/SARH1308447I . .

TY  - JOUR
AU  - Miletić, Vesna
AU  - Beljić-Ivanović, Katarina
AU  - Ivanović, Vladimir
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1620
AB  - Aim To compare the reproducibility of three electronic apex locators (EALs), Dentaport ZX, RomiApex A-15 and Raypex 5, under clinical conditions. Methodology Forty-eight root canals of incisors, canines and premolars with or without radiographically confirmed periapical lesions required root canal treatment in 42 patients. In each root canal, all three EALs were used to determine the working length (WL) that was defined as the zero reading and indicated by 'Apex', '0.0' or 'red square' markings on the EAL display. A new K-file of the same size was used for each measurement. The file length was fixed with a rubber stop and measured to an accuracy of 0.01 mm. Measurements were undertaken by two calibrated operators. Differences in zero readings between the three EALs in the same root canal were statistically analysed using paired t-tests with the Bonferroni correction, Bland-Altman plot and Linn's concordance correlation coefficients at alpha = 0.05. Results Mean and standard deviation values measured by the three EALs showed no statistically significant differences. Identical readings by all three EALs were found in 10.4% of root canals. Forty-three per cent of readings differed by less than +/- 0.5 mm and 31.3% exceeded a difference of +/- 1 mm. Conclusions The clinical reproducibility of Dentaport ZX, RomiApex A-15 and Raypex 5 was confirmed with the majority of readings within the +/- 1.0 mm range. However, the small number of identical zero readings suggests that EALs are not reliable as the sole means of WL determination under clinical conditions.
PB  - Wiley-Blackwell, Malden
T2  - International Endodontic Journal
T1  - Clinical reproducibility of three electronic apex locators
VL  - 44
IS  - 8
SP  - 769
EP  - 776
DO  - 10.1111/j.1365-2591.2011.01897.x
ER  - 

@article{
author = "Miletić, Vesna and Beljić-Ivanović, Katarina and Ivanović, Vladimir",
year = "2011",
abstract = "Aim To compare the reproducibility of three electronic apex locators (EALs), Dentaport ZX, RomiApex A-15 and Raypex 5, under clinical conditions. Methodology Forty-eight root canals of incisors, canines and premolars with or without radiographically confirmed periapical lesions required root canal treatment in 42 patients. In each root canal, all three EALs were used to determine the working length (WL) that was defined as the zero reading and indicated by 'Apex', '0.0' or 'red square' markings on the EAL display. A new K-file of the same size was used for each measurement. The file length was fixed with a rubber stop and measured to an accuracy of 0.01 mm. Measurements were undertaken by two calibrated operators. Differences in zero readings between the three EALs in the same root canal were statistically analysed using paired t-tests with the Bonferroni correction, Bland-Altman plot and Linn's concordance correlation coefficients at alpha = 0.05. Results Mean and standard deviation values measured by the three EALs showed no statistically significant differences. Identical readings by all three EALs were found in 10.4% of root canals. Forty-three per cent of readings differed by less than +/- 0.5 mm and 31.3% exceeded a difference of +/- 1 mm. Conclusions The clinical reproducibility of Dentaport ZX, RomiApex A-15 and Raypex 5 was confirmed with the majority of readings within the +/- 1.0 mm range. However, the small number of identical zero readings suggests that EALs are not reliable as the sole means of WL determination under clinical conditions.",
publisher = "Wiley-Blackwell, Malden",
journal = "International Endodontic Journal",
title = "Clinical reproducibility of three electronic apex locators",
volume = "44",
number = "8",
pages = "769-776",
doi = "10.1111/j.1365-2591.2011.01897.x"
}

Miletić, V., Beljić-Ivanović, K.,& Ivanović, V.. (2011). Clinical reproducibility of three electronic apex locators. in International Endodontic Journal
Wiley-Blackwell, Malden., 44(8), 769-776.
https://doi.org/10.1111/j.1365-2591.2011.01897.x

Miletić V, Beljić-Ivanović K, Ivanović V. Clinical reproducibility of three electronic apex locators. in International Endodontic Journal. 2011;44(8):769-776.
doi:10.1111/j.1365-2591.2011.01897.x .

Miletić, Vesna, Beljić-Ivanović, Katarina, Ivanović, Vladimir, "Clinical reproducibility of three electronic apex locators" in International Endodontic Journal, 44, no. 8 (2011):769-776,
https://doi.org/10.1111/j.1365-2591.2011.01897.x . .

