TY  - JOUR
AU  - Đinić Krasavčević, Ana
AU  - Nikolić, Nadja
AU  - Mijailović, Iva
AU  - Čarkić, Jelena
AU  - Milinković, Iva
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Milašin, Jelena
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2568
AB  - Background and objective
Notch signalling cascade has recently been connected to alveolar bone resorption in periodontitis. Hence, the present cross‐sectional study aimed to analyze the expression of Notch signalling pathway (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1) and periodontitis‐related (tumor necrosis factor alpha‐ TNF‐α, interleukin 17‐IL‐17, receptor activator of nuclear factor‐kappa B ligand—RANKL, osteoprotegerin—OPG) molecules and correlate it with clinical parameters in aggressive (AP) and chronic (CP) periodontitis. Additionally, the aforementioned markers' expression was evaluated in periodontitis patients with different RANKL/OPG ratios.

Material and methods
Eighty patients were enrolled either in AP or CP group. Clinical attachment level (CAL), bleeding on probing (BOP), periodontal probing depth (PPD) and plaque index (PI) were recorded for each patient. Total RNA was extracted from gingival crevicular fluid samples. Relative gene expression of investigated markers was determined by reverse transcriptase‐real‐time polymerase chain reaction.

Results
Significantly higher values of PPD were observed in AP compared to CP (P = .010). Negative correlations between OPG and CAL, and OPG and PI, were found in AP (P = .045, P = .006, respectively), while Hey 1 and PI had a positive correlation (P = .049). In multivariate linear regression analysis, OPG and Notch 2 were predictors of CAL in AP group. TNF‐α and IL‐17 were higher in RANKL predominant than in OPG predominant cases (P = .007, P = .001, respectively). In RANKL predominant lesions Notch 1 and Jagged 1 were down‐regulated in AP compared to CP patients (P = .010, P = .025, respectively).

Conclusion
The present study demonstrated that changes in Notch 2 expression affected CAL in AP cases hence this molecule could be considered as a contributor to alveolar bone loss. In RANKL‐activated settings, the down‐regulation of Notch 1 might participate in more severe bone resorption in AP.
PB  - Wiley
T2  - Journal of Periodontal Research
T1  - Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis
VL  - 56
IS  - 1
SP  - 131
EP  - 138
DO  - 10.1111/jre.12801
ER  - 

@article{
author = "Đinić Krasavčević, Ana and Nikolić, Nadja and Mijailović, Iva and Čarkić, Jelena and Milinković, Iva and Janković, Saša and Aleksić, Zoran and Milašin, Jelena",
year = "2021",
abstract = "Background and objective
Notch signalling cascade has recently been connected to alveolar bone resorption in periodontitis. Hence, the present cross‐sectional study aimed to analyze the expression of Notch signalling pathway (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1) and periodontitis‐related (tumor necrosis factor alpha‐ TNF‐α, interleukin 17‐IL‐17, receptor activator of nuclear factor‐kappa B ligand—RANKL, osteoprotegerin—OPG) molecules and correlate it with clinical parameters in aggressive (AP) and chronic (CP) periodontitis. Additionally, the aforementioned markers' expression was evaluated in periodontitis patients with different RANKL/OPG ratios.

Material and methods
Eighty patients were enrolled either in AP or CP group. Clinical attachment level (CAL), bleeding on probing (BOP), periodontal probing depth (PPD) and plaque index (PI) were recorded for each patient. Total RNA was extracted from gingival crevicular fluid samples. Relative gene expression of investigated markers was determined by reverse transcriptase‐real‐time polymerase chain reaction.

Results
Significantly higher values of PPD were observed in AP compared to CP (P = .010). Negative correlations between OPG and CAL, and OPG and PI, were found in AP (P = .045, P = .006, respectively), while Hey 1 and PI had a positive correlation (P = .049). In multivariate linear regression analysis, OPG and Notch 2 were predictors of CAL in AP group. TNF‐α and IL‐17 were higher in RANKL predominant than in OPG predominant cases (P = .007, P = .001, respectively). In RANKL predominant lesions Notch 1 and Jagged 1 were down‐regulated in AP compared to CP patients (P = .010, P = .025, respectively).

Conclusion
The present study demonstrated that changes in Notch 2 expression affected CAL in AP cases hence this molecule could be considered as a contributor to alveolar bone loss. In RANKL‐activated settings, the down‐regulation of Notch 1 might participate in more severe bone resorption in AP.",
publisher = "Wiley",
journal = "Journal of Periodontal Research",
title = "Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis",
volume = "56",
number = "1",
pages = "131-138",
doi = "10.1111/jre.12801"
}

Đinić Krasavčević, A., Nikolić, N., Mijailović, I., Čarkić, J., Milinković, I., Janković, S., Aleksić, Z.,& Milašin, J.. (2021). Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis. in Journal of Periodontal Research
Wiley., 56(1), 131-138.
https://doi.org/10.1111/jre.12801

Đinić Krasavčević A, Nikolić N, Mijailović I, Čarkić J, Milinković I, Janković S, Aleksić Z, Milašin J. Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis. in Journal of Periodontal Research. 2021;56(1):131-138.
doi:10.1111/jre.12801 .

Đinić Krasavčević, Ana, Nikolić, Nadja, Mijailović, Iva, Čarkić, Jelena, Milinković, Iva, Janković, Saša, Aleksić, Zoran, Milašin, Jelena, "Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis" in Journal of Periodontal Research, 56, no. 1 (2021):131-138,
https://doi.org/10.1111/jre.12801 . .

TY  - JOUR
AU  - Matić Petrović, Sanja
AU  - Nikolić, Nadja
AU  - Toljić, Boško
AU  - Arambašić-Jovanović, Jelena
AU  - Miličić, Biljana
AU  - Miličić, Tanja
AU  - Jotić, Aleksandra
AU  - Vidaković, Melita
AU  - Milašin, Jelena
AU  - Pucar, Ana
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2571
AB  - Objectives: Aiming to show that periodontitis (PD) and type 2 diabetes (T2D) are bidirectionally related and potentially linked by inflammatory cytokines, we searched for association between -308 G/A Tumor necrosis factor-alpha (TNFα), +252A/G Lymphotoxin-alpha (LTα), +36A/G Tumor necrosis factor receptor 1 (TNFR1) and +676 T/G tumor necrosis factor receptor 2 (TNFR2) single nucleotide polymorphisms (SNPs) and: risk of PD or PD + T2D; periodontitis parameters in PD and PD + T2D; serum levels of cytokines/their receptors. Relationship between periodontal inflammation and serum cytokine/receptor levels was also assessed.

Design: Subjects were stratified as: 57 healthy controls (HC); 58 PD; 65 PD + T2D. Sociodemographic, environmental, behavioral and periodontal clinical data were recorded. SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism, while cytokines/receptors levels were quantified by enzyme-linked immunosorbent assay. Impact of periodontal inflammation was measured using periodontal inflamed surface area (PISA).

Results: TNFα AA genotype showed protective effect in T2D + PD compared to PD, even adjusted for behavioral/environmental factors (OR 0.18; 95 %CI 0.037-0.886; p = 0.035). LTα AG heterozygotes had increased risk of PD (OR 3.27; 95 %CI 1.35-7.96; p = 0.016), while TNFR2 TG genotype had protective effect (OR = 0.44; 95 %CI 0.954-0.9794; p = 0.043). TNFR1 AA was predictor of periodontal pocket depth and clinical attachment loss in PD. Correlation between TNFR2 concentration and PISA was negative in PD, positive in PD + T2D.

Conclusions: None of the SNPs showed cross-susceptibility between PD and T2D. + 252A/G LTα and +676 T/G TNFR2 SNPs are associated with PD risk. Periodontal destruction in healthy individuals is influenced by TNFR1 genotype. Impact of periodontal on systemic inflammation is masked by T2D.
PB  - Elsevier Inc.
T2  - Archives of Oral Biology
T1  - The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population
VL  - 120
SP  - 104929
DO  - 10.1016/j.archoralbio.2020.104929
ER  - 

@article{
author = "Matić Petrović, Sanja and Nikolić, Nadja and Toljić, Boško and Arambašić-Jovanović, Jelena and Miličić, Biljana and Miličić, Tanja and Jotić, Aleksandra and Vidaković, Melita and Milašin, Jelena and Pucar, Ana",
year = "2020",
abstract = "Objectives: Aiming to show that periodontitis (PD) and type 2 diabetes (T2D) are bidirectionally related and potentially linked by inflammatory cytokines, we searched for association between -308 G/A Tumor necrosis factor-alpha (TNFα), +252A/G Lymphotoxin-alpha (LTα), +36A/G Tumor necrosis factor receptor 1 (TNFR1) and +676 T/G tumor necrosis factor receptor 2 (TNFR2) single nucleotide polymorphisms (SNPs) and: risk of PD or PD + T2D; periodontitis parameters in PD and PD + T2D; serum levels of cytokines/their receptors. Relationship between periodontal inflammation and serum cytokine/receptor levels was also assessed.

Design: Subjects were stratified as: 57 healthy controls (HC); 58 PD; 65 PD + T2D. Sociodemographic, environmental, behavioral and periodontal clinical data were recorded. SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism, while cytokines/receptors levels were quantified by enzyme-linked immunosorbent assay. Impact of periodontal inflammation was measured using periodontal inflamed surface area (PISA).

Results: TNFα AA genotype showed protective effect in T2D + PD compared to PD, even adjusted for behavioral/environmental factors (OR 0.18; 95 %CI 0.037-0.886; p = 0.035). LTα AG heterozygotes had increased risk of PD (OR 3.27; 95 %CI 1.35-7.96; p = 0.016), while TNFR2 TG genotype had protective effect (OR = 0.44; 95 %CI 0.954-0.9794; p = 0.043). TNFR1 AA was predictor of periodontal pocket depth and clinical attachment loss in PD. Correlation between TNFR2 concentration and PISA was negative in PD, positive in PD + T2D.

Conclusions: None of the SNPs showed cross-susceptibility between PD and T2D. + 252A/G LTα and +676 T/G TNFR2 SNPs are associated with PD risk. Periodontal destruction in healthy individuals is influenced by TNFR1 genotype. Impact of periodontal on systemic inflammation is masked by T2D.",
publisher = "Elsevier Inc.",
journal = "Archives of Oral Biology",
title = "The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population",
volume = "120",
pages = "104929",
doi = "10.1016/j.archoralbio.2020.104929"
}

Matić Petrović, S., Nikolić, N., Toljić, B., Arambašić-Jovanović, J., Miličić, B., Miličić, T., Jotić, A., Vidaković, M., Milašin, J.,& Pucar, A.. (2020). The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population. in Archives of Oral Biology
Elsevier Inc.., 120, 104929.
https://doi.org/10.1016/j.archoralbio.2020.104929

Matić Petrović S, Nikolić N, Toljić B, Arambašić-Jovanović J, Miličić B, Miličić T, Jotić A, Vidaković M, Milašin J, Pucar A. The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population. in Archives of Oral Biology. 2020;120:104929.
doi:10.1016/j.archoralbio.2020.104929 .

Matić Petrović, Sanja, Nikolić, Nadja, Toljić, Boško, Arambašić-Jovanović, Jelena, Miličić, Biljana, Miličić, Tanja, Jotić, Aleksandra, Vidaković, Melita, Milašin, Jelena, Pucar, Ana, "The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population" in Archives of Oral Biology, 120 (2020):104929,
https://doi.org/10.1016/j.archoralbio.2020.104929 . .

TY  - JOUR
AU  - Mijailović, Iva
AU  - Nikolić, Nadja
AU  - Đinić, Ana
AU  - Čarkić, Jelena
AU  - Milinković, Iva
AU  - Perić, Mina
AU  - Janković, Saša
AU  - Milašin, Jelena
AU  - Aleksić, Zoran
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2492
AB  - Background The exact mechanisms of bone resorption in periodontitis have not been fully elucidated. The aims of this study were to analyze the expression of Notch signaling molecules, bone remodeling mediators, and pro-inflammatory cytokines in periodontitis patients and to determine their potential correlations. Methods The study included 130 individuals: 40 with aggressive periodontitis (AP group), 40 with chronic periodontitis (CP group), and 50 periodontally healthy controls. Total RNA was extracted from gingival crevicular fluid samples and relative gene expression of investigated molecules (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1, TNF-alpha, IL-17, RANKL, and OPG) was determined by reverse transcriptase - real-time polymerase chain reaction (RT-qPCR). Results In AP group, a significant increase of Notch 2, TNF-alpha, IL-17 and RANKL and a significant decrease of Notch 1 and Jagged 1 expression were observed compared to control group (P = 0.023, P = 0.005, P = 0.030, and P = 0.001 P = 0.031 and P = 0.029, respectively). Notch 2 and RANKL were also overexpressed in CP group compared to controls (P = 0.001 and P = 0.011). Significant correlations were observed in AP group between expression levels of the analyzed genes. Conclusion The present findings implicate Notch 2 overexpression in the ethiopathogenesis of bone resorption in aggressive and chronic periodontitis. The down-regulation of Notch 1 and Jagged 1 and loss of their osteoprotective function might cause a more excessive osteoclast formation and contribute to greater osteolysis in aggressive periodontitis.
PB  - Wiley, Hoboken
T2  - Journal of Periodontology
T1  - The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis
VL  - 91
IS  - 4
SP  - 554
EP  - 561
DO  - 10.1002/JPER.18-0755
ER  - 

@article{
author = "Mijailović, Iva and Nikolić, Nadja and Đinić, Ana and Čarkić, Jelena and Milinković, Iva and Perić, Mina and Janković, Saša and Milašin, Jelena and Aleksić, Zoran",
year = "2020",
abstract = "Background The exact mechanisms of bone resorption in periodontitis have not been fully elucidated. The aims of this study were to analyze the expression of Notch signaling molecules, bone remodeling mediators, and pro-inflammatory cytokines in periodontitis patients and to determine their potential correlations. Methods The study included 130 individuals: 40 with aggressive periodontitis (AP group), 40 with chronic periodontitis (CP group), and 50 periodontally healthy controls. Total RNA was extracted from gingival crevicular fluid samples and relative gene expression of investigated molecules (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1, TNF-alpha, IL-17, RANKL, and OPG) was determined by reverse transcriptase - real-time polymerase chain reaction (RT-qPCR). Results In AP group, a significant increase of Notch 2, TNF-alpha, IL-17 and RANKL and a significant decrease of Notch 1 and Jagged 1 expression were observed compared to control group (P = 0.023, P = 0.005, P = 0.030, and P = 0.001 P = 0.031 and P = 0.029, respectively). Notch 2 and RANKL were also overexpressed in CP group compared to controls (P = 0.001 and P = 0.011). Significant correlations were observed in AP group between expression levels of the analyzed genes. Conclusion The present findings implicate Notch 2 overexpression in the ethiopathogenesis of bone resorption in aggressive and chronic periodontitis. The down-regulation of Notch 1 and Jagged 1 and loss of their osteoprotective function might cause a more excessive osteoclast formation and contribute to greater osteolysis in aggressive periodontitis.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontology",
title = "The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis",
volume = "91",
number = "4",
pages = "554-561",
doi = "10.1002/JPER.18-0755"
}

Mijailović, I., Nikolić, N., Đinić, A., Čarkić, J., Milinković, I., Perić, M., Janković, S., Milašin, J.,& Aleksić, Z.. (2020). The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis. in Journal of Periodontology
Wiley, Hoboken., 91(4), 554-561.
https://doi.org/10.1002/JPER.18-0755

Mijailović I, Nikolić N, Đinić A, Čarkić J, Milinković I, Perić M, Janković S, Milašin J, Aleksić Z. The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis. in Journal of Periodontology. 2020;91(4):554-561.
doi:10.1002/JPER.18-0755 .

Mijailović, Iva, Nikolić, Nadja, Đinić, Ana, Čarkić, Jelena, Milinković, Iva, Perić, Mina, Janković, Saša, Milašin, Jelena, Aleksić, Zoran, "The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis" in Journal of Periodontology, 91, no. 4 (2020):554-561,
https://doi.org/10.1002/JPER.18-0755 . .

TY  - JOUR
AU  - Nikolić, Ljubinka
AU  - Čakić, Saša
AU  - Perunović, Neda
AU  - Čolak, Emina
AU  - Kotur-Stevuljević, Jelena
AU  - Janković, Saša
AU  - Đurić, Milanko
AU  - Plećaš, Darko
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2496
AB  - Background/Aim. Preterm birth is defined as a delivery prior to the completed 37th week of gestation. Literature data suggested that periodontal processes may influence to the feto-placental unit and induce preterm delivery. The degree of the periodontal disease is influenced by secretor status. Pro-inflammatory cytokines are involved in periodontitis as well as in delivery. The combined influence of these factors on the risk of preterm birth has not been explored. The aim of our study was to investigate the associations between periodontal diseases, secretor status, and interleukin1-b (IL1-ß) and prostaglandine E2 (PGE2) levels in women delivered preterm. Methods. The study included 56 preterm delivery women and 56 women delivered at term as a control group, aged between 17 and 41 years. Periodontal examination, blood and saliva sampling were performed within 48 hours following delivery. Secretor phenotype was determined by hemagglutination inhibition method. The concentrations of IL1-ß and PGE2 were measured by high sensitivity Enzyme-linked Immunosorbent Assay (ELISA). Results. In the pre-term birth group there were 66.1% of women with periodontitis, while in the control one there were 12.5% (p  lt  0.01). Concentrations of IL1-ß and PGE2 in plasma were significantly higher in the non-secretor group of women who gave birth pre-term and had periodontitis comparing to other groups. There was a significant correlation between salivary and plasma levels of PGE2 and IL1-ß in the preterm birth group (R = 0.416, p = 0.017 and R = -0.592, p  lt  0.001, respectively). There were no such correlations in women who delivered at term. Conclusion. Our results support the hypothesis that non-secretor phenotype and periodontitis are at least in part responsible for pathogenesis of preterm birth. This probability of negative impact of non-secretor status cannot be ignored. These findings support the need for additional research into the biology of human parturition.
AB  - Uvod/Cilj. Prevremeni porođaj se definiše kao porođaj pre navršene 37 nedelje gestacije. Podaci iz literature govore u prilog tome da periodontalni procesi mogu uticati na fetoplacentalnu jedinicu i indukovati preterminski porođaj. Sekretorni status može uticati na stepen periodontalne bolesti. Proinflamatorni citokini imaju uticaj na periodontitis kao i na porođaj. Kombinovani uticaj ovih faktora rizika za prevremeni porođaj nije dovoljno istražen. Cilj ove studije je bio da istraži povezanost između periodontalne bolesti, sekretornog statusa, nivoa interleukina 1-b (IL1-b) i prostaglandina E2 (PGE2) kod žena koje su imale prevremeni porođaj. Metode. Studijom je bilo obuhvaćeno 56 žena, koje su imale prevremen porođaj i 56 žena u kontrolnoj grupi koje su se porodile u terminu, starosti između 17 i 41 godine. Periodontalni pregled, uzorkovanje krvi i salive je izvršeno u prvih 48 sati po porođaju. Sekretorni status je određen metodom inhibicije hemaglutinacije. Koncentracije IL1-b i PGE2 su merene visoko senzitivnim Enzyme-linked Immunosorbent Assay (ELISA) testom. Rezultati. U grupi prevremenih porođaja bilo je 66,1% žena sa periodontitisom, a u kontrolnoj grupi 12,5% (p  lt  0.01). Prevremeno porođene žena, nesekretori sa periodontitisom imale su u plazmi značajno više vrednosti IL 1-b i PGE 2 u odnosu na ostale grupe (p  lt  0,01). U grupi prevremeno porođenih žena postojala je značajna korelacija između salivarnih i plazmatskih koncentracija PGE2 i IL1-b (R = 0.416, p = 0.017 i R = -0,592, p  lt  0,001, redom). Ove korelacije nisu postojale kod žena koje su imale terminski porođaj. Zaključak. Naši rezultati podržavaju hipotezu da su sekretorni status i periodontitis, bar delimično, odgovorni za patogenezu preterminskog porođaja. Verovatnoća negativnog uticaja nesekretornog statusa se ne sme ignorisati. Ovi zaključci ukazuju na potrebu za dodatnim istraživanjima porođaja.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Salivary and plasma inflammatory mediators and secretory status in preterm delivery women with periodontitis: A cross sectional study
T1  - Salivarni i inflamatorni medijatori plazme i sekretorni status prevremeno porođenih žena sa periodontitisom - studija preseka
VL  - 77
IS  - 3
SP  - 247
EP  - 255
DO  - 10.2298/VSP171106066N
ER  - 

