TY  - JOUR
AU  - Petrović, Snježana
AU  - Bašić, Jasmina
AU  - Mandinić, Zoran
AU  - Božić, Dragana D.
AU  - Milenković, Marina
AU  - Vujić, Zorica
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2494
AB  - Introduction/Objective Biofilm and pyocyanin production are essential components of Pseudomonas aeruginosa virulence and antibiotic resistance. Our objective was to examine inhibitory effect of synthetized propafenone derivatives 3-(2-Fluorophenyl)-1-(2(2-hydroxy-3-propylamino-propoxy)-phenyl)-propan-1-one hydrochloride (5OF) and 3-(2-Trifluoromethyl-phenyl)-1-(2-(2-hydroxy-3-propylamino-propoxy)-phenyl)-propan-1-one hydrochloride (5CF3) on biofilm and pyocyanin in Pseudomonas aeruginosa clinical strains. Methods Effects were tested on nine clinical isolates and one control laboratory strain of P. aeruginosa. In vitro analysis of biofilm growing was performed by incubating bacteria (0.5 McFarland) with 5OF and 5CF3 (500-31.2 µg/ml) and measuring optical density (OD) at 570 nm. Bacteria in medium without compounds were positive control. Blank medium (an uninoculated medium without test compounds) was used as negative control. Pyocyanin production was estimated by OD at 520 nm, after bacteria incubated with 5CF3 and 5OF (250 and 500 mg/ml), treated with chloroform, and chloroform layer mixed with HCl. Results A total of 500 µg/ml of 5OF and 5CF3 completely inhibited biofilm formation in 10/10 and 4/10 strains, respectively. A total of 250 µg/ml of 5OF and 5CF3 strongly inhibited biofilm formation in 7/10 strains, while inhibition with 125 µg/ml of 5OF and 5CF3 was moderate. Lower concentrations had almost no effect on biofilm production. Pyocyanin production was reduced to less than 40% of the control value in 6/9, and less than 50% of the control in 7/9 strains with 500 mg/ml of 5OF and 5CF3, respectively. At 250 µg/ml 5OF and 5CF3, most strains had pyocyanin production above 50% of the control value. Conclusion Synthetized propafenone derivatives, 5OF and 5CF3, inhibited biofilms and pyocyanin production of Pseudomonas aeruginosa clinical strains. Presented results suggest that propafenone derivatives are potential lead-compounds for synthesis of novel antipseudomonal drugs.
AB  - Uvod/Cilj Proizvodnja biofilma i piocijanina je važan faktor virulencije i antibiotske rezistencije bakterije Pseudomonas aeruginosa. Cilj rada je bio da se ispita inhibitorni efekat sintetisanih propafenonskih derivata, 3-(2-fluoro-fenil)-1-[2-(2-hidroksi-3-propilamino-propoksi)-fenil]-propan-1-on-hidrohlorid) (5OF) i 3-(2-trifluorometilfenil)-1-[2-(2-hidroksi-3-propilamino-propoksi)-fenil]-propan-1-on-hidrohlorid) (5CF3), na produkciju biofilma i piocijanina kod kliničkih izolata bakterije Pseudomonas aeruginosa. Metode Efekat propafenonskih derivata ispitan je na devet kliničkih izolata i jednom standardnom soju bakterije P. aeruginosa. Uticaj na produkciju biofilma ispitan je in vitro, inkubacijom bakterija (0,5 po Makfarlandu) sa 5OF i 5CF3 (500-31,2 µg/ml), i merenjem optičke gustine na 570 nm. Bakterije u medijumu bez ispitivanih jedinjenja su bile pozitivna kontrola, a sam medijum negativna kontrola. Proizvodeni piocijanin, koji je određivan merenjem optičke gustine na 520 nm, na koinkubacije bakterija sa 5CF3 ili 5OF (250 i 500 mg/ml), tretiran je hloroformom i mešanjem hloroformskog sloja sa HCl. Rezultati Pri koncentraciji od 500 µg/ml 5OF je doveo do potpune inhibicije produkcije biofilma kod svih ispitivanih sojeva (10/10). Inhibicija biofilma sa 500 µg/ml 5CF3 bila je potpuna kod 4/10 sojeva. Pri koncentraciji 5OF i 5CF3 od 250 µg/ml produkcija biofilma kod većine ispitanih izolata bila je slaba, dok je pri koncentraciji 125 µg/ml 5OF odnosno 5CF3 produkcija bila umerena. Niže koncentracije 5OF i 5CF3 nisu imale inhibitorni efekat na formiranje biofilma. U prisustvu 500 mg/ml 5OF u 6/10 ispitivanih sojeva produkcija piocijanina pala je na manje od 40% u odnosu na kontrolnu vrednost. Ista koncentracija (500 mg/ml) 5CF3 snizila je produkciju piocijanina na manje od 50% od kontrole u 7/9 sojeva. Pri koncentraciji 250 µg/ ml 5OF ili 5CF3 većina sojeva produkovala je piocijanin iznad 50% u odnosu na pozitivnu kontrolu. Zaključak Sintetisani propafenonski derivati, 5OF i 5CF3, inhibiraju produkciju biofilma i piocijanina kod kliničkih sojeva bakterije Pseudomonas aeruginosa. Dobijeni rezultati ukazuju na to da propafenonski derivati predstavljaju moguća polazna jedinjenja za sintezu novih antipseudomonasnih agenasa.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Inhibitory effect of propafenone derivatives on Pseudomonas aeruginosa biofilm and pyocyanin production
T1  - Inhibitorni efekat propafenonskih derivata na produkciju biofilma i piocijanina kod bakterije Pseudomonas aeruginosa
VL  - 148
IS  - 3-4
SP  - 196
EP  - 202
DO  - 10.2298/SARH180727102P
ER  - 