TY  - JOUR
AU  - Beljić-Ivanović, Katarina
AU  - Teodorović, Nevenka
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1573
AB  - Introduction. The first maxillary molar is a tooth with three roots, and mesiobuccal one is with the most complex canal morphology. Factors influencing variations of its morphology are numerous, and may significantly complicate endodontic treatment. Objective. The objective was to investigate the number, configuration and curvature orientation of the mesiobuccal root canals in the maxillary first molars. Methods. The study was conducted on 200 mesiobuccal (MB) roots of extracted first molars in human subjects using radiography. In each canal Flexofile was introduced until reaching the apical foramen and the root was then radiographed in series from two projections. Number of root canals (MB1, MB2 and MB3), configuration according to Vertucci classification, and the orientation of the curvature were established. Relevant statistical parameters and the significance of differences were computed (p lt 0.05). Results. Of total 200 mesiobuccal roots 86.5% were with two, 9% with three, and 4.5% with a single canal. Most frequent configurations were type IV (36%) and II (34.5%). From the clinical projection all MB1 canals were oriented distally, from the proximal 78% palatally and 22% buccally. The orientation of all MB2 canals was distal from the clinical projection, from the proximal projection 76% were oriented palatally, and 24% buccally. The MB3 canal was always oriented distally from the clinical projection, and buccally from the proximal aspect. Conclusion. The mesiobuccal roots of the first maxillary molars showed multiple canals in 96%, with dominant Vertucci type II and IV of configuration. All canals were curved.
AB  - Uvod. Prvi maksilarni molar je zub koji najčešće ima tri korena, a meziobukalni je s najsloženijom kanalnom morfologijom. Faktora koji utiču na varijabilnost njegove morfologije ima mnogo i značajno otežavaju endodontsko lečenje ovih zuba. Cilj rada. Cilj rada je bio da se na ekstrahovanim prvim maksilarnim molarima ispitaju broj, konfiguracija i smer povijenosti meziobukalnih kanala. Metode rada. Istraživanja su urađena na 200 meziobukalnih (MB) korenova ekstrahovanih humanih prvih maksilarnih molara metodom radiografisanja. U svaki pojedinačni kanal postavljen je instrument tipa Flexofile do pojave na anatomskom otvoru i zatim radiografisan serijom snimaka iz dve projekcije. Zabeleženi su broj kanala (MB1, MB2 i MB3), konfiguracija prema Vertučijevoj (Vertucci) klasifikaciji i smer povijenosti. Utvrđeni su relevantni statistički parametri i razlike na nivou značajnosti p lt 0,05. Rezultati. Od ukupno 200 MB korenova, sa dva kanala bilo je njih 86,5% , sa tri 9%, a s jednim kanalom 4,5%. Najčešći tipovi kanalne konfiguracije bili su IV (36%) i II (34,5%). Smer povijenosti svih MB1 kanala iz kliničke projekcije bio je distalan, a iz aproksimalne 78% palatinalan i 22% bukalan. Svi MB2 kanali iz kliničke projekcije bili su distalno povijeni, a iz aproksimalne 76% palatinalno i 24% bukalno. MB3 kanal je bio povijen uvek distalno u kliničkoj, a najčešće bukalno u aproksimalnoj projekciji snimanja. Zaključak. Meziobukalni korenovi prvih maksilarnih molara su u 96% slučajeva imali višestruki broj kanala i konfiguracijski su pripadali tipu IV i II Vertučijeve klasifikacije. Svi kanali su bili povijeni.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Morphological characteristics of mesiobuccal root canals of the first maxillary molars
T1  - Morfološke odlike meziobukalnih kanala prvih maksilarnih molara
VL  - 138
IS  - 7-8
SP  - 414
EP  - 419
DO  - 10.2298/SARH1008414B
ER  - 

