TY  - JOUR
AU  - Ilić, Jugoslav
AU  - Radović, Katarina
AU  - Brković, Božidar
AU  - Vasić, Jugoslav
AU  - Roganović, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2588
AB  - Introduction/Objective. We aimed to investigate the effects of diabetes mellitus (DM) on rat dental pulp repair by measuring time-dependent changes in expressions of vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP 2) following direct pulp capping. Methods. Two groups, each of 20 Wistar rats, received either streptozotocin (for DM induction) or the same volume of sterile saline. A week later, the pulp of maxillary and mandibular right incisors in diabetic and non-diabetic groups were exposed and capped with calcium hydroxide in order to provoke reparative response. The levels of VEGF and BMP 2 were determined in the pulp tissue lysates one and seven days after the pulp capping, using enzyme-linked immunosorbent assays. Results. Diabetic state per se increased VEGF level, with a peak at first day after the pulp capping (19.3 ± 0.9 pg/mg, p < 0.001), but did not affect BMP 2 levels. Significant increase of BMP 2 expression was noticed on the seventh day in capped pulp, but only in diabetic rats (16.7 ± 1 pg/mg, p = 0.001). Positive correlation between VEGF and BMP 2 was found on the seventh day following capping, only in diabetic pulp (r = 0.905, p = 0.003). Conclusion. Diabetes-induced increase in VEGF expression reflects changes in the inflammatory phase of pulp repair in DM. Increase in BMP 2 expression suggest that stimulating effect of calcium hydroxide appears seven days after diabetic pulp capping.
AB  - Uvod/Cilj Cilj ove studije bio je da se ispita efekat dijabetesa melitusa na reparaciju zubne pulpe pacova utvrđivanjem vremenski zavisnih promena u ekspresiji vaskularnog endotelnog faktora rasta (VEGF) i kostnog morfogenetskog proteina 2 (BMP 2) posle direktnog prekrivanja pulpe. Metode Istraživanje je sprovedeno na pacovima soja vistar, podeljenim u dve grupe od po 20 životinja, pri čemu je jedna grupa dobila streptozotocin (za indukciju dijabetesa melitusa), a druga sterilni fiziološki rastvor u istoj zapremini. Posle nedelju dana pulpe maksilarnih i mandibularnih donjih inciziva kod dijabetičnih i nedijabetičnih životinja su eksponirane i odmah zatim prekrivene kalcijum-hidroksidom da bi se izazvao reparatorni odgovor. Nivoi VEGF i BMP 2 su utvrđivani u lizatima pulpnog tkiva, prvog i sedmog dana posle direktnog prekrivanja imunoenzimskim testom ELISA. Rezultati Dijabetično stanje je dovelo do rasta nivoa VEGF, sa maksimumom utvrđenim prvog dana posle prekrivanja pulpe (19,3 ± 0,9 pg/mg, p < 0,001), ali nije uticalo na nivoe BMP 2. Značajan porast BMP 2 je utvrđen sedmog dana posle prekrivanja pulpe, ali samo kod dijabetičnih pacova (16,7 ± 1 pg/mg, p = 0,001). Kod ovih životinja u istom periodu posle prekrivanja nađena je pozitivna korelacija između nivoa VEGF i BMP 2 (r = 0,905, p = 0,003). Zaključak Dijabetesom indukovan porast ekspresije VEGF ukazuje na promene u inflamatornoj fazi pulpne reparacije. Porast ekspresije BMP 2 ukazuje da se stimulativan reparatorni efekat kalcijum-hidroksida javlja sedmog dana posle prekrivanja dijabetične pulpe.
PB  - Beograd: Srpsko lekarsko društvo
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2
T1  - Reparacija dijabetične zubne pulpe – uloga vaskularnog endotelnog faktora rasta i kostnog morfogenetskog proteina 2
VL  - 148
IS  - 11-12
SP  - 673
EP  - 678
DO  - 10.2298/SARH200228057I
ER  - 

@article{
author = "Ilić, Jugoslav and Radović, Katarina and Brković, Božidar and Vasić, Jugoslav and Roganović, Jelena",
year = "2020",
abstract = "Introduction/Objective. We aimed to investigate the effects of diabetes mellitus (DM) on rat dental pulp repair by measuring time-dependent changes in expressions of vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP 2) following direct pulp capping. Methods. Two groups, each of 20 Wistar rats, received either streptozotocin (for DM induction) or the same volume of sterile saline. A week later, the pulp of maxillary and mandibular right incisors in diabetic and non-diabetic groups were exposed and capped with calcium hydroxide in order to provoke reparative response. The levels of VEGF and BMP 2 were determined in the pulp tissue lysates one and seven days after the pulp capping, using enzyme-linked immunosorbent assays. Results. Diabetic state per se increased VEGF level, with a peak at first day after the pulp capping (19.3 ± 0.9 pg/mg, p < 0.001), but did not affect BMP 2 levels. Significant increase of BMP 2 expression was noticed on the seventh day in capped pulp, but only in diabetic rats (16.7 ± 1 pg/mg, p = 0.001). Positive correlation between VEGF and BMP 2 was found on the seventh day following capping, only in diabetic pulp (r = 0.905, p = 0.003). Conclusion. Diabetes-induced increase in VEGF expression reflects changes in the inflammatory phase of pulp repair in DM. Increase in BMP 2 expression suggest that stimulating effect of calcium hydroxide appears seven days after diabetic pulp capping., Uvod/Cilj Cilj ove studije bio je da se ispita efekat dijabetesa melitusa na reparaciju zubne pulpe pacova utvrđivanjem vremenski zavisnih promena u ekspresiji vaskularnog endotelnog faktora rasta (VEGF) i kostnog morfogenetskog proteina 2 (BMP 2) posle direktnog prekrivanja pulpe. Metode Istraživanje je sprovedeno na pacovima soja vistar, podeljenim u dve grupe od po 20 životinja, pri čemu je jedna grupa dobila streptozotocin (za indukciju dijabetesa melitusa), a druga sterilni fiziološki rastvor u istoj zapremini. Posle nedelju dana pulpe maksilarnih i mandibularnih donjih inciziva kod dijabetičnih i nedijabetičnih životinja su eksponirane i odmah zatim prekrivene kalcijum-hidroksidom da bi se izazvao reparatorni odgovor. Nivoi VEGF i BMP 2 su utvrđivani u lizatima pulpnog tkiva, prvog i sedmog dana posle direktnog prekrivanja imunoenzimskim testom ELISA. Rezultati Dijabetično stanje je dovelo do rasta nivoa VEGF, sa maksimumom utvrđenim prvog dana posle prekrivanja pulpe (19,3 ± 0,9 pg/mg, p < 0,001), ali nije uticalo na nivoe BMP 2. Značajan porast BMP 2 je utvrđen sedmog dana posle prekrivanja pulpe, ali samo kod dijabetičnih pacova (16,7 ± 1 pg/mg, p = 0,001). Kod ovih životinja u istom periodu posle prekrivanja nađena je pozitivna korelacija između nivoa VEGF i BMP 2 (r = 0,905, p = 0,003). Zaključak Dijabetesom indukovan porast ekspresije VEGF ukazuje na promene u inflamatornoj fazi pulpne reparacije. Porast ekspresije BMP 2 ukazuje da se stimulativan reparatorni efekat kalcijum-hidroksida javlja sedmog dana posle prekrivanja dijabetične pulpe.",
publisher = "Beograd: Srpsko lekarsko društvo",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2, Reparacija dijabetične zubne pulpe – uloga vaskularnog endotelnog faktora rasta i kostnog morfogenetskog proteina 2",
volume = "148",
number = "11-12",
pages = "673-678",
doi = "10.2298/SARH200228057I"
}

Ilić, J., Radović, K., Brković, B., Vasić, J.,& Roganović, J.. (2020). The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2. in Srpski arhiv za celokupno lekarstvo
Beograd: Srpsko lekarsko društvo., 148(11-12), 673-678.
https://doi.org/10.2298/SARH200228057I

Ilić J, Radović K, Brković B, Vasić J, Roganović J. The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2. in Srpski arhiv za celokupno lekarstvo. 2020;148(11-12):673-678.
doi:10.2298/SARH200228057I .

Ilić, Jugoslav, Radović, Katarina, Brković, Božidar, Vasić, Jugoslav, Roganović, Jelena, "The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2" in Srpski arhiv za celokupno lekarstvo, 148, no. 11-12 (2020):673-678,
https://doi.org/10.2298/SARH200228057I . .