@article{
author = "Petrović, Snježana and Bašić, Jasmina and Mandinić, Zoran and Božić, Dragana D. and Milenković, Marina and Vujić, Zorica",
year = "2020",
abstract = "Introduction/Objective Biofilm and pyocyanin production are essential components of Pseudomonas aeruginosa virulence and antibiotic resistance. Our objective was to examine inhibitory effect of synthetized propafenone derivatives 3-(2-Fluorophenyl)-1-(2(2-hydroxy-3-propylamino-propoxy)-phenyl)-propan-1-one hydrochloride (5OF) and 3-(2-Trifluoromethyl-phenyl)-1-(2-(2-hydroxy-3-propylamino-propoxy)-phenyl)-propan-1-one hydrochloride (5CF3) on biofilm and pyocyanin in Pseudomonas aeruginosa clinical strains. Methods Effects were tested on nine clinical isolates and one control laboratory strain of P. aeruginosa. In vitro analysis of biofilm growing was performed by incubating bacteria (0.5 McFarland) with 5OF and 5CF3 (500-31.2 µg/ml) and measuring optical density (OD) at 570 nm. Bacteria in medium without compounds were positive control. Blank medium (an uninoculated medium without test compounds) was used as negative control. Pyocyanin production was estimated by OD at 520 nm, after bacteria incubated with 5CF3 and 5OF (250 and 500 mg/ml), treated with chloroform, and chloroform layer mixed with HCl. Results A total of 500 µg/ml of 5OF and 5CF3 completely inhibited biofilm formation in 10/10 and 4/10 strains, respectively. A total of 250 µg/ml of 5OF and 5CF3 strongly inhibited biofilm formation in 7/10 strains, while inhibition with 125 µg/ml of 5OF and 5CF3 was moderate. Lower concentrations had almost no effect on biofilm production. Pyocyanin production was reduced to less than 40% of the control value in 6/9, and less than 50% of the control in 7/9 strains with 500 mg/ml of 5OF and 5CF3, respectively. At 250 µg/ml 5OF and 5CF3, most strains had pyocyanin production above 50% of the control value. Conclusion Synthetized propafenone derivatives, 5OF and 5CF3, inhibited biofilms and pyocyanin production of Pseudomonas aeruginosa clinical strains. Presented results suggest that propafenone derivatives are potential lead-compounds for synthesis of novel antipseudomonal drugs., Uvod/Cilj Proizvodnja biofilma i piocijanina je važan faktor virulencije i antibiotske rezistencije bakterije Pseudomonas aeruginosa. Cilj rada je bio da se ispita inhibitorni efekat sintetisanih propafenonskih derivata, 3-(2-fluoro-fenil)-1-[2-(2-hidroksi-3-propilamino-propoksi)-fenil]-propan-1-on-hidrohlorid) (5OF) i 3-(2-trifluorometilfenil)-1-[2-(2-hidroksi-3-propilamino-propoksi)-fenil]-propan-1-on-hidrohlorid) (5CF3), na produkciju biofilma i piocijanina kod kliničkih izolata bakterije Pseudomonas aeruginosa. Metode Efekat propafenonskih derivata ispitan je na devet kliničkih izolata i jednom standardnom soju bakterije P. aeruginosa. Uticaj na produkciju biofilma ispitan je in vitro, inkubacijom bakterija (0,5 po Makfarlandu) sa 5OF i 5CF3 (500-31,2 µg/ml), i merenjem optičke gustine na 570 nm. Bakterije u medijumu bez ispitivanih jedinjenja su bile pozitivna kontrola, a sam medijum negativna kontrola. Proizvodeni piocijanin, koji je određivan merenjem optičke gustine na 520 nm, na koinkubacije bakterija sa 5CF3 ili 5OF (250 i 500 mg/ml), tretiran je hloroformom i mešanjem hloroformskog sloja sa HCl. Rezultati Pri koncentraciji od 500 µg/ml 5OF je doveo do potpune inhibicije produkcije biofilma kod svih ispitivanih sojeva (10/10). Inhibicija biofilma sa 500 µg/ml 5CF3 bila je potpuna kod 4/10 sojeva. Pri koncentraciji 5OF i 5CF3 od 250 µg/ml produkcija biofilma kod većine ispitanih izolata bila je slaba, dok je pri koncentraciji 125 µg/ml 5OF odnosno 5CF3 produkcija bila umerena. Niže koncentracije 5OF i 5CF3 nisu imale inhibitorni efekat na formiranje biofilma. U prisustvu 500 mg/ml 5OF u 6/10 ispitivanih sojeva produkcija piocijanina pala je na manje od 40% u odnosu na kontrolnu vrednost. Ista koncentracija (500 mg/ml) 5CF3 snizila je produkciju piocijanina na manje od 50% od kontrole u 7/9 sojeva. Pri koncentraciji 250 µg/ ml 5OF ili 5CF3 većina sojeva produkovala je piocijanin iznad 50% u odnosu na pozitivnu kontrolu. Zaključak Sintetisani propafenonski derivati, 5OF i 5CF3, inhibiraju produkciju biofilma i piocijanina kod kliničkih sojeva bakterije Pseudomonas aeruginosa. Dobijeni rezultati ukazuju na to da propafenonski derivati predstavljaju moguća polazna jedinjenja za sintezu novih antipseudomonasnih agenasa.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Inhibitory effect of propafenone derivatives on Pseudomonas aeruginosa biofilm and pyocyanin production, Inhibitorni efekat propafenonskih derivata na produkciju biofilma i piocijanina kod bakterije Pseudomonas aeruginosa",
volume = "148",
number = "3-4",
pages = "196-202",
doi = "10.2298/SARH180727102P"
}

Petrović, S., Bašić, J., Mandinić, Z., Božić, D. D., Milenković, M.,& Vujić, Z.. (2020). Inhibitory effect of propafenone derivatives on Pseudomonas aeruginosa biofilm and pyocyanin production. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 148(3-4), 196-202.
https://doi.org/10.2298/SARH180727102P

Petrović S, Bašić J, Mandinić Z, Božić DD, Milenković M, Vujić Z. Inhibitory effect of propafenone derivatives on Pseudomonas aeruginosa biofilm and pyocyanin production. in Srpski arhiv za celokupno lekarstvo. 2020;148(3-4):196-202.
doi:10.2298/SARH180727102P .

Petrović, Snježana, Bašić, Jasmina, Mandinić, Zoran, Božić, Dragana D., Milenković, Marina, Vujić, Zorica, "Inhibitory effect of propafenone derivatives on Pseudomonas aeruginosa biofilm and pyocyanin production" in Srpski arhiv za celokupno lekarstvo, 148, no. 3-4 (2020):196-202,
https://doi.org/10.2298/SARH180727102P . .

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Evica
AU  - Mandinić, Zoran
AU  - Curcić, Marijana
AU  - Cupic-Miladinović, Dejana
AU  - Antonijević, Biljana
AU  - Matović, Vesna
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2414
AB  - Background/Aim. Fluoride has beneficial effect on dental caries prevention and enables high hardness of enamel. However, fluoride intake above optimal levels can have adverse effects on teeth and bones, especially in young children during the period of intense growth and teeth development. The aim of this study was to assess fluoride intake from water and toothpaste among 3-year-old children in Belgrade, Serbia, in the municipalities of Vracar and Novi Beograd. Methods. A questionnaire for the parents (n = 40) was used to provide information on the water consumption (tap and/or bottled water) and the brand of toothpaste used by children as well as the frequency of tooth brushing and the amount of toothpaste during brushing. Fluoride concentrations in water and toothpaste samples were determined electrochemically by using fluoride-selective electrode. Fluoride intake was estimated through a mathematical model commonly used by the U.S. Environmental Protection Agency. Results. The obtained results indicate no significant difference in daily fluoride intake through drinking water and tooth-paste in 3-year-old children in Vracar (n = 19) compared to Novi Beograd (n = 21) (p > 0.05). However, all estimated fluoride levels (0.089-0.625 mg/day) are significantly lower than the optimal daily intake level for caries protection (0.7 mg/day for children up to 4 years, FNB-USA National Institute of Medicine) and two to six times lower than tolerable upper fluoride level for the children of same age (1.3 mg/day, FNB-USA National Institute of Medicine). Furthermore, calculated daily fluoride intake per kilogram body weight confirm very low fluoride intake by water and toothpaste in children of investigated municipalities in Belgrade, being significantly below the recommended an adequate intake (0.05 mg/kg/day, EFSA). Conclusion. This preliminary study has shown that daily fluoride intake in 3-year-olds is lower than tolerable upper fluoride level, even not sufficient for the prevention of dental caries.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: preliminary results in Belgrade, Republic of Serbia
VL  - 76
IS  - 6
SP  - 607
EP  - 614
DO  - 10.2298/VSP170721136D
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Antonijević, Evica and Mandinić, Zoran and Curcić, Marijana and Cupic-Miladinović, Dejana and Antonijević, Biljana and Matović, Vesna",
year = "2019",
abstract = "Background/Aim. Fluoride has beneficial effect on dental caries prevention and enables high hardness of enamel. However, fluoride intake above optimal levels can have adverse effects on teeth and bones, especially in young children during the period of intense growth and teeth development. The aim of this study was to assess fluoride intake from water and toothpaste among 3-year-old children in Belgrade, Serbia, in the municipalities of Vracar and Novi Beograd. Methods. A questionnaire for the parents (n = 40) was used to provide information on the water consumption (tap and/or bottled water) and the brand of toothpaste used by children as well as the frequency of tooth brushing and the amount of toothpaste during brushing. Fluoride concentrations in water and toothpaste samples were determined electrochemically by using fluoride-selective electrode. Fluoride intake was estimated through a mathematical model commonly used by the U.S. Environmental Protection Agency. Results. The obtained results indicate no significant difference in daily fluoride intake through drinking water and tooth-paste in 3-year-old children in Vracar (n = 19) compared to Novi Beograd (n = 21) (p > 0.05). However, all estimated fluoride levels (0.089-0.625 mg/day) are significantly lower than the optimal daily intake level for caries protection (0.7 mg/day for children up to 4 years, FNB-USA National Institute of Medicine) and two to six times lower than tolerable upper fluoride level for the children of same age (1.3 mg/day, FNB-USA National Institute of Medicine). Furthermore, calculated daily fluoride intake per kilogram body weight confirm very low fluoride intake by water and toothpaste in children of investigated municipalities in Belgrade, being significantly below the recommended an adequate intake (0.05 mg/kg/day, EFSA). Conclusion. This preliminary study has shown that daily fluoride intake in 3-year-olds is lower than tolerable upper fluoride level, even not sufficient for the prevention of dental caries.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: preliminary results in Belgrade, Republic of Serbia",
volume = "76",
number = "6",
pages = "607-614",
doi = "10.2298/VSP170721136D"
}

Đukić-Ćosić, D., Antonijević, E., Mandinić, Z., Curcić, M., Cupic-Miladinović, D., Antonijević, B.,& Matović, V.. (2019). Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: preliminary results in Belgrade, Republic of Serbia. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(6), 607-614.
https://doi.org/10.2298/VSP170721136D

Đukić-Ćosić D, Antonijević E, Mandinić Z, Curcić M, Cupic-Miladinović D, Antonijević B, Matović V. Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: preliminary results in Belgrade, Republic of Serbia. in Vojnosanitetski pregled. 2019;76(6):607-614.
doi:10.2298/VSP170721136D .