@article{
author = "Beljić-Ivanović, Katarina and Teodorović, Nevenka",
year = "2010",
abstract = "Introduction. The first maxillary molar is a tooth with three roots, and mesiobuccal one is with the most complex canal morphology. Factors influencing variations of its morphology are numerous, and may significantly complicate endodontic treatment. Objective. The objective was to investigate the number, configuration and curvature orientation of the mesiobuccal root canals in the maxillary first molars. Methods. The study was conducted on 200 mesiobuccal (MB) roots of extracted first molars in human subjects using radiography. In each canal Flexofile was introduced until reaching the apical foramen and the root was then radiographed in series from two projections. Number of root canals (MB1, MB2 and MB3), configuration according to Vertucci classification, and the orientation of the curvature were established. Relevant statistical parameters and the significance of differences were computed (p lt 0.05). Results. Of total 200 mesiobuccal roots 86.5% were with two, 9% with three, and 4.5% with a single canal. Most frequent configurations were type IV (36%) and II (34.5%). From the clinical projection all MB1 canals were oriented distally, from the proximal 78% palatally and 22% buccally. The orientation of all MB2 canals was distal from the clinical projection, from the proximal projection 76% were oriented palatally, and 24% buccally. The MB3 canal was always oriented distally from the clinical projection, and buccally from the proximal aspect. Conclusion. The mesiobuccal roots of the first maxillary molars showed multiple canals in 96%, with dominant Vertucci type II and IV of configuration. All canals were curved., Uvod. Prvi maksilarni molar je zub koji najčešće ima tri korena, a meziobukalni je s najsloženijom kanalnom morfologijom. Faktora koji utiču na varijabilnost njegove morfologije ima mnogo i značajno otežavaju endodontsko lečenje ovih zuba. Cilj rada. Cilj rada je bio da se na ekstrahovanim prvim maksilarnim molarima ispitaju broj, konfiguracija i smer povijenosti meziobukalnih kanala. Metode rada. Istraživanja su urađena na 200 meziobukalnih (MB) korenova ekstrahovanih humanih prvih maksilarnih molara metodom radiografisanja. U svaki pojedinačni kanal postavljen je instrument tipa Flexofile do pojave na anatomskom otvoru i zatim radiografisan serijom snimaka iz dve projekcije. Zabeleženi su broj kanala (MB1, MB2 i MB3), konfiguracija prema Vertučijevoj (Vertucci) klasifikaciji i smer povijenosti. Utvrđeni su relevantni statistički parametri i razlike na nivou značajnosti p lt 0,05. Rezultati. Od ukupno 200 MB korenova, sa dva kanala bilo je njih 86,5% , sa tri 9%, a s jednim kanalom 4,5%. Najčešći tipovi kanalne konfiguracije bili su IV (36%) i II (34,5%). Smer povijenosti svih MB1 kanala iz kliničke projekcije bio je distalan, a iz aproksimalne 78% palatinalan i 22% bukalan. Svi MB2 kanali iz kliničke projekcije bili su distalno povijeni, a iz aproksimalne 76% palatinalno i 24% bukalno. MB3 kanal je bio povijen uvek distalno u kliničkoj, a najčešće bukalno u aproksimalnoj projekciji snimanja. Zaključak. Meziobukalni korenovi prvih maksilarnih molara su u 96% slučajeva imali višestruki broj kanala i konfiguracijski su pripadali tipu IV i II Vertučijeve klasifikacije. Svi kanali su bili povijeni.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Morphological characteristics of mesiobuccal root canals of the first maxillary molars, Morfološke odlike meziobukalnih kanala prvih maksilarnih molara",
volume = "138",
number = "7-8",
pages = "414-419",
doi = "10.2298/SARH1008414B"
}

Beljić-Ivanović, K.,& Teodorović, N.. (2010). Morphological characteristics of mesiobuccal root canals of the first maxillary molars. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 138(7-8), 414-419.
https://doi.org/10.2298/SARH1008414B

Beljić-Ivanović K, Teodorović N. Morphological characteristics of mesiobuccal root canals of the first maxillary molars. in Srpski arhiv za celokupno lekarstvo. 2010;138(7-8):414-419.
doi:10.2298/SARH1008414B .

Beljić-Ivanović, Katarina, Teodorović, Nevenka, "Morphological characteristics of mesiobuccal root canals of the first maxillary molars" in Srpski arhiv za celokupno lekarstvo, 138, no. 7-8 (2010):414-419,
https://doi.org/10.2298/SARH1008414B . .