@article{
author = "Nikolić, Ljubinka and Čakić, Saša and Perunović, Neda and Čolak, Emina and Kotur-Stevuljević, Jelena and Janković, Saša and Đurić, Milanko and Plećaš, Darko",
year = "2020",
abstract = "Background/Aim. Preterm birth is defined as a delivery prior to the completed 37th week of gestation. Literature data suggested that periodontal processes may influence to the feto-placental unit and induce preterm delivery. The degree of the periodontal disease is influenced by secretor status. Pro-inflammatory cytokines are involved in periodontitis as well as in delivery. The combined influence of these factors on the risk of preterm birth has not been explored. The aim of our study was to investigate the associations between periodontal diseases, secretor status, and interleukin1-b (IL1-ß) and prostaglandine E2 (PGE2) levels in women delivered preterm. Methods. The study included 56 preterm delivery women and 56 women delivered at term as a control group, aged between 17 and 41 years. Periodontal examination, blood and saliva sampling were performed within 48 hours following delivery. Secretor phenotype was determined by hemagglutination inhibition method. The concentrations of IL1-ß and PGE2 were measured by high sensitivity Enzyme-linked Immunosorbent Assay (ELISA). Results. In the pre-term birth group there were 66.1% of women with periodontitis, while in the control one there were 12.5% (p  lt  0.01). Concentrations of IL1-ß and PGE2 in plasma were significantly higher in the non-secretor group of women who gave birth pre-term and had periodontitis comparing to other groups. There was a significant correlation between salivary and plasma levels of PGE2 and IL1-ß in the preterm birth group (R = 0.416, p = 0.017 and R = -0.592, p  lt  0.001, respectively). There were no such correlations in women who delivered at term. Conclusion. Our results support the hypothesis that non-secretor phenotype and periodontitis are at least in part responsible for pathogenesis of preterm birth. This probability of negative impact of non-secretor status cannot be ignored. These findings support the need for additional research into the biology of human parturition., Uvod/Cilj. Prevremeni porođaj se definiše kao porođaj pre navršene 37 nedelje gestacije. Podaci iz literature govore u prilog tome da periodontalni procesi mogu uticati na fetoplacentalnu jedinicu i indukovati preterminski porođaj. Sekretorni status može uticati na stepen periodontalne bolesti. Proinflamatorni citokini imaju uticaj na periodontitis kao i na porođaj. Kombinovani uticaj ovih faktora rizika za prevremeni porođaj nije dovoljno istražen. Cilj ove studije je bio da istraži povezanost između periodontalne bolesti, sekretornog statusa, nivoa interleukina 1-b (IL1-b) i prostaglandina E2 (PGE2) kod žena koje su imale prevremeni porođaj. Metode. Studijom je bilo obuhvaćeno 56 žena, koje su imale prevremen porođaj i 56 žena u kontrolnoj grupi koje su se porodile u terminu, starosti između 17 i 41 godine. Periodontalni pregled, uzorkovanje krvi i salive je izvršeno u prvih 48 sati po porođaju. Sekretorni status je određen metodom inhibicije hemaglutinacije. Koncentracije IL1-b i PGE2 su merene visoko senzitivnim Enzyme-linked Immunosorbent Assay (ELISA) testom. Rezultati. U grupi prevremenih porođaja bilo je 66,1% žena sa periodontitisom, a u kontrolnoj grupi 12,5% (p  lt  0.01). Prevremeno porođene žena, nesekretori sa periodontitisom imale su u plazmi značajno više vrednosti IL 1-b i PGE 2 u odnosu na ostale grupe (p  lt  0,01). U grupi prevremeno porođenih žena postojala je značajna korelacija između salivarnih i plazmatskih koncentracija PGE2 i IL1-b (R = 0.416, p = 0.017 i R = -0,592, p  lt  0,001, redom). Ove korelacije nisu postojale kod žena koje su imale terminski porođaj. Zaključak. Naši rezultati podržavaju hipotezu da su sekretorni status i periodontitis, bar delimično, odgovorni za patogenezu preterminskog porođaja. Verovatnoća negativnog uticaja nesekretornog statusa se ne sme ignorisati. Ovi zaključci ukazuju na potrebu za dodatnim istraživanjima porođaja.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Salivary and plasma inflammatory mediators and secretory status in preterm delivery women with periodontitis: A cross sectional study, Salivarni i inflamatorni medijatori plazme i sekretorni status prevremeno porođenih žena sa periodontitisom - studija preseka",
volume = "77",
number = "3",
pages = "247-255",
doi = "10.2298/VSP171106066N"
}

Nikolić, L., Čakić, S., Perunović, N., Čolak, E., Kotur-Stevuljević, J., Janković, S., Đurić, M.,& Plećaš, D.. (2020). Salivary and plasma inflammatory mediators and secretory status in preterm delivery women with periodontitis: A cross sectional study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 77(3), 247-255.
https://doi.org/10.2298/VSP171106066N

Nikolić L, Čakić S, Perunović N, Čolak E, Kotur-Stevuljević J, Janković S, Đurić M, Plećaš D. Salivary and plasma inflammatory mediators and secretory status in preterm delivery women with periodontitis: A cross sectional study. in Vojnosanitetski pregled. 2020;77(3):247-255.
doi:10.2298/VSP171106066N .

Nikolić, Ljubinka, Čakić, Saša, Perunović, Neda, Čolak, Emina, Kotur-Stevuljević, Jelena, Janković, Saša, Đurić, Milanko, Plećaš, Darko, "Salivary and plasma inflammatory mediators and secretory status in preterm delivery women with periodontitis: A cross sectional study" in Vojnosanitetski pregled, 77, no. 3 (2020):247-255,
https://doi.org/10.2298/VSP171106066N . .

TY  - JOUR
AU  - Radunović, Milena
AU  - Petrini, M.
AU  - Vlajić, T.
AU  - Iezzi, G.
AU  - Di Lodovico, S.
AU  - Piattelli, Adriano
AU  - D'Ercole, S.
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2509
AB  - Antibiotic resistance is a major public health problem worldwide and the finding of alternative methods for eliminating bacteria is one of the prerogatives of medical research. The indiscriminate use of antibiotics in dentistry, especially for the treatment of peri-implantitis, could lead to superinfections. Alternative methods, like photodynamic therapy mediated by the use of aminolevulinic acid and a red light has been largely described, especially in dentistry, but results were encouraging against Gram-positive bacteria, but limited against Gram-negative. The effectiveness of photodynamic therapy mediated by a novel product containing aminolevulinic acid, Aladent (ALAD) has been tested in this in vitro study, against different types of bacteria particularly involved in the infections of the oral cavity and peri-implantitis. The novelty of ALAD is the marked hydrophilicity that should increase the passage of the molecule through the membrane pores of Gram-negative bacteria. Considering the novelty of the product a preliminary experiment permitted to test the effectiveness against Enterococcus faecalis after 1 h of ALAD incubation at different concentrations, with or without different timings of LED irradiation. The count of CFUs and the live/dead observation with fluorescent microscopy showed a significant reduction and killing of bacterium. Then, in the second stage, that could meet the necessity of effectiveness and the clinician's requests to reduce the timing of treatment, ALAD, with and without irradiation, was tested on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Veillonella parvula and Porphyromonas gingivalis. In particular, the efficiency of different concentrations of the product after a 25 min incubation was tested with and without the adjunctive LED irradiation for 5 min. A slight ALAD bactericidal effect was reported for all bacteria, also without LED irradiation, however, the most effective treatment was 25 min of 50% ALAD incubation followed by 5 min of a red LED. The in vitro tests demonstrated that ALAD gel with LED irradiation exerts a potent antibacterial activity on different bacteria, both Gram-positive and Gram-negative.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Photochemistry & Photobiology B-Biology
T1  - Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections
VL  - 205
DO  - 10.1016/j.jphotobiol.2020.111826
ER  - 

@article{
author = "Radunović, Milena and Petrini, M. and Vlajić, T. and Iezzi, G. and Di Lodovico, S. and Piattelli, Adriano and D'Ercole, S.",
year = "2020",
abstract = "Antibiotic resistance is a major public health problem worldwide and the finding of alternative methods for eliminating bacteria is one of the prerogatives of medical research. The indiscriminate use of antibiotics in dentistry, especially for the treatment of peri-implantitis, could lead to superinfections. Alternative methods, like photodynamic therapy mediated by the use of aminolevulinic acid and a red light has been largely described, especially in dentistry, but results were encouraging against Gram-positive bacteria, but limited against Gram-negative. The effectiveness of photodynamic therapy mediated by a novel product containing aminolevulinic acid, Aladent (ALAD) has been tested in this in vitro study, against different types of bacteria particularly involved in the infections of the oral cavity and peri-implantitis. The novelty of ALAD is the marked hydrophilicity that should increase the passage of the molecule through the membrane pores of Gram-negative bacteria. Considering the novelty of the product a preliminary experiment permitted to test the effectiveness against Enterococcus faecalis after 1 h of ALAD incubation at different concentrations, with or without different timings of LED irradiation. The count of CFUs and the live/dead observation with fluorescent microscopy showed a significant reduction and killing of bacterium. Then, in the second stage, that could meet the necessity of effectiveness and the clinician's requests to reduce the timing of treatment, ALAD, with and without irradiation, was tested on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Veillonella parvula and Porphyromonas gingivalis. In particular, the efficiency of different concentrations of the product after a 25 min incubation was tested with and without the adjunctive LED irradiation for 5 min. A slight ALAD bactericidal effect was reported for all bacteria, also without LED irradiation, however, the most effective treatment was 25 min of 50% ALAD incubation followed by 5 min of a red LED. The in vitro tests demonstrated that ALAD gel with LED irradiation exerts a potent antibacterial activity on different bacteria, both Gram-positive and Gram-negative.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Photochemistry & Photobiology B-Biology",
title = "Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections",
volume = "205",
doi = "10.1016/j.jphotobiol.2020.111826"
}

Radunović, M., Petrini, M., Vlajić, T., Iezzi, G., Di Lodovico, S., Piattelli, A.,& D'Ercole, S.. (2020). Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections. in Journal of Photochemistry & Photobiology B-Biology
Elsevier Science Sa, Lausanne., 205.
https://doi.org/10.1016/j.jphotobiol.2020.111826

Radunović M, Petrini M, Vlajić T, Iezzi G, Di Lodovico S, Piattelli A, D'Ercole S. Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections. in Journal of Photochemistry & Photobiology B-Biology. 2020;205.
doi:10.1016/j.jphotobiol.2020.111826 .

Radunović, Milena, Petrini, M., Vlajić, T., Iezzi, G., Di Lodovico, S., Piattelli, Adriano, D'Ercole, S., "Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections" in Journal of Photochemistry & Photobiology B-Biology, 205 (2020),
https://doi.org/10.1016/j.jphotobiol.2020.111826 . .

TY  - JOUR
AU  - Matić-Petrović, Sanja
AU  - Radunović, Milena
AU  - Barać, Milena
AU  - Kuzmanović-Pfićer, Jovana
AU  - Pavlica, Dušan
AU  - Arsić-Arsenijević, Valentina
AU  - Pucar, Ana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2463
AB  - Objectives The aim of this cross-sectional observational study was to compare the prevalence of different oral Candida spp. in patients with Type 2 Diabetes and chronic periodontitis in two oral sites: dorsal surface of the tongue and subgingival area. In order to determine subgingival areas as potential reservoirs of yeasts, this study aimed to find differences in the yeasts' detection between the dorsum of the tongue, as the oral site most commonly inhabited with microorganisms, and subgingival samples. Additionally, potential predictors for the yeasts prevalence were determined. Material and methods Subjects (N = 146) were divided into four groups: group A-healthy individuals without periodontitis, group B-healthy individuals with chronic periodontitis, group C-Type 2 Diabetes patients with good glycoregulation and Chronic periodontitis and group D-Type 2 Diabetes patients with poor glycoregulation and Chronic periodontitis. Samples were obtained from the tongue by swabbing. Subgingival plaque samples were taken by paper points and periodontal curette. Isolation and identification of different Candida spp. was done using ChromAgar medium. In addition, germ-tube production and carbohydrate assimilation tests were performed. Results The prevalence of Candida spp. was higher in diabetics with poor glycoregulation. The most frequently isolated species was Candida albicans followed by Candida glabrata and Candida tropicalis. In 15.6% of cases, Candida spp. was present in the subgingival area while absent on the tongue. Multivariate regression model showed that HbA1c was Candida spp. predictor for both locations. Conclusions Our results confirmed that there are Candida spp. carriers among subjects with clinically healthy oral mucosa. Also, this study identified subgingival areas as potential reservoirs of these pathogenic species. Glycoregulation has been recognized as a positive predictor factor of Candida spp.
PB  - Public Library Science, San Francisco
T2  - PLoS One
T1  - Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects
VL  - 14
IS  - 1
DO  - 10.1371/journal.pone.0210527
ER  - 

@article{
author = "Matić-Petrović, Sanja and Radunović, Milena and Barać, Milena and Kuzmanović-Pfićer, Jovana and Pavlica, Dušan and Arsić-Arsenijević, Valentina and Pucar, Ana",
year = "2019",
abstract = "Objectives The aim of this cross-sectional observational study was to compare the prevalence of different oral Candida spp. in patients with Type 2 Diabetes and chronic periodontitis in two oral sites: dorsal surface of the tongue and subgingival area. In order to determine subgingival areas as potential reservoirs of yeasts, this study aimed to find differences in the yeasts' detection between the dorsum of the tongue, as the oral site most commonly inhabited with microorganisms, and subgingival samples. Additionally, potential predictors for the yeasts prevalence were determined. Material and methods Subjects (N = 146) were divided into four groups: group A-healthy individuals without periodontitis, group B-healthy individuals with chronic periodontitis, group C-Type 2 Diabetes patients with good glycoregulation and Chronic periodontitis and group D-Type 2 Diabetes patients with poor glycoregulation and Chronic periodontitis. Samples were obtained from the tongue by swabbing. Subgingival plaque samples were taken by paper points and periodontal curette. Isolation and identification of different Candida spp. was done using ChromAgar medium. In addition, germ-tube production and carbohydrate assimilation tests were performed. Results The prevalence of Candida spp. was higher in diabetics with poor glycoregulation. The most frequently isolated species was Candida albicans followed by Candida glabrata and Candida tropicalis. In 15.6% of cases, Candida spp. was present in the subgingival area while absent on the tongue. Multivariate regression model showed that HbA1c was Candida spp. predictor for both locations. Conclusions Our results confirmed that there are Candida spp. carriers among subjects with clinically healthy oral mucosa. Also, this study identified subgingival areas as potential reservoirs of these pathogenic species. Glycoregulation has been recognized as a positive predictor factor of Candida spp.",
publisher = "Public Library Science, San Francisco",
journal = "PLoS One",
title = "Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects",
volume = "14",
number = "1",
doi = "10.1371/journal.pone.0210527"
}

Matić-Petrović, S., Radunović, M., Barać, M., Kuzmanović-Pfićer, J., Pavlica, D., Arsić-Arsenijević, V.,& Pucar, A.. (2019). Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects. in PLoS One
Public Library Science, San Francisco., 14(1).
https://doi.org/10.1371/journal.pone.0210527

Matić-Petrović S, Radunović M, Barać M, Kuzmanović-Pfićer J, Pavlica D, Arsić-Arsenijević V, Pucar A. Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects. in PLoS One. 2019;14(1).
doi:10.1371/journal.pone.0210527 .

Matić-Petrović, Sanja, Radunović, Milena, Barać, Milena, Kuzmanović-Pfićer, Jovana, Pavlica, Dušan, Arsić-Arsenijević, Valentina, Pucar, Ana, "Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects" in PLoS One, 14, no. 1 (2019),
https://doi.org/10.1371/journal.pone.0210527 . .

TY  - JOUR
AU  - Matić-Petrović, Sanja
AU  - Đorđević, Mihajlo
AU  - Radunović, Milena
AU  - Živanović, Tanja
AU  - Pavlica, Dušan
AU  - Pucar, Ana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2406
AB  - Background/Aim: Geographic tongue (GT), a benign self-limiting condition (inflammation) is commonly seen in practice. Although quite easy for clinical diagnosis, in clinical practice it is commonly misdiagnosed and treated as Candida infection. The main aim of this study was to compare the prevalence of Candida spp. on tongue in patients with GT and subjects with clinically healthy oral mucosa. Additional aims were to evaluate subjective symptoms, uncontrolled usage of prescribed or non-prescribed antifungal topical medications and the presence of the cancerophobia or other health concerns in patients with GT. Material and Methods: A total of 70 subjects were divided into two groups: Group B - patients with diagnosed Geographic tongue and group A - aged and gender matched controls with clinically health oral mucosa. Anamnestic charts designed for this study included information about symptoms (measured by Visual Analogue Scale), previous knowledge or fear about presence of GT and received therapy for this condition. Detection of Candida spp. from tongue was done using sterile cotton swab and Sabouraud dextrose agar. Results: At the time of this study, 18 (52.94%) of subjects with GT were aware of having this condition and even 12 of them (66.7%) used topical antifungal drugs prescribed by physician. Also, 66.7% of them experienced fear about the presence of GT at some moment. Detection of Candida spp. was similarly distributed in both groups (22.2% in group A and 17.6% in group B). Conclusions: Geographic tongue has frequently been treated by topical antifungal drugs. In this study, GT was not associated with presence of Candida spp.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Dental Medicine
T1  - Geographic tongue: Does Candida play a role in its pathogenesis
VL  - 23
IS  - 3
SP  - 152
EP  - 156
DO  - 10.2478/bjdm-2019-0027
ER  - 

@article{
author = "Matić-Petrović, Sanja and Đorđević, Mihajlo and Radunović, Milena and Živanović, Tanja and Pavlica, Dušan and Pucar, Ana",
year = "2019",
abstract = "Background/Aim: Geographic tongue (GT), a benign self-limiting condition (inflammation) is commonly seen in practice. Although quite easy for clinical diagnosis, in clinical practice it is commonly misdiagnosed and treated as Candida infection. The main aim of this study was to compare the prevalence of Candida spp. on tongue in patients with GT and subjects with clinically healthy oral mucosa. Additional aims were to evaluate subjective symptoms, uncontrolled usage of prescribed or non-prescribed antifungal topical medications and the presence of the cancerophobia or other health concerns in patients with GT. Material and Methods: A total of 70 subjects were divided into two groups: Group B - patients with diagnosed Geographic tongue and group A - aged and gender matched controls with clinically health oral mucosa. Anamnestic charts designed for this study included information about symptoms (measured by Visual Analogue Scale), previous knowledge or fear about presence of GT and received therapy for this condition. Detection of Candida spp. from tongue was done using sterile cotton swab and Sabouraud dextrose agar. Results: At the time of this study, 18 (52.94%) of subjects with GT were aware of having this condition and even 12 of them (66.7%) used topical antifungal drugs prescribed by physician. Also, 66.7% of them experienced fear about the presence of GT at some moment. Detection of Candida spp. was similarly distributed in both groups (22.2% in group A and 17.6% in group B). Conclusions: Geographic tongue has frequently been treated by topical antifungal drugs. In this study, GT was not associated with presence of Candida spp.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Dental Medicine",
title = "Geographic tongue: Does Candida play a role in its pathogenesis",
volume = "23",
number = "3",
pages = "152-156",
doi = "10.2478/bjdm-2019-0027"
}

Matić-Petrović, S., Đorđević, M., Radunović, M., Živanović, T., Pavlica, D.,& Pucar, A.. (2019). Geographic tongue: Does Candida play a role in its pathogenesis. in Balkan Journal of Dental Medicine
Udruženje stomatologa Balkana., 23(3), 152-156.
https://doi.org/10.2478/bjdm-2019-0027

Matić-Petrović S, Đorđević M, Radunović M, Živanović T, Pavlica D, Pucar A. Geographic tongue: Does Candida play a role in its pathogenesis. in Balkan Journal of Dental Medicine. 2019;23(3):152-156.
doi:10.2478/bjdm-2019-0027 .

