TY  - JOUR
AU  - Roganović, Jelena
AU  - Radenković, Miroslav
AU  - Stojić, Dragica
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1592
AB  - Objectives: The influence of carotid artery occlusion (10, 30 and 60 min) on regulatory mechanisms implicated in the vasorelaxant responses of isolated glandular branch of rabbit facial artery to acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) was examined. Design: In organ bath studies with arterial rings precontracted with phenylephrine (1 mu M), before and after carotid artery occlusion, changes in isometric tension were recorded. Results: Endothelium-dependent vasorelaxation by ACh and endothelium-independent vasorelaxation by VIP were significantly reduced, started from 30 and 10 mm of carotid occlusion, respectively. Inhibitory effect of indomethacin on ACh vasorelaxation was enhanced whilst effect of N-G-nitro-L-arginine reduced, started from 30 min of carotid occlusion. Sodium nitroprusside-induced vasorelaxation was not changed after carotid occlusion. Inhibition of VIP vasorelaxation by L-N-omega-nitroarginine-2,4-L-diaminobutyric-amide, was reduced, started from 30 min of carotid occlusion. Forskolin enhanced VIP-induced vasorelaxation in control rings but this effect was reduced started from 30 min of occlusion. In the presence of VIP, vasorelaxant effect of ACh was increased; the increase was reduced, started from 10 min of carotid occlusion. Conclusions: The present investigation provides evidence for the decreased responsiveness to both, ACh-endothelium-dependent and VIP-endothelium-independent vasorelaxation in rabbit facial artery after carotid occlusion. In addition, the data suggest that ischaemia alters contribution of endothelial nitric oxide (eNO) and prostaglandin to ACh, and vascular smooth muscle's cAMP and neuronal NO to VIP vasorelaxant effects.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Archives of Oral Biology
T1  - ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion
VL  - 55
IS  - 5
SP  - 333
EP  - 342
DO  - 10.1016/j.archoralbio.2010.03.006
ER  - 

@article{
author = "Roganović, Jelena and Radenković, Miroslav and Stojić, Dragica",
year = "2010",
abstract = "Objectives: The influence of carotid artery occlusion (10, 30 and 60 min) on regulatory mechanisms implicated in the vasorelaxant responses of isolated glandular branch of rabbit facial artery to acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) was examined. Design: In organ bath studies with arterial rings precontracted with phenylephrine (1 mu M), before and after carotid artery occlusion, changes in isometric tension were recorded. Results: Endothelium-dependent vasorelaxation by ACh and endothelium-independent vasorelaxation by VIP were significantly reduced, started from 30 and 10 mm of carotid occlusion, respectively. Inhibitory effect of indomethacin on ACh vasorelaxation was enhanced whilst effect of N-G-nitro-L-arginine reduced, started from 30 min of carotid occlusion. Sodium nitroprusside-induced vasorelaxation was not changed after carotid occlusion. Inhibition of VIP vasorelaxation by L-N-omega-nitroarginine-2,4-L-diaminobutyric-amide, was reduced, started from 30 min of carotid occlusion. Forskolin enhanced VIP-induced vasorelaxation in control rings but this effect was reduced started from 30 min of occlusion. In the presence of VIP, vasorelaxant effect of ACh was increased; the increase was reduced, started from 10 min of carotid occlusion. Conclusions: The present investigation provides evidence for the decreased responsiveness to both, ACh-endothelium-dependent and VIP-endothelium-independent vasorelaxation in rabbit facial artery after carotid occlusion. In addition, the data suggest that ischaemia alters contribution of endothelial nitric oxide (eNO) and prostaglandin to ACh, and vascular smooth muscle's cAMP and neuronal NO to VIP vasorelaxant effects.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Archives of Oral Biology",
title = "ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion",
volume = "55",
number = "5",
pages = "333-342",
doi = "10.1016/j.archoralbio.2010.03.006"
}

Roganović, J., Radenković, M.,& Stojić, D.. (2010). ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion. in Archives of Oral Biology
Pergamon-Elsevier Science Ltd, Oxford., 55(5), 333-342.
https://doi.org/10.1016/j.archoralbio.2010.03.006

Roganović J, Radenković M, Stojić D. ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion. in Archives of Oral Biology. 2010;55(5):333-342.
doi:10.1016/j.archoralbio.2010.03.006 .

Roganović, Jelena, Radenković, Miroslav, Stojić, Dragica, "ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion" in Archives of Oral Biology, 55, no. 5 (2010):333-342,
https://doi.org/10.1016/j.archoralbio.2010.03.006 . .