Đukić-Ćosić, Danijela, Antonijević, Evica, Mandinić, Zoran, Curcić, Marijana, Cupic-Miladinović, Dejana, Antonijević, Biljana, Matović, Vesna, "Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: preliminary results in Belgrade, Republic of Serbia" in Vojnosanitetski pregled, 76, no. 6 (2019):607-614,
https://doi.org/10.2298/VSP170721136D . .

TY  - JOUR
AU  - Mandić, Jelena
AU  - Jovanović, Svetlana
AU  - Mandinić, Zoran
AU  - Ivanović, Mirjana
AU  - Kosanović, Dušan
AU  - Miličić, Biljana
AU  - Živojinović-Toumba, Vesna
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2331
AB  - Background/Aim. Due to their primary medical condition, children with special needs often display lower levels of oral hygiene, larger prevalence of caries and other oral diseases. The aim of this study was to estimate the prevalence of dental caries, oral cleanliness and presence of malocclusion in children with disabilities, as well as to evaluate eruption time of the permanent molars. Methods. Case-control study was carried out on a group of 107 children with disabilities at the Faculty of Dental Medicine, University of Belgrade, Serbia. The control group comprised of 104 healthy school children. Results. Children with disabilities had statistically higher mean [decayed missing and filled teeth - dmft for primary DMF for permanent dentition (dmft DMFT)] values in both dentitions than children from the control group (p  lt  0.05). Oral cleanliness level was much lower in children with disabilities. A significantly higher percentage of Class II malocclusions and a higher tendency to have a delayed time of eruption of permanent molars were observed in the test group in permanent dentition. Conclusion. Considering poor oral health status and higher tendency for development of malloclusions and delayed eruption, it is necessary to develop preventive dental programmes for children with special needs, as well as improve public awareness about these issues.
AB  - Uvod/Cilj. Deca sa posebnim potrebama često zbog svoje primarne bolesti, imaju niži nivo oralne higijene i veću prevalencu karijesa i drugih oralnih oboljenja. Cilj rada bio je da se proceni prevalenca karijesa, nivoa oralne higijene i prisustvo malokluzija kod dece sa posebnim potrebama, kao i vreme erupcije stalnih molara. Metode. Ispitivanjem oralnog zdravlja obuhvaćeno je 107 dece sa posebnim potrebama na Klinici za dečju i preventivnu stomatologiju Stomatološkog fakulteta u Beogradu. Kontrolnu grupu je činilo 104 zdrave školske dece. Rezultati. Deca sa posebnim potrebama imala su statistički značajno viši nivo indeksa karijesnih, ekstrahovanih i plombiranih zuba (KEP) u obe denticije, u odnosu na kontrolnu grupu (p  lt  0.05). Nivo oralne higijene bio je lošiji kod dece sa posebnim potrebama. Takođe, primećeno je statistički značajno povećanje malokluzija klase II, kao i kasnije vreme erupcije stalnih molara kod dece sa posebnim potrebama u odnosu na kontrolnu grupu. Zaključak. Zbog lošijeg stanja oralnog zdravlja i povećane verovatnoće razvoja malokluzija i odloženog nicanja zuba, neophodno je formirati preventivne stomatološke programe za decu sa posebnim potrebama, kao i poboljšati informisanost javnosti o ovom problemu.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Oral health in children with special needs
T1  - Stanje oralnog zdravlja dece sa posebnim potrebama
VL  - 75
IS  - 7
SP  - 675
EP  - 681
DO  - 10.2298/VSP160707372M
ER  - 

@article{
author = "Mandić, Jelena and Jovanović, Svetlana and Mandinić, Zoran and Ivanović, Mirjana and Kosanović, Dušan and Miličić, Biljana and Živojinović-Toumba, Vesna",
year = "2018",
abstract = "Background/Aim. Due to their primary medical condition, children with special needs often display lower levels of oral hygiene, larger prevalence of caries and other oral diseases. The aim of this study was to estimate the prevalence of dental caries, oral cleanliness and presence of malocclusion in children with disabilities, as well as to evaluate eruption time of the permanent molars. Methods. Case-control study was carried out on a group of 107 children with disabilities at the Faculty of Dental Medicine, University of Belgrade, Serbia. The control group comprised of 104 healthy school children. Results. Children with disabilities had statistically higher mean [decayed missing and filled teeth - dmft for primary DMF for permanent dentition (dmft DMFT)] values in both dentitions than children from the control group (p  lt  0.05). Oral cleanliness level was much lower in children with disabilities. A significantly higher percentage of Class II malocclusions and a higher tendency to have a delayed time of eruption of permanent molars were observed in the test group in permanent dentition. Conclusion. Considering poor oral health status and higher tendency for development of malloclusions and delayed eruption, it is necessary to develop preventive dental programmes for children with special needs, as well as improve public awareness about these issues., Uvod/Cilj. Deca sa posebnim potrebama često zbog svoje primarne bolesti, imaju niži nivo oralne higijene i veću prevalencu karijesa i drugih oralnih oboljenja. Cilj rada bio je da se proceni prevalenca karijesa, nivoa oralne higijene i prisustvo malokluzija kod dece sa posebnim potrebama, kao i vreme erupcije stalnih molara. Metode. Ispitivanjem oralnog zdravlja obuhvaćeno je 107 dece sa posebnim potrebama na Klinici za dečju i preventivnu stomatologiju Stomatološkog fakulteta u Beogradu. Kontrolnu grupu je činilo 104 zdrave školske dece. Rezultati. Deca sa posebnim potrebama imala su statistički značajno viši nivo indeksa karijesnih, ekstrahovanih i plombiranih zuba (KEP) u obe denticije, u odnosu na kontrolnu grupu (p  lt  0.05). Nivo oralne higijene bio je lošiji kod dece sa posebnim potrebama. Takođe, primećeno je statistički značajno povećanje malokluzija klase II, kao i kasnije vreme erupcije stalnih molara kod dece sa posebnim potrebama u odnosu na kontrolnu grupu. Zaključak. Zbog lošijeg stanja oralnog zdravlja i povećane verovatnoće razvoja malokluzija i odloženog nicanja zuba, neophodno je formirati preventivne stomatološke programe za decu sa posebnim potrebama, kao i poboljšati informisanost javnosti o ovom problemu.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Oral health in children with special needs, Stanje oralnog zdravlja dece sa posebnim potrebama",
volume = "75",
number = "7",
pages = "675-681",
doi = "10.2298/VSP160707372M"
}

Mandić, J., Jovanović, S., Mandinić, Z., Ivanović, M., Kosanović, D., Miličić, B.,& Živojinović-Toumba, V.. (2018). Oral health in children with special needs. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(7), 675-681.
https://doi.org/10.2298/VSP160707372M

Mandić J, Jovanović S, Mandinić Z, Ivanović M, Kosanović D, Miličić B, Živojinović-Toumba V. Oral health in children with special needs. in Vojnosanitetski pregled. 2018;75(7):675-681.
doi:10.2298/VSP160707372M .

Mandić, Jelena, Jovanović, Svetlana, Mandinić, Zoran, Ivanović, Mirjana, Kosanović, Dušan, Miličić, Biljana, Živojinović-Toumba, Vesna, "Oral health in children with special needs" in Vojnosanitetski pregled, 75, no. 7 (2018):675-681,
https://doi.org/10.2298/VSP160707372M . .