TY  - JOUR
AU  - Ilić, Jugoslav
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2107
AB  - Anatomically, dental pulp is connective tissue and specific microcirculatory system with significant reparatory abilities intending to preserve pulp vitality. Various therapeutic approaches in the treatment of affected pulp may be compromised by various factors leading to treatment failure. Due to microcirculatory system disorders, treatment of affected dental pulp in patients with diabetes mellitus (DM) is additional challenge. The function and levels of growth factors could be altered in various diabetic tissues including dental pulp. Among them are growth factors important for reparative response of the pulp. There are experimental evidences that DM impede dental pulp reparation. Therefore, clinical procedures aiming to preserve vitality of diabetic dental pulp should be applied with caution. The aim of this paper is to present basic factors and parameters that affect reparative response of dental pulp in patients with DM.
AB  - Zubna pulpa je vezivno tkivo i poseban mikrocirkulatorni sistem sa značajnim reparatornim sposobnostima u cilju očuvanja njenog vitaliteta. Terapijski postupci u lečenju obolele pulpe mogu da budu kompromitovani delovanjem brojnih faktora koji mogu uticati na ishod lečenja. Zubna pulpa kod pacijenata sa dijabetes melitusom (DM), zbog mikrocirkulatornih poremećaja često predstavlja poseban terapijski izazov. Poznato je da funkcije i nivoi faktora rasta mogu biti promenjeni u dijabetičnim tkivima, pa samim tim i u zubnoj pulpi. Ovde su od najveće važnosti faktori rasta značajni za regulaciju reparatornog odgovora pulpe. Postoje eksperimentalni dokazi da DM umanjuje reparativnu aktivnost zubne pulpe, pa zbog toga kliničke procedure vezane za očuvanje vitaliteta dijabetične zubne pulpe treba realizovati uz značajne mere opreza. Cilj ovog rada je da se predstave osnovni faktori i parametri koji utiču na reparatorni odgovor pulpe zuba kod obolelih od DM.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Diabetes mellitus and reparative response of dental pulp
T1  - Dijabetes melitus i reparativni odgovor zubne pulpe
VL  - 63
IS  - 2
SP  - 85
EP  - 90
DO  - 10.1515/sdj-2016-0009
ER  - 

@article{
author = "Ilić, Jugoslav",
year = "2016",
abstract = "Anatomically, dental pulp is connective tissue and specific microcirculatory system with significant reparatory abilities intending to preserve pulp vitality. Various therapeutic approaches in the treatment of affected pulp may be compromised by various factors leading to treatment failure. Due to microcirculatory system disorders, treatment of affected dental pulp in patients with diabetes mellitus (DM) is additional challenge. The function and levels of growth factors could be altered in various diabetic tissues including dental pulp. Among them are growth factors important for reparative response of the pulp. There are experimental evidences that DM impede dental pulp reparation. Therefore, clinical procedures aiming to preserve vitality of diabetic dental pulp should be applied with caution. The aim of this paper is to present basic factors and parameters that affect reparative response of dental pulp in patients with DM., Zubna pulpa je vezivno tkivo i poseban mikrocirkulatorni sistem sa značajnim reparatornim sposobnostima u cilju očuvanja njenog vitaliteta. Terapijski postupci u lečenju obolele pulpe mogu da budu kompromitovani delovanjem brojnih faktora koji mogu uticati na ishod lečenja. Zubna pulpa kod pacijenata sa dijabetes melitusom (DM), zbog mikrocirkulatornih poremećaja često predstavlja poseban terapijski izazov. Poznato je da funkcije i nivoi faktora rasta mogu biti promenjeni u dijabetičnim tkivima, pa samim tim i u zubnoj pulpi. Ovde su od najveće važnosti faktori rasta značajni za regulaciju reparatornog odgovora pulpe. Postoje eksperimentalni dokazi da DM umanjuje reparativnu aktivnost zubne pulpe, pa zbog toga kliničke procedure vezane za očuvanje vitaliteta dijabetične zubne pulpe treba realizovati uz značajne mere opreza. Cilj ovog rada je da se predstave osnovni faktori i parametri koji utiču na reparatorni odgovor pulpe zuba kod obolelih od DM.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Diabetes mellitus and reparative response of dental pulp, Dijabetes melitus i reparativni odgovor zubne pulpe",
volume = "63",
number = "2",
pages = "85-90",
doi = "10.1515/sdj-2016-0009"
}

Ilić, J.. (2016). Diabetes mellitus and reparative response of dental pulp. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 63(2), 85-90.
https://doi.org/10.1515/sdj-2016-0009

Ilić J. Diabetes mellitus and reparative response of dental pulp. in Stomatološki glasnik Srbije. 2016;63(2):85-90.
doi:10.1515/sdj-2016-0009 .

Ilić, Jugoslav, "Diabetes mellitus and reparative response of dental pulp" in Stomatološki glasnik Srbije, 63, no. 2 (2016):85-90,
https://doi.org/10.1515/sdj-2016-0009 . .

TY  - JOUR
AU  - Ilić, Jugoslav
AU  - Vujašković, Mirjana
AU  - Tihaček-Šojić, Ljiljana
AU  - Milić-Lemić, Aleksandra
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1911
AB  - Introduction Estimation of frequency and quality of root canal fillings is the way to evaluate endodontic treatment needs and success/failure rates of performed endodontic procedures. Objective The aim of this study was to determine the frequency and quality of root canal fillings and the frequency of apical periodontitis on endodontically treated teeth in a group of adult patients from Serbia. Methods In order to analyze the presence and quality of root canal fillings and the frequency of periapical radiolucencies on endodontically treated teeth, 3526 teeth were examined on orthopantomograms of 153 adult patients. Results Overall, 12.5% of examined teeth were root filled, and 51.8% of them had radiographic signs of apical periodontitis. The analysis of root fillings quality revealed the presence of more inadequate ones (55.9%). The frequency of apical periodontitis was significantly higher in teeth with inadequate than in those having adequate root canal obturation (72.2% and 25.9%, respectively). Conclusion The frequency of apical periodontitis on root-filled teeth in this group of patients was high, indicating a low success rate of performed endodotic procedures and high endodontic retreatment needs.
AB  - Uvod Utvrđivanje učestalosti i kvaliteta punjenja kanala zuba jeste način da se procene potrebe za endodontskim lečenjem i stepen uspeha primenjenih endodontskih procedura. Cilj rada Cilj ovog rada je bio da se odrede učestalost i kvalitet punjenja kanala korena zuba, kao i učestalost apeksnih parodontitisa endodontski lečenih zuba kod odraslih pacijenata u Srbiji. Metode rada Radi utvrđivanja postojanja i kvaliteta punjenja kanala korena i učestalosti rasvetljenja u periapeksu endodontski lečenih zuba, analizirano je 3.526 zuba na ortopantomogramima 153 odrasle osobe. Rezultati Ukupno je endodontski lečeno 12,5% pregledanih zuba, od kojih je 51,8% imalo radiografske znake apeksnih parodontitisa. Analiza kvaliteta punjenja kanala pokazala je da je bilo više neadekvatnih punjenja (55,9%). Učestalost apeksnih parodontitisa je bila značajno veća kod zuba s neodgovarajućim kanalnim opturacijama (72,2%) u odnosu na one s odgovarajućim punjenjem kanala korena (25,9%). Zaključak Kod ispitanih pacijenata utvrđena je visoka učestalost apeksnih parodontitisa zuba s punjenim kanalima korena, što ukazuje na slabu uspešnost primenjenih endodontskih zahvata, kao i na potrebu za ponovljenim endodontskim lečenjem.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Frequency and quality of root canal fillings in an adult Serbian population
T1  - Učestalost i kvalitet punjenja kanala korena zuba kod odraslih osoba u Srbiji
VL  - 142
IS  - 11-12
SP  - 663
EP  - 668
DO  - 10.2298/SARH1412663I
ER  - 

@article{
author = "Ilić, Jugoslav and Vujašković, Mirjana and Tihaček-Šojić, Ljiljana and Milić-Lemić, Aleksandra",
year = "2014",
abstract = "Introduction Estimation of frequency and quality of root canal fillings is the way to evaluate endodontic treatment needs and success/failure rates of performed endodontic procedures. Objective The aim of this study was to determine the frequency and quality of root canal fillings and the frequency of apical periodontitis on endodontically treated teeth in a group of adult patients from Serbia. Methods In order to analyze the presence and quality of root canal fillings and the frequency of periapical radiolucencies on endodontically treated teeth, 3526 teeth were examined on orthopantomograms of 153 adult patients. Results Overall, 12.5% of examined teeth were root filled, and 51.8% of them had radiographic signs of apical periodontitis. The analysis of root fillings quality revealed the presence of more inadequate ones (55.9%). The frequency of apical periodontitis was significantly higher in teeth with inadequate than in those having adequate root canal obturation (72.2% and 25.9%, respectively). Conclusion The frequency of apical periodontitis on root-filled teeth in this group of patients was high, indicating a low success rate of performed endodotic procedures and high endodontic retreatment needs., Uvod Utvrđivanje učestalosti i kvaliteta punjenja kanala zuba jeste način da se procene potrebe za endodontskim lečenjem i stepen uspeha primenjenih endodontskih procedura. Cilj rada Cilj ovog rada je bio da se odrede učestalost i kvalitet punjenja kanala korena zuba, kao i učestalost apeksnih parodontitisa endodontski lečenih zuba kod odraslih pacijenata u Srbiji. Metode rada Radi utvrđivanja postojanja i kvaliteta punjenja kanala korena i učestalosti rasvetljenja u periapeksu endodontski lečenih zuba, analizirano je 3.526 zuba na ortopantomogramima 153 odrasle osobe. Rezultati Ukupno je endodontski lečeno 12,5% pregledanih zuba, od kojih je 51,8% imalo radiografske znake apeksnih parodontitisa. Analiza kvaliteta punjenja kanala pokazala je da je bilo više neadekvatnih punjenja (55,9%). Učestalost apeksnih parodontitisa je bila značajno veća kod zuba s neodgovarajućim kanalnim opturacijama (72,2%) u odnosu na one s odgovarajućim punjenjem kanala korena (25,9%). Zaključak Kod ispitanih pacijenata utvrđena je visoka učestalost apeksnih parodontitisa zuba s punjenim kanalima korena, što ukazuje na slabu uspešnost primenjenih endodontskih zahvata, kao i na potrebu za ponovljenim endodontskim lečenjem.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Frequency and quality of root canal fillings in an adult Serbian population, Učestalost i kvalitet punjenja kanala korena zuba kod odraslih osoba u Srbiji",
volume = "142",
number = "11-12",
pages = "663-668",
doi = "10.2298/SARH1412663I"
}

Ilić, J., Vujašković, M., Tihaček-Šojić, L.,& Milić-Lemić, A.. (2014). Frequency and quality of root canal fillings in an adult Serbian population. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(11-12), 663-668.
https://doi.org/10.2298/SARH1412663I

Ilić J, Vujašković M, Tihaček-Šojić L, Milić-Lemić A. Frequency and quality of root canal fillings in an adult Serbian population. in Srpski arhiv za celokupno lekarstvo. 2014;142(11-12):663-668.
doi:10.2298/SARH1412663I .