TY  - JOUR
AU  - Beljić-Ivanović, Katarina
AU  - Teodorović, Nevenka
AU  - Ostojić, Dejan
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1469
AB  - Endodontic treatment of the teeth with severe root canal curvatures has become one of the greatest problems in clinical practice. Recently, new instruments and techniques have been introduced in the endodontic procedure. The aim of this study was, on the basis of clinical practice, to show the possibilities of the endodontic treatment in the teeth with severely curved root canals, after dependable decision about endodontic instruments and techniques. This article presents a complete endodontic procedure in two teeth with different curvature shape of the root canal in patients that were treated at the Department of Restorative Dentistry and Endodontics, School of Dentistry, Belgrade. Coronal to apical 'crown down' technique was used for the root canal preparation with hand NiTi ProTaper instruments with progressive multicone design. The main reasons for choosing manual technique were complexity, shape of presented curvatures and better tactile sensation control of canal instruments in order to avoid possible mistakes and complications. Clinical X-rays of the teeth with permanent obturation clearly showed that extremes of the root canal morphology could be successfully solved by the right choice of all factors during endodontic procedure.
AB  - Endodontsko lečenje zuba s jako zakrivljenim korenovima je značajan problem u praksi. Primena novih instrumenata i tehnika u lečenju ovakvih zuba poslednjih godina je postala sve izvesnija.Cilj ovog rada je bio da se na primerima iz kliničke prakse ukaže na mogućnost endodontskog lečenjazuba s veoma izraženim krivinama kanala korena nakon pravilnog izbora endodontskih instrumenata, odnosno tehnike instrumentacije. U ovom radu je prikazan celokupni endodontski postupak lečenja dva zuba pacijenata Klinike za bolesti zuba Stomatološkog fakulteta u Beogradu sa različitim oblicima krivine centralnog korenskog kanala. Prime-njena je krunično-apeksna 'crown-down' tehnika preparacije uz korišćenje ručnih nikl-titanijumskih instrumenata tipa ProTaper s progresivnom multikoničnošću. Osnovni razlozi za odabir ručne tehnike preparacije bili su složenost morfologije, oblik prikazanih krivina i bolja taktilno-senzorna kontrola kanalnih instrumenata; cilj je bio da se izbegnu moguće greške i komplikacije. Prikazani radiografski snimci zuba sa jasno opturiranim kanalnim sistemom pokazuju da su i ekstremi morfološkog izgleda kanala rešivi pravilnim odabirom svih činilaca endodontske procedure. .
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Endodontic treatment of the teeth with different root canal curvatures: Two case reports
T1  - Endodontsko lečenje zuba s različitim oblicima krivina korenskih kanala - dva prikaza iz prakse
VL  - 56
IS  - 2
SP  - 91
EP  - 96
DO  - 10.2298/SGS0902091B
ER  - 

@article{
author = "Beljić-Ivanović, Katarina and Teodorović, Nevenka and Ostojić, Dejan",
year = "2009",
abstract = "Endodontic treatment of the teeth with severe root canal curvatures has become one of the greatest problems in clinical practice. Recently, new instruments and techniques have been introduced in the endodontic procedure. The aim of this study was, on the basis of clinical practice, to show the possibilities of the endodontic treatment in the teeth with severely curved root canals, after dependable decision about endodontic instruments and techniques. This article presents a complete endodontic procedure in two teeth with different curvature shape of the root canal in patients that were treated at the Department of Restorative Dentistry and Endodontics, School of Dentistry, Belgrade. Coronal to apical 'crown down' technique was used for the root canal preparation with hand NiTi ProTaper instruments with progressive multicone design. The main reasons for choosing manual technique were complexity, shape of presented curvatures and better tactile sensation control of canal instruments in order to avoid possible mistakes and complications. Clinical X-rays of the teeth with permanent obturation clearly showed that extremes of the root canal morphology could be successfully solved by the right choice of all factors during endodontic procedure., Endodontsko lečenje zuba s jako zakrivljenim korenovima je značajan problem u praksi. Primena novih instrumenata i tehnika u lečenju ovakvih zuba poslednjih godina je postala sve izvesnija.Cilj ovog rada je bio da se na primerima iz kliničke prakse ukaže na mogućnost endodontskog lečenjazuba s veoma izraženim krivinama kanala korena nakon pravilnog izbora endodontskih instrumenata, odnosno tehnike instrumentacije. U ovom radu je prikazan celokupni endodontski postupak lečenja dva zuba pacijenata Klinike za bolesti zuba Stomatološkog fakulteta u Beogradu sa različitim oblicima krivine centralnog korenskog kanala. Prime-njena je krunično-apeksna 'crown-down' tehnika preparacije uz korišćenje ručnih nikl-titanijumskih instrumenata tipa ProTaper s progresivnom multikoničnošću. Osnovni razlozi za odabir ručne tehnike preparacije bili su složenost morfologije, oblik prikazanih krivina i bolja taktilno-senzorna kontrola kanalnih instrumenata; cilj je bio da se izbegnu moguće greške i komplikacije. Prikazani radiografski snimci zuba sa jasno opturiranim kanalnim sistemom pokazuju da su i ekstremi morfološkog izgleda kanala rešivi pravilnim odabirom svih činilaca endodontske procedure. .",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Endodontic treatment of the teeth with different root canal curvatures: Two case reports, Endodontsko lečenje zuba s različitim oblicima krivina korenskih kanala - dva prikaza iz prakse",
volume = "56",
number = "2",
pages = "91-96",
doi = "10.2298/SGS0902091B"
}