Matić-Petrović, Sanja, Đorđević, Mihajlo, Radunović, Milena, Živanović, Tanja, Pavlica, Dušan, Pucar, Ana, "Geographic tongue: Does Candida play a role in its pathogenesis" in Balkan Journal of Dental Medicine, 23, no. 3 (2019):152-156,
https://doi.org/10.2478/bjdm-2019-0027 . .

TY  - JOUR
AU  - Matić-Petrović, Sanja
AU  - Barać, Milena
AU  - Kuzmanović-Pfićer, Jovana
AU  - Radunović, Milena
AU  - Jotić, Aleksandra
AU  - Pucar, Ana
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2365
AB  - Background/Aim: The aim of this study was to examine prevalence of different Candida spp. at diabetics and nondiabetics wearing dentures without clinical signs of Denture Stomatitis (DS) and to study if some local and systematic factors are confounders for harboring Candida at these subjects. Material and Methods: Total of 60 subjects wearing partial or complete upper acrylic denture having at least half of palatal mucosa covered by denture were selected and stratified into three experimental groups: systematically health subjects; patients with diagnosed Type 2 Diabetes (T2D) and good glycoregulation; and T2D subjects with poorly regulated blood sugar level. Cotton swab samples were obtained from each patient from hard palate mucosa and denture surface. Swab cultures were made on Sabouraud dextrose agar and ChromAgar Media for distinciton of various Candida spp. Density growth was also measured. Results: Frequency of Candida spp. findings were similar between groups. At healthy subjects, only C.albicans was detected. At diabetics, C.albicans was the most common isolated species, followed by C.glabrata and C.tropicalis. Negative finding of yeasts on palatal mucosa, but positive on denture surface were detected at all groups, with the highest frequency (33.4%) at diabetics with poor glycoregulation. Denture surface was heavier colonized than hard palate mucosa. Duration of diabetes in years were only independent predictors for harboring Candida spp. at denture surface (Exp B=1.186, CI=1.047-1.344, p=0.007). Conclusions: Prosthesis of denture wearers without DS may serve as reservoir of Candida spp. Presence of more pathogenic and resistant non-albicans species are related to diabetics, even without clinical signs of DS.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Dental Medicine
T1  - Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study
VL  - 22
IS  - 1
SP  - 15
EP  - 21
DO  - 10.2478/bjdm-2018-0003
ER  - 

@article{
author = "Matić-Petrović, Sanja and Barać, Milena and Kuzmanović-Pfićer, Jovana and Radunović, Milena and Jotić, Aleksandra and Pucar, Ana",
year = "2018",
abstract = "Background/Aim: The aim of this study was to examine prevalence of different Candida spp. at diabetics and nondiabetics wearing dentures without clinical signs of Denture Stomatitis (DS) and to study if some local and systematic factors are confounders for harboring Candida at these subjects. Material and Methods: Total of 60 subjects wearing partial or complete upper acrylic denture having at least half of palatal mucosa covered by denture were selected and stratified into three experimental groups: systematically health subjects; patients with diagnosed Type 2 Diabetes (T2D) and good glycoregulation; and T2D subjects with poorly regulated blood sugar level. Cotton swab samples were obtained from each patient from hard palate mucosa and denture surface. Swab cultures were made on Sabouraud dextrose agar and ChromAgar Media for distinciton of various Candida spp. Density growth was also measured. Results: Frequency of Candida spp. findings were similar between groups. At healthy subjects, only C.albicans was detected. At diabetics, C.albicans was the most common isolated species, followed by C.glabrata and C.tropicalis. Negative finding of yeasts on palatal mucosa, but positive on denture surface were detected at all groups, with the highest frequency (33.4%) at diabetics with poor glycoregulation. Denture surface was heavier colonized than hard palate mucosa. Duration of diabetes in years were only independent predictors for harboring Candida spp. at denture surface (Exp B=1.186, CI=1.047-1.344, p=0.007). Conclusions: Prosthesis of denture wearers without DS may serve as reservoir of Candida spp. Presence of more pathogenic and resistant non-albicans species are related to diabetics, even without clinical signs of DS.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Dental Medicine",
title = "Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study",
volume = "22",
number = "1",
pages = "15-21",
doi = "10.2478/bjdm-2018-0003"
}

Matić-Petrović, S., Barać, M., Kuzmanović-Pfićer, J., Radunović, M., Jotić, A.,& Pucar, A.. (2018). Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study. in Balkan Journal of Dental Medicine
Udruženje stomatologa Balkana., 22(1), 15-21.
https://doi.org/10.2478/bjdm-2018-0003

Matić-Petrović S, Barać M, Kuzmanović-Pfićer J, Radunović M, Jotić A, Pucar A. Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study. in Balkan Journal of Dental Medicine. 2018;22(1):15-21.
doi:10.2478/bjdm-2018-0003 .

Matić-Petrović, Sanja, Barać, Milena, Kuzmanović-Pfićer, Jovana, Radunović, Milena, Jotić, Aleksandra, Pucar, Ana, "Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study" in Balkan Journal of Dental Medicine, 22, no. 1 (2018):15-21,
https://doi.org/10.2478/bjdm-2018-0003 . .

TY  - THES
AU  - Radaković, Tijana
PY  - 2018
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=6580
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:19362/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50907151
UR  - http://nardus.mpn.gov.rs/123456789/10745
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1036
AB  - Shortened dental arch represents a functional, aesthetic and natural dentition with no more than 20 teeth, where the anterior region is preserved and the occlusal tooth units in the posterior segment are missing. The main unresolved question about shortened dental arch is if therapeutic intervention is required. Physiological mechanisms that compensate masticatory function can be effective enough to provide a level of chewing function that allows many patients to be satisfied with their quality of life related to oral health. However, the long-term reliance on these compensatory mechanisms entails significant complications and risks. Therefore, some of the authors emphasize the necessity of complete reconstruction of the dental arch, in order to achieve appropriate aesthetic effects and provide a better masticatory function, but also, more importantly, change the position of the occlusal plane and shift the remaining teeth. Insofar as it results in a decrease in mastication efficiency, a shortened dental arch potentially leads to compromised nutritional status. People with shortened dental arch often change their eating habits, avoiding food that is harder to chew, potentially leading to nutritional imbalance and consequent risk of various diseases associated with inadequate nutritional status. Nutritional status is one of the main determinants of health-related quality of life. Quality of life in patients with shortened dental arch, as a rule, is reduced in a mild or more severe degree. The aim of this doctoral dissertation was to determine the level of incidence of shortened dental arch, the need for conducting prosthetic rehabilitation of shortened dental arches with adequate dental restoration, and its effects on nutritional status and quality of life. The first part of the research was carried out as a retrospective epidemiological study in order to determine the incidence of shortened dental arch by analysing medical documentation of patients who were rehabilitated with dental restorations at the Clinic for Prosthodontics, School of Dental Medicine, University of Belgrade in the period from 2006. to 2015. The research involved 4000 dental cards...
AB  - Skraćen zubni niz predstavlja funkcionalnu, estetsku i prirodnu denticiju sa ne više od 20 zuba, gde je očuvan anteriorni segment, a nedostaju okluzalne jedinice u posteriornom segmentu. Glavno nerazrešeno pitanje u vezi sa skraćenim zubnim nizom je da li ovakvo stanje zubika zahteva terapijsku intervenciju. Fiziološki mehanizmi kompenzacije mastikatorne funkcije usled nedostatka zuba mogu biti delotvorni u dovoljnoj meri da obezbede nivo funkcije žvakanja koji dopušta mnogim pacijentima da budu zadovoljni svojim kvalitetom života vezanim za oralno zdravlje. Međutim, dugotrajno oslanjanje na ove kompenzatorne mehanizme povlači sa sobom značajne komplikacije i rizike. Stoga neki od autora naglašavaju neophodnost kompletne rekonstrukcije zubnog niza, kako bi ostvarili i obezbedili bolju mastikatornu funkciju, kao i odgovarajući estetski učinak, ali i, što je još važnije, promenu položaja okluzalne ravni i pomeranje preostalih zuba. Ukoliko to rezultira smanjenjem mastikatorne efikasnosti, skraćeni zubni niz potencijalno dovodi do kompromitovanja nutritivnog statusa. Zbog toga osobe sa skraćenim zubnim nizom često menjaju navike u ishrani, izbegavajući hranu koja se teže žvaće, što potencijalno dovodi do nutritivnog disbalansa i sledstvenog rizika pojave raznovrsnih oboljenja povezanih sa neadekvatnim nutritivnim statusom. Nutritivni status je jedna od glavnih determinanti kvaliteta života povezanog sa zdravljem. Kvalitet života pacijenata sa skraćenim zubnim nizom po pravilu je umanjen u blažem ili težem stepenu. Cilj doktorske disertacije bio je da se utvrdi stepen učestalosti pojave skraćenog zubnog niza, potreba za sprovođenjem protetske rehabilitacije skraćenog zubnog niza odgovarajućim zubnim nadoknadama i njene efekte na nutritivni status i kvalitet života pacijenata. Prvi deo istraživanja sproveden je kao retrospektivna epidemiološka studija u cilju utvrđivanja učestalosti skraćenog zubnog niza analizom medicinske dokumentacije pacijenata koji su protetski rehabilitovani zubnim nadoknadama na Klinici za stomatološku protetiku Stomatološkog fakulteta Univerziteta u Beogradu u periodu od 2006. do 2015. godine. Istraživanje je obuhvatilo 4000 stomatoloških kartona...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Evaluation of prosthetic rehabilitation of shortened dental arch with different dental appliances.
T1  - Procena rehabilitacije skraćenog zubnog niza različitim zubnim nadoknadama
UR  - https://hdl.handle.net/21.15107/rcub_nardus_10745
ER  - 

@phdthesis{
author = "Radaković, Tijana",
year = "2018",
abstract = "Shortened dental arch represents a functional, aesthetic and natural dentition with no more than 20 teeth, where the anterior region is preserved and the occlusal tooth units in the posterior segment are missing. The main unresolved question about shortened dental arch is if therapeutic intervention is required. Physiological mechanisms that compensate masticatory function can be effective enough to provide a level of chewing function that allows many patients to be satisfied with their quality of life related to oral health. However, the long-term reliance on these compensatory mechanisms entails significant complications and risks. Therefore, some of the authors emphasize the necessity of complete reconstruction of the dental arch, in order to achieve appropriate aesthetic effects and provide a better masticatory function, but also, more importantly, change the position of the occlusal plane and shift the remaining teeth. Insofar as it results in a decrease in mastication efficiency, a shortened dental arch potentially leads to compromised nutritional status. People with shortened dental arch often change their eating habits, avoiding food that is harder to chew, potentially leading to nutritional imbalance and consequent risk of various diseases associated with inadequate nutritional status. Nutritional status is one of the main determinants of health-related quality of life. Quality of life in patients with shortened dental arch, as a rule, is reduced in a mild or more severe degree. The aim of this doctoral dissertation was to determine the level of incidence of shortened dental arch, the need for conducting prosthetic rehabilitation of shortened dental arches with adequate dental restoration, and its effects on nutritional status and quality of life. The first part of the research was carried out as a retrospective epidemiological study in order to determine the incidence of shortened dental arch by analysing medical documentation of patients who were rehabilitated with dental restorations at the Clinic for Prosthodontics, School of Dental Medicine, University of Belgrade in the period from 2006. to 2015. The research involved 4000 dental cards..., Skraćen zubni niz predstavlja funkcionalnu, estetsku i prirodnu denticiju sa ne više od 20 zuba, gde je očuvan anteriorni segment, a nedostaju okluzalne jedinice u posteriornom segmentu. Glavno nerazrešeno pitanje u vezi sa skraćenim zubnim nizom je da li ovakvo stanje zubika zahteva terapijsku intervenciju. Fiziološki mehanizmi kompenzacije mastikatorne funkcije usled nedostatka zuba mogu biti delotvorni u dovoljnoj meri da obezbede nivo funkcije žvakanja koji dopušta mnogim pacijentima da budu zadovoljni svojim kvalitetom života vezanim za oralno zdravlje. Međutim, dugotrajno oslanjanje na ove kompenzatorne mehanizme povlači sa sobom značajne komplikacije i rizike. Stoga neki od autora naglašavaju neophodnost kompletne rekonstrukcije zubnog niza, kako bi ostvarili i obezbedili bolju mastikatornu funkciju, kao i odgovarajući estetski učinak, ali i, što je još važnije, promenu položaja okluzalne ravni i pomeranje preostalih zuba. Ukoliko to rezultira smanjenjem mastikatorne efikasnosti, skraćeni zubni niz potencijalno dovodi do kompromitovanja nutritivnog statusa. Zbog toga osobe sa skraćenim zubnim nizom često menjaju navike u ishrani, izbegavajući hranu koja se teže žvaće, što potencijalno dovodi do nutritivnog disbalansa i sledstvenog rizika pojave raznovrsnih oboljenja povezanih sa neadekvatnim nutritivnim statusom. Nutritivni status je jedna od glavnih determinanti kvaliteta života povezanog sa zdravljem. Kvalitet života pacijenata sa skraćenim zubnim nizom po pravilu je umanjen u blažem ili težem stepenu. Cilj doktorske disertacije bio je da se utvrdi stepen učestalosti pojave skraćenog zubnog niza, potreba za sprovođenjem protetske rehabilitacije skraćenog zubnog niza odgovarajućim zubnim nadoknadama i njene efekte na nutritivni status i kvalitet života pacijenata. Prvi deo istraživanja sproveden je kao retrospektivna epidemiološka studija u cilju utvrđivanja učestalosti skraćenog zubnog niza analizom medicinske dokumentacije pacijenata koji su protetski rehabilitovani zubnim nadoknadama na Klinici za stomatološku protetiku Stomatološkog fakulteta Univerziteta u Beogradu u periodu od 2006. do 2015. godine. Istraživanje je obuhvatilo 4000 stomatoloških kartona...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Evaluation of prosthetic rehabilitation of shortened dental arch with different dental appliances., Procena rehabilitacije skraćenog zubnog niza različitim zubnim nadoknadama",
url = "https://hdl.handle.net/21.15107/rcub_nardus_10745"
}

Radaković, T.. (2018). Evaluation of prosthetic rehabilitation of shortened dental arch with different dental appliances.. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_10745

Radaković T. Evaluation of prosthetic rehabilitation of shortened dental arch with different dental appliances.. 2018;.
https://hdl.handle.net/21.15107/rcub_nardus_10745 .

Radaković, Tijana, "Evaluation of prosthetic rehabilitation of shortened dental arch with different dental appliances." (2018),
https://hdl.handle.net/21.15107/rcub_nardus_10745 .

TY  - JOUR
AU  - Canullo, Luigi
AU  - Pesce, Paolo
AU  - Botticelli, Daniele
AU  - Covani, Ugo
AU  - Janković, Saša
AU  - Jovanović, Tanja
AU  - Rakić, Mia
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2309
AB  - Purpose: To compare the qualitative and quantitative profile of Epstein-Barr virus (EBV) at external and internal implant surfaces between participants with peri-implantitis and healthy peri-implant tissues and to quantitatively assess the relation between EBV and periopathogens inside the microbiologic profile associated with peri-implantitis. Materials and Methods: Microbiologic specimens were retrieved from 84 patients wearing 190 implants to estimate the levels of EBV and 10 periopathogens in the peri-implant pocket and internal-implant connection using quantitative polymerase chain reaction. Results: The study sample consisted of 113 healthy and 77 peri-implantitis-affected implants. Statistical significance was not reached in EBV prevalence between peri-implantitis and healthy controls. EBV-positive participants demonstrated higher levels of Prevotella intermedia (Pi) and Campylobacter rectus (Cr) compared with EBV-negative participants. A positive correlation was demonstrated among EBV and Tannerella forsythia (Tf), Parvimonas micra (Pm), Fusobacterium nucleatum (Fn), and Cr levels in peri-implantitis-affected implants, while healthy controls demonstrated a positive correlation between EBV and Aggregatibacter actinomycetemcomitans (Aa), Pi, and Pm. Conclusion: EBV cannot be considered as a microbiologic marker of peri-implantitis. However, EBV could be considered as a risk factor and a peri-implantitis enhancer based on its positive correlations with pathogens associated with peri-implantitis.
PB  - Quintessence Publishing Co Inc, Hanover Park
T2  - International Journal of Oral & Maxillofacial Implants
T1  - What is the Impact of Epstein-Barr Virus in Peri-implant Infection?
VL  - 33
IS  - 1
SP  - 58
EP  - 63
DO  - 10.11607/jomi.5972
ER  - 

@article{
author = "Canullo, Luigi and Pesce, Paolo and Botticelli, Daniele and Covani, Ugo and Janković, Saša and Jovanović, Tanja and Rakić, Mia",
year = "2018",
abstract = "Purpose: To compare the qualitative and quantitative profile of Epstein-Barr virus (EBV) at external and internal implant surfaces between participants with peri-implantitis and healthy peri-implant tissues and to quantitatively assess the relation between EBV and periopathogens inside the microbiologic profile associated with peri-implantitis. Materials and Methods: Microbiologic specimens were retrieved from 84 patients wearing 190 implants to estimate the levels of EBV and 10 periopathogens in the peri-implant pocket and internal-implant connection using quantitative polymerase chain reaction. Results: The study sample consisted of 113 healthy and 77 peri-implantitis-affected implants. Statistical significance was not reached in EBV prevalence between peri-implantitis and healthy controls. EBV-positive participants demonstrated higher levels of Prevotella intermedia (Pi) and Campylobacter rectus (Cr) compared with EBV-negative participants. A positive correlation was demonstrated among EBV and Tannerella forsythia (Tf), Parvimonas micra (Pm), Fusobacterium nucleatum (Fn), and Cr levels in peri-implantitis-affected implants, while healthy controls demonstrated a positive correlation between EBV and Aggregatibacter actinomycetemcomitans (Aa), Pi, and Pm. Conclusion: EBV cannot be considered as a microbiologic marker of peri-implantitis. However, EBV could be considered as a risk factor and a peri-implantitis enhancer based on its positive correlations with pathogens associated with peri-implantitis.",
publisher = "Quintessence Publishing Co Inc, Hanover Park",
journal = "International Journal of Oral & Maxillofacial Implants",
title = "What is the Impact of Epstein-Barr Virus in Peri-implant Infection?",
volume = "33",
number = "1",
pages = "58-63",
doi = "10.11607/jomi.5972"
}

Canullo, L., Pesce, P., Botticelli, D., Covani, U., Janković, S., Jovanović, T.,& Rakić, M.. (2018). What is the Impact of Epstein-Barr Virus in Peri-implant Infection?. in International Journal of Oral & Maxillofacial Implants
Quintessence Publishing Co Inc, Hanover Park., 33(1), 58-63.
https://doi.org/10.11607/jomi.5972

Canullo L, Pesce P, Botticelli D, Covani U, Janković S, Jovanović T, Rakić M. What is the Impact of Epstein-Barr Virus in Peri-implant Infection?. in International Journal of Oral & Maxillofacial Implants. 2018;33(1):58-63.
doi:10.11607/jomi.5972 .