Ilić, Jugoslav, Vujašković, Mirjana, Tihaček-Šojić, Ljiljana, Milić-Lemić, Aleksandra, "Frequency and quality of root canal fillings in an adult Serbian population" in Srpski arhiv za celokupno lekarstvo, 142, no. 11-12 (2014):663-668,
https://doi.org/10.2298/SARH1412663I . .

TY  - JOUR
AU  - Radović, Katarina
AU  - Ilić, Jugoslav
AU  - Roganović, Jelena
AU  - Stojić, Dragica
AU  - Brković, Božidar
AU  - Pudar, Georgina
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1939
AB  - Statement of problem. Diabetes mellitus type 2 is associated with a variety of oral mucosal changes, including an altered level of salivary vascular endothelial growth factor. However, the authors identified no studies concerning denture stomatitis and salivary vascular endothelial growth factor in immediate denture wearers with diabetes mellitus type 2. Purpose. The purpose of this study was to investigate the incidence of and risk factors for denture stomatitis in immediate complete denture wearers with and without diabetes mellitus type 2 and to investigate the relationship between levels of salivary vascular endothelial growth factor and clinical forms of denture stomatitis in both groups. Material and methods. Individuals without diabetes (n=42) or with diabetes mellitus type 2 (n=36) who were candidates for complete immediate dentures were included in the study. After 1 year of wearing relined immediate dentures, participants were evaluated for denture stomatitis and potential contributing factors. Salivary vascular endothelial growth factor levels were measured with enzyme-linked immunosorbent assays. Data were analyzed with the chi(2) test or the Student t test where appropriate, as well as with binary logistic regression analysis. Results. The incidence of denture stomatitis was 61% in participants with diabetes mellitus type 2 and 38% in those without diabetes. Low denture stability and diabetes mellitus type 2 were risk factors for denture stomatitis. Salivary vascular endothelial growth factor concentrations at the beginning of the study were 557.6 +/- 94.7 pg/mL in participants with diabetes mellitus type 2 and 103.5 +/- 21.6 pg/mL in those without diabetes. In Newton Type I and Newton Type II denture stomatitis, vascular endothelial growth factor levels were 460.9 +/- 55.4 pg/mL and 1445.2 +/- 422.1 pg/mL in individuals with diabetes and 73.2 +/- 10.0 pg/mL and 306.5 +/- 22.6 pg/mL in those without diabetes. Conclusions. Perceived denture stability and diabetes mellitus type 2 are independent risk factors for the occurrence of denture stomatitis. Altered salivary vascular endothelial growth factor levels and denture stomatitis are more prevalent in denture wearers with diabetes mellitus type 2.
PB  - Mosby-Elsevier, New York
T2  - Journal of Prosthetic Dentistry
T1  - Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes
VL  - 111
IS  - 5
SP  - 373
EP  - 379
DO  - 10.1016/j.prosdent.2013.07.019
ER  - 

@article{
author = "Radović, Katarina and Ilić, Jugoslav and Roganović, Jelena and Stojić, Dragica and Brković, Božidar and Pudar, Georgina",
year = "2014",
abstract = "Statement of problem. Diabetes mellitus type 2 is associated with a variety of oral mucosal changes, including an altered level of salivary vascular endothelial growth factor. However, the authors identified no studies concerning denture stomatitis and salivary vascular endothelial growth factor in immediate denture wearers with diabetes mellitus type 2. Purpose. The purpose of this study was to investigate the incidence of and risk factors for denture stomatitis in immediate complete denture wearers with and without diabetes mellitus type 2 and to investigate the relationship between levels of salivary vascular endothelial growth factor and clinical forms of denture stomatitis in both groups. Material and methods. Individuals without diabetes (n=42) or with diabetes mellitus type 2 (n=36) who were candidates for complete immediate dentures were included in the study. After 1 year of wearing relined immediate dentures, participants were evaluated for denture stomatitis and potential contributing factors. Salivary vascular endothelial growth factor levels were measured with enzyme-linked immunosorbent assays. Data were analyzed with the chi(2) test or the Student t test where appropriate, as well as with binary logistic regression analysis. Results. The incidence of denture stomatitis was 61% in participants with diabetes mellitus type 2 and 38% in those without diabetes. Low denture stability and diabetes mellitus type 2 were risk factors for denture stomatitis. Salivary vascular endothelial growth factor concentrations at the beginning of the study were 557.6 +/- 94.7 pg/mL in participants with diabetes mellitus type 2 and 103.5 +/- 21.6 pg/mL in those without diabetes. In Newton Type I and Newton Type II denture stomatitis, vascular endothelial growth factor levels were 460.9 +/- 55.4 pg/mL and 1445.2 +/- 422.1 pg/mL in individuals with diabetes and 73.2 +/- 10.0 pg/mL and 306.5 +/- 22.6 pg/mL in those without diabetes. Conclusions. Perceived denture stability and diabetes mellitus type 2 are independent risk factors for the occurrence of denture stomatitis. Altered salivary vascular endothelial growth factor levels and denture stomatitis are more prevalent in denture wearers with diabetes mellitus type 2.",
publisher = "Mosby-Elsevier, New York",
journal = "Journal of Prosthetic Dentistry",
title = "Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes",
volume = "111",
number = "5",
pages = "373-379",
doi = "10.1016/j.prosdent.2013.07.019"
}

Radović, K., Ilić, J., Roganović, J., Stojić, D., Brković, B.,& Pudar, G.. (2014). Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes. in Journal of Prosthetic Dentistry
Mosby-Elsevier, New York., 111(5), 373-379.
https://doi.org/10.1016/j.prosdent.2013.07.019

Radović K, Ilić J, Roganović J, Stojić D, Brković B, Pudar G. Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes. in Journal of Prosthetic Dentistry. 2014;111(5):373-379.
doi:10.1016/j.prosdent.2013.07.019 .

Radović, Katarina, Ilić, Jugoslav, Roganović, Jelena, Stojić, Dragica, Brković, Božidar, Pudar, Georgina, "Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes" in Journal of Prosthetic Dentistry, 111, no. 5 (2014):373-379,
https://doi.org/10.1016/j.prosdent.2013.07.019 . .