TY  - JOUR
AU  - Vuković, Ana
AU  - Vuković, Rade
AU  - Marković, Dejan
AU  - Soldatović, Ivan
AU  - Mandinić, Zoran
AU  - Beloica, Miloš
AU  - Stojan, George
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2133
AB  - Aim. The aim of this study was to analyze the outcomes and factors associated with after-hours dental trauma. Methods. Study sample consisted of 1762 permanent teeth injuries in children, gender and age matched with office-hours injuries. Epidemiological and clinical data were collected from 4 university dental trauma centers. Results. During median follow-up time of 4.3 years, complications have occurred in 14.5% of injured teeth. Age, type, and degree of tissue injury and after-hours time of injury were significantly associated with complications. Unfavorable outcomes were 34% more likely in the after-hours group compared with office-hours. Urgent treatment was significantly delayed in after-hours group with a delay of more than 3 hours in 90.5% versus 38.9% in the office-hours group. Multivariate regression model showed that after-hours time of injury was significant predictor of complications. Conclusion. Delayed urgent treatment was one of the main factors associated with unfavorable outcome of after-hours injuries.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Clinical Pediatrics
T1  - After-Hours Versus Office-Hours Dental Injuries in Children: Does Timing Influence Outcome?
VL  - 55
IS  - 1
SP  - 29
EP  - 35
DO  - 10.1177/0009922815584214
ER  - 

@article{
author = "Vuković, Ana and Vuković, Rade and Marković, Dejan and Soldatović, Ivan and Mandinić, Zoran and Beloica, Miloš and Stojan, George",
year = "2016",
abstract = "Aim. The aim of this study was to analyze the outcomes and factors associated with after-hours dental trauma. Methods. Study sample consisted of 1762 permanent teeth injuries in children, gender and age matched with office-hours injuries. Epidemiological and clinical data were collected from 4 university dental trauma centers. Results. During median follow-up time of 4.3 years, complications have occurred in 14.5% of injured teeth. Age, type, and degree of tissue injury and after-hours time of injury were significantly associated with complications. Unfavorable outcomes were 34% more likely in the after-hours group compared with office-hours. Urgent treatment was significantly delayed in after-hours group with a delay of more than 3 hours in 90.5% versus 38.9% in the office-hours group. Multivariate regression model showed that after-hours time of injury was significant predictor of complications. Conclusion. Delayed urgent treatment was one of the main factors associated with unfavorable outcome of after-hours injuries.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Clinical Pediatrics",
title = "After-Hours Versus Office-Hours Dental Injuries in Children: Does Timing Influence Outcome?",
volume = "55",
number = "1",
pages = "29-35",
doi = "10.1177/0009922815584214"
}

Vuković, A., Vuković, R., Marković, D., Soldatović, I., Mandinić, Z., Beloica, M.,& Stojan, G.. (2016). After-Hours Versus Office-Hours Dental Injuries in Children: Does Timing Influence Outcome?. in Clinical Pediatrics
Sage Publications Inc, Thousand Oaks., 55(1), 29-35.
https://doi.org/10.1177/0009922815584214

Vuković A, Vuković R, Marković D, Soldatović I, Mandinić Z, Beloica M, Stojan G. After-Hours Versus Office-Hours Dental Injuries in Children: Does Timing Influence Outcome?. in Clinical Pediatrics. 2016;55(1):29-35.
doi:10.1177/0009922815584214 .

Vuković, Ana, Vuković, Rade, Marković, Dejan, Soldatović, Ivan, Mandinić, Zoran, Beloica, Miloš, Stojan, George, "After-Hours Versus Office-Hours Dental Injuries in Children: Does Timing Influence Outcome?" in Clinical Pediatrics, 55, no. 1 (2016):29-35,
https://doi.org/10.1177/0009922815584214 . .

TY  - JOUR
AU  - Antonijević, Evica
AU  - Mandinić, Zoran
AU  - Curcić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Milicević, Nemanja
AU  - Ivanović, Mirjana
AU  - Carević, Momir
AU  - Antonijević, Biljana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2170
AB  - This study explores relation between dental fluorosis occurrence in schoolchildren, residents of Ritopek, a small local community near Belgrade, and fluoride exposure via drinking water. Additionally, fluoride levels were determined in children's urine and hair samples, and efforts were made to correlate them with dental fluorosis. Dental fluorosis and caries prevalence were examined in a total of 52 schoolchildren aged 7-15 years (29 boys and 23 girls). Fluoride levels in three types of samples were analyzed using composite fluoride ion-selective electrode. Results showed high prevalence of dental fluorosis (34.6 %) and low prevalence of dental caries (23.1 %, mean DMFT 0.96) among children exposed to wide range of water fluoride levels (0.11-4.14 mg/L, n = 27). About 11 % of water samples exceeded 1.5 mg/L, a drinking-water quality guideline value for fluoride given by the World Health Organization (2006). Fluoride levels in urine and hair samples ranged between 0.07-2.59 (n = 48) and 1.07-19.83 mg/L (n = 33), respectively. Severity of dental fluorosis was positively and linearly correlated with fluoride levels in drinking water (r = 0.79). Fluoride levels in urine and hair were strongly and positively correlated with levels in drinking water (r = 0.92 and 0.94, respectively). Fluoride levels in hair samples appeared to be a potentially promising biomarker of fluoride intake via drinking water on one hand, and severity of dental fluorosis on the other hand. Based on community fluorosis index value of 0.58, dental fluorosis revealed in Ritopek can be considered as "borderline" public health issue.
PB  - Springer, Dordrecht
T2  - Environmental Geochemistry & Health
T1  - 'Borderline' fluorotic region in Serbia: correlations among fluoride in drinking water, biomarkers of exposure and dental fluorosis in schoolchildren
VL  - 38
IS  - 3
SP  - 885
EP  - 896
DO  - 10.1007/s10653-015-9769-x
ER  - 

@article{
author = "Antonijević, Evica and Mandinić, Zoran and Curcić, Marijana and Đukić-Ćosić, Danijela and Milicević, Nemanja and Ivanović, Mirjana and Carević, Momir and Antonijević, Biljana",
year = "2016",
abstract = "This study explores relation between dental fluorosis occurrence in schoolchildren, residents of Ritopek, a small local community near Belgrade, and fluoride exposure via drinking water. Additionally, fluoride levels were determined in children's urine and hair samples, and efforts were made to correlate them with dental fluorosis. Dental fluorosis and caries prevalence were examined in a total of 52 schoolchildren aged 7-15 years (29 boys and 23 girls). Fluoride levels in three types of samples were analyzed using composite fluoride ion-selective electrode. Results showed high prevalence of dental fluorosis (34.6 %) and low prevalence of dental caries (23.1 %, mean DMFT 0.96) among children exposed to wide range of water fluoride levels (0.11-4.14 mg/L, n = 27). About 11 % of water samples exceeded 1.5 mg/L, a drinking-water quality guideline value for fluoride given by the World Health Organization (2006). Fluoride levels in urine and hair samples ranged between 0.07-2.59 (n = 48) and 1.07-19.83 mg/L (n = 33), respectively. Severity of dental fluorosis was positively and linearly correlated with fluoride levels in drinking water (r = 0.79). Fluoride levels in urine and hair were strongly and positively correlated with levels in drinking water (r = 0.92 and 0.94, respectively). Fluoride levels in hair samples appeared to be a potentially promising biomarker of fluoride intake via drinking water on one hand, and severity of dental fluorosis on the other hand. Based on community fluorosis index value of 0.58, dental fluorosis revealed in Ritopek can be considered as "borderline" public health issue.",
publisher = "Springer, Dordrecht",
journal = "Environmental Geochemistry & Health",
title = "'Borderline' fluorotic region in Serbia: correlations among fluoride in drinking water, biomarkers of exposure and dental fluorosis in schoolchildren",
volume = "38",
number = "3",
pages = "885-896",
doi = "10.1007/s10653-015-9769-x"
}

Antonijević, E., Mandinić, Z., Curcić, M., Đukić-Ćosić, D., Milicević, N., Ivanović, M., Carević, M.,& Antonijević, B.. (2016). 'Borderline' fluorotic region in Serbia: correlations among fluoride in drinking water, biomarkers of exposure and dental fluorosis in schoolchildren. in Environmental Geochemistry & Health
Springer, Dordrecht., 38(3), 885-896.
https://doi.org/10.1007/s10653-015-9769-x

Antonijević E, Mandinić Z, Curcić M, Đukić-Ćosić D, Milicević N, Ivanović M, Carević M, Antonijević B. 'Borderline' fluorotic region in Serbia: correlations among fluoride in drinking water, biomarkers of exposure and dental fluorosis in schoolchildren. in Environmental Geochemistry & Health. 2016;38(3):885-896.
doi:10.1007/s10653-015-9769-x .