Canullo, Luigi, Pesce, Paolo, Botticelli, Daniele, Covani, Ugo, Janković, Saša, Jovanović, Tanja, Rakić, Mia, "What is the Impact of Epstein-Barr Virus in Peri-implant Infection?" in International Journal of Oral & Maxillofacial Implants, 33, no. 1 (2018):58-63,
https://doi.org/10.11607/jomi.5972 . .

TY  - JOUR
AU  - Zorić, Bojana
AU  - Janković, Ljiljana
AU  - Kuzmanović-Pfićer, Jovana
AU  - Zidverc-Trajković, Jasna
AU  - Mijajlović, Milija
AU  - Stanimirović, Dragan
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2288
AB  - Background: Burning mouth syndrome (BMS) is an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than 3 months. The objective was to evaluate and analyse the efficacy of serotonin reuptake inhibitor fluoxetine on psychological factors, as well as on pain in participants with BMS. Methods: In a 6-month study, 100 participants with primary and secondary BMS were divided into two groups-fluoxetine and control (placebo) and examined by the dentist and the neurologist. Depression and anxiety were estimated by Hamilton Scale for Depression (HAM-D) and Anxiety (HAM-A) and Beck Depression Inventory (BDI) and the pain intensity by visual analogue scale (VAS). Results: Mean age of the participants was 60.33 in fluoxetine group and 67.4 in control group. Most of the participants were female-74% in the fluoxetine and 78% in the control group. Statistical difference between the fluoxetine and the control group was found in HAM-D results (P  lt  .05). Values of other scales and VAS decreased significantly after the therapy in both groups (P  lt  .05). Conclusions: Our trial results indicate that fluoxetine therapy not only improves the psychological status of participants with BMS but also fluoxetine decreases the intensity of pain in these patients.
PB  - Wiley, Hoboken
T2  - Gerodontology
T1  - The efficacy of fluoxetine in BMS-A cross-over study
VL  - 35
IS  - 2
SP  - 123
EP  - 128
DO  - 10.1111/ger.12332
ER  - 

@article{
author = "Zorić, Bojana and Janković, Ljiljana and Kuzmanović-Pfićer, Jovana and Zidverc-Trajković, Jasna and Mijajlović, Milija and Stanimirović, Dragan",
year = "2018",
abstract = "Background: Burning mouth syndrome (BMS) is an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than 3 months. The objective was to evaluate and analyse the efficacy of serotonin reuptake inhibitor fluoxetine on psychological factors, as well as on pain in participants with BMS. Methods: In a 6-month study, 100 participants with primary and secondary BMS were divided into two groups-fluoxetine and control (placebo) and examined by the dentist and the neurologist. Depression and anxiety were estimated by Hamilton Scale for Depression (HAM-D) and Anxiety (HAM-A) and Beck Depression Inventory (BDI) and the pain intensity by visual analogue scale (VAS). Results: Mean age of the participants was 60.33 in fluoxetine group and 67.4 in control group. Most of the participants were female-74% in the fluoxetine and 78% in the control group. Statistical difference between the fluoxetine and the control group was found in HAM-D results (P  lt  .05). Values of other scales and VAS decreased significantly after the therapy in both groups (P  lt  .05). Conclusions: Our trial results indicate that fluoxetine therapy not only improves the psychological status of participants with BMS but also fluoxetine decreases the intensity of pain in these patients.",
publisher = "Wiley, Hoboken",
journal = "Gerodontology",
title = "The efficacy of fluoxetine in BMS-A cross-over study",
volume = "35",
number = "2",
pages = "123-128",
doi = "10.1111/ger.12332"
}

Zorić, B., Janković, L., Kuzmanović-Pfićer, J., Zidverc-Trajković, J., Mijajlović, M.,& Stanimirović, D.. (2018). The efficacy of fluoxetine in BMS-A cross-over study. in Gerodontology
Wiley, Hoboken., 35(2), 123-128.
https://doi.org/10.1111/ger.12332

Zorić B, Janković L, Kuzmanović-Pfićer J, Zidverc-Trajković J, Mijajlović M, Stanimirović D. The efficacy of fluoxetine in BMS-A cross-over study. in Gerodontology. 2018;35(2):123-128.
doi:10.1111/ger.12332 .

Zorić, Bojana, Janković, Ljiljana, Kuzmanović-Pfićer, Jovana, Zidverc-Trajković, Jasna, Mijajlović, Milija, Stanimirović, Dragan, "The efficacy of fluoxetine in BMS-A cross-over study" in Gerodontology, 35, no. 2 (2018):123-128,
https://doi.org/10.1111/ger.12332 . .

TY  - THES
AU  - Zorić, Bojana
PY  - 2018
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=6563
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:19337/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50909455
UR  - http://nardus.mpn.gov.rs/123456789/10718
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1033
AB  - Affective disorders, particularly depression, are frequent comorbidities in patients with primary Burning mouth syndrome (pBMS). Brainstem raphe (BR) represents main source of serotonin and it is assumed that it´s deficiency can cause pBMS symptoms. Studies with transcranial parenchymal sonography (TCS) determined the presence of BR hypoehogenicity in 50-70% of patients with unipolar depression which is linked with responsivity to serotonin-reuptake inhibitors (SSRI). The latter supports the hypothesis that raphe hypoehogenicity can be a marker of damaged serotonin central transmission. Etiology of pBMS, also, refers to the changes in dopamine nigrostraital pathway that starts in substantia nigra (SN) toward basal ganglia (corpus striatum). BMS manifests with chronic intraoral burning sensations and represents an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than three months without any pathological changes of oral mucosa. BMS is more frequent in women, mostly middle aged and elderly, and it can be divided into primary and secondary form. Etiology of secondary BMS (sBMS) can be local and systemic. The onset of the pBMS is related to BR hypoechogenicity which can be noticed in patients with unipolar depression and depression in Parkinson disease. Objective: The aims of this study were to evaluate clinical characterstics of BMS, neurological and psychological status of patients with elimination of local and systemic etiological factors. Additionally, aim was to determine connection between raphe and substantia nigra echogenicity and clinical and affective status of patients. Also, this study had objective to define therapy efficiency. Methods: The study included 70 patients with complaint of oral burning sensation, from which 30 patients were included into the research after taking anamnesis, clinical examination and supplementary tests. Echogenicity of BR and SN was determined with TCS examination. Medication fluoxetine from the SSRI group was prescribed to all patients. Control examinations were conducted after 3 and 6 months...
AB  - Afektivni poremećaji, pogotovo depresija, su česti komorbiditeti kod pacijenata sa primarnim Sindromom pekućeg bola usne duplje (pSPU). Jedra rafe (RM) predstavljaju glavni izvor serotonina u mozgu i smatra se da njegov nedostatak može izazvati simptome pSPU. Ispitivanja sa primenom transkranijalne parenhimske sonografije (TCS) su utvrdila hipoehogenost struktura RM kod 50-70% pacijenata sa unipolarnom depresijom koja je povezana sa odgovorom na inhibitore preuzimanja serotonina, što podržava hipotezu da hipoehogenost RM može biti marker oštećene centralne transmisije serotonina. Takođe se u etiologiji pSPU govori o izmenjenom dopaminergičkom nigrostrijatnom putu, koji polazi iz supstancije nigre (SN) ka bazalnim ganglijama (corpus striatum-u). SPU se manifestuje hroničnim osećajem peckanja i žarenja u usnoj dupllji i predstavlja osećaj pečenja u ustima i dizestezije koje se ponavljaju tokom dana, više od 2 sata i duže od 3 meseca, bez klinički evidentnih lezija. Pojava ovog oboljenja češća je kod osoba ženskog pola, srednje i starije životne dobi. Ovaj Sindrom može biti primarni i sekundarni. Etiologija sekundarnog SPU može biti lokalna i sistemska. Nastanak pSPU se dovodi u vezu sa sniženom ehogenosti jedara rafe, koje je prisutna i kod pacijenata sa unipolarnom depresijom i depresijom udruženom sa Parkinsonovom bolesti. Cilj: Cilj ovog istraživanja je bio da se evaluiraju kliničke karakteristike SPU, neurološki i psihološki profil pacijenata, uz eliminaciju lokalnih i sistemskih etioloških faktora. Dodatno, cilj je bio utvrđivanje povezanosti ehogenosti jedara rafe i SN sa kliničkim i afektivnim statusom pacijenata. Takođe, istraživanje je imalo za cilj procenu efikasnosti primenjene terapije. Materijal i metode: Istraživanjem je obuhvaćeno 70 pacijenata sa simptomima SPU, od kojih je nakon anamneze, kliničkog pregleda i dopunskih ispitivanja, u studiju uključeno njih 30. Ehogenost RM i SN je procenjivana upotrebom TCS. Svim pacijentima je ordiniran lek fluoksetin iz grupe selektivnih inhibitora preuzimanja serotonina. Kontrolni pregledi su se obavljali nakon 3 i 6 meseci...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Affective disorders and brainstem raphe and substantia nigra echogenicity in evaluation of Burning mouth syndrome therapy efficiency
T1  - Afektivni status i ehogenost jedara rafe i supstancije nigre u proceni efikasnosti terapije Sindroma pekućeg bola usne duplje
UR  - https://hdl.handle.net/21.15107/rcub_nardus_10718
ER  - 

@phdthesis{
author = "Zorić, Bojana",
year = "2018",
abstract = "Affective disorders, particularly depression, are frequent comorbidities in patients with primary Burning mouth syndrome (pBMS). Brainstem raphe (BR) represents main source of serotonin and it is assumed that it´s deficiency can cause pBMS symptoms. Studies with transcranial parenchymal sonography (TCS) determined the presence of BR hypoehogenicity in 50-70% of patients with unipolar depression which is linked with responsivity to serotonin-reuptake inhibitors (SSRI). The latter supports the hypothesis that raphe hypoehogenicity can be a marker of damaged serotonin central transmission. Etiology of pBMS, also, refers to the changes in dopamine nigrostraital pathway that starts in substantia nigra (SN) toward basal ganglia (corpus striatum). BMS manifests with chronic intraoral burning sensations and represents an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than three months without any pathological changes of oral mucosa. BMS is more frequent in women, mostly middle aged and elderly, and it can be divided into primary and secondary form. Etiology of secondary BMS (sBMS) can be local and systemic. The onset of the pBMS is related to BR hypoechogenicity which can be noticed in patients with unipolar depression and depression in Parkinson disease. Objective: The aims of this study were to evaluate clinical characterstics of BMS, neurological and psychological status of patients with elimination of local and systemic etiological factors. Additionally, aim was to determine connection between raphe and substantia nigra echogenicity and clinical and affective status of patients. Also, this study had objective to define therapy efficiency. Methods: The study included 70 patients with complaint of oral burning sensation, from which 30 patients were included into the research after taking anamnesis, clinical examination and supplementary tests. Echogenicity of BR and SN was determined with TCS examination. Medication fluoxetine from the SSRI group was prescribed to all patients. Control examinations were conducted after 3 and 6 months..., Afektivni poremećaji, pogotovo depresija, su česti komorbiditeti kod pacijenata sa primarnim Sindromom pekućeg bola usne duplje (pSPU). Jedra rafe (RM) predstavljaju glavni izvor serotonina u mozgu i smatra se da njegov nedostatak može izazvati simptome pSPU. Ispitivanja sa primenom transkranijalne parenhimske sonografije (TCS) su utvrdila hipoehogenost struktura RM kod 50-70% pacijenata sa unipolarnom depresijom koja je povezana sa odgovorom na inhibitore preuzimanja serotonina, što podržava hipotezu da hipoehogenost RM može biti marker oštećene centralne transmisije serotonina. Takođe se u etiologiji pSPU govori o izmenjenom dopaminergičkom nigrostrijatnom putu, koji polazi iz supstancije nigre (SN) ka bazalnim ganglijama (corpus striatum-u). SPU se manifestuje hroničnim osećajem peckanja i žarenja u usnoj dupllji i predstavlja osećaj pečenja u ustima i dizestezije koje se ponavljaju tokom dana, više od 2 sata i duže od 3 meseca, bez klinički evidentnih lezija. Pojava ovog oboljenja češća je kod osoba ženskog pola, srednje i starije životne dobi. Ovaj Sindrom može biti primarni i sekundarni. Etiologija sekundarnog SPU može biti lokalna i sistemska. Nastanak pSPU se dovodi u vezu sa sniženom ehogenosti jedara rafe, koje je prisutna i kod pacijenata sa unipolarnom depresijom i depresijom udruženom sa Parkinsonovom bolesti. Cilj: Cilj ovog istraživanja je bio da se evaluiraju kliničke karakteristike SPU, neurološki i psihološki profil pacijenata, uz eliminaciju lokalnih i sistemskih etioloških faktora. Dodatno, cilj je bio utvrđivanje povezanosti ehogenosti jedara rafe i SN sa kliničkim i afektivnim statusom pacijenata. Takođe, istraživanje je imalo za cilj procenu efikasnosti primenjene terapije. Materijal i metode: Istraživanjem je obuhvaćeno 70 pacijenata sa simptomima SPU, od kojih je nakon anamneze, kliničkog pregleda i dopunskih ispitivanja, u studiju uključeno njih 30. Ehogenost RM i SN je procenjivana upotrebom TCS. Svim pacijentima je ordiniran lek fluoksetin iz grupe selektivnih inhibitora preuzimanja serotonina. Kontrolni pregledi su se obavljali nakon 3 i 6 meseci...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Affective disorders and brainstem raphe and substantia nigra echogenicity in evaluation of Burning mouth syndrome therapy efficiency, Afektivni status i ehogenost jedara rafe i supstancije nigre u proceni efikasnosti terapije Sindroma pekućeg bola usne duplje",
url = "https://hdl.handle.net/21.15107/rcub_nardus_10718"
}

Zorić, B.. (2018). Affective disorders and brainstem raphe and substantia nigra echogenicity in evaluation of Burning mouth syndrome therapy efficiency. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_10718

Zorić B. Affective disorders and brainstem raphe and substantia nigra echogenicity in evaluation of Burning mouth syndrome therapy efficiency. 2018;.
https://hdl.handle.net/21.15107/rcub_nardus_10718 .

Zorić, Bojana, "Affective disorders and brainstem raphe and substantia nigra echogenicity in evaluation of Burning mouth syndrome therapy efficiency" (2018),
https://hdl.handle.net/21.15107/rcub_nardus_10718 .

TY  - JOUR
AU  - Pejčić, Nataša
AU  - Petrović, Vanja
AU  - Marković, Dejan
AU  - Miličić, Biljana
AU  - Ilic-Dimitrijević, Ivana
AU  - Perunović, Neda
AU  - Čakić, Saša
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2205
AB  - BACKGROUND: Dentists have a high prevalence of musculoskeletal (MS) pain, which is the most common symptom associated with work-related musculoskeletal disorders (WMSDs). To overcome this problem, identification of the risk factors and preventive measures for MS pain are of paramount importance to dentists in order to improve their quality of life and work. OBJECTIVES: The aims of this study were to recognize the risk factors for MS pain and their impact on dental work, as well as to identify preventive measures of MS pain among dentists. METHODS: Self-reporting questionnaire consisting of 78 questions was exclusively developed for the study and sent to 500 working active dentists in Serbia. RESULTS: Response rate was 71.2% (356 dentists). The prevalence of MS pain was 82.6% among dentists. The main risk factors for MS pain were advanced age, female dentists, presence of chronic diseases, long working hours, and high frequency of treated patients. The most effective preventive measures in preventing MS pain were massage treatments and physical activities. Followed by use of ergonomically designed equipment, correct and dynamic working positions, and an adequate workflow organization. CONCLUSION: The risk factors for MS pain and their impact on dental work should widely be disseminated among dentists. Importantly, proper implementation in everyday life of adequate preventive measures is essential for preventing MS pain and development of WMSDs.
PB  - Ios Press, Amsterdam
T2  - Work - A Journal of Prevention Assessment & Rehabilitation
T1  - Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists
VL  - 57
IS  - 4
SP  - 573
EP  - 593
DO  - 10.3233/WOR-172588
ER  - 

@article{
author = "Pejčić, Nataša and Petrović, Vanja and Marković, Dejan and Miličić, Biljana and Ilic-Dimitrijević, Ivana and Perunović, Neda and Čakić, Saša",
year = "2017",
abstract = "BACKGROUND: Dentists have a high prevalence of musculoskeletal (MS) pain, which is the most common symptom associated with work-related musculoskeletal disorders (WMSDs). To overcome this problem, identification of the risk factors and preventive measures for MS pain are of paramount importance to dentists in order to improve their quality of life and work. OBJECTIVES: The aims of this study were to recognize the risk factors for MS pain and their impact on dental work, as well as to identify preventive measures of MS pain among dentists. METHODS: Self-reporting questionnaire consisting of 78 questions was exclusively developed for the study and sent to 500 working active dentists in Serbia. RESULTS: Response rate was 71.2% (356 dentists). The prevalence of MS pain was 82.6% among dentists. The main risk factors for MS pain were advanced age, female dentists, presence of chronic diseases, long working hours, and high frequency of treated patients. The most effective preventive measures in preventing MS pain were massage treatments and physical activities. Followed by use of ergonomically designed equipment, correct and dynamic working positions, and an adequate workflow organization. CONCLUSION: The risk factors for MS pain and their impact on dental work should widely be disseminated among dentists. Importantly, proper implementation in everyday life of adequate preventive measures is essential for preventing MS pain and development of WMSDs.",
publisher = "Ios Press, Amsterdam",
journal = "Work - A Journal of Prevention Assessment & Rehabilitation",
title = "Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists",
volume = "57",
number = "4",
pages = "573-593",
doi = "10.3233/WOR-172588"
}

Pejčić, N., Petrović, V., Marković, D., Miličić, B., Ilic-Dimitrijević, I., Perunović, N.,& Čakić, S.. (2017). Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists. in Work - A Journal of Prevention Assessment & Rehabilitation
Ios Press, Amsterdam., 57(4), 573-593.
https://doi.org/10.3233/WOR-172588

Pejčić N, Petrović V, Marković D, Miličić B, Ilic-Dimitrijević I, Perunović N, Čakić S. Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists. in Work - A Journal of Prevention Assessment & Rehabilitation. 2017;57(4):573-593.
doi:10.3233/WOR-172588 .

Pejčić, Nataša, Petrović, Vanja, Marković, Dejan, Miličić, Biljana, Ilic-Dimitrijević, Ivana, Perunović, Neda, Čakić, Saša, "Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists" in Work - A Journal of Prevention Assessment & Rehabilitation, 57, no. 4 (2017):573-593,
https://doi.org/10.3233/WOR-172588 . .

