@article{
author = "Milošević-Marković, Maja and Lazarević, Miloš and Toljić, Boško and Petrović, Milan and Vukadinović, Miroslav and Jezdić, Zoran and Aničić, Boban and Jelovac, Drago and Jovanović, Svetlana and Milašin, Jelena",
year = "2021",
abstract = "Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.",
publisher = "TECH SCIENCE PRESS",
journal = "BIOCELL",
title = "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential",
volume = "45",
number = "6",
pages = "1543-1550",
doi = "10.32604/biocell.2021.015060"
}