TY  - JOUR
AU  - Supić, Gordana
AU  - Kozomara, Ružica
AU  - Zeljić, Katarina
AU  - Stanimirović, Dragan
AU  - Magić, Marko
AU  - Surbatović, M.
AU  - Jović, N.
AU  - Magić, Zvonko
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1976
AB  - ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients
VL  - 21
IS  - 4
SP  - 536
EP  - 543
DO  - 10.1111/odi.12318
ER  - 

@article{
author = "Supić, Gordana and Kozomara, Ružica and Zeljić, Katarina and Stanimirović, Dragan and Magić, Marko and Surbatović, M. and Jović, N. and Magić, Zvonko",
year = "2015",
abstract = "ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients",
volume = "21",
number = "4",
pages = "536-543",
doi = "10.1111/odi.12318"
}

Supić, G., Kozomara, R., Zeljić, K., Stanimirović, D., Magić, M., Surbatović, M., Jović, N.,& Magić, Z.. (2015). HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases
Wiley, Hoboken., 21(4), 536-543.
https://doi.org/10.1111/odi.12318

Supić G, Kozomara R, Zeljić K, Stanimirović D, Magić M, Surbatović M, Jović N, Magić Z. HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases. 2015;21(4):536-543.
doi:10.1111/odi.12318 .

Supić, Gordana, Kozomara, Ružica, Zeljić, Katarina, Stanimirović, Dragan, Magić, Marko, Surbatović, M., Jović, N., Magić, Zvonko, "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients" in Oral Diseases, 21, no. 4 (2015):536-543,
https://doi.org/10.1111/odi.12318 . .

TY  - JOUR
AU  - Brković, Božidar
AU  - Gardašević, Milka
AU  - Roganović, Jelena
AU  - Jović, N.
AU  - Todorović, L.
AU  - Stojić, Dragica
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1426
AB  - The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 mu g/ml; n = 20) or epinephrine (12.5 mu g/ml; n = 20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine + clonidine were similar to those obtained with lidocaine + epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine + clonidine group and significant increase in heart rate in the lidocaine + epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) and 10(-5) M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine + clonidine combination could be a useful and safe alternative to lidocaine + epinephrine for intraoral infiltration anaesthesia.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects
VL  - 37
IS  - 2
SP  - 149
EP  - 155
DO  - 10.1016/j.ijom.2007.07.019
ER  - 

@article{
author = "Brković, Božidar and Gardašević, Milka and Roganović, Jelena and Jović, N. and Todorović, L. and Stojić, Dragica",
year = "2008",
abstract = "The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 mu g/ml; n = 20) or epinephrine (12.5 mu g/ml; n = 20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine + clonidine were similar to those obtained with lidocaine + epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine + clonidine group and significant increase in heart rate in the lidocaine + epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) and 10(-5) M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine + clonidine combination could be a useful and safe alternative to lidocaine + epinephrine for intraoral infiltration anaesthesia.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects",
volume = "37",
number = "2",
pages = "149-155",
doi = "10.1016/j.ijom.2007.07.019"
}

Brković, B., Gardašević, M., Roganović, J., Jović, N., Todorović, L.,& Stojić, D.. (2008). Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 37(2), 149-155.
https://doi.org/10.1016/j.ijom.2007.07.019

Brković B, Gardašević M, Roganović J, Jović N, Todorović L, Stojić D. Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. in International Journal of Oral & Maxillofacial Surgery. 2008;37(2):149-155.
doi:10.1016/j.ijom.2007.07.019 .

Brković, Božidar, Gardašević, Milka, Roganović, Jelena, Jović, N., Todorović, L., Stojić, Dragica, "Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects" in International Journal of Oral & Maxillofacial Surgery, 37, no. 2 (2008):149-155,
https://doi.org/10.1016/j.ijom.2007.07.019 . .