TY  - JOUR
AU  - Popović, Jelena
AU  - Cvetković, Tatjana
AU  - Džopalić, Tanja
AU  - Nikolić, Marija
AU  - Mitić, Aleksandar
AU  - Barac, Radomir
AU  - Živković, Slavoljub
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2366
AB  - Introduction Cytokine network plays an important role in pathogenesis of chronic periapical lesions. The aim of this study was to determine the concentration of interleukin-6 (IL-6) in tissue homogenates of human periapical lesions and correlate its levels with symptomatology and size of the lesions. Materials and Methods 93 samples of chronic periapical lesions were obtained after extraction of teeth. Samples were divided according to the clinical presentation as symptomatic and asymptomatic, and according to the size as large and small. The concentration of IL-6 was analyzed using ELISA. Results Statistically significant difference in IL-6 concentration was observed in symptomatic lesions compared to asymptomatic (p lt 0.001). Analysis showed statistically higher concentration in large symptomatic lesions compared to large asymptomatic lesions (p lt 0.001), and in small symptomatic lesions compared to small asymptomatic (p lt 0.05). Higher production of IL-6 was observed in large lesions compared to small but this difference was not statistically significant. Conclusion Higher concentration of IL-6 in lesions with expressed clinical symptoms as well as in large lesions indicates that IL-6 is an important factor responsible for the progression of lesions and bone resorption.
AB  - Uvod Mreža citokina igra značajnu ulogu u patogenezi hroničnih periapeksnih lezija. Cilj studije je bio da se odredi koncentracija IL-6 u tkivnim homogenatima hroničnih periapeksnih lezija i da se proveri korelacija sa simptomatologijom i veličinom lezija. Materijal i metode Ispitana su 93 uzorka hroničnih periapeksnih lezija dobijenih nakon ekstrakcije zuba. Uzorci lezija su podeljeni prema simptomatologiji pacijenata na simptomatske i asimptomatske, a prema veličini na velike i male. Koncentracija IL-6 je ispitivana pomoću ELISA testa, a dobijene vrednosti su analizirane u odnosu na grupe. Rezultati Statistički značajna razlika u koncentraciji IL-6 je uočena u grupi simptomatskih lezija u poređenju sa asimptomatskim (p  lt  0,001). Analiza je pokazala i statistički značajno veću koncentraciju u velikim simptomatskim lezijama u odnosu na velike asimptomatske (p  lt  0,001) i u malim simptomatskim lezijama u odnosu na male asimptomatske (p  lt  0,05). Zapažena je i povećana produkciju IL-6 u velikim lezijama u odnosu na male, međutim, razlika nije bila statistički značajna. Zaključak Veća koncentracija IL-6 u lezijama sa izraženim kliničkim simptomima kao i velikim lezijama ukazuje na njegovu važnu ulogu u progresiji periapeksnih lezija i koštane resorpcije. .
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - The role of interleukin-6 in pathogenesis of chronic periapical lesions
T1  - Uloga interleukina-6 u patogenezi hroničnih periapeksnih lezija
VL  - 65
IS  - 3
SP  - 126
EP  - 132
DO  - 10.2478/sdj-2018-0012
ER  - 

@article{
author = "Popović, Jelena and Cvetković, Tatjana and Džopalić, Tanja and Nikolić, Marija and Mitić, Aleksandar and Barac, Radomir and Živković, Slavoljub",
year = "2018",
abstract = "Introduction Cytokine network plays an important role in pathogenesis of chronic periapical lesions. The aim of this study was to determine the concentration of interleukin-6 (IL-6) in tissue homogenates of human periapical lesions and correlate its levels with symptomatology and size of the lesions. Materials and Methods 93 samples of chronic periapical lesions were obtained after extraction of teeth. Samples were divided according to the clinical presentation as symptomatic and asymptomatic, and according to the size as large and small. The concentration of IL-6 was analyzed using ELISA. Results Statistically significant difference in IL-6 concentration was observed in symptomatic lesions compared to asymptomatic (p lt 0.001). Analysis showed statistically higher concentration in large symptomatic lesions compared to large asymptomatic lesions (p lt 0.001), and in small symptomatic lesions compared to small asymptomatic (p lt 0.05). Higher production of IL-6 was observed in large lesions compared to small but this difference was not statistically significant. Conclusion Higher concentration of IL-6 in lesions with expressed clinical symptoms as well as in large lesions indicates that IL-6 is an important factor responsible for the progression of lesions and bone resorption., Uvod Mreža citokina igra značajnu ulogu u patogenezi hroničnih periapeksnih lezija. Cilj studije je bio da se odredi koncentracija IL-6 u tkivnim homogenatima hroničnih periapeksnih lezija i da se proveri korelacija sa simptomatologijom i veličinom lezija. Materijal i metode Ispitana su 93 uzorka hroničnih periapeksnih lezija dobijenih nakon ekstrakcije zuba. Uzorci lezija su podeljeni prema simptomatologiji pacijenata na simptomatske i asimptomatske, a prema veličini na velike i male. Koncentracija IL-6 je ispitivana pomoću ELISA testa, a dobijene vrednosti su analizirane u odnosu na grupe. Rezultati Statistički značajna razlika u koncentraciji IL-6 je uočena u grupi simptomatskih lezija u poređenju sa asimptomatskim (p  lt  0,001). Analiza je pokazala i statistički značajno veću koncentraciju u velikim simptomatskim lezijama u odnosu na velike asimptomatske (p  lt  0,001) i u malim simptomatskim lezijama u odnosu na male asimptomatske (p  lt  0,05). Zapažena je i povećana produkciju IL-6 u velikim lezijama u odnosu na male, međutim, razlika nije bila statistički značajna. Zaključak Veća koncentracija IL-6 u lezijama sa izraženim kliničkim simptomima kao i velikim lezijama ukazuje na njegovu važnu ulogu u progresiji periapeksnih lezija i koštane resorpcije. .",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "The role of interleukin-6 in pathogenesis of chronic periapical lesions, Uloga interleukina-6 u patogenezi hroničnih periapeksnih lezija",
volume = "65",
number = "3",
pages = "126-132",
doi = "10.2478/sdj-2018-0012"
}