TY  - JOUR
AU  - Ivanović, Vladimir
AU  - Savić-Stanković, Tatjana
AU  - Karadžić, Branislav
AU  - Ilić, Jugoslav
AU  - Santini, Ario
AU  - Beljić-Ivanović, Katarina
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1799
AB  - Introduction. Postoperative sensitivity in restorative dentistry can be related to preparation trauma, dentin adhesives' ability to seal open dentinal tubules, deformation of restorations under occlusal stresses and microleakage. Objective. The study assessed possible reduction in postoperative sensitivity with low shrinkage compared to conventional composites using different bonding agents and the influence of the operator skill on the incidence of postoperative sensitivity. Methods. Nine hundred and sixty permanent premolars and molars with primary carious lesions from patients 21 to 40 years old were used. Cavities 2 to 3 mm deep and with margins in enamel were prepared by four operators. Two operators had five years (A and B) and two had over 20 years (C and D) of clinical experience. Teeth were divided into eight groups each contained 120 restorations: (1) Els®+James-2 (original formula), (2) Els®+James-2 (new formula), (3) Els®+Excite, (4) InTenSe®+James-2 (original formula), (5) InTenSe®+James-2 (new formula), (6) InTenSe®+Excite, (7) Tetric Ceram®+Excite, and (8) Point 4®+OptiBond Solo Plus. At 14 days postoperatively, two independent operators, who did not take part in the clinical procedure, assessed postoperative teeth sensitivity using special questionnaires. Data were analyzed using non-parametric chi-square, Mann-Whitney and ANOVA tests. Results. Group 8 showed significantly higher score than the other groups. Less postoperative sensitivity was reported with two low-shrinkage composites (groups 2, 3, and 5) but with no significant difference. There was no statistical difference between groups 1, 2, 3, 4, 5, 6 and 7. Operator A had the highest postoperative sensitivity score compared to the other three. Conclusion. Conventional composite material Point 4® with its bonding agent caused significantly more postoperative sensitivity than low shrinkage composites combined with different adhesives. Operator skill influenced the incidence of postoperative sensitivity.
AB  - Uvod. Posle postavljanja kompozitnih ispuna može da se javi postoperaciona osetljivost izazvana preparacionom traumom, sposobnošću adhezivnog sistema da hermetički zatvori dentinske kanaliće, deformacijom pod okluzalnim opterećenjem ili prodorom bakterijskih toksina. Cilj rada. Cilj istraživanja je bio da se ispita da li je osetljivost zuba manja kod kompozita s malom kontrakcijom u poređenju s konvencionalnim kompozitima i odgovarajućim adhezivnim sistemima, kao i uticaj veštine stomatologa na incidenciju postoperacione osetljivosti zuba. Metode rada. Na 960 premolara i molara stalne denticije s primarnim karijesom, pacijenata starosti od 21 godine do 40 godina, preparisani su kaviteti dubine 2-3 mm s rubovima u gleđi. Čitavu proceduru su obavila četiri specijalista stomatologije, od kojih su dva imala pet (A i B), a druga dva više od 20 godina kliničkog iskustva (C i D). Zubi su svrstani u osam grupa od po 120 uzoraka prema korišćenom kompozitnom i adhezivnom sistemu: 1) Els®+James-2; 2) Els®+James-2 (nova formula); 3) Els®+Excite; 4) InTenSe®+James-2; 5) InTenSe®+James-2 (nova formula); 6) InTenSe®+Excite; 7) Tetric Ceram®+Excite; i 8) Point 4®+OptiBond Solo Plus. Dve nedelje posle intervencije dva nezavisna stomatologa (koja nisu učestvovala u kliničkoj proceduri) ocenjivala su posebnim upitnicima postoperacionu osetljivost zuba. Podaci su analizirani neparametrijskim c2, Man-Vitnijevim (Mann-Whitney) i ANOVA testom. Rezultati. U osmoj grupi utvrđena je statistički značajno češća postoperaciona osetljivost nego u ostalim grupama zuba. Nije bilo statistički značajne razlike između grupa 1, 2, 3, 4, 5, 6 i 7. Kompoziti sa nižom polimerizacionom kontrakcijom izazvali su manju postoperacionu ostetljivost, ali bez statističke značajnosti razlika (grupe 2, 3 i 5). Kod stomatologa A javljala se statistički značajno češće postoperaciona osetljivost nego kod ostala tri. Zaključak. Tip kompozitnog materijala s odgovarajućim adhezivnim sistemom i spretnost stomatologa utiču na učestalost pojave osetljivosti zuba posle restauracija srednje dubokih kaviteta II klase.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Postoperative sensitivity associated with low shrinkage versus conventional composites
T1  - Uticaj kompozita s malom kontrakcijom i konvencionalnih kompozita na postoperacionu osetljivost zuba
VL  - 141
IS  - 7-8
SP  - 447
EP  - 453
DO  - 10.2298/SARH1308447I
ER  - 

@article{
author = "Ivanović, Vladimir and Savić-Stanković, Tatjana and Karadžić, Branislav and Ilić, Jugoslav and Santini, Ario and Beljić-Ivanović, Katarina",
year = "2013",
abstract = "Introduction. Postoperative sensitivity in restorative dentistry can be related to preparation trauma, dentin adhesives' ability to seal open dentinal tubules, deformation of restorations under occlusal stresses and microleakage. Objective. The study assessed possible reduction in postoperative sensitivity with low shrinkage compared to conventional composites using different bonding agents and the influence of the operator skill on the incidence of postoperative sensitivity. Methods. Nine hundred and sixty permanent premolars and molars with primary carious lesions from patients 21 to 40 years old were used. Cavities 2 to 3 mm deep and with margins in enamel were prepared by four operators. Two operators had five years (A and B) and two had over 20 years (C and D) of clinical experience. Teeth were divided into eight groups each contained 120 restorations: (1) Els®+James-2 (original formula), (2) Els®+James-2 (new formula), (3) Els®+Excite, (4) InTenSe®+James-2 (original formula), (5) InTenSe®+James-2 (new formula), (6) InTenSe®+Excite, (7) Tetric Ceram®+Excite, and (8) Point 4®+OptiBond Solo Plus. At 14 days postoperatively, two independent operators, who did not take part in the clinical procedure, assessed postoperative teeth sensitivity using special questionnaires. Data were analyzed using non-parametric chi-square, Mann-Whitney and ANOVA tests. Results. Group 8 showed significantly higher score than the other groups. Less postoperative sensitivity was reported with two low-shrinkage composites (groups 2, 3, and 5) but with no significant difference. There was no statistical difference between groups 1, 2, 3, 4, 5, 6 and 7. Operator A had the highest postoperative sensitivity score compared to the other three. Conclusion. Conventional composite material Point 4® with its bonding agent caused significantly more postoperative sensitivity than low shrinkage composites combined with different adhesives. Operator skill influenced the incidence of postoperative sensitivity., Uvod. Posle postavljanja kompozitnih ispuna može da se javi postoperaciona osetljivost izazvana preparacionom traumom, sposobnošću adhezivnog sistema da hermetički zatvori dentinske kanaliće, deformacijom pod okluzalnim opterećenjem ili prodorom bakterijskih toksina. Cilj rada. Cilj istraživanja je bio da se ispita da li je osetljivost zuba manja kod kompozita s malom kontrakcijom u poređenju s konvencionalnim kompozitima i odgovarajućim adhezivnim sistemima, kao i uticaj veštine stomatologa na incidenciju postoperacione osetljivosti zuba. Metode rada. Na 960 premolara i molara stalne denticije s primarnim karijesom, pacijenata starosti od 21 godine do 40 godina, preparisani su kaviteti dubine 2-3 mm s rubovima u gleđi. Čitavu proceduru su obavila četiri specijalista stomatologije, od kojih su dva imala pet (A i B), a druga dva više od 20 godina kliničkog iskustva (C i D). Zubi su svrstani u osam grupa od po 120 uzoraka prema korišćenom kompozitnom i adhezivnom sistemu: 1) Els®+James-2; 2) Els®+James-2 (nova formula); 3) Els®+Excite; 4) InTenSe®+James-2; 5) InTenSe®+James-2 (nova formula); 6) InTenSe®+Excite; 7) Tetric Ceram®+Excite; i 8) Point 4®+OptiBond Solo Plus. Dve nedelje posle intervencije dva nezavisna stomatologa (koja nisu učestvovala u kliničkoj proceduri) ocenjivala su posebnim upitnicima postoperacionu osetljivost zuba. Podaci su analizirani neparametrijskim c2, Man-Vitnijevim (Mann-Whitney) i ANOVA testom. Rezultati. U osmoj grupi utvrđena je statistički značajno češća postoperaciona osetljivost nego u ostalim grupama zuba. Nije bilo statistički značajne razlike između grupa 1, 2, 3, 4, 5, 6 i 7. Kompoziti sa nižom polimerizacionom kontrakcijom izazvali su manju postoperacionu ostetljivost, ali bez statističke značajnosti razlika (grupe 2, 3 i 5). Kod stomatologa A javljala se statistički značajno češće postoperaciona osetljivost nego kod ostala tri. Zaključak. Tip kompozitnog materijala s odgovarajućim adhezivnim sistemom i spretnost stomatologa utiču na učestalost pojave osetljivosti zuba posle restauracija srednje dubokih kaviteta II klase.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Postoperative sensitivity associated with low shrinkage versus conventional composites, Uticaj kompozita s malom kontrakcijom i konvencionalnih kompozita na postoperacionu osetljivost zuba",
volume = "141",
number = "7-8",
pages = "447-453",
doi = "10.2298/SARH1308447I"
}

Ivanović, V., Savić-Stanković, T., Karadžić, B., Ilić, J., Santini, A.,& Beljić-Ivanović, K.. (2013). Postoperative sensitivity associated with low shrinkage versus conventional composites. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 141(7-8), 447-453.
https://doi.org/10.2298/SARH1308447I

Ivanović V, Savić-Stanković T, Karadžić B, Ilić J, Santini A, Beljić-Ivanović K. Postoperative sensitivity associated with low shrinkage versus conventional composites. in Srpski arhiv za celokupno lekarstvo. 2013;141(7-8):447-453.
doi:10.2298/SARH1308447I .

Ivanović, Vladimir, Savić-Stanković, Tatjana, Karadžić, Branislav, Ilić, Jugoslav, Santini, Ario, Beljić-Ivanović, Katarina, "Postoperative sensitivity associated with low shrinkage versus conventional composites" in Srpski arhiv za celokupno lekarstvo, 141, no. 7-8 (2013):447-453,
https://doi.org/10.2298/SARH1308447I . .