Beljić-Ivanović, K., Teodorović, N.,& Ostojić, D.. (2009). Endodontic treatment of the teeth with different root canal curvatures: Two case reports. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 56(2), 91-96.
https://doi.org/10.2298/SGS0902091B

Beljić-Ivanović K, Teodorović N, Ostojić D. Endodontic treatment of the teeth with different root canal curvatures: Two case reports. in Stomatološki glasnik Srbije. 2009;56(2):91-96.
doi:10.2298/SGS0902091B .

Beljić-Ivanović, Katarina, Teodorović, Nevenka, Ostojić, Dejan, "Endodontic treatment of the teeth with different root canal curvatures: Two case reports" in Stomatološki glasnik Srbije, 56, no. 2 (2009):91-96,
https://doi.org/10.2298/SGS0902091B . .

TY  - JOUR
AU  - Beljić-Ivanović, Katarina
AU  - Ivanović, Vladimir
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1442
AB  - Introduction: More detailed acquaintance with specialist endodontic literature and treating complicated endodontic cases have revealed that the palatal root canal in maxillary first molars has different features from generally accepted simplicity. Aim: The aim of this study was to investigate the number, orientation and shape of the curvature of the palatal root canal in maxillary first molars, characteristics that may have great influence on the procedure and outcome of endodontic therapy. Materials and methods: Material consisted of 100 left and 100 right extracted human first maxillary molars. Extended access cavity was prepared, and canal orifices were detected using an endodontic probe. K-flex file no 15 or 20 was then introduced into the palatal root canal until the tip appeared at the apical foramen. The tooth was radiographed from buccal-oral (clinical) and mesial-distal (proximal) aspect under standardized conditions. On magnified images, the number and character of canal, orientation and shape of the curvature were determined. Results: One palatal root canal was found in each of 200 teeth. From the clinical projection, 60% of the palatal canals appeared curved and from the proximal 93.5% (p lt 0.05). Out of 120 curved canals from the clinical aspect, 66.7% were oriented distally and 33.3% mesially. From the proximal projection, of 187 curved canals 68,4% were oriented buccally, and 31,6% palatally. From the clinical projection, 49.2% were C-shaped, and 32.5 % with the J-shaped curvature. Only 18.3% of the palatal canals were with the S-shaped curvature (p lt 0.05). Conclusions: Upon presented results, practitioners may predict with high significance the character, orientation and curvature shape of the palatal root canal in maxillary first molars in the buccal-oral dimension which is not visible on clinical radiographs and, therefore, perform more successful endodontic treatment.
AB  - Uvod: Detaljnijim upoznavanjem sa specijalističkom endodontskom literaturom i bavljenjem komplikovanijim endodontskim zahvatima, uočava se da anatomija palatinalnog kanala prvih maksilarnih molara ima značajna odstupanja od opšteprihvaćene jednostavnosti. Cilj rada je bio da se ispitaju broj, smer i oblik povijenosti palatinalnog kanala prvih maksilarnih molara, što je sve od velikog značaja za tok i krajnji uspeh endodontske terapije. Materijal i metod: Materijal se sastojao od sto levih i sto desnih humanih ekstrahovanih prvih maksilarnih molara. Preparisan je ekstendivan pristupni kavitet, a ulazi u kanale su pronađeni pomoću endodontske sonde. U palatinalni kanal je uvođena Kflex turpija n0 15 ili 20 do pojave na vrhu korena. Fiksiran zub je radiografisan iz kliničke i aproksimalne projekcije pod jednakim uslovima snimanja i razvijanja. Na 3,5 puta povećanim snimcima određivan je karakter kanala, smer i oblik povijenosti i potvrđivanje broja korenskih kanala. Rezultati: U svakom od 200 ispitivanih prvih maksilarnih molara bio je registrovan samo po jedan kanal. Iz kliničke projekcije bilo je povijeno 60%, a iz aproksimalne projekcije 93,5% (p lt 0.05). U kliničkoj projekciji od 120 zakrivljenih kanala 66,7% ih je bilo usmereno distalno, a 33,3% mezijalno. Iz aproksimalne projekcije od 187 povijenih kanala 68,4% je bilo usmereno bukalno, a 31,6% palatinalno. Iz kliničke projekcije 49,2% uzoraka je bilo sa krivinom C-oblika, a 32,5 % sa krivinom J-oblika. Sa krivinom S-oblika bilo je 18,3% kanala, što je statistički značajno najmanje. Zaključak: Prikazani rezultati pokazuju da se u praktičnom radu sa značajnom pouzdanošću mogu predvideti karakter, smer i oblik povijenosti palatinalnih kanala prvih maksilarnih molara u vestibulo-oralnoj dimenziji, nevidljivoj na kliničkoj radiografiji i time obezbedi uspešnija endodontska terapija.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Anatomical features of the palatal root canal in maxillary first molars and their influence on endodontic procedure
T1  - Anatomske karakteristike palatinalnog kanala prvog maksilarnog molara i njihov značaj za endodontsku preparaciju
VL  - 55
IS  - 1
SP  - 43
EP  - 53
DO  - 10.2298/SGS0801043B
ER  - 