TY  - THES
AU  - Rakašević, Dragana
PY  - 2017
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=5602
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:17131/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49850127
UR  - http://nardus.mpn.gov.rs/123456789/9156
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1026
AB  - Peri-implantitis is defined as an inflammatory process in the soft and hard tissue of surrounding osseointegrate implants in the function. The main aetiology factor in the development of the peri-implantitis is anaerobes, associated with the excessive immunological answer of the host, responsible for peri-implant tissue loss. Moreover, there are additional factors- general and local, which could promote development and progression of peri-implantitis. The subpopulation of Th lymphocytes such as Th1, Th2 and Th17 cells plays an important role in a pathogenesis of peri-impantitis. Different pro- and anti-inflammatory cells have been produced by an induced Th cell. Production and secretion of IL-17 are followed by the cascade interactions and activations of interleukins IL-1 β, IL-6, IL-21 and IL–23. IL-17 has an important role in different inflammatory diseases such as rheumatoid arthritis, periodontitis and peri-implantitis. The total amount of IL-17 is increased significantly in a peri-implant cervical fluid. Furthermore, differentiation of Th17 and secretion of IL-17 could have been induced by the microorganisms and their products such as Porphyromonas gingivitis. Synergistically, IL- 17 with IL-6 and IL-1β produced differentiation of osteoclasts, contributing directly or indirectly to osteoclastogenesis. The main goal of peri-implant therapy is a reduction of inflammation and creation of favourable conditions for the tissue repair and regeneration. Eradication of the causative bacteria and decontamination of the implant surface is essential in achieving predictable and stable clinical results. Photodynamic therapy (PDT) is a non-invasive adjuvant therapeutic method in the treatment of bacterial, viral and fungal infection. It is defined as an oxygen-dependent photochemical reaction that occurs upon light–mediated activation of a photosensitizing compound leading to the generation of cytotoxic reactive oxygen species, predominantly singlet oxygen. This reaction induces oxidative damage to the cell membrane and cell wall causing the death of cells. Objective The aim of this study was to evaluate clinical, immunological and microbiological outcomes of peri-implantitis when diverse surgical methods were used (with or without an adjunctive PDT). Methods Fifty-two diagnosed peri-implantitis sites were divided into two groups: experimental and control group. Before the surgical procedure, the initial- nonsurgical therapy followed by mechanical debridement of peri-implant pocket, was used in order to reduce the signs of inflammation...
AB  - Peri-implantitis se definiše kao inflamatorni proces koji zahvata pored mekih tkiva i potpornu kost oko oseointegrisanog implantata u funkciji. Osnovni etiološki faktor u razvoju peri-implantitisa su mikroorganizmi dentalnog plaka, koji udruženi sa ekstenzivnim imunim odgovorom domaćina dovode do gubitaka peri-implantnih tkiva. Pored glavnih etioloških faktora, brojni akcesorni faktori- opšti i lokalni, mogu da potspeše nastanak i progresiju peri-implantitisa. U patogenezi peri-implantnih oboljenja važnu ulogu imaju sve subpopulacije Th limfocita: Th1, Th2 i Th17 ćelije koje sekretuju različite pro- i anti-inflamatorne citokine. Produkcija i izlučivanje IL-17 praćena je kaskadnim reakcijama i međusobnim aktivacijama interleukina kao što su IL-1β, IL-6, IL-21 i IL-23. Značajna uloga IL-17 ogleda se u raznim inflamatornim oboljenjima kao što je reumatoidni artritis, parodontopatija i peri-implantitis. Značajno povišena koncentracija IL-17 detektovana je u periimplantnoj cervikalnoj tečnosti kod osoba sa dijagnostikovanim peri-implantitisom. Mikroorganizmi i njeni produkti kao što je Porphyromonas gingivalis, mogu da indukuju diferencijaciju Th17 ćelije i da omoguće produkciju IL-17. IL-17 ćelija uzajamnim dejstvom sa IL-6 i IL-1β sudeluju u diferencijaciji osteoklasta, uzrokujući indirektnu ili direktnu osteoklastogenezu. Osnovni cilj terapije peri-implantitisa je redukcija zapaljenja u peri-implantnom tkivu i stvaranje povoljnih uslova za reparaciju i regeneraciju zahvaćenih tkiva. Eliminacija patogenih mikroorganizama i dekontaminacija implantne površine predstavlja najbitniji korak u postizanju stabilnih kliničkih rezultata. Fotodinamska terapija (FDT), predstavlja novo pomoćno ne-invazivno terapijsko sredstvo u terapiji bakterijskih, virusnih i gljivičnih infekcija. Definiše se kao kiseonik-zavisna fotohemijska reakcija, koja nastaje aktivacijom fotoaktivne materije (engl. photosensitizer), pomoću svetlosti lasera niske talasne dužine (630 nm-700 nm) u prisustvu kiseonika. Izlaganjem fotodinamskog sredstva svetlosti lasera, dolazi do stvaranja slobodnih radikala i slobodnog kiseonika, prouzrokujući fotohemijsko oštećenje i smrt ćelije. Cilj rada bila je procena kliničkih, imunoloških i mikrobioloških parametara pre i 3 meseca nakon hirurške terapije, sa ili bez primene dodatne FDT. Metode rada. Implantati sa dijagnostikovanim peri-implantitisom (n = 52) bili su podeljeni u dve grupe: eksperimentalnu grupu (n=27) i kontrolnu grupu (n=25)...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - The evaluation of efficiency of the photodynamic therapy in peri-implantitis
T1  - Procena efikasnosti fotodinamske terapije kod periimplantitisa
UR  - https://hdl.handle.net/21.15107/rcub_nardus_9156
ER  - 

@phdthesis{
author = "Rakašević, Dragana",
year = "2017",
abstract = "Peri-implantitis is defined as an inflammatory process in the soft and hard tissue of surrounding osseointegrate implants in the function. The main aetiology factor in the development of the peri-implantitis is anaerobes, associated with the excessive immunological answer of the host, responsible for peri-implant tissue loss. Moreover, there are additional factors- general and local, which could promote development and progression of peri-implantitis. The subpopulation of Th lymphocytes such as Th1, Th2 and Th17 cells plays an important role in a pathogenesis of peri-impantitis. Different pro- and anti-inflammatory cells have been produced by an induced Th cell. Production and secretion of IL-17 are followed by the cascade interactions and activations of interleukins IL-1 β, IL-6, IL-21 and IL–23. IL-17 has an important role in different inflammatory diseases such as rheumatoid arthritis, periodontitis and peri-implantitis. The total amount of IL-17 is increased significantly in a peri-implant cervical fluid. Furthermore, differentiation of Th17 and secretion of IL-17 could have been induced by the microorganisms and their products such as Porphyromonas gingivitis. Synergistically, IL- 17 with IL-6 and IL-1β produced differentiation of osteoclasts, contributing directly or indirectly to osteoclastogenesis. The main goal of peri-implant therapy is a reduction of inflammation and creation of favourable conditions for the tissue repair and regeneration. Eradication of the causative bacteria and decontamination of the implant surface is essential in achieving predictable and stable clinical results. Photodynamic therapy (PDT) is a non-invasive adjuvant therapeutic method in the treatment of bacterial, viral and fungal infection. It is defined as an oxygen-dependent photochemical reaction that occurs upon light–mediated activation of a photosensitizing compound leading to the generation of cytotoxic reactive oxygen species, predominantly singlet oxygen. This reaction induces oxidative damage to the cell membrane and cell wall causing the death of cells. Objective The aim of this study was to evaluate clinical, immunological and microbiological outcomes of peri-implantitis when diverse surgical methods were used (with or without an adjunctive PDT). Methods Fifty-two diagnosed peri-implantitis sites were divided into two groups: experimental and control group. Before the surgical procedure, the initial- nonsurgical therapy followed by mechanical debridement of peri-implant pocket, was used in order to reduce the signs of inflammation..., Peri-implantitis se definiše kao inflamatorni proces koji zahvata pored mekih tkiva i potpornu kost oko oseointegrisanog implantata u funkciji. Osnovni etiološki faktor u razvoju peri-implantitisa su mikroorganizmi dentalnog plaka, koji udruženi sa ekstenzivnim imunim odgovorom domaćina dovode do gubitaka peri-implantnih tkiva. Pored glavnih etioloških faktora, brojni akcesorni faktori- opšti i lokalni, mogu da potspeše nastanak i progresiju peri-implantitisa. U patogenezi peri-implantnih oboljenja važnu ulogu imaju sve subpopulacije Th limfocita: Th1, Th2 i Th17 ćelije koje sekretuju različite pro- i anti-inflamatorne citokine. Produkcija i izlučivanje IL-17 praćena je kaskadnim reakcijama i međusobnim aktivacijama interleukina kao što su IL-1β, IL-6, IL-21 i IL-23. Značajna uloga IL-17 ogleda se u raznim inflamatornim oboljenjima kao što je reumatoidni artritis, parodontopatija i peri-implantitis. Značajno povišena koncentracija IL-17 detektovana je u periimplantnoj cervikalnoj tečnosti kod osoba sa dijagnostikovanim peri-implantitisom. Mikroorganizmi i njeni produkti kao što je Porphyromonas gingivalis, mogu da indukuju diferencijaciju Th17 ćelije i da omoguće produkciju IL-17. IL-17 ćelija uzajamnim dejstvom sa IL-6 i IL-1β sudeluju u diferencijaciji osteoklasta, uzrokujući indirektnu ili direktnu osteoklastogenezu. Osnovni cilj terapije peri-implantitisa je redukcija zapaljenja u peri-implantnom tkivu i stvaranje povoljnih uslova za reparaciju i regeneraciju zahvaćenih tkiva. Eliminacija patogenih mikroorganizama i dekontaminacija implantne površine predstavlja najbitniji korak u postizanju stabilnih kliničkih rezultata. Fotodinamska terapija (FDT), predstavlja novo pomoćno ne-invazivno terapijsko sredstvo u terapiji bakterijskih, virusnih i gljivičnih infekcija. Definiše se kao kiseonik-zavisna fotohemijska reakcija, koja nastaje aktivacijom fotoaktivne materije (engl. photosensitizer), pomoću svetlosti lasera niske talasne dužine (630 nm-700 nm) u prisustvu kiseonika. Izlaganjem fotodinamskog sredstva svetlosti lasera, dolazi do stvaranja slobodnih radikala i slobodnog kiseonika, prouzrokujući fotohemijsko oštećenje i smrt ćelije. Cilj rada bila je procena kliničkih, imunoloških i mikrobioloških parametara pre i 3 meseca nakon hirurške terapije, sa ili bez primene dodatne FDT. Metode rada. Implantati sa dijagnostikovanim peri-implantitisom (n = 52) bili su podeljeni u dve grupe: eksperimentalnu grupu (n=27) i kontrolnu grupu (n=25)...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "The evaluation of efficiency of the photodynamic therapy in peri-implantitis, Procena efikasnosti fotodinamske terapije kod periimplantitisa",
url = "https://hdl.handle.net/21.15107/rcub_nardus_9156"
}

Rakašević, D.. (2017). The evaluation of efficiency of the photodynamic therapy in peri-implantitis. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_9156

Rakašević D. The evaluation of efficiency of the photodynamic therapy in peri-implantitis. 2017;.
https://hdl.handle.net/21.15107/rcub_nardus_9156 .

Rakašević, Dragana, "The evaluation of efficiency of the photodynamic therapy in peri-implantitis" (2017),
https://hdl.handle.net/21.15107/rcub_nardus_9156 .

TY  - THES
AU  - Todorović, Vladimir S.
PY  - 2017
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=6045
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:18379/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49918223
UR  - http://nardus.mpn.gov.rs/123456789/10086
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1017
AB  - INTRODUCTION: The placement of endoseous dental implants to replace lost teeth has become a routine and predictable treatment modality. Dental implant macro- and microdesign, materials, as well as loading protocols have improved over time. The aim of shortening the overall treatment time has led to the introduction of immediate or early loading protocols that replaced the conventional (i.e. two-phase or Branemark`s) loading protocol, which required 3 to 6 months of undisturbed healing prior to implant loading. Several clinical trials have analysed immediate or early loading protocols using different implant designs. In most of these studies implants were inserted predominantly in sites with good bone quality in order to achieve adequate primary stability, which is one of the prerequisites for implant treatment success, but even more important when implants are loaded immediately. The posterior maxilla has been considered an anatomical region not suitable for immediate or early loading protocols, due to poor bone quality, and few studies on this could be found in the literature. AIM: The aim of the present study was to evaluate the overall success rate of immediately and early loaded short, hybrid self-tapping implants inserted in the posterior maxilla by analysing clinical parameters such as primary implant stability, implant stability changes during observation period, peri-implant crestal bone loss, peri-implant soft tissue healing and criteria for implant treatment success. MATERIAL AND METHOD: The present prospective, randomized controlled (splitmouth) clinical trial included eight patients with bilateral posterior edentulism in the maxilla. After meticulous planning and preoperative procedures done, each patient received 6 implants in total (split-mouth design) in the first and second premolar and first molar sites. Both sides of the maxilla were assigned randomly to either immediate (IL) or early (EL) loading group. Total of 48 implants were analyzed, 24 implants in both investigated groups...
AB  - UVOD: Ugradnja zubnih implanata danas predstavlja rutinsku terapiju parcijalne i totalne bezubosti, sa predvidljivim ishodom. Period razvoja oralne implantologije obeležio je konstantan rad na unapređenju makro- i mikro-dizajna implanta, materijala za implantaciju, kao i protokola opterećenja. Sa ciljem skraćenja sveukupnog vremena implantne terapije došlo je do predstavljanja protokola imedijatnog ili ranog opterećenja, koji su zamenili inicijalno preporučeni konvencionalni (tzv. dvofazni ili Branemarkov) protokol opterećenja, koji je podrazumevao period mirovanja od 3 do 6 meseci nakon ugradnje implanata. Analiza uspešnosti implantne terapije primenom implanata različitog makro- i mikro-dizajna, uz primenu protokola imedijatnog ili ranog opterećenja, sprovedena je u brojnim kliničkim studijama. Adekvatna primarna stabilnost implanta jedan je od osnovnih preduslova za uspeh implantne terapije, posebno kod primene protokola imedijatnog i ranog opterećenja, te su u pomenutim studijama implanti uglavnom ugrađivani u regije vilica sa dobrim kvalitetom kosti. Bočna regija gornje vilice, u kojoj preovlađuje slabiji kvalitet kosti, smatrana je nepovoljnom za primenu protokola imedijatnog ili ranog opterećenja, što je rezultiralo malim brojem studija na tu temu, kao i potrebom za dodatnom naučnom vrerifikacijom primene protokola imedijatnog opterećenja u pomenutoj anatomskog regiji. CILJ: Cilj ovog kliničkog istraživanja je bio da se ispita i uporedi uspešnost imedijatno i rano opterećenih kratkih, samourezujućih implanata ugrađenih u bočnu regiju gornje vilice, praćenjem i poređenjem odgovarajućih kliničkih parametara (vrednost primarne stabilnosti, promena vrednosti implantne stabilnosti u različitim vremenskim tačkama tokom perioda praćenja, vrednosti peri-implantne koštane resorpcije i vrednosti modifikovanog indeksa krvarenja (MBI) i modifikovanog plak indeksa (MPI)) i vrednosti kriterijuma uspešnosti. MATERIJAL I METOD: U ovu prospektivnu randomizovanu kliničku studiju, sa «splithmouth » dizajnom, bilo je uključeno osam pacijenata sa obostranom terminalnom bezubosti u gornjoj vilici...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Clinical evaluation of immediately loaded short hybrid self-tapping implants inserted in the posterior maxilla
T1  - Klinička procena uspešnosti imedijatno opterećenih kratkih samourezujućih implantata ugrađenih u bočnu regiju gornje vilice
UR  - https://hdl.handle.net/21.15107/rcub_nardus_10086
ER  - 

@phdthesis{
author = "Todorović, Vladimir S.",
year = "2017",
abstract = "INTRODUCTION: The placement of endoseous dental implants to replace lost teeth has become a routine and predictable treatment modality. Dental implant macro- and microdesign, materials, as well as loading protocols have improved over time. The aim of shortening the overall treatment time has led to the introduction of immediate or early loading protocols that replaced the conventional (i.e. two-phase or Branemark`s) loading protocol, which required 3 to 6 months of undisturbed healing prior to implant loading. Several clinical trials have analysed immediate or early loading protocols using different implant designs. In most of these studies implants were inserted predominantly in sites with good bone quality in order to achieve adequate primary stability, which is one of the prerequisites for implant treatment success, but even more important when implants are loaded immediately. The posterior maxilla has been considered an anatomical region not suitable for immediate or early loading protocols, due to poor bone quality, and few studies on this could be found in the literature. AIM: The aim of the present study was to evaluate the overall success rate of immediately and early loaded short, hybrid self-tapping implants inserted in the posterior maxilla by analysing clinical parameters such as primary implant stability, implant stability changes during observation period, peri-implant crestal bone loss, peri-implant soft tissue healing and criteria for implant treatment success. MATERIAL AND METHOD: The present prospective, randomized controlled (splitmouth) clinical trial included eight patients with bilateral posterior edentulism in the maxilla. After meticulous planning and preoperative procedures done, each patient received 6 implants in total (split-mouth design) in the first and second premolar and first molar sites. Both sides of the maxilla were assigned randomly to either immediate (IL) or early (EL) loading group. Total of 48 implants were analyzed, 24 implants in both investigated groups..., UVOD: Ugradnja zubnih implanata danas predstavlja rutinsku terapiju parcijalne i totalne bezubosti, sa predvidljivim ishodom. Period razvoja oralne implantologije obeležio je konstantan rad na unapređenju makro- i mikro-dizajna implanta, materijala za implantaciju, kao i protokola opterećenja. Sa ciljem skraćenja sveukupnog vremena implantne terapije došlo je do predstavljanja protokola imedijatnog ili ranog opterećenja, koji su zamenili inicijalno preporučeni konvencionalni (tzv. dvofazni ili Branemarkov) protokol opterećenja, koji je podrazumevao period mirovanja od 3 do 6 meseci nakon ugradnje implanata. Analiza uspešnosti implantne terapije primenom implanata različitog makro- i mikro-dizajna, uz primenu protokola imedijatnog ili ranog opterećenja, sprovedena je u brojnim kliničkim studijama. Adekvatna primarna stabilnost implanta jedan je od osnovnih preduslova za uspeh implantne terapije, posebno kod primene protokola imedijatnog i ranog opterećenja, te su u pomenutim studijama implanti uglavnom ugrađivani u regije vilica sa dobrim kvalitetom kosti. Bočna regija gornje vilice, u kojoj preovlađuje slabiji kvalitet kosti, smatrana je nepovoljnom za primenu protokola imedijatnog ili ranog opterećenja, što je rezultiralo malim brojem studija na tu temu, kao i potrebom za dodatnom naučnom vrerifikacijom primene protokola imedijatnog opterećenja u pomenutoj anatomskog regiji. CILJ: Cilj ovog kliničkog istraživanja je bio da se ispita i uporedi uspešnost imedijatno i rano opterećenih kratkih, samourezujućih implanata ugrađenih u bočnu regiju gornje vilice, praćenjem i poređenjem odgovarajućih kliničkih parametara (vrednost primarne stabilnosti, promena vrednosti implantne stabilnosti u različitim vremenskim tačkama tokom perioda praćenja, vrednosti peri-implantne koštane resorpcije i vrednosti modifikovanog indeksa krvarenja (MBI) i modifikovanog plak indeksa (MPI)) i vrednosti kriterijuma uspešnosti. MATERIJAL I METOD: U ovu prospektivnu randomizovanu kliničku studiju, sa «splithmouth » dizajnom, bilo je uključeno osam pacijenata sa obostranom terminalnom bezubosti u gornjoj vilici...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Clinical evaluation of immediately loaded short hybrid self-tapping implants inserted in the posterior maxilla, Klinička procena uspešnosti imedijatno opterećenih kratkih samourezujućih implantata ugrađenih u bočnu regiju gornje vilice",
url = "https://hdl.handle.net/21.15107/rcub_nardus_10086"
}

Todorović, V. S.. (2017). Clinical evaluation of immediately loaded short hybrid self-tapping implants inserted in the posterior maxilla. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_10086

Todorović VS. Clinical evaluation of immediately loaded short hybrid self-tapping implants inserted in the posterior maxilla. 2017;.
https://hdl.handle.net/21.15107/rcub_nardus_10086 .