TY  - THES
AU  - Ilić, Jugoslav
PY  - 2012
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=588
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:6748/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024187022
UR  - http://nardus.mpn.gov.rs/123456789/2691
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/956
AB  - Dental pulp is a connective tissue which makes embryologic, anatomic and functional entity with surrounding dentin referred to as the pulp-dentin complex. Due to specific localization within solid dentinal walls, as well as unique vasculature, pulp reactions significantly differ to reactions of other connective tissues. Commence, type and intensity of pulp reparative response depend on cellular events including upregulation of synthetic and secretory activity of odontoblasts, specific cytodifferentiation, and neovascularization at the injury site. The signaling molecules involved in induction and regulation of these events are growth factors including very important bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor (VEGF). BMP-2 expression was found to be increased during tertiary dentinogenesis, and significant role of this growth factor in differentiation of cells involved in pulp reparative response was established. Neovascularization, regulated by VEGF activity, was found to be critical for pulp reparative reaction. Diabetes mellitus (DM) is wide spread disease causing metabolic alterations as a result of increased oxidative stress in tissues. Significant consequence of this pathogenic mechanism is alteration in tissue levels of growth factors, particularly VEGF, but also BMP-2. Considering the importance of BMP-2 and VEGF in processes of dentinal reparation, and the fact that DM alters the function of these growth factors in various tissues, the hypothesis of this study was that DM significantly alters the level and role of BMP-2 and VEGF in pulp reparative responses...
AB  - Zubna pulpa je vezivno tkivo koje sa dentinom, koji je okružuje čini jedinstvenu embriološku i anatomsko-fiziolšku celinu koja se uobičajno naziva pulpodentinski kompleks. Reakcije pulpe, uključujući i reparatorne procese, razlikuju se u osnovi od reakcije drugih vezivnih tkiva zbog njene specifične lokalizacije unutar čvrstih dentinskih zidova, kao i jedinstvenog vaskularnog sistema. Početak, vrsta i intenzitet reparatornog odgovora pulpe zavisi od niza ćelijskih procesa kao što su stimulacija sekrecije odontoblasta, specifična citodiferencijacija (odontoblasti, endotelijalne ćelije), kao i neovaskularizacija na mestu povrede. Signalni molekuli uključeni u transdukcione mehanizme ovih procesa su tkivni faktori rasta od kojih su od posebne važnosti koštani morfogenetski protein 2 (BMP-2) i faktor rasta vaskularnog endotela (VEGF). Povećana ekspresija BMP-2 je nađena u ćelijama pulpe tokom tercijerne dentinogeneze i utvrđena je uloga ovog faktora rasta na diferencijaciju specifičnih ćelija pulpe neophodnih u reparatornom odgovoru. Proces neovaskularizacije, regulisan aktivnošću VEGF, kritičan je za adekvatan pulpni reparativni odgovor. Diabetes mellitus (DM) je rasprostranjeno oboljenje koje dovodi do brojnih metaboličkih poremećaja sa povećanjem oksidativnog stresa u tkivima. Značajne posledice ovog patofiziološkog procesa su i promene u tkivnim koncentracijama raznih faktora rasta, posebno VEGF ali i BMP-2. Imajući u vidu značaj BMP-2 i VEGF u procesima reparacije dentina u zdravim zubima, kao i činjenicu da dijabetes u mnogim tkivima menja funkciju ovih faktora rasta, postavili smo hipotezu da dijabetes značajno menja nivo i ulogu BMP-2 i VEGF u reparatornim odgovorima pulpe...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - The significance of vascular endothelial growth factor and bone morphogenetic protein-2 in reparative abilities of healthy and diabetic dental pulp
T1  - Značaj vaskularnog endotelnog faktora rasta i kostnog morfogenetskog proteina-2 za reparatorne sposobnosti zdrave i dijabetesom izmenjene zubne pulpe
UR  - https://hdl.handle.net/21.15107/rcub_nardus_2691
ER  - 

@phdthesis{
author = "Ilić, Jugoslav",
year = "2012",
abstract = "Dental pulp is a connective tissue which makes embryologic, anatomic and functional entity with surrounding dentin referred to as the pulp-dentin complex. Due to specific localization within solid dentinal walls, as well as unique vasculature, pulp reactions significantly differ to reactions of other connective tissues. Commence, type and intensity of pulp reparative response depend on cellular events including upregulation of synthetic and secretory activity of odontoblasts, specific cytodifferentiation, and neovascularization at the injury site. The signaling molecules involved in induction and regulation of these events are growth factors including very important bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor (VEGF). BMP-2 expression was found to be increased during tertiary dentinogenesis, and significant role of this growth factor in differentiation of cells involved in pulp reparative response was established. Neovascularization, regulated by VEGF activity, was found to be critical for pulp reparative reaction. Diabetes mellitus (DM) is wide spread disease causing metabolic alterations as a result of increased oxidative stress in tissues. Significant consequence of this pathogenic mechanism is alteration in tissue levels of growth factors, particularly VEGF, but also BMP-2. Considering the importance of BMP-2 and VEGF in processes of dentinal reparation, and the fact that DM alters the function of these growth factors in various tissues, the hypothesis of this study was that DM significantly alters the level and role of BMP-2 and VEGF in pulp reparative responses..., Zubna pulpa je vezivno tkivo koje sa dentinom, koji je okružuje čini jedinstvenu embriološku i anatomsko-fiziolšku celinu koja se uobičajno naziva pulpodentinski kompleks. Reakcije pulpe, uključujući i reparatorne procese, razlikuju se u osnovi od reakcije drugih vezivnih tkiva zbog njene specifične lokalizacije unutar čvrstih dentinskih zidova, kao i jedinstvenog vaskularnog sistema. Početak, vrsta i intenzitet reparatornog odgovora pulpe zavisi od niza ćelijskih procesa kao što su stimulacija sekrecije odontoblasta, specifična citodiferencijacija (odontoblasti, endotelijalne ćelije), kao i neovaskularizacija na mestu povrede. Signalni molekuli uključeni u transdukcione mehanizme ovih procesa su tkivni faktori rasta od kojih su od posebne važnosti koštani morfogenetski protein 2 (BMP-2) i faktor rasta vaskularnog endotela (VEGF). Povećana ekspresija BMP-2 je nađena u ćelijama pulpe tokom tercijerne dentinogeneze i utvrđena je uloga ovog faktora rasta na diferencijaciju specifičnih ćelija pulpe neophodnih u reparatornom odgovoru. Proces neovaskularizacije, regulisan aktivnošću VEGF, kritičan je za adekvatan pulpni reparativni odgovor. Diabetes mellitus (DM) je rasprostranjeno oboljenje koje dovodi do brojnih metaboličkih poremećaja sa povećanjem oksidativnog stresa u tkivima. Značajne posledice ovog patofiziološkog procesa su i promene u tkivnim koncentracijama raznih faktora rasta, posebno VEGF ali i BMP-2. Imajući u vidu značaj BMP-2 i VEGF u procesima reparacije dentina u zdravim zubima, kao i činjenicu da dijabetes u mnogim tkivima menja funkciju ovih faktora rasta, postavili smo hipotezu da dijabetes značajno menja nivo i ulogu BMP-2 i VEGF u reparatornim odgovorima pulpe...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "The significance of vascular endothelial growth factor and bone morphogenetic protein-2 in reparative abilities of healthy and diabetic dental pulp, Značaj vaskularnog endotelnog faktora rasta i kostnog morfogenetskog proteina-2 za reparatorne sposobnosti zdrave i dijabetesom izmenjene zubne pulpe",
url = "https://hdl.handle.net/21.15107/rcub_nardus_2691"
}

Ilić, J.. (2012). The significance of vascular endothelial growth factor and bone morphogenetic protein-2 in reparative abilities of healthy and diabetic dental pulp. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_2691

Ilić J. The significance of vascular endothelial growth factor and bone morphogenetic protein-2 in reparative abilities of healthy and diabetic dental pulp. 2012;.
https://hdl.handle.net/21.15107/rcub_nardus_2691 .

Ilić, Jugoslav, "The significance of vascular endothelial growth factor and bone morphogenetic protein-2 in reparative abilities of healthy and diabetic dental pulp" (2012),
https://hdl.handle.net/21.15107/rcub_nardus_2691 .

TY  - JOUR
AU  - Ilić, Jugoslav
AU  - Radović, Katarina
AU  - Roganović, Jelena
AU  - Brković, Božidar
AU  - Stojić, Dragica
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1735
AB  - Introduction: Vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP 2) are growth factors (GFs) identified within the dentine-pulp complex and involved into the cellular events connected to the pulp-healing response. It is well established that the expression of these GFs is increased in different tissues in diabetes mellitus. Because there are no data concerning the levels of VEGF and BMP 2 in human dental pulp, the aim of present study was to quantify VEGF and BMP 2 levels in intact dental pulp and dental pulp that underwent reactive dentinogenesis in healthy and diabetic human subjects. Methods: The study was conducted on 28 healthy and 28 subjects with controlled diabetes type II who underwent pulp extirpation as a part of prosthetic rehabilitation. Pulp were collected from intact teeth and teeth treated by indirect pulp capping. The levels of VEGF and BMP 2 were determined in the pulp tissue lysates with enzyme-linked immunosorbent assay. Results: The levels of VEGF and BMP 2 were significantly higher in intact teeth pulp of diabetic than in healthy subjects. The concentrations of these GFs were significantly lowered in teeth with indirect pulp capping both in healthy and diabetic persons. Furthermore, VEGF and BMP 2 levels were in strong positive correlation. Conclusions: Similar changes in the levels of VEGF and BMP 2 in intact and treated teeth of healthy and diabetic patients could be suggestive of associated roles of these GFs in responses of healthy and diabetic dental pulp. (J Endod 2012;38:764-768)
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients
VL  - 38
IS  - 6
SP  - 764
EP  - 768
DO  - 10.1016/j.joen.2012.03.016
ER  - 

