TY  - JOUR
AU  - Popović, Jelena
AU  - Kršljak, Elena
AU  - Grbović, Leposava
AU  - Stojić, Dragica
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2591
AB  - Objective: Acute and chronic actions of lithium on salivation induced by agonists associated with receptor-linked hydrolysis of membrane inositol phospholipids (carbachol and phenylephrine) and by agonist linked to activation of adenylate cyclase (isoproterenol) were investigated. 
Material and methods: In anaesthetized rats, submandibular salivation induced by intravenous injection of carbachol, phenylephrine and isoproterenol, was measured and expressed as volume of fluid (microl) elicited per 100 mg wet weight of each gland per minute. The experiments were repeated after acute and chronic treatment of lithium (7 mg kg(-1)). The results were analysed with unpaired t-test. 
Results: Chronic, but not acute lithium treatment significantly decreases carbachol- and phenylephrine-induced salivation while isoproterenol-induced salivation was not changed neither after acute nor after chronic administration of lithium. 
Conclusion: The results suggest that hyposalivation during chronic lithium therapy could be mediated by alterations in the phosphatidylinositol cycle and a consequent lack of inositol after agonist stimulation.
PB  - John Wiley & Sons, Inc.
PB  - Blackwell Munksgaard
T2  - Oral Diseases
T1  - The effects of acute and chronic lithium treatment on rat submandibular salivation
VL  - 11
IS  - 2
SP  - 100
EP  - 103
DO  - 10.1111/j.1601-0825.2004.01066.x
ER  - 

@article{
author = "Popović, Jelena and Kršljak, Elena and Grbović, Leposava and Stojić, Dragica",
year = "2005",
abstract = "Objective: Acute and chronic actions of lithium on salivation induced by agonists associated with receptor-linked hydrolysis of membrane inositol phospholipids (carbachol and phenylephrine) and by agonist linked to activation of adenylate cyclase (isoproterenol) were investigated. 
Material and methods: In anaesthetized rats, submandibular salivation induced by intravenous injection of carbachol, phenylephrine and isoproterenol, was measured and expressed as volume of fluid (microl) elicited per 100 mg wet weight of each gland per minute. The experiments were repeated after acute and chronic treatment of lithium (7 mg kg(-1)). The results were analysed with unpaired t-test. 
Results: Chronic, but not acute lithium treatment significantly decreases carbachol- and phenylephrine-induced salivation while isoproterenol-induced salivation was not changed neither after acute nor after chronic administration of lithium. 
Conclusion: The results suggest that hyposalivation during chronic lithium therapy could be mediated by alterations in the phosphatidylinositol cycle and a consequent lack of inositol after agonist stimulation.",
publisher = "John Wiley & Sons, Inc., Blackwell Munksgaard",
journal = "Oral Diseases",
title = "The effects of acute and chronic lithium treatment on rat submandibular salivation",
volume = "11",
number = "2",
pages = "100-103",
doi = "10.1111/j.1601-0825.2004.01066.x"
}

Popović, J., Kršljak, E., Grbović, L.,& Stojić, D.. (2005). The effects of acute and chronic lithium treatment on rat submandibular salivation. in Oral Diseases
John Wiley & Sons, Inc.., 11(2), 100-103.
https://doi.org/10.1111/j.1601-0825.2004.01066.x

Popović J, Kršljak E, Grbović L, Stojić D. The effects of acute and chronic lithium treatment on rat submandibular salivation. in Oral Diseases. 2005;11(2):100-103.
doi:10.1111/j.1601-0825.2004.01066.x .

Popović, Jelena, Kršljak, Elena, Grbović, Leposava, Stojić, Dragica, "The effects of acute and chronic lithium treatment on rat submandibular salivation" in Oral Diseases, 11, no. 2 (2005):100-103,
https://doi.org/10.1111/j.1601-0825.2004.01066.x . .