Todorović, Vladimir S., "Clinical evaluation of immediately loaded short hybrid self-tapping implants inserted in the posterior maxilla" (2017),
https://hdl.handle.net/21.15107/rcub_nardus_10086 .

TY  - JOUR
AU  - Vlahović, Zoran
AU  - Marković, Aleksa
AU  - Lazić, Zoran
AU  - Šćepanović, Miodrag
AU  - Đinić, Ana
AU  - Kalanović, Milena
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2219
AB  - AimTo evaluate by histopathological analysis the peri-implant bone inflammation degree, in certain time intervals (7, 14, 21 and 28days), following mini-incision flapless and flap implant placement. Material and methodsThe experiment was conducted on four domestic pigs. Nine weeks prior to implant insertion, second and third mandibular premolars were extracted. Each animal received six implants in lower jaw. On one randomly chosen side of jaw flapless technique using mini-incision was performed, while on the other side implants were inserted after flap raising. After 7, 14, 21, and 28days, the experimental animals were sacrificed. Following mandibular resection and decalcification, the samples for histopathological analysis of the peri-implant bone were obtained in the empty implant bed area, from the buccal side of the mandible, adjacent to implant neck region and parallel to crestal edge of implant bed. The degree of inflammatory response of the peri-implant bone was estimated through ordinal scores from 0 to 2. ResultsSeven days after the surgery all samples in the flap group had score 2 indicating high inflammation degree, in contrast to lower inflammatory reaction in flapless group. On the 14th and 21st postoperative day decreasing of inflammation degree was noted in all samples of the flapless group (score 1), while in flap group samples presented scores 1 and 2. Twenty-eight days after the implant placement, further reduction of inflammation in the flapless group (33% of samples had score 0) was observed. ConclusionFlapless technique in comparison to conventional flap procedure minimizes postoperative bone inflammatory reactions.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs
VL  - 28
IS  - 9
SP  - 1067
EP  - 1073
DO  - 10.1111/clr.12919
ER  - 

@article{
author = "Vlahović, Zoran and Marković, Aleksa and Lazić, Zoran and Šćepanović, Miodrag and Đinić, Ana and Kalanović, Milena",
year = "2017",
abstract = "AimTo evaluate by histopathological analysis the peri-implant bone inflammation degree, in certain time intervals (7, 14, 21 and 28days), following mini-incision flapless and flap implant placement. Material and methodsThe experiment was conducted on four domestic pigs. Nine weeks prior to implant insertion, second and third mandibular premolars were extracted. Each animal received six implants in lower jaw. On one randomly chosen side of jaw flapless technique using mini-incision was performed, while on the other side implants were inserted after flap raising. After 7, 14, 21, and 28days, the experimental animals were sacrificed. Following mandibular resection and decalcification, the samples for histopathological analysis of the peri-implant bone were obtained in the empty implant bed area, from the buccal side of the mandible, adjacent to implant neck region and parallel to crestal edge of implant bed. The degree of inflammatory response of the peri-implant bone was estimated through ordinal scores from 0 to 2. ResultsSeven days after the surgery all samples in the flap group had score 2 indicating high inflammation degree, in contrast to lower inflammatory reaction in flapless group. On the 14th and 21st postoperative day decreasing of inflammation degree was noted in all samples of the flapless group (score 1), while in flap group samples presented scores 1 and 2. Twenty-eight days after the implant placement, further reduction of inflammation in the flapless group (33% of samples had score 0) was observed. ConclusionFlapless technique in comparison to conventional flap procedure minimizes postoperative bone inflammatory reactions.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs",
volume = "28",
number = "9",
pages = "1067-1073",
doi = "10.1111/clr.12919"
}

Vlahović, Z., Marković, A., Lazić, Z., Šćepanović, M., Đinić, A.,& Kalanović, M.. (2017). Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs. in Clinical Oral Implants Research
Wiley, Hoboken., 28(9), 1067-1073.
https://doi.org/10.1111/clr.12919

Vlahović Z, Marković A, Lazić Z, Šćepanović M, Đinić A, Kalanović M. Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs. in Clinical Oral Implants Research. 2017;28(9):1067-1073.
doi:10.1111/clr.12919 .

Vlahović, Zoran, Marković, Aleksa, Lazić, Zoran, Šćepanović, Miodrag, Đinić, Ana, Kalanović, Milena, "Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs" in Clinical Oral Implants Research, 28, no. 9 (2017):1067-1073,
https://doi.org/10.1111/clr.12919 . .

TY  - JOUR
AU  - Cimbaljević, Milena
AU  - Misić, J.
AU  - Janković, Saša
AU  - Nikolić-Jakoba, Nataša
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2164
AB  - Background: The use of cone-beam computed tomography (CBCT), as an additional diagnostic tool in daily dental practice, has expanded rapidly in recent years. Since CBCT allows assessment of dento-maxillofacial structures in three-dimensional manner, its use may be very tempting in alveolar bone furcation defects (FDs) diagnosis. Aim: The aim of this study was to determine the impact of clinical experience and experience with CBCT on FD detection in patients with periodontitis. Material and Methods: Fifteen patients with chronic generalized severe periodontitis were included in the study. In total, 168 furcation sites were analyzed on CBCT images by a previously trained senior year undergraduate student (O1) and a PhD student with three years of CBCT experience (O2), and compared to clinical findings (probing). CBCT images were analyzed on two separate occasions, within a 7-day interval. FDs were assessed both clinically and on CBCT images, using a dichotomous scale (present/absent). Intraobserver agreement for each observer was calculated by using Kappa coefficient (k). Interobserver agreement and agreement between CBCT and clinical findings for both observers were calculated. Results: Kappa coefficient value for both observers indicated a high intraobserver agreement (k1=0.75; k2=0.94). Interobserver agreement of CBCT image analyses was present in 72.6% (73.0% in maxilla, 71.7% in mandible). Agreement between CBCT image analyses and clinical findings for O1 was 48.8% and 51.2% for O2. Conclusion: It can be assumed that clinical experience and CBCT proficiency do not have an impact on FD detection on CBCT images, if an appropriate training was previously performed.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Dental Medicine
T1  - The use of cone-beam computed tomography in furcation defects diagnosis
VL  - 20
IS  - 3
SP  - 143
EP  - 148
DO  - 10.1515/bjdm-2016-0023
ER  - 

@article{
author = "Cimbaljević, Milena and Misić, J. and Janković, Saša and Nikolić-Jakoba, Nataša",
year = "2016",
abstract = "Background: The use of cone-beam computed tomography (CBCT), as an additional diagnostic tool in daily dental practice, has expanded rapidly in recent years. Since CBCT allows assessment of dento-maxillofacial structures in three-dimensional manner, its use may be very tempting in alveolar bone furcation defects (FDs) diagnosis. Aim: The aim of this study was to determine the impact of clinical experience and experience with CBCT on FD detection in patients with periodontitis. Material and Methods: Fifteen patients with chronic generalized severe periodontitis were included in the study. In total, 168 furcation sites were analyzed on CBCT images by a previously trained senior year undergraduate student (O1) and a PhD student with three years of CBCT experience (O2), and compared to clinical findings (probing). CBCT images were analyzed on two separate occasions, within a 7-day interval. FDs were assessed both clinically and on CBCT images, using a dichotomous scale (present/absent). Intraobserver agreement for each observer was calculated by using Kappa coefficient (k). Interobserver agreement and agreement between CBCT and clinical findings for both observers were calculated. Results: Kappa coefficient value for both observers indicated a high intraobserver agreement (k1=0.75; k2=0.94). Interobserver agreement of CBCT image analyses was present in 72.6% (73.0% in maxilla, 71.7% in mandible). Agreement between CBCT image analyses and clinical findings for O1 was 48.8% and 51.2% for O2. Conclusion: It can be assumed that clinical experience and CBCT proficiency do not have an impact on FD detection on CBCT images, if an appropriate training was previously performed.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Dental Medicine",
title = "The use of cone-beam computed tomography in furcation defects diagnosis",
volume = "20",
number = "3",
pages = "143-148",
doi = "10.1515/bjdm-2016-0023"
}

Cimbaljević, M., Misić, J., Janković, S.,& Nikolić-Jakoba, N.. (2016). The use of cone-beam computed tomography in furcation defects diagnosis. in Balkan Journal of Dental Medicine
Udruženje stomatologa Balkana., 20(3), 143-148.
https://doi.org/10.1515/bjdm-2016-0023

Cimbaljević M, Misić J, Janković S, Nikolić-Jakoba N. The use of cone-beam computed tomography in furcation defects diagnosis. in Balkan Journal of Dental Medicine. 2016;20(3):143-148.
doi:10.1515/bjdm-2016-0023 .

Cimbaljević, Milena, Misić, J., Janković, Saša, Nikolić-Jakoba, Nataša, "The use of cone-beam computed tomography in furcation defects diagnosis" in Balkan Journal of Dental Medicine, 20, no. 3 (2016):143-148,
https://doi.org/10.1515/bjdm-2016-0023 . .

TY  - JOUR
AU  - Nikolić-Jakoba, Nataša
AU  - Spin-Neto, Rubens
AU  - Wenzel, Ann
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2086
AB  - Background: The aim of this review is to assess the diagnostic efficacy of cone-beam computed tomography (CBCT) for the diagnosis of and/or treatment planning for intrabony and furcation defects, using a well-known six-tiered hierarchical model for diagnostic efficacy. Methods: The MEDLINE, EMBASE, and Cochrane Library bibliographic databases were searched until August 2015 for studies evaluating CBCT imaging for the diagnosis of and/or treatment planning for intrabony and/or furcation defects. The search strategy was restricted to English language publications using the combination of MeSH terms, free terms, and key words. Results: The search strategy yielded 16 publications that qualitatively or quantitatively evaluated the use of CBCT for the detection of intrabony and/or furcation defects and how CBCT influenced the diagnosis and/or treatment plan. According to Quality Assessment of Studies of Diagnostic Accuracy-2, all included studies were medium to low risk of bias. The review identified only one study that investigated the societal efficacy, and none evaluated the patient outcome efficacy or therapeutic efficacy. One study investigated the diagnostic thinking efficacy. All other included studies investigated the diagnostic accuracy of CBCT. Conclusions: From the assessed studies, it can be concluded that there is not sufficient scientific evidence to justify the use of CBCT for the diagnosis of and/or treatment planning for intrabony and furcation defects. Furthermore, the effectiveness of CBCT for such diagnostic tasks has been assessed only at low diagnostic efficacy levels.
PB  - Wiley, Hoboken
T2  - Journal of Periodontology
T1  - Cone-Beam Computed Tomography for Detection of Intrabony and Furcation Defects: A Systematic Review Based on a Hierarchical Model for Diagnostic Efficacy
VL  - 87
IS  - 6
SP  - 630
EP  - 644
DO  - 10.1902/jop.2016.150636
ER  - 

@article{
author = "Nikolić-Jakoba, Nataša and Spin-Neto, Rubens and Wenzel, Ann",
year = "2016",
abstract = "Background: The aim of this review is to assess the diagnostic efficacy of cone-beam computed tomography (CBCT) for the diagnosis of and/or treatment planning for intrabony and furcation defects, using a well-known six-tiered hierarchical model for diagnostic efficacy. Methods: The MEDLINE, EMBASE, and Cochrane Library bibliographic databases were searched until August 2015 for studies evaluating CBCT imaging for the diagnosis of and/or treatment planning for intrabony and/or furcation defects. The search strategy was restricted to English language publications using the combination of MeSH terms, free terms, and key words. Results: The search strategy yielded 16 publications that qualitatively or quantitatively evaluated the use of CBCT for the detection of intrabony and/or furcation defects and how CBCT influenced the diagnosis and/or treatment plan. According to Quality Assessment of Studies of Diagnostic Accuracy-2, all included studies were medium to low risk of bias. The review identified only one study that investigated the societal efficacy, and none evaluated the patient outcome efficacy or therapeutic efficacy. One study investigated the diagnostic thinking efficacy. All other included studies investigated the diagnostic accuracy of CBCT. Conclusions: From the assessed studies, it can be concluded that there is not sufficient scientific evidence to justify the use of CBCT for the diagnosis of and/or treatment planning for intrabony and furcation defects. Furthermore, the effectiveness of CBCT for such diagnostic tasks has been assessed only at low diagnostic efficacy levels.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontology",
title = "Cone-Beam Computed Tomography for Detection of Intrabony and Furcation Defects: A Systematic Review Based on a Hierarchical Model for Diagnostic Efficacy",
volume = "87",
number = "6",
pages = "630-644",
doi = "10.1902/jop.2016.150636"
}

Nikolić-Jakoba, N., Spin-Neto, R.,& Wenzel, A.. (2016). Cone-Beam Computed Tomography for Detection of Intrabony and Furcation Defects: A Systematic Review Based on a Hierarchical Model for Diagnostic Efficacy. in Journal of Periodontology
Wiley, Hoboken., 87(6), 630-644.
https://doi.org/10.1902/jop.2016.150636

Nikolić-Jakoba N, Spin-Neto R, Wenzel A. Cone-Beam Computed Tomography for Detection of Intrabony and Furcation Defects: A Systematic Review Based on a Hierarchical Model for Diagnostic Efficacy. in Journal of Periodontology. 2016;87(6):630-644.
doi:10.1902/jop.2016.150636 .

Nikolić-Jakoba, Nataša, Spin-Neto, Rubens, Wenzel, Ann, "Cone-Beam Computed Tomography for Detection of Intrabony and Furcation Defects: A Systematic Review Based on a Hierarchical Model for Diagnostic Efficacy" in Journal of Periodontology, 87, no. 6 (2016):630-644,
https://doi.org/10.1902/jop.2016.150636 . .

TY  - JOUR
AU  - Pejčić, Nataša
AU  - Đurić-Jovičić, Milica
AU  - Miljković, Nadica
AU  - Popović, Dejan B.
AU  - Petrović, Vanja
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2160
AB  - Introduction Adequate working posture is important for overall health. Inappropriate posture may increase fatigue, decrease efficiency, and eventually lead to injuries. Objective The purpose was to examine posture positions used during dentistry work. Methods In order to quantify different posture positions, we recorded muscle activity and positions of body segments. The position (inclination) data of the back was used to assess two postures: sitting and standing during standard dental interventions. Results During standard interventions, whether sitting or standing, a tilt of less than 20 degrees was most prevalent in the forward and lateral flexion directions. Amplitude of electromyography signals corresponding to the level of muscle activity were higher in sitting compared with the electromyography in standing position for all muscle groups on the left and right side of the body. Significant difference between muscle activity in two working postures was evident in splenius capitis muscle on the left (p = 0.032), on the right side of the body (p = 0.049) and in muscle activity of mastoid muscle on the left side (p = 0.029). Conclusion These findings show that risk for increased fatigue and possible injures can be reduced by combining the sitting and standing occupational postures.
AB  - Uvod Neadekvatan radni položaj tokom rada stomatologa dovodi do povećanog zamora, smanjuje efikasnost i jedan je od vodećih faktora za razvoj povreda na radu među stomatolozima. Ciljevi rada Cilj rada je bio ispitati različite položaje stomatologa tokom kliničkog rada i dati preporuke za poboljšanje radne pozicije. Metode rada Površinskom elektromiografijom (EMG) registrovana je mišićna aktivnost, kao i stepen nagiba tela tokom uobičajnog stomatološkog rada prilikom rada na terapeutskoj stolici i u stajaćem položaju. Rezultati Nagib manji od 20 stepeni bio je izmeren tokom većeg dela kliničkog rada stomatologa u obe radne pozicije. Povećanje mišićne aktivnosti uočeno je prilikom rada u sedećem položaju kod svih ispitivanih mišića. Statistički značajna razlika uočena je kod M. splenius capitisa sa leve (p = 0,032) i sa desne strane (p = 0,049), dok je kod M. sternocleidomastoideusa postojala samo na levoj strani tela (p = 0,029). Zaključak Da bi se smanjio zamor i rizik za nastanak mišićno-skeletnih oboljenja, preporučuje se da stomatolozi tokom kliničkog rada kombinuju sedeći i stajaći radni položaj.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Posture in dentists: Sitting vs. standing positions during dentistry work: An EMG study
T1  - Elektromiografska studija posturalnog položaja tela tokom rada kod stomatologa - poređenje sedećeg i stajaćeg položaja tokom stomatološkog rada
VL  - 144
IS  - 3-4
SP  - 181
EP  - 187
DO  - 10.2298/sarh1604181P
ER  - 

@article{
author = "Pejčić, Nataša and Đurić-Jovičić, Milica and Miljković, Nadica and Popović, Dejan B. and Petrović, Vanja",
year = "2016",
abstract = "Introduction Adequate working posture is important for overall health. Inappropriate posture may increase fatigue, decrease efficiency, and eventually lead to injuries. Objective The purpose was to examine posture positions used during dentistry work. Methods In order to quantify different posture positions, we recorded muscle activity and positions of body segments. The position (inclination) data of the back was used to assess two postures: sitting and standing during standard dental interventions. Results During standard interventions, whether sitting or standing, a tilt of less than 20 degrees was most prevalent in the forward and lateral flexion directions. Amplitude of electromyography signals corresponding to the level of muscle activity were higher in sitting compared with the electromyography in standing position for all muscle groups on the left and right side of the body. Significant difference between muscle activity in two working postures was evident in splenius capitis muscle on the left (p = 0.032), on the right side of the body (p = 0.049) and in muscle activity of mastoid muscle on the left side (p = 0.029). Conclusion These findings show that risk for increased fatigue and possible injures can be reduced by combining the sitting and standing occupational postures., Uvod Neadekvatan radni položaj tokom rada stomatologa dovodi do povećanog zamora, smanjuje efikasnost i jedan je od vodećih faktora za razvoj povreda na radu među stomatolozima. Ciljevi rada Cilj rada je bio ispitati različite položaje stomatologa tokom kliničkog rada i dati preporuke za poboljšanje radne pozicije. Metode rada Površinskom elektromiografijom (EMG) registrovana je mišićna aktivnost, kao i stepen nagiba tela tokom uobičajnog stomatološkog rada prilikom rada na terapeutskoj stolici i u stajaćem položaju. Rezultati Nagib manji od 20 stepeni bio je izmeren tokom većeg dela kliničkog rada stomatologa u obe radne pozicije. Povećanje mišićne aktivnosti uočeno je prilikom rada u sedećem položaju kod svih ispitivanih mišića. Statistički značajna razlika uočena je kod M. splenius capitisa sa leve (p = 0,032) i sa desne strane (p = 0,049), dok je kod M. sternocleidomastoideusa postojala samo na levoj strani tela (p = 0,029). Zaključak Da bi se smanjio zamor i rizik za nastanak mišićno-skeletnih oboljenja, preporučuje se da stomatolozi tokom kliničkog rada kombinuju sedeći i stajaći radni položaj.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Posture in dentists: Sitting vs. standing positions during dentistry work: An EMG study, Elektromiografska studija posturalnog položaja tela tokom rada kod stomatologa - poređenje sedećeg i stajaćeg položaja tokom stomatološkog rada",
volume = "144",
number = "3-4",
pages = "181-187",
doi = "10.2298/sarh1604181P"
}

Pejčić, N., Đurić-Jovičić, M., Miljković, N., Popović, D. B.,& Petrović, V.. (2016). Posture in dentists: Sitting vs. standing positions during dentistry work: An EMG study. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 144(3-4), 181-187.
https://doi.org/10.2298/sarh1604181P

Pejčić N, Đurić-Jovičić M, Miljković N, Popović DB, Petrović V. Posture in dentists: Sitting vs. standing positions during dentistry work: An EMG study. in Srpski arhiv za celokupno lekarstvo. 2016;144(3-4):181-187.
doi:10.2298/sarh1604181P .