@article{
author = "Ilić, Jugoslav and Radović, Katarina and Roganović, Jelena and Brković, Božidar and Stojić, Dragica",
year = "2012",
abstract = "Introduction: Vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP 2) are growth factors (GFs) identified within the dentine-pulp complex and involved into the cellular events connected to the pulp-healing response. It is well established that the expression of these GFs is increased in different tissues in diabetes mellitus. Because there are no data concerning the levels of VEGF and BMP 2 in human dental pulp, the aim of present study was to quantify VEGF and BMP 2 levels in intact dental pulp and dental pulp that underwent reactive dentinogenesis in healthy and diabetic human subjects. Methods: The study was conducted on 28 healthy and 28 subjects with controlled diabetes type II who underwent pulp extirpation as a part of prosthetic rehabilitation. Pulp were collected from intact teeth and teeth treated by indirect pulp capping. The levels of VEGF and BMP 2 were determined in the pulp tissue lysates with enzyme-linked immunosorbent assay. Results: The levels of VEGF and BMP 2 were significantly higher in intact teeth pulp of diabetic than in healthy subjects. The concentrations of these GFs were significantly lowered in teeth with indirect pulp capping both in healthy and diabetic persons. Furthermore, VEGF and BMP 2 levels were in strong positive correlation. Conclusions: Similar changes in the levels of VEGF and BMP 2 in intact and treated teeth of healthy and diabetic patients could be suggestive of associated roles of these GFs in responses of healthy and diabetic dental pulp. (J Endod 2012;38:764-768)",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients",
volume = "38",
number = "6",
pages = "764-768",
doi = "10.1016/j.joen.2012.03.016"
}

Ilić, J., Radović, K., Roganović, J., Brković, B.,& Stojić, D.. (2012). The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients. in Journal of Endodontics
Elsevier Science Inc, New York., 38(6), 764-768.
https://doi.org/10.1016/j.joen.2012.03.016

Ilić J, Radović K, Roganović J, Brković B, Stojić D. The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients. in Journal of Endodontics. 2012;38(6):764-768.
doi:10.1016/j.joen.2012.03.016 .

Ilić, Jugoslav, Radović, Katarina, Roganović, Jelena, Brković, Božidar, Stojić, Dragica, "The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients" in Journal of Endodontics, 38, no. 6 (2012):764-768,
https://doi.org/10.1016/j.joen.2012.03.016 . .

TY  - JOUR
AU  - Ilić, Jugoslav
AU  - Vujašković, Mirjana
AU  - Nedeljković, Ružica
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1604
AB  - The most important requirements for successful endodontic treatment are accurate diagnosis and good knowledge of canal morphology. A mandibular second premolars rarely have more than one root and one root canal. Data from the literature indicate low percentage of a mandibular premolars with three or more root canals. Unusual morphology of the root canal system is diagnostic and therapeutic challenge. It is very important to analyze preoperative radiograph and to explore thoroughly the entrance of the root canal. The aim of this study was to present two patients who had lower second premolars with three canals that required endodontic therapy.
AB  - Jedan od osnovnih uslova uspešnog endodontskog lečenja je precizna dijagnostika i dobro poznavanje morfologije kanalnog sistema zuba. Donji drugi premolar retko ima više od jednog korena i jednog kanala. Podaci iz literature ukazuju na izuzetno mali procenat donjih drugih premolara sa tri i više kanala korena. Neuobičajeni morfološki izgled kanalnog sistema predstavlja dijagnostički i terapijski izazov. Za postavljanje tačne dijagnoze od izuzetne važnosti su analiza radiograma načinjenog pre hirurškog zahvata i pažljiva eksploracija ulaza u kanale korena. U ovom radu prikazana su dva pacijenta sa trokanalnim donjim drugim premolarima koje je bilo potrebno endodontski lečiti.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Endodontic therapy of a mandibular premolar with three root canals: Two case reports
T1  - Endodontsko lečenje donjeg drugog premolara sa tri kanala korena - prikaz dva klinička slučaja
VL  - 57
IS  - 3
SP  - 163
EP  - 169
DO  - 10.2298/SGS1003163I
ER  - 

@article{
author = "Ilić, Jugoslav and Vujašković, Mirjana and Nedeljković, Ružica",
year = "2010",
abstract = "The most important requirements for successful endodontic treatment are accurate diagnosis and good knowledge of canal morphology. A mandibular second premolars rarely have more than one root and one root canal. Data from the literature indicate low percentage of a mandibular premolars with three or more root canals. Unusual morphology of the root canal system is diagnostic and therapeutic challenge. It is very important to analyze preoperative radiograph and to explore thoroughly the entrance of the root canal. The aim of this study was to present two patients who had lower second premolars with three canals that required endodontic therapy., Jedan od osnovnih uslova uspešnog endodontskog lečenja je precizna dijagnostika i dobro poznavanje morfologije kanalnog sistema zuba. Donji drugi premolar retko ima više od jednog korena i jednog kanala. Podaci iz literature ukazuju na izuzetno mali procenat donjih drugih premolara sa tri i više kanala korena. Neuobičajeni morfološki izgled kanalnog sistema predstavlja dijagnostički i terapijski izazov. Za postavljanje tačne dijagnoze od izuzetne važnosti su analiza radiograma načinjenog pre hirurškog zahvata i pažljiva eksploracija ulaza u kanale korena. U ovom radu prikazana su dva pacijenta sa trokanalnim donjim drugim premolarima koje je bilo potrebno endodontski lečiti.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Endodontic therapy of a mandibular premolar with three root canals: Two case reports, Endodontsko lečenje donjeg drugog premolara sa tri kanala korena - prikaz dva klinička slučaja",
volume = "57",
number = "3",
pages = "163-169",
doi = "10.2298/SGS1003163I"
}

Ilić, J., Vujašković, M.,& Nedeljković, R.. (2010). Endodontic therapy of a mandibular premolar with three root canals: Two case reports. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 57(3), 163-169.
https://doi.org/10.2298/SGS1003163I

Ilić J, Vujašković M, Nedeljković R. Endodontic therapy of a mandibular premolar with three root canals: Two case reports. in Stomatološki glasnik Srbije. 2010;57(3):163-169.
doi:10.2298/SGS1003163I .

Ilić, Jugoslav, Vujašković, Mirjana, Nedeljković, Ružica, "Endodontic therapy of a mandibular premolar with three root canals: Two case reports" in Stomatološki glasnik Srbije, 57, no. 3 (2010):163-169,
https://doi.org/10.2298/SGS1003163I . .

TY  - JOUR
AU  - Živković, Rade
AU  - Milić-Lemić, Aleksandra
AU  - Tihaček-Šojić, Ljiljana
AU  - Ilić, Jugoslav
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1583
AB  - Feline dental resorptive lesions affect more than one third of all adult domestic cats and continue to be an enigma in the veterinary dental science although different theories about the pathogenesis of these lesions have been proposed. Recently, a hypothesis was introduced that local mechanical trauma could be an important factor in the initiation of feline dental resorptive lesions and that there is a correlation between the occurrence of resorptive lesions and occlusal trauma in cats. The aim of this study was to analyze stress distribution in feline tooth during occlusal loading in order to accept or reject the hypothesis that dental resorptive lesions in cats might be caused by occlusal trauma. A solid model of feline tooth had to be created in order to perform the investigation. The idea was to gain data for tooth displacement (deformation) and stress and strain distribution under loading generally for any feline tooth using the finite element method. The results of the study contribute to the theory that occlusal overload might be one of the causes in multifactorial resorptive lesions in cats. Succession of tensile and compressive stresses and tooth displacement during occlusal loading might be a contributive factor in the pathogenesis of feline resorptive lesions. However, further research is required to confirm this statement.
AB  - Dentalne resorptivne lezije kod mačaka su vrlo čest nalaz, i mogu se uočiti u više od jedne trećine domaćih mačaka. One su i dalje enigma u veterinarskoj stomatologiji iako je do sada postavljeno mnogo teorija o njihovom nastanku. Nedavno je predložena hipoteza da je lokalna mehanička trauma veoma značajan faktor u inicijaciji dentalnih resorptivnih lezija u mačaka i da postoji veza između nastajanja lezija i postojanja okluzalne traume. Cilj ove studije je da se analizira distribucija napona i deformacija unutar bilo kog zuba mačke tokom okluzalnog opterećenja, kako bi se potvrdila ili odbacila hipoteza da je okluzalna trauma mogući etiološki faktor u nastajanju dentalnih resorptivnih lezija u mačaka. Za sprovođenje ovog istraživanja bilo je potrebno krerirati matematički model bilo kog zuba mačke. Osnovna ideja je bila analizirati distribuciju napona i pomeranja tokom okluzalnog opterećenja pomoću metode konačnih elemenata. Rezultati ove studije daju doprinos teoriji da okluzalno preopterećenje može biti etiološki faktor nastajanja dentalnih resorptivnih lezija u mačaka. Naizmenično smenjivanje zateznog i kompresionog napona u strukturama zuba tokom mastikacije može imati uticaja u patogenezi dentalnih resorptivnih lezija u mačaka.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Biomechanical aspect of feline dental resorptive lesions formation
T1  - Biomehanički aspekt nastajanja dentalnih resorptivnih lezija u mačaka
VL  - 60
IS  - 2-3
SP  - 303
EP  - 311
DO  - 10.2298/AVB1003303Z
ER  - 