Popović, J., Cvetković, T., Džopalić, T., Nikolić, M., Mitić, A., Barac, R.,& Živković, S.. (2018). The role of interleukin-6 in pathogenesis of chronic periapical lesions. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 65(3), 126-132.
https://doi.org/10.2478/sdj-2018-0012

Popović J, Cvetković T, Džopalić T, Nikolić M, Mitić A, Barac R, Živković S. The role of interleukin-6 in pathogenesis of chronic periapical lesions. in Stomatološki glasnik Srbije. 2018;65(3):126-132.
doi:10.2478/sdj-2018-0012 .

Popović, Jelena, Cvetković, Tatjana, Džopalić, Tanja, Nikolić, Marija, Mitić, Aleksandar, Barac, Radomir, Živković, Slavoljub, "The role of interleukin-6 in pathogenesis of chronic periapical lesions" in Stomatološki glasnik Srbije, 65, no. 3 (2018):126-132,
https://doi.org/10.2478/sdj-2018-0012 . .

TY  - JOUR
AU  - Popović, Jelena
AU  - Cvetković, Tatjana
AU  - Džopalić, Tanja
AU  - Mitić, Aleksandar
AU  - Nikolić, Marija
AU  - Barac, Radomir
AU  - Živković, Slavoljub
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1870
AB  - Introduction The balance between proinflammatory and anti-inflammatory cytokines plays an important role in the pathogenesis of chronic periapical lesions. The aim of this study was to determine the concentration of TNF-α in tissue homogenates of periapical lesions and analyze its levels in relation to the symptomatology and the size of lesions. Materials and Methods 93 samples of chronic periapical lesions were obtained after extraction of teeth. Samples were classified according to the clinical presentation as symptomatic and asymptomatic, and according to the size as large and small. The concentration of TNF-α was analyzed using ELISA. Results The results showed increased production of TNF-α in symptomatic lesions compared to asymptomatic. Higher concentration of TNF-α was demonstrated in large lesions compared to small. Large symptomatic lesions showed greater concentration of TNF-α compared to small symptomatic lesions, while bigger asymptomatic lesions demonstrated higher amount of the cytokines compared to small asymptomatic lesions. Conclusion Higher concentration of TNF-α in large symptomatic lesions indicates that TNF-α is an important factor responsible for the progression of lesions.
AB  - Uvod Balans između proinflamatornih i antiinflamatornih citokina igra važnu ulogu u patogenezi hroničnih periapeksnih lezija. Cilj ove studije je bio da se odredi koncentracija faktora nekroze tumora alfa (TNF-α) u homogenatima tkiva periapeksnih lezija i rezultati analiziraju u pogledu simptomatologije tih lezija kod pacijenata, odnosno veličine lezije. Materijal i metode rada Ispitana su 93 uzorka hroničnih periapeksnih lezija dobijenih nakon ekstrakcije zuba. Uzorci lezija su, prema simptomatologiji pacijenata, podeljeni na simptomatske i asimptomatske, a prema veličini na velike i male. Koncentracija TNF-α u uzorku ispitivana je pomoću testa ELISA. Rezultati Kod klinički simptomatskih lezija uočeno je povećano stvaranje TNF-α u odnosu na asimptomatske. Veća koncentracija TNF-α je dokazana i u velikim lezijama u odnosu na male. Velike simptomatske lezije su pokazale veću koncentraciju TNF-α u odnosu na male simptomatske lezije, dok su velike asimptomatske lezije imale veću količinu ovog citokina u odnosu na male asimptomatske lezije. Zaključak Veća koncentracija TNF-α u velikim i u lezijama s pojačanim kliničkim simptomima pokazuje da je TNF-α važan faktor odgovoran za napredovanje lezije.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - The concentration of tumor necrosis factor alpha in periapical lesions
T1  - Ispitivanje koncentracije faktora nekroze tumora alfa u tkivnim homogenatima periapeksnih lezija
VL  - 61
IS  - 1
SP  - 7
EP  - 13
DO  - 10.2298/sgs1401007p
ER  - 