Pejčić, Nataša, Đurić-Jovičić, Milica, Miljković, Nadica, Popović, Dejan B., Petrović, Vanja, "Posture in dentists: Sitting vs. standing positions during dentistry work: An EMG study" in Srpski arhiv za celokupno lekarstvo, 144, no. 3-4 (2016):181-187,
https://doi.org/10.2298/sarh1604181P . .

TY  - JOUR
AU  - Matić-Petrović, Sanja
AU  - Pucar, Ana
AU  - Jotić, Aleksandra
AU  - Miličić, Biljana
AU  - Arambašić-Jovanović, Jelena
AU  - Vidaković, Melita
AU  - Leković, Vojislav
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2158
AB  - Introduction: The role of tumor necrosis factor-α (TNFα) is well documented in pathogenesis of chronic periodontitis (CP) and type 2 diabetes (T2D). Considering short half-life of TNFα, tumor necrosis factor receptor-2 (TNFR2) is used as prosperous surrogate marker of TNFα activity. Objective The aim was to detect TNFR2 serum concentration and correlate it with periodontal destruction in patients with diagnosed T2D and nondiabetics. Methods The study included 85 patients divided into three groups: T2D + CP (group T2D, n = 34); nondiabetics + CP (Group PD, n = 27); and healthy controls (group HC, n = 24). T2D was diagnosed according to WHO criteria (2013) and periodontitis was diagnosed using International Workshop for a Classification of Periodontal Diseases and Conditions criteria (1999). TNFR2 level was measured by enzyme-linked immunosorbent assay (ELISA). Results There was no difference in TNFR2 level among the groups (Kruskal-Wallis, p = 0.482). Significant correlation (Pearson's correlation coefficient) was observed between clinical attachment loss (CAL) and TNFR2 concentration in PD group (rp = -0.460, p = 0.016). In T2D group, correlations were observed between TNFR2 concentration and CaL (rp = 0.363, p = 0.005) and periodontal inflamed surface area (PISA) (rp = 0.345, p = 0.046) and periodontalepithelial surface area (PESA) (rp = 0.578, p = 0.000). Conclusion Higher concentration of TNFR2 was associated with higher CAL, PESA, and PISA scores in T2D group. Contrary to that, nondiabetics with higher values of CAL exhibited lower concentration of TNFR2, presenting potential protective effect on periodontal destruction. These results imply that diabetes may alter TNFR2 secretion originated from periodontium.
AB  - Uvod: Uloga faktora nekroze tumora-alfa (TNFα) dokazana je u patogenezi hronične parodontopatije (HP) i dijabetesa melitusa tipa 2 (DM tip 2). S obzirom na to da je poluživot TNFα veoma kratak, receptor 2 faktora nekroze tumora (TNFR2) koristi se kao marker aktivnosti TNFα. Cilj rada Cilj ovog rada je određivanje koncentracije TNFR2 u serumu i koreliranje sa parametrima destrukcije parodoncijuma kod zdravih i ispitanika sa dijagnostikovanim DM tip 2. Metode rada U studiju je uključeno 85 pacijenata podeljenih u tri grupe: DM tip 2 + HP (DM grupa, n = 34), zdravi ispitanici + HP (PD grupa, n = 27) i zdrave kontrole (ZK grupa, n = 24). Dijagnoza DM tip 2 postavljena je na osnovu kriterijuma SZO (2013), dok je dijagnoza HP postavljena na osnovu kriterijuma Internacionalne radionice za klasifikaciju stanja i oboljenja parodoncijuma (1999). Koncentracija TNFR2 merena je ELISA metodom. Rezultati Koncentracija serumskog TNFR2 nije se razlikovala među grupama (Kraskal-Volis, p = 0,482). Postoji značajna korelacija (Pirson) između nivoa pripojnog epitela (NPE) i koncentracije TNFR2 u PD grupi (rp = -0,460, p = 0,016). U DM tip 2 grupi, statistički značajna korelacija uočena je između koncentracije TNFR2 i NPE (rp = 0,363, p = 0,005), kao i parametara uticaja inflamacije iz parodoncijuma na sistemsko zdravlje - PISA (rp = 0,345, p = 0,046) i PESA (rp = 0,578, p = 0,000). Zaključak Kod pacijenata sa dijabetesom veće koncentracije TNFR2 odgovaraju većim vrednostima NPE, PESA i PISA. Nasuprot tome, kod sistemski zdravih ispitanika sa HP veće vrednosti NPE su povezane sa manjim koncentracijama TNFR2, što bi moglo govoriti o potencijalnoj zaštitnoj ulozi ovog citokina na destrukciju parodoncijuma. Rezultati govore da dijabetes može uticati na sekreciju TNFR2 iz parodoncijuma.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study
T1  - Korelacija između koncentracije receptora 2 faktora nekroze tumora u serumu i destrukcije parodoncijuma kod bolesnika sa dijabetes melitusom tip 2 - studija preseka
VL  - 144
IS  - 5-6
SP  - 266
EP  - 272
DO  - 10.2298/SARH1606266M
ER  - 

@article{
author = "Matić-Petrović, Sanja and Pucar, Ana and Jotić, Aleksandra and Miličić, Biljana and Arambašić-Jovanović, Jelena and Vidaković, Melita and Leković, Vojislav",
year = "2016",
abstract = "Introduction: The role of tumor necrosis factor-α (TNFα) is well documented in pathogenesis of chronic periodontitis (CP) and type 2 diabetes (T2D). Considering short half-life of TNFα, tumor necrosis factor receptor-2 (TNFR2) is used as prosperous surrogate marker of TNFα activity. Objective The aim was to detect TNFR2 serum concentration and correlate it with periodontal destruction in patients with diagnosed T2D and nondiabetics. Methods The study included 85 patients divided into three groups: T2D + CP (group T2D, n = 34); nondiabetics + CP (Group PD, n = 27); and healthy controls (group HC, n = 24). T2D was diagnosed according to WHO criteria (2013) and periodontitis was diagnosed using International Workshop for a Classification of Periodontal Diseases and Conditions criteria (1999). TNFR2 level was measured by enzyme-linked immunosorbent assay (ELISA). Results There was no difference in TNFR2 level among the groups (Kruskal-Wallis, p = 0.482). Significant correlation (Pearson's correlation coefficient) was observed between clinical attachment loss (CAL) and TNFR2 concentration in PD group (rp = -0.460, p = 0.016). In T2D group, correlations were observed between TNFR2 concentration and CaL (rp = 0.363, p = 0.005) and periodontal inflamed surface area (PISA) (rp = 0.345, p = 0.046) and periodontalepithelial surface area (PESA) (rp = 0.578, p = 0.000). Conclusion Higher concentration of TNFR2 was associated with higher CAL, PESA, and PISA scores in T2D group. Contrary to that, nondiabetics with higher values of CAL exhibited lower concentration of TNFR2, presenting potential protective effect on periodontal destruction. These results imply that diabetes may alter TNFR2 secretion originated from periodontium., Uvod: Uloga faktora nekroze tumora-alfa (TNFα) dokazana je u patogenezi hronične parodontopatije (HP) i dijabetesa melitusa tipa 2 (DM tip 2). S obzirom na to da je poluživot TNFα veoma kratak, receptor 2 faktora nekroze tumora (TNFR2) koristi se kao marker aktivnosti TNFα. Cilj rada Cilj ovog rada je određivanje koncentracije TNFR2 u serumu i koreliranje sa parametrima destrukcije parodoncijuma kod zdravih i ispitanika sa dijagnostikovanim DM tip 2. Metode rada U studiju je uključeno 85 pacijenata podeljenih u tri grupe: DM tip 2 + HP (DM grupa, n = 34), zdravi ispitanici + HP (PD grupa, n = 27) i zdrave kontrole (ZK grupa, n = 24). Dijagnoza DM tip 2 postavljena je na osnovu kriterijuma SZO (2013), dok je dijagnoza HP postavljena na osnovu kriterijuma Internacionalne radionice za klasifikaciju stanja i oboljenja parodoncijuma (1999). Koncentracija TNFR2 merena je ELISA metodom. Rezultati Koncentracija serumskog TNFR2 nije se razlikovala među grupama (Kraskal-Volis, p = 0,482). Postoji značajna korelacija (Pirson) između nivoa pripojnog epitela (NPE) i koncentracije TNFR2 u PD grupi (rp = -0,460, p = 0,016). U DM tip 2 grupi, statistički značajna korelacija uočena je između koncentracije TNFR2 i NPE (rp = 0,363, p = 0,005), kao i parametara uticaja inflamacije iz parodoncijuma na sistemsko zdravlje - PISA (rp = 0,345, p = 0,046) i PESA (rp = 0,578, p = 0,000). Zaključak Kod pacijenata sa dijabetesom veće koncentracije TNFR2 odgovaraju većim vrednostima NPE, PESA i PISA. Nasuprot tome, kod sistemski zdravih ispitanika sa HP veće vrednosti NPE su povezane sa manjim koncentracijama TNFR2, što bi moglo govoriti o potencijalnoj zaštitnoj ulozi ovog citokina na destrukciju parodoncijuma. Rezultati govore da dijabetes može uticati na sekreciju TNFR2 iz parodoncijuma.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study, Korelacija između koncentracije receptora 2 faktora nekroze tumora u serumu i destrukcije parodoncijuma kod bolesnika sa dijabetes melitusom tip 2 - studija preseka",
volume = "144",
number = "5-6",
pages = "266-272",
doi = "10.2298/SARH1606266M"
}

Matić-Petrović, S., Pucar, A., Jotić, A., Miličić, B., Arambašić-Jovanović, J., Vidaković, M.,& Leković, V.. (2016). Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 144(5-6), 266-272.
https://doi.org/10.2298/SARH1606266M

Matić-Petrović S, Pucar A, Jotić A, Miličić B, Arambašić-Jovanović J, Vidaković M, Leković V. Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study. in Srpski arhiv za celokupno lekarstvo. 2016;144(5-6):266-272.
doi:10.2298/SARH1606266M .

Matić-Petrović, Sanja, Pucar, Ana, Jotić, Aleksandra, Miličić, Biljana, Arambašić-Jovanović, Jelena, Vidaković, Melita, Leković, Vojislav, "Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study" in Srpski arhiv za celokupno lekarstvo, 144, no. 5-6 (2016):266-272,
https://doi.org/10.2298/SARH1606266M . .

TY  - THES
AU  - Cimbaljević, Milena
PY  - 2016
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=3962
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:13292/bdef:Content/download
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:13378/bdef:Izvestaj/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48252175
UR  - http://nardus.mpn.gov.rs/123456789/6631
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1012
AB  - Background: Cone beam computed tomography (CBCT) is three-dimensional imaging modality which was used in different area of dentistry. CBCT method was commonly used in the assessment of furcation and intrabony defects. According to the literature, there is a lack of information regarding the precision of CBCT method in in vivo studies. However, there is no clear protocol for the CBCT image analysis. Finite element analysis (FEA) is mathematical method which can be used for the assessment of biomechanical behavior of dentoalveolar structure. The impact of horizontal and vertical alveolar bone loss on the biomechanical characteristics of the periodontal tissues is still unknown. Likewise, the biomechanical aspect of regenerative periodontal therapy should be assessed. The aim of this study was to compare intrasurgical measurements and CBCT findings of alveolar bone level in periodontal patients. Furthermore, diagnosis of furcation involvement (FI) by probing and detection of furcation defect on the CBCT images, was compared. Additionally, the biomechanical aspect of horizontal and vertical periodontal bone loss, and the impact of regenerative periodontal therapy were assessed by means of FEA. Materials and Methods: Twenty-one patients with chronic generalized severe periodontitis were included in the study. Sixty-six intrabony defects in molar and premolar regions were analyzed. Linear radiographic measurements of alveolar bone level, obtained from preoperative CBCT images with different slice thickness (voxel size, 1mm, 3mm), were compared with clinical measurements obtained during surgical procedure. All CBCT measurements were performed in three sessions by two independent observers. To provide identical reference point for clinical and CBCT measurements, individually prepared grooves on the recording device were prepared for each tooth involved with in the study periodontal defect site. Furthermore, 174 furcation sites of upper and lower molars were analyzed. Furcation defects were analyzed in all three CBCT planes. Obtained clinical and CBCT-based findings were presented using a dichotomous scale (present / absent) and the agreement between these two methods was calculated. Additionally, three patient-specific 3D FE models were developed from the acquired CBCT scans, comprising the patient's upper left canine, first and second premolar, and adjacent alveolar bone...
AB  - Uvod: Kompjuterizovana tomografija koničnog oblika X-zračnog snopa (CBCT metod) je radiološki metod koji omogućava trodimenzionalno prikazivanje regije od interesa. Mali broj istraživanja se bavio korelacijom kliničkog i CBCT nalaza u in vivo uslovima u cilju ispitivanja infrakoštanih i defekata u regiji furkacija zuba nastalih kao posledica parodontopatije. Takođe, ne postoje ni jasni protokoli za analizu radioloških slika dobijenih ovim metodom Matematički metod konačnih elemenata je korišćen u različitim oblastima stomatologije u ciju ispitivanja biomehaničkog ponašanja struktura dentoalveolarnog kompleksa. Međutim, u literaturi nisu pronađene studije koje su se bavile ispitivanjem biomehaničkog aspekta različitih tipova resorpcije alveolarne kosti nastalih kao posledica parodontopatije. Takođe, ne postoje podaci o biomehaničkom ponašanju zuba i okolnih parodontalnih tkiva nakon regenerativne terapije parodontopatije. Cilj ove studije je bio ispitati korelaciju između rezultata radioloških analiza dobijenih CBCT metodom i relevantnih intraoperativnih merenja dubine infrakoštanih defekata dobijenih tokom režanj operacije, kao i da se uporedi prisustvo parodontalnih džepova u predelu furkacija detektovanih sondiranjem u toku kliničkog pregleda sa nalazima statusa alveolarne kosti u regiji furkacije detektovanih na CBCT slikama. Cilj drugog dela istraživanja je bio da se ispita biomehaničko ponašanje zuba, periodoncijuma i okolne alveolarne kosti u slučaju prisustva različitih tipova resorpcije alveolarne kosti, kao i biomehaničko ponašanje navedenih struktura nakon regenerativne terapije parodontopatije. Materijal i metode: U studiju je bilo uključeno 21 pacijenta obolelih od hronične generalizovane parodontopatije, a nakon sprovedene kauzalne terapije parodontopatije. Ukupno je analizirano 66 infrakoštanih defekata kod kojih je postojala indikacija za hiruršku terapiju parodontopatije. Na stentovima, individualizovanim za svakog pacijenta posebno, pravljeni su useci za svaki infrakoštani defekt i to u cilju obezbeđivanja istovetnih referentnih tačaka za intaoperativna i radiološka merenja Dva istraživača su nezavisno vršila radiološka merenja na različitim debljinama tomografskih preseka (veličina voksela, 1mm, 3mm) u tri serije...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - The use of cone beam computed tomography in the assessment of periodontal therapy outcome
T1  - Primena kompjuterizovane tomografije koničnog oblika x-zračnog snopa u analizi uspeha terapije parodontopatije
UR  - https://hdl.handle.net/21.15107/rcub_nardus_6631
ER  - 

@phdthesis{
author = "Cimbaljević, Milena",
year = "2016",
abstract = "Background: Cone beam computed tomography (CBCT) is three-dimensional imaging modality which was used in different area of dentistry. CBCT method was commonly used in the assessment of furcation and intrabony defects. According to the literature, there is a lack of information regarding the precision of CBCT method in in vivo studies. However, there is no clear protocol for the CBCT image analysis. Finite element analysis (FEA) is mathematical method which can be used for the assessment of biomechanical behavior of dentoalveolar structure. The impact of horizontal and vertical alveolar bone loss on the biomechanical characteristics of the periodontal tissues is still unknown. Likewise, the biomechanical aspect of regenerative periodontal therapy should be assessed. The aim of this study was to compare intrasurgical measurements and CBCT findings of alveolar bone level in periodontal patients. Furthermore, diagnosis of furcation involvement (FI) by probing and detection of furcation defect on the CBCT images, was compared. Additionally, the biomechanical aspect of horizontal and vertical periodontal bone loss, and the impact of regenerative periodontal therapy were assessed by means of FEA. Materials and Methods: Twenty-one patients with chronic generalized severe periodontitis were included in the study. Sixty-six intrabony defects in molar and premolar regions were analyzed. Linear radiographic measurements of alveolar bone level, obtained from preoperative CBCT images with different slice thickness (voxel size, 1mm, 3mm), were compared with clinical measurements obtained during surgical procedure. All CBCT measurements were performed in three sessions by two independent observers. To provide identical reference point for clinical and CBCT measurements, individually prepared grooves on the recording device were prepared for each tooth involved with in the study periodontal defect site. Furthermore, 174 furcation sites of upper and lower molars were analyzed. Furcation defects were analyzed in all three CBCT planes. Obtained clinical and CBCT-based findings were presented using a dichotomous scale (present / absent) and the agreement between these two methods was calculated. Additionally, three patient-specific 3D FE models were developed from the acquired CBCT scans, comprising the patient's upper left canine, first and second premolar, and adjacent alveolar bone..., Uvod: Kompjuterizovana tomografija koničnog oblika X-zračnog snopa (CBCT metod) je radiološki metod koji omogućava trodimenzionalno prikazivanje regije od interesa. Mali broj istraživanja se bavio korelacijom kliničkog i CBCT nalaza u in vivo uslovima u cilju ispitivanja infrakoštanih i defekata u regiji furkacija zuba nastalih kao posledica parodontopatije. Takođe, ne postoje ni jasni protokoli za analizu radioloških slika dobijenih ovim metodom Matematički metod konačnih elemenata je korišćen u različitim oblastima stomatologije u ciju ispitivanja biomehaničkog ponašanja struktura dentoalveolarnog kompleksa. Međutim, u literaturi nisu pronađene studije koje su se bavile ispitivanjem biomehaničkog aspekta različitih tipova resorpcije alveolarne kosti nastalih kao posledica parodontopatije. Takođe, ne postoje podaci o biomehaničkom ponašanju zuba i okolnih parodontalnih tkiva nakon regenerativne terapije parodontopatije. Cilj ove studije je bio ispitati korelaciju između rezultata radioloških analiza dobijenih CBCT metodom i relevantnih intraoperativnih merenja dubine infrakoštanih defekata dobijenih tokom režanj operacije, kao i da se uporedi prisustvo parodontalnih džepova u predelu furkacija detektovanih sondiranjem u toku kliničkog pregleda sa nalazima statusa alveolarne kosti u regiji furkacije detektovanih na CBCT slikama. Cilj drugog dela istraživanja je bio da se ispita biomehaničko ponašanje zuba, periodoncijuma i okolne alveolarne kosti u slučaju prisustva različitih tipova resorpcije alveolarne kosti, kao i biomehaničko ponašanje navedenih struktura nakon regenerativne terapije parodontopatije. Materijal i metode: U studiju je bilo uključeno 21 pacijenta obolelih od hronične generalizovane parodontopatije, a nakon sprovedene kauzalne terapije parodontopatije. Ukupno je analizirano 66 infrakoštanih defekata kod kojih je postojala indikacija za hiruršku terapiju parodontopatije. Na stentovima, individualizovanim za svakog pacijenta posebno, pravljeni su useci za svaki infrakoštani defekt i to u cilju obezbeđivanja istovetnih referentnih tačaka za intaoperativna i radiološka merenja Dva istraživača su nezavisno vršila radiološka merenja na različitim debljinama tomografskih preseka (veličina voksela, 1mm, 3mm) u tri serije...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "The use of cone beam computed tomography in the assessment of periodontal therapy outcome, Primena kompjuterizovane tomografije koničnog oblika x-zračnog snopa u analizi uspeha terapije parodontopatije",
url = "https://hdl.handle.net/21.15107/rcub_nardus_6631"
}

Cimbaljević, M.. (2016). The use of cone beam computed tomography in the assessment of periodontal therapy outcome. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_6631

Cimbaljević M. The use of cone beam computed tomography in the assessment of periodontal therapy outcome. 2016;.
https://hdl.handle.net/21.15107/rcub_nardus_6631 .

