Preventive, therapeutic, and ethical approach in preclinical and clinical studies of the genes and modulators of redox cell signaling in immune, inflammatory and proliferative cell response

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Preventive, therapeutic, and ethical approach in preclinical and clinical studies of the genes and modulators of redox cell signaling in immune, inflammatory and proliferative cell response (en)
Превентивни, терапијски и етички приступ преклиничким и клиничким истраживањима гена и модулатора редокс ћелијске сигнализације у имунском, инфламаторном и пролиферативном одговору ћелије (sr)
Preventivni, terapijski i etički pristup prekliničkim i kliničkim istraživanjima gena i modulatora redoks ćelijske signalizacije u imunskom, inflamatornom i proliferativnom odgovoru ćelije (sr_RS)
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Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid

Taso, Ervin; Stefanović, Vladimir; Stevanović, Ivana; Vojvodić, Danilo; Topić, Aleksandra; Petković-Ćurčin, Aleksandra; Obradović-Đuričić, Kosovka; Marković, Aleksa; Đukić, Mirjana; Vujanović, Dragana

(Hindawi Ltd, London, 2018)

TY  - JOUR
AU  - Taso, Ervin
AU  - Stefanović, Vladimir
AU  - Stevanović, Ivana
AU  - Vojvodić, Danilo
AU  - Topić, Aleksandra
AU  - Petković-Ćurčin, Aleksandra
AU  - Obradović-Đuričić, Kosovka
AU  - Marković, Aleksa
AU  - Đukić, Mirjana
AU  - Vujanović, Dragana
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2324
AB  - Biocompatibility of dental materials (DM) can be evaluated by gingival crevicular fluid (GCF) oxidative stress (OS) status. The goal of the study was to ascertain influence of dental caries degree, teeth position, and type and amount of applied DM on GCF OS profile. For this purpose, we tested six DMs that were sealed in one session: amalgam (Amg), composites: Tetric EvoCeram and Beautifil (BF), phosphate cement-zinc phosphate and polycarboxylate cements zinc polycarboxylate cements, and glass ionomer cement (GIC). The study included 88 dental outpatients. Follow-up was scheduled at 7th and 30th day. Oxidative stress parameters (malondialdehyde (MDA) and glutathione (GSH) levels and total superoxide dismutase (tSOD) activity) were measured before (0th day) and after the treatment (7th and 30th day) in GCF. Control teeth were mirror-positioned healthy teeth. The DM accomplished the following effects (listed in descending order): increase of GSH in GCF was realized by ZPoC > BF > GIC > Amg; tSOD activity increase by ZPoC > BF > Amg; and MDA decrease by ZPoC > ZPhC > Amg > TEC. Dental caries provokes insignificant rise of OS in GCF. ZPoC and ZPhC showed the highest antioxidant effect, contrary to GIC. Restorations with antioxidant properties may reduce gum diseases initiated by caries lesion, what is of great clinical relevance in dentistry.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine & Cellular Longevity
T1  - Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid
VL  - 2018
DO  - 10.1155/2018/1823189
ER  - 
@article{
author = "Taso, Ervin and Stefanović, Vladimir and Stevanović, Ivana and Vojvodić, Danilo and Topić, Aleksandra and Petković-Ćurčin, Aleksandra and Obradović-Đuričić, Kosovka and Marković, Aleksa and Đukić, Mirjana and Vujanović, Dragana",
year = "2018",
abstract = "Biocompatibility of dental materials (DM) can be evaluated by gingival crevicular fluid (GCF) oxidative stress (OS) status. The goal of the study was to ascertain influence of dental caries degree, teeth position, and type and amount of applied DM on GCF OS profile. For this purpose, we tested six DMs that were sealed in one session: amalgam (Amg), composites: Tetric EvoCeram and Beautifil (BF), phosphate cement-zinc phosphate and polycarboxylate cements zinc polycarboxylate cements, and glass ionomer cement (GIC). The study included 88 dental outpatients. Follow-up was scheduled at 7th and 30th day. Oxidative stress parameters (malondialdehyde (MDA) and glutathione (GSH) levels and total superoxide dismutase (tSOD) activity) were measured before (0th day) and after the treatment (7th and 30th day) in GCF. Control teeth were mirror-positioned healthy teeth. The DM accomplished the following effects (listed in descending order): increase of GSH in GCF was realized by ZPoC > BF > GIC > Amg; tSOD activity increase by ZPoC > BF > Amg; and MDA decrease by ZPoC > ZPhC > Amg > TEC. Dental caries provokes insignificant rise of OS in GCF. ZPoC and ZPhC showed the highest antioxidant effect, contrary to GIC. Restorations with antioxidant properties may reduce gum diseases initiated by caries lesion, what is of great clinical relevance in dentistry.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine & Cellular Longevity",
title = "Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid",
volume = "2018",
doi = "10.1155/2018/1823189"
}
Taso, E., Stefanović, V., Stevanović, I., Vojvodić, D., Topić, A., Petković-Ćurčin, A., Obradović-Đuričić, K., Marković, A., Đukić, M.,& Vujanović, D.. (2018). Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid. in Oxidative Medicine & Cellular Longevity
Hindawi Ltd, London., 2018.
https://doi.org/10.1155/2018/1823189
Taso E, Stefanović V, Stevanović I, Vojvodić D, Topić A, Petković-Ćurčin A, Obradović-Đuričić K, Marković A, Đukić M, Vujanović D. Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid. in Oxidative Medicine & Cellular Longevity. 2018;2018.
doi:10.1155/2018/1823189 .
Taso, Ervin, Stefanović, Vladimir, Stevanović, Ivana, Vojvodić, Danilo, Topić, Aleksandra, Petković-Ćurčin, Aleksandra, Obradović-Đuričić, Kosovka, Marković, Aleksa, Đukić, Mirjana, Vujanović, Dragana, "Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid" in Oxidative Medicine & Cellular Longevity, 2018 (2018),
https://doi.org/10.1155/2018/1823189 . .
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T4 Glottic carcinoma: oncological results and survival rate