Antonijević, Evica, Mandinić, Zoran, Curcić, Marijana, Đukić-Ćosić, Danijela, Milicević, Nemanja, Ivanović, Mirjana, Carević, Momir, Antonijević, Biljana, "'Borderline' fluorotic region in Serbia: correlations among fluoride in drinking water, biomarkers of exposure and dental fluorosis in schoolchildren" in Environmental Geochemistry & Health, 38, no. 3 (2016):885-896,
https://doi.org/10.1007/s10653-015-9769-x . .

TY  - JOUR
AU  - Mandinić, Zoran
AU  - Vulićević, Zoran
AU  - Beloica, Miloš
AU  - Radović, Ivana
AU  - Mandić, Jelena
AU  - Carević, Momir
AU  - Tekić, Jasmina
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1920
AB  - One of the main objectives of contemporary dentistry is to preserve healthy tooth structure by applying techniques of noninvasive treatment. Air abrasion is a minimally invasive non mechanical technique of tooth preparation that uses kinetic energy to remove carious tooth structure. A powerful narrow stream of moving aluminum-oxide particles hit the tooth surface and they abrade it without heat, vibration or noise. Variables that affect speed of cutting include air pressure, particle size, powder flow, tip's size, angle and distance from the tooth. It has been proposed that air abrasion can be used to diagnose early occlusal-surface lesions and treat them with minimal tooth preparation using magnifier. Reported advantages of air abrasion include reduced noise, vibration and sensitivity. Air abrasion cavity preparations have more rounded internal contours than those prepared with straight burs. This may increase the longevity of placed restorations because it reduces the incidence of fractures and a consequence of decreased internal stresses. However, air abrasion cannot be used for all patients, i.e. in cases involving severe dust allergy, asthma, chronic obstructive lung disease, recent extraction or other oral surgery, open wounds, advanced periodontal disease, recent placement of orthodontic appliances and oral abrasions, or subgingival caries removal. Many of these conditions increase the risk of air embolism in the oral soft tissues. Dust control is a challenge, and it necessitates the use of rubber dam, high-volume evacuation, protective masks and safety eyewear for both the patient and the therapist.
AB  - Jedan od osnovnih ciljeva savremene stomatologije jeste očuvanje zdravog zubnog tkiva primenom preventivnih metoda i tehnika neinvazivnog lečenja. Vazdušna abrazija je minimalno invazivna tehnika preparacije kaviteta koja koristi kinetičku energiju za uklanjanje karijesa. Usmeravanje pravolinijskog mlaza čestica aluminijum- oksida na površinu zuba koja se obrađuje dovodi do abrazije supstrata bez toplote, vibracija i zvuka. Faktori koji utiču na brzinu preparacije uključuju intenzitet vazdušnog pritiska, veličinu čestica abraziva, brzinu protoka čestica, prečnik vrha kanile, veličinu ugla kanile i udaljenost vrha kanile od površine zuba koja se obrađuje. Njena upotreba se savetuje u dijagnostici rane karijesne lezije gleđi na okluzalnim površinama zuba i minimalnoj preparaciji kaviteta. Pojedini autori preporučuju i upotrebu optičkih pomagala. Prednosti tehnike vazdušne abrazije uključuju smanjenje buke, vibracija i operativne osetljivosti, koja je veoma subjektivna i promenljiva kod pacijenata. Kaviteti preparisani vazdušnom abrazijom imaju zaobljene ivice, za razliku od kaviteta preparisanih standardnim tehnikama. To može povećati dugotrajnost postavljenih ispuna, jer se smanjuje mogućnost nastanka njihovog odlamanja, neutralisanjem sila unutrašnjeg napona u poređenju sa stresom koji se javlja kod angularnih preparacija. Primena tehnike vazdušne abrazije je kontraindikovana kod osoba alergičnih na prašinu, obolelih od astme ili hronične opstruktivne bolesti pluća, pacijenata sa postekstrakcionim ranama, parodontopatijom, ortodontskim aparatima ili dubokim karijesom, jer se ovom tehnikom preparacije ne odstranjuje uspešno mekana dentinska struktura. Mnoga ova stanja povećavaju rizik od nastanka vazdušne embolije u mekim oralnim tkivima. Kontrola rasejanja čestica abraziva predstavlja izazov kliničkom stomatologu, a zahteva i primenu koferdama, jakih aspiratora, zaštitnih maski i zaštitnih naočara kako kod pacijenta, tako i kod terapeuta.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The application of air abrasion in dentistry
T1  - Primena vazdušne abrazije u stomatologiji
VL  - 142
IS  - 1-2
SP  - 99
EP  - 105
DO  - 10.2298/SARH1402099M
ER  - 

@article{
author = "Mandinić, Zoran and Vulićević, Zoran and Beloica, Miloš and Radović, Ivana and Mandić, Jelena and Carević, Momir and Tekić, Jasmina",
year = "2014",
abstract = "One of the main objectives of contemporary dentistry is to preserve healthy tooth structure by applying techniques of noninvasive treatment. Air abrasion is a minimally invasive non mechanical technique of tooth preparation that uses kinetic energy to remove carious tooth structure. A powerful narrow stream of moving aluminum-oxide particles hit the tooth surface and they abrade it without heat, vibration or noise. Variables that affect speed of cutting include air pressure, particle size, powder flow, tip's size, angle and distance from the tooth. It has been proposed that air abrasion can be used to diagnose early occlusal-surface lesions and treat them with minimal tooth preparation using magnifier. Reported advantages of air abrasion include reduced noise, vibration and sensitivity. Air abrasion cavity preparations have more rounded internal contours than those prepared with straight burs. This may increase the longevity of placed restorations because it reduces the incidence of fractures and a consequence of decreased internal stresses. However, air abrasion cannot be used for all patients, i.e. in cases involving severe dust allergy, asthma, chronic obstructive lung disease, recent extraction or other oral surgery, open wounds, advanced periodontal disease, recent placement of orthodontic appliances and oral abrasions, or subgingival caries removal. Many of these conditions increase the risk of air embolism in the oral soft tissues. Dust control is a challenge, and it necessitates the use of rubber dam, high-volume evacuation, protective masks and safety eyewear for both the patient and the therapist., Jedan od osnovnih ciljeva savremene stomatologije jeste očuvanje zdravog zubnog tkiva primenom preventivnih metoda i tehnika neinvazivnog lečenja. Vazdušna abrazija je minimalno invazivna tehnika preparacije kaviteta koja koristi kinetičku energiju za uklanjanje karijesa. Usmeravanje pravolinijskog mlaza čestica aluminijum- oksida na površinu zuba koja se obrađuje dovodi do abrazije supstrata bez toplote, vibracija i zvuka. Faktori koji utiču na brzinu preparacije uključuju intenzitet vazdušnog pritiska, veličinu čestica abraziva, brzinu protoka čestica, prečnik vrha kanile, veličinu ugla kanile i udaljenost vrha kanile od površine zuba koja se obrađuje. Njena upotreba se savetuje u dijagnostici rane karijesne lezije gleđi na okluzalnim površinama zuba i minimalnoj preparaciji kaviteta. Pojedini autori preporučuju i upotrebu optičkih pomagala. Prednosti tehnike vazdušne abrazije uključuju smanjenje buke, vibracija i operativne osetljivosti, koja je veoma subjektivna i promenljiva kod pacijenata. Kaviteti preparisani vazdušnom abrazijom imaju zaobljene ivice, za razliku od kaviteta preparisanih standardnim tehnikama. To može povećati dugotrajnost postavljenih ispuna, jer se smanjuje mogućnost nastanka njihovog odlamanja, neutralisanjem sila unutrašnjeg napona u poređenju sa stresom koji se javlja kod angularnih preparacija. Primena tehnike vazdušne abrazije je kontraindikovana kod osoba alergičnih na prašinu, obolelih od astme ili hronične opstruktivne bolesti pluća, pacijenata sa postekstrakcionim ranama, parodontopatijom, ortodontskim aparatima ili dubokim karijesom, jer se ovom tehnikom preparacije ne odstranjuje uspešno mekana dentinska struktura. Mnoga ova stanja povećavaju rizik od nastanka vazdušne embolije u mekim oralnim tkivima. Kontrola rasejanja čestica abraziva predstavlja izazov kliničkom stomatologu, a zahteva i primenu koferdama, jakih aspiratora, zaštitnih maski i zaštitnih naočara kako kod pacijenta, tako i kod terapeuta.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The application of air abrasion in dentistry, Primena vazdušne abrazije u stomatologiji",
volume = "142",
number = "1-2",
pages = "99-105",
doi = "10.2298/SARH1402099M"
}

Mandinić, Z., Vulićević, Z., Beloica, M., Radović, I., Mandić, J., Carević, M.,& Tekić, J.. (2014). The application of air abrasion in dentistry. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(1-2), 99-105.
https://doi.org/10.2298/SARH1402099M

Mandinić Z, Vulićević Z, Beloica M, Radović I, Mandić J, Carević M, Tekić J. The application of air abrasion in dentistry. in Srpski arhiv za celokupno lekarstvo. 2014;142(1-2):99-105.
doi:10.2298/SARH1402099M .