@article{
author = "Popović, Jelena and Cvetković, Tatjana and Džopalić, Tanja and Mitić, Aleksandar and Nikolić, Marija and Barac, Radomir and Živković, Slavoljub",
year = "2014",
abstract = "Introduction The balance between proinflammatory and anti-inflammatory cytokines plays an important role in the pathogenesis of chronic periapical lesions. The aim of this study was to determine the concentration of TNF-α in tissue homogenates of periapical lesions and analyze its levels in relation to the symptomatology and the size of lesions. Materials and Methods 93 samples of chronic periapical lesions were obtained after extraction of teeth. Samples were classified according to the clinical presentation as symptomatic and asymptomatic, and according to the size as large and small. The concentration of TNF-α was analyzed using ELISA. Results The results showed increased production of TNF-α in symptomatic lesions compared to asymptomatic. Higher concentration of TNF-α was demonstrated in large lesions compared to small. Large symptomatic lesions showed greater concentration of TNF-α compared to small symptomatic lesions, while bigger asymptomatic lesions demonstrated higher amount of the cytokines compared to small asymptomatic lesions. Conclusion Higher concentration of TNF-α in large symptomatic lesions indicates that TNF-α is an important factor responsible for the progression of lesions., Uvod Balans između proinflamatornih i antiinflamatornih citokina igra važnu ulogu u patogenezi hroničnih periapeksnih lezija. Cilj ove studije je bio da se odredi koncentracija faktora nekroze tumora alfa (TNF-α) u homogenatima tkiva periapeksnih lezija i rezultati analiziraju u pogledu simptomatologije tih lezija kod pacijenata, odnosno veličine lezije. Materijal i metode rada Ispitana su 93 uzorka hroničnih periapeksnih lezija dobijenih nakon ekstrakcije zuba. Uzorci lezija su, prema simptomatologiji pacijenata, podeljeni na simptomatske i asimptomatske, a prema veličini na velike i male. Koncentracija TNF-α u uzorku ispitivana je pomoću testa ELISA. Rezultati Kod klinički simptomatskih lezija uočeno je povećano stvaranje TNF-α u odnosu na asimptomatske. Veća koncentracija TNF-α je dokazana i u velikim lezijama u odnosu na male. Velike simptomatske lezije su pokazale veću koncentraciju TNF-α u odnosu na male simptomatske lezije, dok su velike asimptomatske lezije imale veću količinu ovog citokina u odnosu na male asimptomatske lezije. Zaključak Veća koncentracija TNF-α u velikim i u lezijama s pojačanim kliničkim simptomima pokazuje da je TNF-α važan faktor odgovoran za napredovanje lezije.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "The concentration of tumor necrosis factor alpha in periapical lesions, Ispitivanje koncentracije faktora nekroze tumora alfa u tkivnim homogenatima periapeksnih lezija",
volume = "61",
number = "1",
pages = "7-13",
doi = "10.2298/sgs1401007p"
}

Popović, J., Cvetković, T., Džopalić, T., Mitić, A., Nikolić, M., Barac, R.,& Živković, S.. (2014). The concentration of tumor necrosis factor alpha in periapical lesions. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 61(1), 7-13.
https://doi.org/10.2298/sgs1401007p

Popović J, Cvetković T, Džopalić T, Mitić A, Nikolić M, Barac R, Živković S. The concentration of tumor necrosis factor alpha in periapical lesions. in Stomatološki glasnik Srbije. 2014;61(1):7-13.
doi:10.2298/sgs1401007p .

Popović, Jelena, Cvetković, Tatjana, Džopalić, Tanja, Mitić, Aleksandar, Nikolić, Marija, Barac, Radomir, Živković, Slavoljub, "The concentration of tumor necrosis factor alpha in periapical lesions" in Stomatološki glasnik Srbije, 61, no. 1 (2014):7-13,
https://doi.org/10.2298/sgs1401007p . .