Jancić, Slavisa; Zivić, Miško; Radovanović, Zoran; Miličić, Biljana; Đinđić, Nataša; Đinđić, Boris; Jančić, Snežana

(Drunpp-Sarajevo, Sarajevo, 2011)

TY  - JOUR
AU  - Jancić, Slavisa
AU  - Zivić, Miško
AU  - Radovanović, Zoran
AU  - Miličić, Biljana
AU  - Đinđić, Nataša
AU  - Đinđić, Boris
AU  - Jančić, Snežana
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1611
AB  - Objectives/Background: The best course of action in the case of T4 glottic carcinoma is chosen for each individual case. The aim of this study was to evaluate the potential prognostic factors and influence of postoperative and radical radiotherapy on the survival rate of patients suffering from T4 glottic carcinoma and to analyze the most appropriate conservative treatment for these patients. Methods: Study Design: A retrospective study (1995-2000) enrolled 63 patients with squamo-cellular glottic cancer in T4N1M0 stage, monitored for 5 years, divided into two groups: 30 postoperatively irradiated patients and 33 radically irradiated patients. Analysed variables were: age, sex, total therapeutical dose, number of fractions, dose per fraction and type of radiotherapeutical treatment. Standard therapeutical fractionation regimens were used, with daily sessions of 2-3 Gy, five times a week. Radiotherapy consisted of mega-voltage 10 MEV X-ray therapy. Log Rank test, Kaplan-Meier survival study, t-test, Pearson X2 - test and Cox regression were used in order to select the factors with independent effect. Results: Multivariate analysis demonstrated that none of the predictors, not even the type of radiation therapy, were statistically significant, with independent influence on survival. Conclusion: There is no significant difference in survival of patients with T4 glottic carcinoma among postoperatively and radically irradiated patients. Our results imply that the optimal radiotherapeutic modality for these patients is a total therapeutical dose no less than 65 Gy and daily fractionation with dose no less than 2,51Gy.
PB  - Drunpp-Sarajevo, Sarajevo
T2  - HealthMED
T1  - T4 Glottic carcinoma: oncological results and survival rate
VL  - 5
IS  - 6
SP  - 1737
EP  - 1743
UR  - https://hdl.handle.net/21.15107/rcub_smile_1611
ER  - 
@article{
author = "Jancić, Slavisa and Zivić, Miško and Radovanović, Zoran and Miličić, Biljana and Đinđić, Nataša and Đinđić, Boris and Jančić, Snežana",
year = "2011",
abstract = "Objectives/Background: The best course of action in the case of T4 glottic carcinoma is chosen for each individual case. The aim of this study was to evaluate the potential prognostic factors and influence of postoperative and radical radiotherapy on the survival rate of patients suffering from T4 glottic carcinoma and to analyze the most appropriate conservative treatment for these patients. Methods: Study Design: A retrospective study (1995-2000) enrolled 63 patients with squamo-cellular glottic cancer in T4N1M0 stage, monitored for 5 years, divided into two groups: 30 postoperatively irradiated patients and 33 radically irradiated patients. Analysed variables were: age, sex, total therapeutical dose, number of fractions, dose per fraction and type of radiotherapeutical treatment. Standard therapeutical fractionation regimens were used, with daily sessions of 2-3 Gy, five times a week. Radiotherapy consisted of mega-voltage 10 MEV X-ray therapy. Log Rank test, Kaplan-Meier survival study, t-test, Pearson X2 - test and Cox regression were used in order to select the factors with independent effect. Results: Multivariate analysis demonstrated that none of the predictors, not even the type of radiation therapy, were statistically significant, with independent influence on survival. Conclusion: There is no significant difference in survival of patients with T4 glottic carcinoma among postoperatively and radically irradiated patients. Our results imply that the optimal radiotherapeutic modality for these patients is a total therapeutical dose no less than 65 Gy and daily fractionation with dose no less than 2,51Gy.",
publisher = "Drunpp-Sarajevo, Sarajevo",
journal = "HealthMED",
title = "T4 Glottic carcinoma: oncological results and survival rate",
volume = "5",
number = "6",
pages = "1737-1743",
url = "https://hdl.handle.net/21.15107/rcub_smile_1611"
}
Jancić, S., Zivić, M., Radovanović, Z., Miličić, B., Đinđić, N., Đinđić, B.,& Jančić, S.. (2011). T4 Glottic carcinoma: oncological results and survival rate. in HealthMED
Drunpp-Sarajevo, Sarajevo., 5(6), 1737-1743.
https://hdl.handle.net/21.15107/rcub_smile_1611
Jancić S, Zivić M, Radovanović Z, Miličić B, Đinđić N, Đinđić B, Jančić S. T4 Glottic carcinoma: oncological results and survival rate. in HealthMED. 2011;5(6):1737-1743.
https://hdl.handle.net/21.15107/rcub_smile_1611 .
Jancić, Slavisa, Zivić, Miško, Radovanović, Zoran, Miličić, Biljana, Đinđić, Nataša, Đinđić, Boris, Jančić, Snežana, "T4 Glottic carcinoma: oncological results and survival rate" in HealthMED, 5, no. 6 (2011):1737-1743,
https://hdl.handle.net/21.15107/rcub_smile_1611 .