Mandinić, Zoran, Vulićević, Zoran, Beloica, Miloš, Radović, Ivana, Mandić, Jelena, Carević, Momir, Tekić, Jasmina, "The application of air abrasion in dentistry" in Srpski arhiv za celokupno lekarstvo, 142, no. 1-2 (2014):99-105,
https://doi.org/10.2298/SARH1402099M . .

TY  - JOUR
AU  - Beloica, Miloš
AU  - Vulićević, Zoran
AU  - Mandinić, Zoran
AU  - Radović, Ivana
AU  - Jovičić, Olivera
AU  - Carević, Momir
AU  - Tekić, Jasmina
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1915
AB  - Goal of contemporary dentistry is to decrease the patient's discomfort during treatment. Dentists aim to achieve maximum with the newly developed dental materials as well as with new cavity preparation techniques in the shortest time span. Since the development of the first constructed borer (drilling machine) for caries removal, the preparation techniques have considerably changed. The progress of dental materials as well as the cavity preparation techniques has led us to contemporary carbide tungsten and diamond borers that are used with obligatory water cooling. The innovation within this field represents newly developed polymer borers that can detect the difference between carious lesions and healthy tooth structure. In this way the cavity preparation may be performed without damaging dental healthy tissue. This is possible owing to their hardness which is lower than the hardness of intact dentin. Polymer borer preparation is painless with less vibration, while the increase in temperature is negligible. Lasers have been used in clinical dentistry since 1980s so it can be said that they represent a new technology. The function of lasers is based on ablation which requires water. Erbium lasers have shown the highest potential with their ability to produce effective ablation of hard dental tissues. Laser application in dentistry requires special training as well as some protective measures. Laser advantages, compared to traditional preparation techniques, involve the absence of vibration, painless preparation, possibility of preparation without anesthetic and easier patient's adjustment to dental intervention which is of importance, especially in pediatric dentistry.
AB  - Savremena stomatologija teži ka što manjoj traumatizaciji pacijenta prilikom rada uz maksimalni učinak. Savremeni materijali uz nove vidove preparacije kaviteta pružaju mogućnost sanacije karijesnih lezija u najkraćem vremenskom roku. Vidovi preparacije kaviteta su se znatno promenili otkako je uvedeno prvo mašinski napravljeno svrdlo za uklanjanje karijesa. Tehnološki napredak materijala za ispune i načina preparacije doveli su do savremenih karbidnih i dijamantskih svrdla koja se koriste uz obavezno vodeno hlađenje. Inovaciju na polju rotirajućih instrumenata predstavljaju polimerna 'pametna' svrdla, koja uklanjaju karijesnu leziju bez mogućnosti povređivanja i uklanjanja zdrave zubne strukture. Ovo je moguće zahvaljujući čvrstoći koju poseduju, koja je manja od čvrstoće zdravog dentina. Zahvaljujući prirodi materijala od kojih su izrađena, ova svrdla omogućuju bezbolniji rad uz manje vibracija i slabije zagrevanje zubne supstance. Laseri su relativno novo tehnološko sredstvo u stomatologiji, a njihova klinička upotreba počela je osamdesetih godina dvadesetog veka. Laseri funkcionišu po principu ablacije, za šta je neophodno prisustvo vode. Najveći potencijal među ispitivanim laserima pokazali su erbijumski laseri, kojima je moguće uraditi efikasnu ablaciju čvrstih zubnih tkiva. Za korišćenje lasera u stomatologiji neophodni su posebna obuka i odgovarajuće mere zaštite. Prednosti lasera u poređenju sa drugim metodama preparacije čvrstih zubnih tkiva su nepostojanje vibracija, bezbolan rad, mogućnost rada bez anestezije i lakše prilagođavanje pacijenta stomatološkim intervencijama, što je veoma značajno u dečjoj stomatologiji.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Hard dental tissue minimal-invasive preparation using contemporary polymer rotating instruments and laser
T1  - Minimalno invazivna preparacija čvrstih zubnih tkiva savremenim polimernim rotirajućim instrumentima i laserom
VL  - 142
IS  - 5-6
SP  - 365
EP  - 370
DO  - 10.2298/SARH1406365B
ER  - 

@article{
author = "Beloica, Miloš and Vulićević, Zoran and Mandinić, Zoran and Radović, Ivana and Jovičić, Olivera and Carević, Momir and Tekić, Jasmina",
year = "2014",
abstract = "Goal of contemporary dentistry is to decrease the patient's discomfort during treatment. Dentists aim to achieve maximum with the newly developed dental materials as well as with new cavity preparation techniques in the shortest time span. Since the development of the first constructed borer (drilling machine) for caries removal, the preparation techniques have considerably changed. The progress of dental materials as well as the cavity preparation techniques has led us to contemporary carbide tungsten and diamond borers that are used with obligatory water cooling. The innovation within this field represents newly developed polymer borers that can detect the difference between carious lesions and healthy tooth structure. In this way the cavity preparation may be performed without damaging dental healthy tissue. This is possible owing to their hardness which is lower than the hardness of intact dentin. Polymer borer preparation is painless with less vibration, while the increase in temperature is negligible. Lasers have been used in clinical dentistry since 1980s so it can be said that they represent a new technology. The function of lasers is based on ablation which requires water. Erbium lasers have shown the highest potential with their ability to produce effective ablation of hard dental tissues. Laser application in dentistry requires special training as well as some protective measures. Laser advantages, compared to traditional preparation techniques, involve the absence of vibration, painless preparation, possibility of preparation without anesthetic and easier patient's adjustment to dental intervention which is of importance, especially in pediatric dentistry., Savremena stomatologija teži ka što manjoj traumatizaciji pacijenta prilikom rada uz maksimalni učinak. Savremeni materijali uz nove vidove preparacije kaviteta pružaju mogućnost sanacije karijesnih lezija u najkraćem vremenskom roku. Vidovi preparacije kaviteta su se znatno promenili otkako je uvedeno prvo mašinski napravljeno svrdlo za uklanjanje karijesa. Tehnološki napredak materijala za ispune i načina preparacije doveli su do savremenih karbidnih i dijamantskih svrdla koja se koriste uz obavezno vodeno hlađenje. Inovaciju na polju rotirajućih instrumenata predstavljaju polimerna 'pametna' svrdla, koja uklanjaju karijesnu leziju bez mogućnosti povređivanja i uklanjanja zdrave zubne strukture. Ovo je moguće zahvaljujući čvrstoći koju poseduju, koja je manja od čvrstoće zdravog dentina. Zahvaljujući prirodi materijala od kojih su izrađena, ova svrdla omogućuju bezbolniji rad uz manje vibracija i slabije zagrevanje zubne supstance. Laseri su relativno novo tehnološko sredstvo u stomatologiji, a njihova klinička upotreba počela je osamdesetih godina dvadesetog veka. Laseri funkcionišu po principu ablacije, za šta je neophodno prisustvo vode. Najveći potencijal među ispitivanim laserima pokazali su erbijumski laseri, kojima je moguće uraditi efikasnu ablaciju čvrstih zubnih tkiva. Za korišćenje lasera u stomatologiji neophodni su posebna obuka i odgovarajuće mere zaštite. Prednosti lasera u poređenju sa drugim metodama preparacije čvrstih zubnih tkiva su nepostojanje vibracija, bezbolan rad, mogućnost rada bez anestezije i lakše prilagođavanje pacijenta stomatološkim intervencijama, što je veoma značajno u dečjoj stomatologiji.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Hard dental tissue minimal-invasive preparation using contemporary polymer rotating instruments and laser, Minimalno invazivna preparacija čvrstih zubnih tkiva savremenim polimernim rotirajućim instrumentima i laserom",
volume = "142",
number = "5-6",
pages = "365-370",
doi = "10.2298/SARH1406365B"
}

Beloica, M., Vulićević, Z., Mandinić, Z., Radović, I., Jovičić, O., Carević, M.,& Tekić, J.. (2014). Hard dental tissue minimal-invasive preparation using contemporary polymer rotating instruments and laser. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(5-6), 365-370.
https://doi.org/10.2298/SARH1406365B

Beloica M, Vulićević Z, Mandinić Z, Radović I, Jovičić O, Carević M, Tekić J. Hard dental tissue minimal-invasive preparation using contemporary polymer rotating instruments and laser. in Srpski arhiv za celokupno lekarstvo. 2014;142(5-6):365-370.
doi:10.2298/SARH1406365B .

