TY  - JOUR
AU  - Jung, Ronald
AU  - Koković, Vladimir
AU  - Jurišić, Milan
AU  - Yaman, Duygu
AU  - Subramani, Karthikeyan
AU  - Weber, Franz E.
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1610
AB  - Objectives: The aim of the present study was to compare a newly developed biodegradable polylactide/polyglycolide/N-methyl-2-pyrrolidone (PLGA/NMP) membrane with a standard resorbable collagen membrane (RCM) in combination with and without the use of a bone substitute material (deproteinized bovine bone mineral [DBBM]) looking at the proposed tenting effect and bone regeneration. Materials and methods: In five adult German sheepdogs, the mandibular premolars P2, P3, P4, and the molar M1 were bilaterally extracted creating two bony defects on each site. A total of 20 dental implants were inserted and allocated to four different treatment modalities within each dog: PLGA/NMP membrane only (Test 1), PLGA/NMP membrane with DBBM (Test 2), RCM only (negative control), and RCM with DBBM (positive control). A histomorphometric analysis was performed 12 weeks after implantation. For statistical analysis, a Friedman test and subsequently a Wilcoxon signed ranks test were applied. Results: In four out of five PLGA/NMP membrane-treated defects, the membranes had broken into pieces without the support of DBBM. This led to a worse outcome than in the RCM group. In combination with DBBM, both membranes revealed similar amounts of area of bone regeneration and bone-to-implant contact without significant differences. On the level of the third implant thread, the PLGA/NMP membrane induced more horizontal bone formation beyond the graft than the RCM. Conclusion: The newly developed PLGA/NMP membrane performs equally well as the RCM when applied in combination with DBBM. Without bone substitute material, the PLGA/NMP membrane performed worse than the RCM in challenging defects, and therefore, a combination with a bone substitute material is recommended.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs
VL  - 22
IS  - 8
SP  - 802
EP  - 807
DO  - 10.1111/j.1600-0501.2010.02068.x
ER  - 

@article{
author = "Jung, Ronald and Koković, Vladimir and Jurišić, Milan and Yaman, Duygu and Subramani, Karthikeyan and Weber, Franz E.",
year = "2011",
abstract = "Objectives: The aim of the present study was to compare a newly developed biodegradable polylactide/polyglycolide/N-methyl-2-pyrrolidone (PLGA/NMP) membrane with a standard resorbable collagen membrane (RCM) in combination with and without the use of a bone substitute material (deproteinized bovine bone mineral [DBBM]) looking at the proposed tenting effect and bone regeneration. Materials and methods: In five adult German sheepdogs, the mandibular premolars P2, P3, P4, and the molar M1 were bilaterally extracted creating two bony defects on each site. A total of 20 dental implants were inserted and allocated to four different treatment modalities within each dog: PLGA/NMP membrane only (Test 1), PLGA/NMP membrane with DBBM (Test 2), RCM only (negative control), and RCM with DBBM (positive control). A histomorphometric analysis was performed 12 weeks after implantation. For statistical analysis, a Friedman test and subsequently a Wilcoxon signed ranks test were applied. Results: In four out of five PLGA/NMP membrane-treated defects, the membranes had broken into pieces without the support of DBBM. This led to a worse outcome than in the RCM group. In combination with DBBM, both membranes revealed similar amounts of area of bone regeneration and bone-to-implant contact without significant differences. On the level of the third implant thread, the PLGA/NMP membrane induced more horizontal bone formation beyond the graft than the RCM. Conclusion: The newly developed PLGA/NMP membrane performs equally well as the RCM when applied in combination with DBBM. Without bone substitute material, the PLGA/NMP membrane performed worse than the RCM in challenging defects, and therefore, a combination with a bone substitute material is recommended.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs",
volume = "22",
number = "8",
pages = "802-807",
doi = "10.1111/j.1600-0501.2010.02068.x"
}

Jung, R., Koković, V., Jurišić, M., Yaman, D., Subramani, K.,& Weber, F. E.. (2011). Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs. in Clinical Oral Implants Research
Wiley, Hoboken., 22(8), 802-807.
https://doi.org/10.1111/j.1600-0501.2010.02068.x

Jung R, Koković V, Jurišić M, Yaman D, Subramani K, Weber FE. Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs. in Clinical Oral Implants Research. 2011;22(8):802-807.
doi:10.1111/j.1600-0501.2010.02068.x .

Jung, Ronald, Koković, Vladimir, Jurišić, Milan, Yaman, Duygu, Subramani, Karthikeyan, Weber, Franz E., "Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs" in Clinical Oral Implants Research, 22, no. 8 (2011):802-807,
https://doi.org/10.1111/j.1600-0501.2010.02068.x . .