@article{
author = "Živković, Rade and Milić-Lemić, Aleksandra and Tihaček-Šojić, Ljiljana and Ilić, Jugoslav",
year = "2010",
abstract = "Feline dental resorptive lesions affect more than one third of all adult domestic cats and continue to be an enigma in the veterinary dental science although different theories about the pathogenesis of these lesions have been proposed. Recently, a hypothesis was introduced that local mechanical trauma could be an important factor in the initiation of feline dental resorptive lesions and that there is a correlation between the occurrence of resorptive lesions and occlusal trauma in cats. The aim of this study was to analyze stress distribution in feline tooth during occlusal loading in order to accept or reject the hypothesis that dental resorptive lesions in cats might be caused by occlusal trauma. A solid model of feline tooth had to be created in order to perform the investigation. The idea was to gain data for tooth displacement (deformation) and stress and strain distribution under loading generally for any feline tooth using the finite element method. The results of the study contribute to the theory that occlusal overload might be one of the causes in multifactorial resorptive lesions in cats. Succession of tensile and compressive stresses and tooth displacement during occlusal loading might be a contributive factor in the pathogenesis of feline resorptive lesions. However, further research is required to confirm this statement., Dentalne resorptivne lezije kod mačaka su vrlo čest nalaz, i mogu se uočiti u više od jedne trećine domaćih mačaka. One su i dalje enigma u veterinarskoj stomatologiji iako je do sada postavljeno mnogo teorija o njihovom nastanku. Nedavno je predložena hipoteza da je lokalna mehanička trauma veoma značajan faktor u inicijaciji dentalnih resorptivnih lezija u mačaka i da postoji veza između nastajanja lezija i postojanja okluzalne traume. Cilj ove studije je da se analizira distribucija napona i deformacija unutar bilo kog zuba mačke tokom okluzalnog opterećenja, kako bi se potvrdila ili odbacila hipoteza da je okluzalna trauma mogući etiološki faktor u nastajanju dentalnih resorptivnih lezija u mačaka. Za sprovođenje ovog istraživanja bilo je potrebno krerirati matematički model bilo kog zuba mačke. Osnovna ideja je bila analizirati distribuciju napona i pomeranja tokom okluzalnog opterećenja pomoću metode konačnih elemenata. Rezultati ove studije daju doprinos teoriji da okluzalno preopterećenje može biti etiološki faktor nastajanja dentalnih resorptivnih lezija u mačaka. Naizmenično smenjivanje zateznog i kompresionog napona u strukturama zuba tokom mastikacije može imati uticaja u patogenezi dentalnih resorptivnih lezija u mačaka.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Biomechanical aspect of feline dental resorptive lesions formation, Biomehanički aspekt nastajanja dentalnih resorptivnih lezija u mačaka",
volume = "60",
number = "2-3",
pages = "303-311",
doi = "10.2298/AVB1003303Z"
}

Živković, R., Milić-Lemić, A., Tihaček-Šojić, L.,& Ilić, J.. (2010). Biomechanical aspect of feline dental resorptive lesions formation. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 60(2-3), 303-311.
https://doi.org/10.2298/AVB1003303Z

Živković R, Milić-Lemić A, Tihaček-Šojić L, Ilić J. Biomechanical aspect of feline dental resorptive lesions formation. in Acta veterinaria. 2010;60(2-3):303-311.
doi:10.2298/AVB1003303Z .

Živković, Rade, Milić-Lemić, Aleksandra, Tihaček-Šojić, Ljiljana, Ilić, Jugoslav, "Biomechanical aspect of feline dental resorptive lesions formation" in Acta veterinaria, 60, no. 2-3 (2010):303-311,
https://doi.org/10.2298/AVB1003303Z . .

TY  - JOUR
AU  - Tihaček-Šojić, Ljiljana
AU  - Milić, Aleksandra
AU  - Živković, Rade
AU  - Ilić, Jugoslav
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1322
AB  - Mechanical behavior of biological structures is a common subject of scientific research. The results of such investigations offer the precise insight into the biomechanical properties of biological structures and are usefull for predicting their behavior when subjected to loading. Although, such biomechanical investigations were conducted on experimental animals nowadays are very popular investigations concerning mathematical experimental models. The most common is the finite element method analysis. A digital model of a structure of interest has to be created for an investigation with the finite element method. Once the digital model is created with the use of computer technology numerous changes of elements and structures are possible, with different applications of the simulated load. The aim of this paper was to to present the development of our own three-dimensional tooth model created for finite element analyses of intact tooth behavior under functional loading. Also, the idea was to evaluate the possibility for using finite element analysis in veterinary biomechanical research. Our own 3D model was created using computer software according to available literature data, and facts gained from freshly extracted intact teeth and plaster models. It is necessary to emphasize that FEM is an effective tool that has been adapted from the engineering arena to biomechanic research and has the potential to contribute to the growing scientific basis of knowledge in veterinary dentistry.
AB  - Mehaničko ponašanje bioloških struktura je vrlo čest predmet naučnih istraživanja. Rezultati takvih istraživanja pružaju precizne podatke o biomehaničkim karakteristikama bioloških struktura i kao takvi su korisni za predviđanje ponašanja struktura kada su izložene opterećenjima. Iako su za sprovođenje takvih istraživanja često korišćene ekesperimentalne životinje, u novije vreme sve su češća takva istraživanja na matematičkim modelima. Pri tome primat ima metoda konačnih elemenata. Da bi se sprovelo istraživanje metodom konačnih elemenata potrebno je napraviti digitalni model strukture koja je predmet istraživanja. Jednom napravljen matematički digitalni model omogućuje primenom računara beskonačan broj promena oblika pojedinih elemenata i struktura, ali takođe i bezbroj simulacija aplikacija sila. Cilj ovog rada bio je prikazati način dobijanja trodimezionalnog modela zuba potrebnog za sprovođenje analiza ponašanja zuba nakon okluzalnog opterećenja metodom konačnih elemenata kao i proceniti mogućnost primene ove metode u biomehaničkim istraživanjima u veterinarskoj nauci. Na osnovu podataka iz literature, analizom morfologije ekstrahovanih zuba i plastičnih zuba u odgovarajućim kompjuterskim programima izvršeno je kreiranje sopstvenog modela intaktnog zuba. Posebno treba istaći da je MKE vrlo efikasan istraživački alat koji je preuzet iz inžinjerskih oblasti i ima potencijala za širu primenu u veterinarskoj nauci, posebno stomatologiji. .
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Anatomically based 3D geometric modeling of specific biological structures
T1  - Anatomsko 3D modeliranje specifičnih bioloških struktura
VL  - 57
IS  - 4
SP  - 381
EP  - 390
DO  - 10.2298/AVB0704381T
ER  - 

@article{
author = "Tihaček-Šojić, Ljiljana and Milić, Aleksandra and Živković, Rade and Ilić, Jugoslav",
year = "2007",
abstract = "Mechanical behavior of biological structures is a common subject of scientific research. The results of such investigations offer the precise insight into the biomechanical properties of biological structures and are usefull for predicting their behavior when subjected to loading. Although, such biomechanical investigations were conducted on experimental animals nowadays are very popular investigations concerning mathematical experimental models. The most common is the finite element method analysis. A digital model of a structure of interest has to be created for an investigation with the finite element method. Once the digital model is created with the use of computer technology numerous changes of elements and structures are possible, with different applications of the simulated load. The aim of this paper was to to present the development of our own three-dimensional tooth model created for finite element analyses of intact tooth behavior under functional loading. Also, the idea was to evaluate the possibility for using finite element analysis in veterinary biomechanical research. Our own 3D model was created using computer software according to available literature data, and facts gained from freshly extracted intact teeth and plaster models. It is necessary to emphasize that FEM is an effective tool that has been adapted from the engineering arena to biomechanic research and has the potential to contribute to the growing scientific basis of knowledge in veterinary dentistry., Mehaničko ponašanje bioloških struktura je vrlo čest predmet naučnih istraživanja. Rezultati takvih istraživanja pružaju precizne podatke o biomehaničkim karakteristikama bioloških struktura i kao takvi su korisni za predviđanje ponašanja struktura kada su izložene opterećenjima. Iako su za sprovođenje takvih istraživanja često korišćene ekesperimentalne životinje, u novije vreme sve su češća takva istraživanja na matematičkim modelima. Pri tome primat ima metoda konačnih elemenata. Da bi se sprovelo istraživanje metodom konačnih elemenata potrebno je napraviti digitalni model strukture koja je predmet istraživanja. Jednom napravljen matematički digitalni model omogućuje primenom računara beskonačan broj promena oblika pojedinih elemenata i struktura, ali takođe i bezbroj simulacija aplikacija sila. Cilj ovog rada bio je prikazati način dobijanja trodimezionalnog modela zuba potrebnog za sprovođenje analiza ponašanja zuba nakon okluzalnog opterećenja metodom konačnih elemenata kao i proceniti mogućnost primene ove metode u biomehaničkim istraživanjima u veterinarskoj nauci. Na osnovu podataka iz literature, analizom morfologije ekstrahovanih zuba i plastičnih zuba u odgovarajućim kompjuterskim programima izvršeno je kreiranje sopstvenog modela intaktnog zuba. Posebno treba istaći da je MKE vrlo efikasan istraživački alat koji je preuzet iz inžinjerskih oblasti i ima potencijala za širu primenu u veterinarskoj nauci, posebno stomatologiji. .",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Anatomically based 3D geometric modeling of specific biological structures, Anatomsko 3D modeliranje specifičnih bioloških struktura",
volume = "57",
number = "4",
pages = "381-390",
doi = "10.2298/AVB0704381T"
}

Tihaček-Šojić, L., Milić, A., Živković, R.,& Ilić, J.. (2007). Anatomically based 3D geometric modeling of specific biological structures. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 57(4), 381-390.
https://doi.org/10.2298/AVB0704381T

Tihaček-Šojić L, Milić A, Živković R, Ilić J. Anatomically based 3D geometric modeling of specific biological structures. in Acta veterinaria. 2007;57(4):381-390.
doi:10.2298/AVB0704381T .

