TY  - JOUR
AU  - Shin, Ki-Hyuk
AU  - Kim, Reuben H.
AU  - Yu, Bo
AU  - Kang, Mo K.
AU  - Elashoff, David
AU  - Christensen, Russell
AU  - Pucar, Ana
AU  - Park, No-Hee
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1607
AB  - We previously reported that wild type (wt) hnRNP G exhibited tumor suppressive activity in human oral squamous cell carcinoma (HOSCC) cell lines lacking hnRNP G. Wt hnRNP G markedly inhibited the proliferation capacity, anchorage independency and in vivo tumorigenicity of HOSCC cells and notably enhanced the DNA repair capabilities of these cells. In the present study, we studied the genetic and expression states of hnRNP G in normal, premalignant and malignant human oral tissues to further understand the relationship between the hnRNP G alterations and the development of human oral cancer. To correlate the cancer development and the level of hnRNP G expression, we performed an immunohistochemistry staining of hnRNP G in normal, premalignant and malignant human oral tissues. Moreover, we examined the entire coding regions of hnRNP G from selected samples to understand the cause of the alterations of the gene expression. The expression of hnRNP G was notably decreased or completely abolished in 80% of premalignant-dysplastic and malignant oral epithelial tissues, whereas 100% of normal and 90% of hyperplastic non-dysplastic epithelium showed high level of hnRNP G in the nucleus of the basal cell layers. Approximately 80% of HOSCC lacking the expression of hnRNP G showed genetic alteration in hnRNP G, i.e., point mutation and exonic deletion. This study suggest that genetic alterations and aberrant expression of hnRNP G occurring during oral carcinogenesis might be useful markers for the early detection of human oral cancer. Published by Elsevier Ltd.
PB  - Elsevier Science Bv, Amsterdam
T2  - Oral Oncology
T1  - Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer
VL  - 47
IS  - 11
SP  - 1011
EP  - 1016
DO  - 10.1016/j.oraloncology.2011.07.012
ER  - 

@article{
author = "Shin, Ki-Hyuk and Kim, Reuben H. and Yu, Bo and Kang, Mo K. and Elashoff, David and Christensen, Russell and Pucar, Ana and Park, No-Hee",
year = "2011",
abstract = "We previously reported that wild type (wt) hnRNP G exhibited tumor suppressive activity in human oral squamous cell carcinoma (HOSCC) cell lines lacking hnRNP G. Wt hnRNP G markedly inhibited the proliferation capacity, anchorage independency and in vivo tumorigenicity of HOSCC cells and notably enhanced the DNA repair capabilities of these cells. In the present study, we studied the genetic and expression states of hnRNP G in normal, premalignant and malignant human oral tissues to further understand the relationship between the hnRNP G alterations and the development of human oral cancer. To correlate the cancer development and the level of hnRNP G expression, we performed an immunohistochemistry staining of hnRNP G in normal, premalignant and malignant human oral tissues. Moreover, we examined the entire coding regions of hnRNP G from selected samples to understand the cause of the alterations of the gene expression. The expression of hnRNP G was notably decreased or completely abolished in 80% of premalignant-dysplastic and malignant oral epithelial tissues, whereas 100% of normal and 90% of hyperplastic non-dysplastic epithelium showed high level of hnRNP G in the nucleus of the basal cell layers. Approximately 80% of HOSCC lacking the expression of hnRNP G showed genetic alteration in hnRNP G, i.e., point mutation and exonic deletion. This study suggest that genetic alterations and aberrant expression of hnRNP G occurring during oral carcinogenesis might be useful markers for the early detection of human oral cancer. Published by Elsevier Ltd.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Oral Oncology",
title = "Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer",
volume = "47",
number = "11",
pages = "1011-1016",
doi = "10.1016/j.oraloncology.2011.07.012"
}

Shin, K., Kim, R. H., Yu, B., Kang, M. K., Elashoff, D., Christensen, R., Pucar, A.,& Park, N.. (2011). Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer. in Oral Oncology
Elsevier Science Bv, Amsterdam., 47(11), 1011-1016.
https://doi.org/10.1016/j.oraloncology.2011.07.012

Shin K, Kim RH, Yu B, Kang MK, Elashoff D, Christensen R, Pucar A, Park N. Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer. in Oral Oncology. 2011;47(11):1011-1016.
doi:10.1016/j.oraloncology.2011.07.012 .

Shin, Ki-Hyuk, Kim, Reuben H., Yu, Bo, Kang, Mo K., Elashoff, David, Christensen, Russell, Pucar, Ana, Park, No-Hee, "Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer" in Oral Oncology, 47, no. 11 (2011):1011-1016,
https://doi.org/10.1016/j.oraloncology.2011.07.012 . .