@article{
author = "Beljić-Ivanović, Katarina and Ivanović, Vladimir",
year = "2008",
abstract = "Introduction: More detailed acquaintance with specialist endodontic literature and treating complicated endodontic cases have revealed that the palatal root canal in maxillary first molars has different features from generally accepted simplicity. Aim: The aim of this study was to investigate the number, orientation and shape of the curvature of the palatal root canal in maxillary first molars, characteristics that may have great influence on the procedure and outcome of endodontic therapy. Materials and methods: Material consisted of 100 left and 100 right extracted human first maxillary molars. Extended access cavity was prepared, and canal orifices were detected using an endodontic probe. K-flex file no 15 or 20 was then introduced into the palatal root canal until the tip appeared at the apical foramen. The tooth was radiographed from buccal-oral (clinical) and mesial-distal (proximal) aspect under standardized conditions. On magnified images, the number and character of canal, orientation and shape of the curvature were determined. Results: One palatal root canal was found in each of 200 teeth. From the clinical projection, 60% of the palatal canals appeared curved and from the proximal 93.5% (p lt 0.05). Out of 120 curved canals from the clinical aspect, 66.7% were oriented distally and 33.3% mesially. From the proximal projection, of 187 curved canals 68,4% were oriented buccally, and 31,6% palatally. From the clinical projection, 49.2% were C-shaped, and 32.5 % with the J-shaped curvature. Only 18.3% of the palatal canals were with the S-shaped curvature (p lt 0.05). Conclusions: Upon presented results, practitioners may predict with high significance the character, orientation and curvature shape of the palatal root canal in maxillary first molars in the buccal-oral dimension which is not visible on clinical radiographs and, therefore, perform more successful endodontic treatment., Uvod: Detaljnijim upoznavanjem sa specijalističkom endodontskom literaturom i bavljenjem komplikovanijim endodontskim zahvatima, uočava se da anatomija palatinalnog kanala prvih maksilarnih molara ima značajna odstupanja od opšteprihvaćene jednostavnosti. Cilj rada je bio da se ispitaju broj, smer i oblik povijenosti palatinalnog kanala prvih maksilarnih molara, što je sve od velikog značaja za tok i krajnji uspeh endodontske terapije. Materijal i metod: Materijal se sastojao od sto levih i sto desnih humanih ekstrahovanih prvih maksilarnih molara. Preparisan je ekstendivan pristupni kavitet, a ulazi u kanale su pronađeni pomoću endodontske sonde. U palatinalni kanal je uvođena Kflex turpija n0 15 ili 20 do pojave na vrhu korena. Fiksiran zub je radiografisan iz kliničke i aproksimalne projekcije pod jednakim uslovima snimanja i razvijanja. Na 3,5 puta povećanim snimcima određivan je karakter kanala, smer i oblik povijenosti i potvrđivanje broja korenskih kanala. Rezultati: U svakom od 200 ispitivanih prvih maksilarnih molara bio je registrovan samo po jedan kanal. Iz kliničke projekcije bilo je povijeno 60%, a iz aproksimalne projekcije 93,5% (p lt 0.05). U kliničkoj projekciji od 120 zakrivljenih kanala 66,7% ih je bilo usmereno distalno, a 33,3% mezijalno. Iz aproksimalne projekcije od 187 povijenih kanala 68,4% je bilo usmereno bukalno, a 31,6% palatinalno. Iz kliničke projekcije 49,2% uzoraka je bilo sa krivinom C-oblika, a 32,5 % sa krivinom J-oblika. Sa krivinom S-oblika bilo je 18,3% kanala, što je statistički značajno najmanje. Zaključak: Prikazani rezultati pokazuju da se u praktičnom radu sa značajnom pouzdanošću mogu predvideti karakter, smer i oblik povijenosti palatinalnih kanala prvih maksilarnih molara u vestibulo-oralnoj dimenziji, nevidljivoj na kliničkoj radiografiji i time obezbedi uspešnija endodontska terapija.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Anatomical features of the palatal root canal in maxillary first molars and their influence on endodontic procedure, Anatomske karakteristike palatinalnog kanala prvog maksilarnog molara i njihov značaj za endodontsku preparaciju",
volume = "55",
number = "1",
pages = "43-53",
doi = "10.2298/SGS0801043B"
}