TY  - JOUR
AU  - Stojić, Dragica
AU  - Radenković, Miroslav
AU  - Kršljak, Elena
AU  - Popović, Jelena
AU  - Pešić, Srđan
AU  - Grbović, Leposava
PY  - 2003
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2590
AB  - The aim was to examine the influence of the endothelium on acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) functional responses in the isolated glandular branch of rabbit facial artery precontracted with phenylephrine as well as the potential contribution of nitric oxide (NO) and prostanoids in the ACh- and VIP-induced effects. Acetylcholine caused endothelium-dependent and VIP endothelium-independent relaxations of facial artery. The effect of ACh was partly inhibited by NG-monomethyl-l-arginine (l-NMMA, a non-selective NO synthase inhibitor) or by indomethacin (a cyclooxygenase inhibitor) while being completely blocked after concomitant addition of l-NMMA and indomethacin. The relaxation of the facial artery caused by ACh was unaffected by 65 mm KCl. The VIP-induced vasodilation was potentiated by forskolin (an adenylate cyclase stimulator) and partly reduced by l-NMMA or S-methyl-l-thiocitrulline (l-SMTC, a neuronal NO synthase inhibitor), whereas it was unaffected by indomethacin. These results suggest that ACh effects on the rabbit facial artery are mediated through release of endothelium-derived NO and cyclooxygenase products, while the effect of VIP is most probably mediated by an increase of cyclic adenosine 3',5'-monophosphate (cAMP) in vascular smooth muscles and by VIP-induced release of NO from perivascular nerve fibers.
PB  - John Wiley & Sons, Inc.
T2  - European Journal of Oral Sciences
T1  - Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery
VL  - 111
IS  - 2
SP  - 137
EP  - 143
DO  - 10.1034/j.1600-0722.2003.00021.x
ER  - 

@article{
author = "Stojić, Dragica and Radenković, Miroslav and Kršljak, Elena and Popović, Jelena and Pešić, Srđan and Grbović, Leposava",
year = "2003",
abstract = "The aim was to examine the influence of the endothelium on acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) functional responses in the isolated glandular branch of rabbit facial artery precontracted with phenylephrine as well as the potential contribution of nitric oxide (NO) and prostanoids in the ACh- and VIP-induced effects. Acetylcholine caused endothelium-dependent and VIP endothelium-independent relaxations of facial artery. The effect of ACh was partly inhibited by NG-monomethyl-l-arginine (l-NMMA, a non-selective NO synthase inhibitor) or by indomethacin (a cyclooxygenase inhibitor) while being completely blocked after concomitant addition of l-NMMA and indomethacin. The relaxation of the facial artery caused by ACh was unaffected by 65 mm KCl. The VIP-induced vasodilation was potentiated by forskolin (an adenylate cyclase stimulator) and partly reduced by l-NMMA or S-methyl-l-thiocitrulline (l-SMTC, a neuronal NO synthase inhibitor), whereas it was unaffected by indomethacin. These results suggest that ACh effects on the rabbit facial artery are mediated through release of endothelium-derived NO and cyclooxygenase products, while the effect of VIP is most probably mediated by an increase of cyclic adenosine 3',5'-monophosphate (cAMP) in vascular smooth muscles and by VIP-induced release of NO from perivascular nerve fibers.",
publisher = "John Wiley & Sons, Inc.",
journal = "European Journal of Oral Sciences",
title = "Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery",
volume = "111",
number = "2",
pages = "137-143",
doi = "10.1034/j.1600-0722.2003.00021.x"
}

Stojić, D., Radenković, M., Kršljak, E., Popović, J., Pešić, S.,& Grbović, L.. (2003). Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery. in European Journal of Oral Sciences
John Wiley & Sons, Inc.., 111(2), 137-143.
https://doi.org/10.1034/j.1600-0722.2003.00021.x

Stojić D, Radenković M, Kršljak E, Popović J, Pešić S, Grbović L. Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery. in European Journal of Oral Sciences. 2003;111(2):137-143.
doi:10.1034/j.1600-0722.2003.00021.x .

Stojić, Dragica, Radenković, Miroslav, Kršljak, Elena, Popović, Jelena, Pešić, Srđan, Grbović, Leposava, "Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery" in European Journal of Oral Sciences, 111, no. 2 (2003):137-143,
https://doi.org/10.1034/j.1600-0722.2003.00021.x . .