Beloica, Miloš, Vulićević, Zoran, Mandinić, Zoran, Radović, Ivana, Jovičić, Olivera, Carević, Momir, Tekić, Jasmina, "Hard dental tissue minimal-invasive preparation using contemporary polymer rotating instruments and laser" in Srpski arhiv za celokupno lekarstvo, 142, no. 5-6 (2014):365-370,
https://doi.org/10.2298/SARH1406365B . .

TY  - THES
AU  - Mandinić, Zoran
PY  - 2011
UR  - https://plus.sr.cobiss.net/opac7/bib/38202639
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/510
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Uticaj fluorida na parametre oksidativnog stresa kod eksperimentalnih životinja
UR  - https://hdl.handle.net/21.15107/rcub_smile_510
ER  - 

@phdthesis{
author = "Mandinić, Zoran",
year = "2011",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Uticaj fluorida na parametre oksidativnog stresa kod eksperimentalnih životinja",
url = "https://hdl.handle.net/21.15107/rcub_smile_510"
}

Mandinić, Z.. (2011). Uticaj fluorida na parametre oksidativnog stresa kod eksperimentalnih životinja. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_510

Mandinić Z. Uticaj fluorida na parametre oksidativnog stresa kod eksperimentalnih životinja. 2011;.
https://hdl.handle.net/21.15107/rcub_smile_510 .

Mandinić, Zoran, "Uticaj fluorida na parametre oksidativnog stresa kod eksperimentalnih životinja" (2011),
https://hdl.handle.net/21.15107/rcub_smile_510 .

TY  - JOUR
AU  - Mandinić, Zoran
AU  - Curcić, Marijana
AU  - Antonijević, Biljana
AU  - Carević, Momir
AU  - Mandić, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Lekić, Charles P.
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1605
AB  - In this study we determined the fluoride content in drinking water and hair of 12-year-old schoolchildren from different Serbian municipalities, i.e. Valley, Veliko Gradiste, Kacarevo and Vranjska Banja. The analyses were performed using composite fluoride ion-selective electrode. Average fluoride levels were 0.10, 0.15, 0.79 and 11 ppm in well water, 0.07, 0.10, 0.17 and 0.15 ppm in tap water, 19.3, 21.5, 25.4, and 32.5 ppm in hair samples, in Valjevo, Veliko Gradiste, Kacarevo and Vranjska Banja, respectively. Correlation analysis indicated statistically significant positive relationship between fluoride in wells water and fluoride in hair, for all municipalities: correlation coefficients were 0.54 (p lt 0.05), 0.89, 0.97 and 0.99 (p lt 0.001), in Vranjska Banja, Valjevo, Veliko Gradiste, and Kacarevo, respectively. Positive correlation was obtained also between fluoride in tap water and hair samples in all regions under the study, with statistical significance only in Valjevo municipality, p lt 0.05. Dental examination of schoolchildren confirmed dental fluorosis only in the region of Vranjska Banja. Moreover, in endemic fluorotic region of Vranjska Banja, positive and statistically significant correlations were confirmed between fluoride in well water and dental fluorosis level (r = 0.61; p lt 0.01) and additionally between fluoride in hair and dental fluorosis level (0.62; p lt 0.01). The primary findings from this study have shown that fluoride content in hair is highly correlated with fluoride content in drinking water and dental fluorosis level, indicating that hair may be regarded as biomaterial of high informative potential in evaluating prolonged exposure to fluorides and to individuate children at risk of fluorosis regardless of the phase of teeth eruption.
PB  - Elsevier, Amsterdam
T2  - Science of the Total Environment
T1  - Fluoride in drinking water and dental fluorosis
VL  - 408
IS  - 17
SP  - 3507
EP  - 3512
DO  - 10.1016/j.scitotenv.2010.04.029
ER  - 

@article{
author = "Mandinić, Zoran and Curcić, Marijana and Antonijević, Biljana and Carević, Momir and Mandić, Jelena and Đukić-Ćosić, Danijela and Lekić, Charles P.",
year = "2010",
abstract = "In this study we determined the fluoride content in drinking water and hair of 12-year-old schoolchildren from different Serbian municipalities, i.e. Valley, Veliko Gradiste, Kacarevo and Vranjska Banja. The analyses were performed using composite fluoride ion-selective electrode. Average fluoride levels were 0.10, 0.15, 0.79 and 11 ppm in well water, 0.07, 0.10, 0.17 and 0.15 ppm in tap water, 19.3, 21.5, 25.4, and 32.5 ppm in hair samples, in Valjevo, Veliko Gradiste, Kacarevo and Vranjska Banja, respectively. Correlation analysis indicated statistically significant positive relationship between fluoride in wells water and fluoride in hair, for all municipalities: correlation coefficients were 0.54 (p lt 0.05), 0.89, 0.97 and 0.99 (p lt 0.001), in Vranjska Banja, Valjevo, Veliko Gradiste, and Kacarevo, respectively. Positive correlation was obtained also between fluoride in tap water and hair samples in all regions under the study, with statistical significance only in Valjevo municipality, p lt 0.05. Dental examination of schoolchildren confirmed dental fluorosis only in the region of Vranjska Banja. Moreover, in endemic fluorotic region of Vranjska Banja, positive and statistically significant correlations were confirmed between fluoride in well water and dental fluorosis level (r = 0.61; p lt 0.01) and additionally between fluoride in hair and dental fluorosis level (0.62; p lt 0.01). The primary findings from this study have shown that fluoride content in hair is highly correlated with fluoride content in drinking water and dental fluorosis level, indicating that hair may be regarded as biomaterial of high informative potential in evaluating prolonged exposure to fluorides and to individuate children at risk of fluorosis regardless of the phase of teeth eruption.",
publisher = "Elsevier, Amsterdam",
journal = "Science of the Total Environment",
title = "Fluoride in drinking water and dental fluorosis",
volume = "408",
number = "17",
pages = "3507-3512",
doi = "10.1016/j.scitotenv.2010.04.029"
}

Mandinić, Z., Curcić, M., Antonijević, B., Carević, M., Mandić, J., Đukić-Ćosić, D.,& Lekić, C. P.. (2010). Fluoride in drinking water and dental fluorosis. in Science of the Total Environment
Elsevier, Amsterdam., 408(17), 3507-3512.
https://doi.org/10.1016/j.scitotenv.2010.04.029

Mandinić Z, Curcić M, Antonijević B, Carević M, Mandić J, Đukić-Ćosić D, Lekić CP. Fluoride in drinking water and dental fluorosis. in Science of the Total Environment. 2010;408(17):3507-3512.
doi:10.1016/j.scitotenv.2010.04.029 .

Mandinić, Zoran, Curcić, Marijana, Antonijević, Biljana, Carević, Momir, Mandić, Jelena, Đukić-Ćosić, Danijela, Lekić, Charles P., "Fluoride in drinking water and dental fluorosis" in Science of the Total Environment, 408, no. 17 (2010):3507-3512,
https://doi.org/10.1016/j.scitotenv.2010.04.029 . .