Beljić-Ivanović, K.,& Ivanović, V.. (2008). Anatomical features of the palatal root canal in maxillary first molars and their influence on endodontic procedure. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 55(1), 43-53.
https://doi.org/10.2298/SGS0801043B

Beljić-Ivanović K, Ivanović V. Anatomical features of the palatal root canal in maxillary first molars and their influence on endodontic procedure. in Stomatološki glasnik Srbije. 2008;55(1):43-53.
doi:10.2298/SGS0801043B .

Beljić-Ivanović, Katarina, Ivanović, Vladimir, "Anatomical features of the palatal root canal in maxillary first molars and their influence on endodontic procedure" in Stomatološki glasnik Srbije, 55, no. 1 (2008):43-53,
https://doi.org/10.2298/SGS0801043B . .

TY  - JOUR
AU  - Teodorović, Nevenka
AU  - Beljić-Ivanović, Katarina
AU  - Matović, Ivan
PY  - 2004
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1201
AB  - The purpose of this paper was to report on the possibility for successful endodontic treatment of the complex case of maxillary first premolar with three roots and three canals. Systematic examination of preoperative X-rays and correct access cavity preparation were performed. Crown-down Ni-Ti rotary instrumentation technique was chosen for root canal preparation, and obturation was accomplished using resin cement and greater taper gutta-percha cones (monocone technique). This methodology contributed to efficient preparation and suitable definitive root canals obturation.
AB  - Cilj ovog rada je bio da se prikaže mogućnost uspešnog endodontskog tretmana u kompleksnom slučaju kod prvog maksilarnog premolara sa tri korena i tri kanala. Pristupilo se sistematičnoj analizi preoperativnih rentgen snimaka, kao i adekvatnoj preparaciji pristupnog kaviteta. Za instrumentaciju je odabrana krunično apeksna tehnika uz primenu Ni-Ti rotirajučih instrumenata, a opturacijaje ostvarena uz primenu cementa na bazi smole kao i gutaperka kocica veće koničnosti, monokonom tehnikom. Ova metodologija je pomogla da se izvede kako efikasna preparacija tako i zadovoljavajuća definitivna opturacija kanala korena zuba.
PB  - Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš
T2  - Acta stomatologica Naissi
T1  - Endodontic treatment of a maxillary first premolar with three canals: Case report
T1  - Endodontski tretman maksilarnog prvog premolara sa tri kanala - prikaz slučaja
VL  - 20
IS  - 45
SP  - 227
EP  - 232
UR  - https://hdl.handle.net/21.15107/rcub_smile_1201
ER  - 

@article{
author = "Teodorović, Nevenka and Beljić-Ivanović, Katarina and Matović, Ivan",
year = "2004",
abstract = "The purpose of this paper was to report on the possibility for successful endodontic treatment of the complex case of maxillary first premolar with three roots and three canals. Systematic examination of preoperative X-rays and correct access cavity preparation were performed. Crown-down Ni-Ti rotary instrumentation technique was chosen for root canal preparation, and obturation was accomplished using resin cement and greater taper gutta-percha cones (monocone technique). This methodology contributed to efficient preparation and suitable definitive root canals obturation., Cilj ovog rada je bio da se prikaže mogućnost uspešnog endodontskog tretmana u kompleksnom slučaju kod prvog maksilarnog premolara sa tri korena i tri kanala. Pristupilo se sistematičnoj analizi preoperativnih rentgen snimaka, kao i adekvatnoj preparaciji pristupnog kaviteta. Za instrumentaciju je odabrana krunično apeksna tehnika uz primenu Ni-Ti rotirajučih instrumenata, a opturacijaje ostvarena uz primenu cementa na bazi smole kao i gutaperka kocica veće koničnosti, monokonom tehnikom. Ova metodologija je pomogla da se izvede kako efikasna preparacija tako i zadovoljavajuća definitivna opturacija kanala korena zuba.",
publisher = "Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš",
journal = "Acta stomatologica Naissi",
title = "Endodontic treatment of a maxillary first premolar with three canals: Case report, Endodontski tretman maksilarnog prvog premolara sa tri kanala - prikaz slučaja",
volume = "20",
number = "45",
pages = "227-232",
url = "https://hdl.handle.net/21.15107/rcub_smile_1201"
}