Tihaček-Šojić, Ljiljana, Milić, Aleksandra, Živković, Rade, Ilić, Jugoslav, "Anatomically based 3D geometric modeling of specific biological structures" in Acta veterinaria, 57, no. 4 (2007):381-390,
https://doi.org/10.2298/AVB0704381T . .

TY  - JOUR
AU  - Milić-Lemić, Aleksandra
AU  - Tihaček-Šojić, Ljiljana
AU  - Ilić, Jugoslav
AU  - Živković, Rade
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1274
AB  - Biomechanical experimental studies are often a subject of interest to many researchers. The results of such investigations give a full insight of complex structural behavior under loading, visualize potential material weaknesses and evaluate if mechanical factors play a substantial role in the pathogenesis of the lesions of the investigated biological structure. The use of FEM enables most of the researchers to abandon the experimental animal models and expand the investigation on computational models, analyzing stress and strain distribution as an indicator of structural biomechanical behavior. The aim of this paper was to present computational modeling of any (human or animal) intact tooth behavior under loading and evaluate the intact tooth stress and strain distribution pattern. For the investigation to be carried out a mathematical model of an intact tooth had to be created. The difference in stress concentration, when masticatory forces are acting lateraly comparing to the ones acting vertically, can be attributed to the basic mechanical principle of leverage which states that forces concentrate at or near the fulcrum. When subjected to lateral loading, tooth with its root acts as a simple lever that fulcrums near the cervical region. This paper offers the new approach in veterinary dental scientific research. Once when a mathematical model is made, it is possible by changing the parameters to investigate different clinical situations. With increasing popularity of veterinary dentistry, the FEM/computational analyses could became a useful tool in biomechanical veterinary dental research due to its noninvasiveness.
AB  - Biomehanička eksperimentalna istraživanja pružaju potpuni uvid u kompleksno ponašanje bioloških struktura pod opterećenjem, vizualizuju potencijalna slaba mesta u samom materijalu i analiziraju da li mehaničko opterećenje igra ulogu u nastajanju pojedinih patoloških lezija. Primena MKE omogućuje istraživačima da napuste istraživanja na eksperimentalnim životinjama, i da se fokusiraju na kompjuterske modele i analizu distribucije napona i deformacija koji su pokazatelji biomehaničkog ponašanja strukture. Cilj ovog rada je bio da se prikaže ponašanje kompjuterskog modela intaktnog zuba nakon opterećenja i evaluira distribucija napona i deformacija. Da bi se sprovelo ovo istraživanje bilo je potrebno kreirati digitalni model bilo kog zuba (ljudskog ili životinjskog). Razlike u distribuciji napona kod lateralnog opterećenja u odnosu na vertikalno mogu se pripisati jednostavnom mehaničkom principu poluge, koji kaže da se sile koncentrišu na mestu oslanjanja. Kada je zub izložen lateralnim silama, on se ponaša kao jednostavna poluga čiji je oslonac u cervikalnom delu. Ovaj rad unosi novi pristup u istraživanjima u veterinarskoj stomatologiji. Jednom izrađen model, omogućava da se menjanjem parametara ispituju i analiziraju različite kliničke situacije. Sa narastajućom popularnošću veterinarske stomatologije analize MKE mogu postati veoma koristan alat u biomehaničkim istraživanjima, posebno zbog svoje neinvazivnosti.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Computational modeling of specific biological structures behavior
T1  - Kompjutersko modeliranje specifičnih biološko-strukturnih odlika zuba
VL  - 56
IS  - 4
SP  - 367
EP  - 374
DO  - 10.2298/AVB0604367L
ER  - 

@article{
author = "Milić-Lemić, Aleksandra and Tihaček-Šojić, Ljiljana and Ilić, Jugoslav and Živković, Rade",
year = "2006",
abstract = "Biomechanical experimental studies are often a subject of interest to many researchers. The results of such investigations give a full insight of complex structural behavior under loading, visualize potential material weaknesses and evaluate if mechanical factors play a substantial role in the pathogenesis of the lesions of the investigated biological structure. The use of FEM enables most of the researchers to abandon the experimental animal models and expand the investigation on computational models, analyzing stress and strain distribution as an indicator of structural biomechanical behavior. The aim of this paper was to present computational modeling of any (human or animal) intact tooth behavior under loading and evaluate the intact tooth stress and strain distribution pattern. For the investigation to be carried out a mathematical model of an intact tooth had to be created. The difference in stress concentration, when masticatory forces are acting lateraly comparing to the ones acting vertically, can be attributed to the basic mechanical principle of leverage which states that forces concentrate at or near the fulcrum. When subjected to lateral loading, tooth with its root acts as a simple lever that fulcrums near the cervical region. This paper offers the new approach in veterinary dental scientific research. Once when a mathematical model is made, it is possible by changing the parameters to investigate different clinical situations. With increasing popularity of veterinary dentistry, the FEM/computational analyses could became a useful tool in biomechanical veterinary dental research due to its noninvasiveness., Biomehanička eksperimentalna istraživanja pružaju potpuni uvid u kompleksno ponašanje bioloških struktura pod opterećenjem, vizualizuju potencijalna slaba mesta u samom materijalu i analiziraju da li mehaničko opterećenje igra ulogu u nastajanju pojedinih patoloških lezija. Primena MKE omogućuje istraživačima da napuste istraživanja na eksperimentalnim životinjama, i da se fokusiraju na kompjuterske modele i analizu distribucije napona i deformacija koji su pokazatelji biomehaničkog ponašanja strukture. Cilj ovog rada je bio da se prikaže ponašanje kompjuterskog modela intaktnog zuba nakon opterećenja i evaluira distribucija napona i deformacija. Da bi se sprovelo ovo istraživanje bilo je potrebno kreirati digitalni model bilo kog zuba (ljudskog ili životinjskog). Razlike u distribuciji napona kod lateralnog opterećenja u odnosu na vertikalno mogu se pripisati jednostavnom mehaničkom principu poluge, koji kaže da se sile koncentrišu na mestu oslanjanja. Kada je zub izložen lateralnim silama, on se ponaša kao jednostavna poluga čiji je oslonac u cervikalnom delu. Ovaj rad unosi novi pristup u istraživanjima u veterinarskoj stomatologiji. Jednom izrađen model, omogućava da se menjanjem parametara ispituju i analiziraju različite kliničke situacije. Sa narastajućom popularnošću veterinarske stomatologije analize MKE mogu postati veoma koristan alat u biomehaničkim istraživanjima, posebno zbog svoje neinvazivnosti.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Computational modeling of specific biological structures behavior, Kompjutersko modeliranje specifičnih biološko-strukturnih odlika zuba",
volume = "56",
number = "4",
pages = "367-374",
doi = "10.2298/AVB0604367L"
}

Milić-Lemić, A., Tihaček-Šojić, L., Ilić, J.,& Živković, R.. (2006). Computational modeling of specific biological structures behavior. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 56(4), 367-374.
https://doi.org/10.2298/AVB0604367L

Milić-Lemić A, Tihaček-Šojić L, Ilić J, Živković R. Computational modeling of specific biological structures behavior. in Acta veterinaria. 2006;56(4):367-374.
doi:10.2298/AVB0604367L .

Milić-Lemić, Aleksandra, Tihaček-Šojić, Ljiljana, Ilić, Jugoslav, Živković, Rade, "Computational modeling of specific biological structures behavior" in Acta veterinaria, 56, no. 4 (2006):367-374,
https://doi.org/10.2298/AVB0604367L . .

TY  - THES
AU  - Ilić, Jugoslav
PY  - 2005
UR  - https://plus.sr.cobiss.net/opac7/bib/1024034190
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/419
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Učestalost apeksnih periodontitisa endodontski tretiranih zuba
UR  - https://hdl.handle.net/21.15107/rcub_smile_419
ER  - 

@mastersthesis{
author = "Ilić, Jugoslav",
year = "2005",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Učestalost apeksnih periodontitisa endodontski tretiranih zuba",
url = "https://hdl.handle.net/21.15107/rcub_smile_419"
}

Ilić, J.. (2005). Učestalost apeksnih periodontitisa endodontski tretiranih zuba. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_419

Ilić J. Učestalost apeksnih periodontitisa endodontski tretiranih zuba. 2005;.
https://hdl.handle.net/21.15107/rcub_smile_419 .

Ilić, Jugoslav, "Učestalost apeksnih periodontitisa endodontski tretiranih zuba" (2005),
https://hdl.handle.net/21.15107/rcub_smile_419 .