TY  - JOUR
AU  - Mandinić, Zoran
AU  - Curdc, Marijana
AU  - Antonijević, Biljana
AU  - Lekić, Charles P.
AU  - Carević, Momir
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1507
AB  - The amount of fluoride present naturally in drinking water is highly variable, being dependent upon the individual geological environment from which the water is obtained. Chronic exposure to exceeding fluoride doses induces set of toxic effects, i.e. fluorosis. The aim of this study was to examine fluoride content in water and in the most frequently used vegetables, potato and bean, grown in two different Serbian regions. Le. control region (Valjevo) and high naturally occurring fluoride region (Vranjska Banja), and moreover, to correlate estimated daily intake with dental fluorosis occurrence as an adverse effect of fluoride exposure of schoolchildren in Serbia. Study confirmed significant difference in fluoride content in water, potato and bean, consumed by 12-year-old children in two investigated municipalities. Results of the study indicated positive and statistically significant correlation between daily intake of fluoride and dental fluorosis level in the fluorotic municipality of Vranjska Banja (r = 0.61: p = 0.000017). Obtained relationship could be evaluated by means of binary logistic regression analysis, whereas probability for fluorosis occurrence could be predicted using the following equation: fluorosis occurence (%) (34.852 x C-water - 12.644 x C-potato - 9.362 x C-bean - 7.673) x 100 (Chi-square (3) = 33.033; p  lt  0.001).
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food & Chemical Toxicology
T1  - Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis
VL  - 47
IS  - 6
SP  - 1080
EP  - 1084
DO  - 10.1016/j.fct.2009.01.038
ER  - 

@article{
author = "Mandinić, Zoran and Curdc, Marijana and Antonijević, Biljana and Lekić, Charles P. and Carević, Momir",
year = "2009",
abstract = "The amount of fluoride present naturally in drinking water is highly variable, being dependent upon the individual geological environment from which the water is obtained. Chronic exposure to exceeding fluoride doses induces set of toxic effects, i.e. fluorosis. The aim of this study was to examine fluoride content in water and in the most frequently used vegetables, potato and bean, grown in two different Serbian regions. Le. control region (Valjevo) and high naturally occurring fluoride region (Vranjska Banja), and moreover, to correlate estimated daily intake with dental fluorosis occurrence as an adverse effect of fluoride exposure of schoolchildren in Serbia. Study confirmed significant difference in fluoride content in water, potato and bean, consumed by 12-year-old children in two investigated municipalities. Results of the study indicated positive and statistically significant correlation between daily intake of fluoride and dental fluorosis level in the fluorotic municipality of Vranjska Banja (r = 0.61: p = 0.000017). Obtained relationship could be evaluated by means of binary logistic regression analysis, whereas probability for fluorosis occurrence could be predicted using the following equation: fluorosis occurence (%) (34.852 x C-water - 12.644 x C-potato - 9.362 x C-bean - 7.673) x 100 (Chi-square (3) = 33.033; p  lt  0.001).",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food & Chemical Toxicology",
title = "Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis",
volume = "47",
number = "6",
pages = "1080-1084",
doi = "10.1016/j.fct.2009.01.038"
}

Mandinić, Z., Curdc, M., Antonijević, B., Lekić, C. P.,& Carević, M.. (2009). Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis. in Food & Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 47(6), 1080-1084.
https://doi.org/10.1016/j.fct.2009.01.038

Mandinić Z, Curdc M, Antonijević B, Lekić CP, Carević M. Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis. in Food & Chemical Toxicology. 2009;47(6):1080-1084.
doi:10.1016/j.fct.2009.01.038 .

Mandinić, Zoran, Curdc, Marijana, Antonijević, Biljana, Lekić, Charles P., Carević, Momir, "Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis" in Food & Chemical Toxicology, 47, no. 6 (2009):1080-1084,
https://doi.org/10.1016/j.fct.2009.01.038 . .

TY  - CONF
AU  - Mandinić, Zoran
AU  - Curcić, Marijana
AU  - Antonijević, Biljana
AU  - Carević, Momir
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1488
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Relationship between dental fluorosis and fluoride content in hair of schoolchildren from fluorotic and non-fluorotic regions in Serbia
VL  - 189
SP  - S236
EP  - S236
DO  - 10.1016/j.toxlet.2009.06.443
ER  - 

@conference{
author = "Mandinić, Zoran and Curcić, Marijana and Antonijević, Biljana and Carević, Momir",
year = "2009",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Relationship between dental fluorosis and fluoride content in hair of schoolchildren from fluorotic and non-fluorotic regions in Serbia",
volume = "189",
pages = "S236-S236",
doi = "10.1016/j.toxlet.2009.06.443"
}

Mandinić, Z., Curcić, M., Antonijević, B.,& Carević, M.. (2009). Relationship between dental fluorosis and fluoride content in hair of schoolchildren from fluorotic and non-fluorotic regions in Serbia. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 189, S236-S236.
https://doi.org/10.1016/j.toxlet.2009.06.443

Mandinić Z, Curcić M, Antonijević B, Carević M. Relationship between dental fluorosis and fluoride content in hair of schoolchildren from fluorotic and non-fluorotic regions in Serbia. in Toxicology Letters. 2009;189:S236-S236.
doi:10.1016/j.toxlet.2009.06.443 .

Mandinić, Zoran, Curcić, Marijana, Antonijević, Biljana, Carević, Momir, "Relationship between dental fluorosis and fluoride content in hair of schoolchildren from fluorotic and non-fluorotic regions in Serbia" in Toxicology Letters, 189 (2009):S236-S236,
https://doi.org/10.1016/j.toxlet.2009.06.443 . .

TY  - THES
AU  - Mandinić, Zoran
PY  - 2008
UR  - https://plus.sr.cobiss.net/opac7/bib/1024062862
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/463
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Rasprostranjenost karijesa u školske dece u lokalitetima sa različitim prirodnim sadržajem fluorida
UR  - https://hdl.handle.net/21.15107/rcub_smile_463
ER  - 

@mastersthesis{
author = "Mandinić, Zoran",
year = "2008",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Rasprostranjenost karijesa u školske dece u lokalitetima sa različitim prirodnim sadržajem fluorida",
url = "https://hdl.handle.net/21.15107/rcub_smile_463"
}

Mandinić, Z.. (2008). Rasprostranjenost karijesa u školske dece u lokalitetima sa različitim prirodnim sadržajem fluorida. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_463

Mandinić Z. Rasprostranjenost karijesa u školske dece u lokalitetima sa različitim prirodnim sadržajem fluorida. 2008;.
https://hdl.handle.net/21.15107/rcub_smile_463 .

Mandinić, Zoran, "Rasprostranjenost karijesa u školske dece u lokalitetima sa različitim prirodnim sadržajem fluorida" (2008),
https://hdl.handle.net/21.15107/rcub_smile_463 .

TY  - CONF
AU  - Mandinić, Zoran
AU  - Curcić, Marijana
AU  - Antonijević, Biljana
AU  - Nedeljković, Mirjana
AU  - Carević, Momir
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1331
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Fluoride levels in hair samples - Biomarker of exposure
VL  - 172
SP  - S119
EP  - S119
DO  - 10.1016/j.toxlet.2007.05.316
ER  - 

@conference{
author = "Mandinić, Zoran and Curcić, Marijana and Antonijević, Biljana and Nedeljković, Mirjana and Carević, Momir",
year = "2007",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Fluoride levels in hair samples - Biomarker of exposure",
volume = "172",
pages = "S119-S119",
doi = "10.1016/j.toxlet.2007.05.316"
}

Mandinić, Z., Curcić, M., Antonijević, B., Nedeljković, M.,& Carević, M.. (2007). Fluoride levels in hair samples - Biomarker of exposure. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 172, S119-S119.
https://doi.org/10.1016/j.toxlet.2007.05.316

Mandinić Z, Curcić M, Antonijević B, Nedeljković M, Carević M. Fluoride levels in hair samples - Biomarker of exposure. in Toxicology Letters. 2007;172:S119-S119.
doi:10.1016/j.toxlet.2007.05.316 .

Mandinić, Zoran, Curcić, Marijana, Antonijević, Biljana, Nedeljković, Mirjana, Carević, Momir, "Fluoride levels in hair samples - Biomarker of exposure" in Toxicology Letters, 172 (2007):S119-S119,
https://doi.org/10.1016/j.toxlet.2007.05.316 . .