Teodorović, N., Beljić-Ivanović, K.,& Matović, I.. (2004). Endodontic treatment of a maxillary first premolar with three canals: Case report. in Acta stomatologica Naissi
Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš., 20(45), 227-232.
https://hdl.handle.net/21.15107/rcub_smile_1201

Teodorović N, Beljić-Ivanović K, Matović I. Endodontic treatment of a maxillary first premolar with three canals: Case report. in Acta stomatologica Naissi. 2004;20(45):227-232.
https://hdl.handle.net/21.15107/rcub_smile_1201 .

Teodorović, Nevenka, Beljić-Ivanović, Katarina, Matović, Ivan, "Endodontic treatment of a maxillary first premolar with three canals: Case report" in Acta stomatologica Naissi, 20, no. 45 (2004):227-232,
https://hdl.handle.net/21.15107/rcub_smile_1201 .

TY  - THES
AU  - Beljić-Ivanović, Katarina
PY  - 2003
UR  - https://plus.sr.cobiss.net/opac7/bib/1024032654
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/391
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Broj, konfiguracija, smer i oblik povijenosti korenskih kanala prvih maksilarnih molara
UR  - https://hdl.handle.net/21.15107/rcub_smile_391
ER  - 

@mastersthesis{
author = "Beljić-Ivanović, Katarina",
year = "2003",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Broj, konfiguracija, smer i oblik povijenosti korenskih kanala prvih maksilarnih molara",
url = "https://hdl.handle.net/21.15107/rcub_smile_391"
}

Beljić-Ivanović, K.. (2003). Broj, konfiguracija, smer i oblik povijenosti korenskih kanala prvih maksilarnih molara. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_391

Beljić-Ivanović K. Broj, konfiguracija, smer i oblik povijenosti korenskih kanala prvih maksilarnih molara. 2003;.
https://hdl.handle.net/21.15107/rcub_smile_391 .

Beljić-Ivanović, Katarina, "Broj, konfiguracija, smer i oblik povijenosti korenskih kanala prvih maksilarnih molara" (2003),
https://hdl.handle.net/21.15107/rcub_smile_391 .

TY  - CONF
AU  - Beljić, Katarina
AU  - Pap, Katarina
AU  - Ivanović, V
AU  - Dacić, D
PY  - 1998
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1099
PB  - Sage Publications Inc, Thousand Oaks
C3  - Journal of Dental Research
T1  - Something different in number of canals in maxillary second bicuspids and first molars.
VL  - 77
IS  - 5
SP  - 1249
EP  - 1249
UR  - https://hdl.handle.net/21.15107/rcub_smile_1099
ER  - 

@conference{
author = "Beljić, Katarina and Pap, Katarina and Ivanović, V and Dacić, D",
year = "1998",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Journal of Dental Research",
title = "Something different in number of canals in maxillary second bicuspids and first molars.",
volume = "77",
number = "5",
pages = "1249-1249",
url = "https://hdl.handle.net/21.15107/rcub_smile_1099"
}

Beljić, K., Pap, K., Ivanović, V.,& Dacić, D.. (1998). Something different in number of canals in maxillary second bicuspids and first molars.. in Journal of Dental Research
Sage Publications Inc, Thousand Oaks., 77(5), 1249-1249.
https://hdl.handle.net/21.15107/rcub_smile_1099

Beljić K, Pap K, Ivanović V, Dacić D. Something different in number of canals in maxillary second bicuspids and first molars.. in Journal of Dental Research. 1998;77(5):1249-1249.
https://hdl.handle.net/21.15107/rcub_smile_1099 .

Beljić, Katarina, Pap, Katarina, Ivanović, V, Dacić, D, "Something different in number of canals in maxillary second bicuspids and first molars." in Journal of Dental Research, 77, no. 5 (1998):1249-1249,
https://hdl.handle.net/21.15107/rcub_smile_1099 .