Cimbaljević, Milena, "The use of cone beam computed tomography in the assessment of periodontal therapy outcome" (2016),
https://hdl.handle.net/21.15107/rcub_nardus_6631 .

TY  - JOUR
AU  - Todorović, Vladimir S.
AU  - Vasović, Miroslav
AU  - Andrić, Miroslav
AU  - Todorović, Ljubomir
AU  - Koković, Vladimir
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2121
AB  - Background: Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery. Material and Methods: Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analgesic, after the second operation. Analgesia was evaluated during first 24 hours postoperatively according to patients' reports about time of first pain appearance and additional analgesic consumption. Pain severity was rated using a 10 cm long visual analogue scale (VAS). Results: Intensity of postoperative pain and postoperative analgesic consumption were significantly lower after the Fentanyl Transdermal System (FTS) was applied (p lt 0.05). Duration of postoperative analgesia was significantly higher with FTS when compared to control treatment (p lt 0.05). Conclusions: Based on the results of this preliminary study, transdermal system with fentanyl significantly reduced postoperative pain after third molar surgery.
PB  - Medicina Oral S L, Valencia
T2  - Medicina Oral Patologia Oral Y Cirugia Bucal
T1  - Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study
VL  - 21
IS  - 5
SP  - E621
EP  - E625
DO  - 10.4317/medoral.21161
ER  - 

@article{
author = "Todorović, Vladimir S. and Vasović, Miroslav and Andrić, Miroslav and Todorović, Ljubomir and Koković, Vladimir",
year = "2016",
abstract = "Background: Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery. Material and Methods: Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analgesic, after the second operation. Analgesia was evaluated during first 24 hours postoperatively according to patients' reports about time of first pain appearance and additional analgesic consumption. Pain severity was rated using a 10 cm long visual analogue scale (VAS). Results: Intensity of postoperative pain and postoperative analgesic consumption were significantly lower after the Fentanyl Transdermal System (FTS) was applied (p lt 0.05). Duration of postoperative analgesia was significantly higher with FTS when compared to control treatment (p lt 0.05). Conclusions: Based on the results of this preliminary study, transdermal system with fentanyl significantly reduced postoperative pain after third molar surgery.",
publisher = "Medicina Oral S L, Valencia",
journal = "Medicina Oral Patologia Oral Y Cirugia Bucal",
title = "Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study",
volume = "21",
number = "5",
pages = "E621-E625",
doi = "10.4317/medoral.21161"
}

Todorović, V. S., Vasović, M., Andrić, M., Todorović, L.,& Koković, V.. (2016). Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study. in Medicina Oral Patologia Oral Y Cirugia Bucal
Medicina Oral S L, Valencia., 21(5), E621-E625.
https://doi.org/10.4317/medoral.21161

Todorović VS, Vasović M, Andrić M, Todorović L, Koković V. Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study. in Medicina Oral Patologia Oral Y Cirugia Bucal. 2016;21(5):E621-E625.
doi:10.4317/medoral.21161 .

Todorović, Vladimir S., Vasović, Miroslav, Andrić, Miroslav, Todorović, Ljubomir, Koković, Vladimir, "Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study" in Medicina Oral Patologia Oral Y Cirugia Bucal, 21, no. 5 (2016):E621-E625,
https://doi.org/10.4317/medoral.21161 . .

TY  - JOUR
AU  - Ivanjac, Filip
AU  - Konstantinović, Vitomir
AU  - Lazić, Vojkan
AU  - Đorđević, Igor
AU  - Ihde, Stefan
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2166
AB  - Implant stability is a principal precondition for the success of implant therapy. Extraoral implants (EO) are mainly used for anchoring of maxillofacial epithesis. However, assessment of implant stability is mostly based on principles derived from oral implants. The aim of this study was to investigate clinical stability of EO craniofacial disk implants (single, double, and triple) by resonance frequency analysis at different stages of the bone's healing. Twenty patients with orbital (11), nasal (5), and auricular (4) defects with 50 EO implants placed for epithesis anchorage were included. Implant stability was measured 3 times; after implant placement, at 3 months and at least after 6 months. A significant increase in implant stability values was noted between all of the measurements, except for triple-disk implants between third and sixth months, and screw implants between 0 and third months. Disk implants showed lower implant stability quotient (ISQ) values compared with screw implants. Triple-disk implants showed better stability compared with single and double-disk implants. Based on resonance frequency analysis values, disk implants could be safely loaded when their ISQ values are 38 (single disks), 47 (double disks), and 48 (triple disks). According to resonance frequency analysis, disk implant stability increased over time, which showed good osseointegration and increasing mineralization. Although EO screw implants showed higher ISQ values than disk implants, disk-type implants can be safely loaded even if lower values of stability are measured.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Craniofacial Surgery
T1  - Assessment of Stability of Craniofacial Implants by Resonant Frequency Analysis
VL  - 27
IS  - 2
SP  - E185
EP  - E189
DO  - 10.1097/SCS.0000000000002443
ER  - 

@article{
author = "Ivanjac, Filip and Konstantinović, Vitomir and Lazić, Vojkan and Đorđević, Igor and Ihde, Stefan",
year = "2016",
abstract = "Implant stability is a principal precondition for the success of implant therapy. Extraoral implants (EO) are mainly used for anchoring of maxillofacial epithesis. However, assessment of implant stability is mostly based on principles derived from oral implants. The aim of this study was to investigate clinical stability of EO craniofacial disk implants (single, double, and triple) by resonance frequency analysis at different stages of the bone's healing. Twenty patients with orbital (11), nasal (5), and auricular (4) defects with 50 EO implants placed for epithesis anchorage were included. Implant stability was measured 3 times; after implant placement, at 3 months and at least after 6 months. A significant increase in implant stability values was noted between all of the measurements, except for triple-disk implants between third and sixth months, and screw implants between 0 and third months. Disk implants showed lower implant stability quotient (ISQ) values compared with screw implants. Triple-disk implants showed better stability compared with single and double-disk implants. Based on resonance frequency analysis values, disk implants could be safely loaded when their ISQ values are 38 (single disks), 47 (double disks), and 48 (triple disks). According to resonance frequency analysis, disk implant stability increased over time, which showed good osseointegration and increasing mineralization. Although EO screw implants showed higher ISQ values than disk implants, disk-type implants can be safely loaded even if lower values of stability are measured.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Craniofacial Surgery",
title = "Assessment of Stability of Craniofacial Implants by Resonant Frequency Analysis",
volume = "27",
number = "2",
pages = "E185-E189",
doi = "10.1097/SCS.0000000000002443"
}

Ivanjac, F., Konstantinović, V., Lazić, V., Đorđević, I.,& Ihde, S.. (2016). Assessment of Stability of Craniofacial Implants by Resonant Frequency Analysis. in Journal of Craniofacial Surgery
Lippincott Williams & Wilkins, Philadelphia., 27(2), E185-E189.
https://doi.org/10.1097/SCS.0000000000002443

Ivanjac F, Konstantinović V, Lazić V, Đorđević I, Ihde S. Assessment of Stability of Craniofacial Implants by Resonant Frequency Analysis. in Journal of Craniofacial Surgery. 2016;27(2):E185-E189.
doi:10.1097/SCS.0000000000002443 .

Ivanjac, Filip, Konstantinović, Vitomir, Lazić, Vojkan, Đorđević, Igor, Ihde, Stefan, "Assessment of Stability of Craniofacial Implants by Resonant Frequency Analysis" in Journal of Craniofacial Surgery, 27, no. 2 (2016):E185-E189,
https://doi.org/10.1097/SCS.0000000000002443 . .

TY  - JOUR
AU  - Rakašević, Dragana
AU  - Lazić, Zoran
AU  - Rakonjac, Bojan
AU  - Soldatović, Ivan
AU  - Janković, Saša
AU  - Magić, Marko
AU  - Aleksić, Zoran
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2174
AB  - Introduction Peri-implantitis is an inflammatory lesion of peri-implant tissues. Eradication of the causative bacteria and decontamination of the implant surface is essential in achieving predictable and stabile clinical results. Photodynamic therapy (PDT) is non-invasive adjuvant therapeutic method to surgery in the treatment of bacterial infection. Objective The aim of this study was to evaluate early clinical and microbiological outcomes of periimplantitis after surgical therapy with adjuvant PDT. Methods Fifty-two diagnosed peri-implantitis sites were divided into two groups. PDT was used for decontamination of implant surface in the study group; in the control group, chlorhexidine gel (CHX) followed by saline irrigation was applied. Several clinical parameters were recorded before the treatment (baseline values) and three months after surgical treatment. Samples for microbiological identification were collected before therapy, during the surgical therapy (before and after decontamination of implant surface), and three months thereafter, and analyzed with identification systems using biochemical analysis. Results The use of PDT resulted in significant decrease of bleeding on probing in comparison to CHX (p  lt  0.001). It showed significant decontamination of implant surfaces with complete elimination of anaerobic bacteria immediately after surgical procedure and three months later. Conclusion The results indicate that PDT can be used as an adjuvant therapy to surgery for decontamination of implant surface and surrounding peri-implant tissues within the treatment of peri-implantitis.
AB  - Uvod Periimplantitis je inflamatorni proces koji zahvata meka tkiva i potpornu kost oko oseointegrisanog implantata. Eliminacija patogenih mikroorganizama i dekontaminacija implantne površine predstavlju najbitniji korak u postizanju stabilnih kliničkih rezultata. Fotodinamska terapija (FDT) predstavlja dodatni neinvazivni metod u terapiji bakterijskih infekcija. Cilj rada Cilj rada bila je procena kliničkih i mikrobioloških parametara nakon hirurške terapije periimplantitisa uz dodatnu primenu FDT. Metode rada Sva dijagnostikovana mesta periimplantitisa (n = 52) bila su podeljena u dve grupe: u studijskoj grupi, za dekontaminaciju implantne površine tokom hirurške procedure korišćena je FDT; u kontrolnoj grupi, za dekontaminaciju implantne površine korišćen je hlorheksidin u gelu (CHX). Klinički parametri praćeni su pre terapijske procedure i tri meseca posle terapije. Uzorci za mikrobiološku analizu uzimani su pre i tri meseca posle terapije, kao i tokom hirurške procedure, pre i posle dekontaminacije implantne površine. Za identifikaciju izolovanih anaeroba korišćen je sistem koji radi po principu biohemijske analize izolovanih mikrobioloških sojeva. Rezultati studije su pokazali da primenom FDT dolazi do znatne redukcije krvarenja na provokaciju u poređenju sa primenom CHX (p  lt  0,001). Primena FDT, kao pomoćnog terapijskog sredstva, omogućava potpunu eliminaciju anaerobnih bakterija sa implantne površine. Zaključak Rezultati pokazuju da FDT može da se koristi kao pomoćno terapijsko sredstvo za dekontaminaciju implantne površine i periimplantnog tkiva u okviru terapije periimplantitisa.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial
T1  - Procena efikasnosti fotodinamske terapije u terapiji periimplantitisa posle tri meseca - randomizirana kontrolisana klinička studija
VL  - 144
IS  - 9-10
SP  - 478
EP  - 484
DO  - 10.2298/sarh1610478r
ER  - 

@article{
author = "Rakašević, Dragana and Lazić, Zoran and Rakonjac, Bojan and Soldatović, Ivan and Janković, Saša and Magić, Marko and Aleksić, Zoran",
year = "2016",
abstract = "Introduction Peri-implantitis is an inflammatory lesion of peri-implant tissues. Eradication of the causative bacteria and decontamination of the implant surface is essential in achieving predictable and stabile clinical results. Photodynamic therapy (PDT) is non-invasive adjuvant therapeutic method to surgery in the treatment of bacterial infection. Objective The aim of this study was to evaluate early clinical and microbiological outcomes of periimplantitis after surgical therapy with adjuvant PDT. Methods Fifty-two diagnosed peri-implantitis sites were divided into two groups. PDT was used for decontamination of implant surface in the study group; in the control group, chlorhexidine gel (CHX) followed by saline irrigation was applied. Several clinical parameters were recorded before the treatment (baseline values) and three months after surgical treatment. Samples for microbiological identification were collected before therapy, during the surgical therapy (before and after decontamination of implant surface), and three months thereafter, and analyzed with identification systems using biochemical analysis. Results The use of PDT resulted in significant decrease of bleeding on probing in comparison to CHX (p  lt  0.001). It showed significant decontamination of implant surfaces with complete elimination of anaerobic bacteria immediately after surgical procedure and three months later. Conclusion The results indicate that PDT can be used as an adjuvant therapy to surgery for decontamination of implant surface and surrounding peri-implant tissues within the treatment of peri-implantitis., Uvod Periimplantitis je inflamatorni proces koji zahvata meka tkiva i potpornu kost oko oseointegrisanog implantata. Eliminacija patogenih mikroorganizama i dekontaminacija implantne površine predstavlju najbitniji korak u postizanju stabilnih kliničkih rezultata. Fotodinamska terapija (FDT) predstavlja dodatni neinvazivni metod u terapiji bakterijskih infekcija. Cilj rada Cilj rada bila je procena kliničkih i mikrobioloških parametara nakon hirurške terapije periimplantitisa uz dodatnu primenu FDT. Metode rada Sva dijagnostikovana mesta periimplantitisa (n = 52) bila su podeljena u dve grupe: u studijskoj grupi, za dekontaminaciju implantne površine tokom hirurške procedure korišćena je FDT; u kontrolnoj grupi, za dekontaminaciju implantne površine korišćen je hlorheksidin u gelu (CHX). Klinički parametri praćeni su pre terapijske procedure i tri meseca posle terapije. Uzorci za mikrobiološku analizu uzimani su pre i tri meseca posle terapije, kao i tokom hirurške procedure, pre i posle dekontaminacije implantne površine. Za identifikaciju izolovanih anaeroba korišćen je sistem koji radi po principu biohemijske analize izolovanih mikrobioloških sojeva. Rezultati studije su pokazali da primenom FDT dolazi do znatne redukcije krvarenja na provokaciju u poređenju sa primenom CHX (p  lt  0,001). Primena FDT, kao pomoćnog terapijskog sredstva, omogućava potpunu eliminaciju anaerobnih bakterija sa implantne površine. Zaključak Rezultati pokazuju da FDT može da se koristi kao pomoćno terapijsko sredstvo za dekontaminaciju implantne površine i periimplantnog tkiva u okviru terapije periimplantitisa.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial, Procena efikasnosti fotodinamske terapije u terapiji periimplantitisa posle tri meseca - randomizirana kontrolisana klinička studija",
volume = "144",
number = "9-10",
pages = "478-484",
doi = "10.2298/sarh1610478r"
}

Rakašević, D., Lazić, Z., Rakonjac, B., Soldatović, I., Janković, S., Magić, M.,& Aleksić, Z.. (2016). Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 144(9-10), 478-484.
https://doi.org/10.2298/sarh1610478r

Rakašević D, Lazić Z, Rakonjac B, Soldatović I, Janković S, Magić M, Aleksić Z. Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial. in Srpski arhiv za celokupno lekarstvo. 2016;144(9-10):478-484.
doi:10.2298/sarh1610478r .

Rakašević, Dragana, Lazić, Zoran, Rakonjac, Bojan, Soldatović, Ivan, Janković, Saša, Magić, Marko, Aleksić, Zoran, "Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial" in Srpski arhiv za celokupno lekarstvo, 144, no. 9-10 (2016):478-484,
https://doi.org/10.2298/sarh1610478r . .

TY  - THES
AU  - Matić, Sanja D.
PY  - 2016
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=3934
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:13234/bdef:Content/download
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:13307/bdef:Izvestaj/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48250383
UR  - http://nardus.mpn.gov.rs/123456789/6743
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1011
AB  - Introduction: Chronic periodontitis (CP) and Type 2 Diabetes (T2D) are two common chronic inflammatory diseases. Although of different origin, they share some pathogenetic mechanisms. CP has been considered as the sixth complication of T2D for 30 years now, but also there is increasing evidence about the influence of inflammation from periodontium on T2D onset and progression. According that both diseases are polygenic and genetic susceptibility for CP or T2D is widely studied, it would be useful to explore if some genetic variations are responsible for cross-susceptibility or bidirectional relationship of mentioned diseases. Tumor Necrosis Factor (TNFα) plays key role in pathogenesis of both diseases and could explain their bidirectional relationship. TNFα is structurally, functionally or genetically related with Lymphotoxin alpha (LTα) and their receptors TNFR1 and TNFR2. Aims: According that Single Nucleotide Polymorphisms (SNPs) on genes for mentioned molecules regulates their expression, function or cleavage, it would be interesting to explore if SNPs of TNFα and its related molecules may be responsible for susceptibility for CP and/or T2D. Further, the aims of this study were to study if serum levels of TNFα, LTα, TNFR1 and TNFR2 are influenced by clinical periodontal parameters (inflammation from periodontium) or SNPs (-308G/A TNFα, +252A/G LTα, +36A/G TNFR1 and +676T/G TNFR2). Subjects, Materials and Methods: This study of association included 180 subjects divided into three groups: systematically health subjects without CP (HC group), systematically health subjects with CP (PD group) and patients with diagnosed CP and T2D (T2D group). Plaque Index (PI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL) were measured at six points of each tooth except third molars. Impact of inflammation from periodontium on circulating levels were measured by Periodontal Epithelial, Surface Area (PESA) and Periodontal Inflamed Surface Area (PISA) parameters. SNPs were detected using Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) from DNA isolated from buccal epithelial cells. Serum concentrations of TNFα, LTα, TNFR1 and TNFR2 were measured by ELISA method. Impact of behavioral characetistic on clinical parameters and serum concentrations of cytokines were measured. Results: -308G/A TNFα SNP did not show risk effect for PD or T2D...
AB  - Uvod: Hronična parodontopatija (PD) i tip 2 dijabetesa melitusa (T2D) su hronična, inflamatorna poligena oboljenja, koja dele zajedničke patogenetske mehanizme. Već 30 godina parodontopatija se smatra šestom komplikacijom T2D, ali je sve više dokaza o uticaju inflamacije iz parodoncijuma na pojavu i kliničku sliku dijabetesa. S obzirom da je genska podložnos bitna u nastanku i progresiji oba oboljenja, sve je veće interesovanje da se ispita da li su neke varijacije genoma odgovorne za zajedničku podložnost i dvosmernu povezanost ovih oboljenja. Faktor nekroze tumora (TNFα) igra ključnu ulogu u patogenezi oba oboljenja i objašnjava pomenutu dvosmernu povezanost. Blisko strukturalno, funkcionalno odnosno genski povezani sa TNFα su limfotoksin alfa (LTα), kao i njihovi receptori -TNFR1 i TNFR2. Ciljevi studije: S ozirom da polimorfizmi gena ovih molekula utiču na ekspresiju, funkciju ili oslobađanje solubilnih formi ovih citokina/receptora, zanimljivo je bilo ispitati da li polimorfizam na ovim molekulima mogu uticati na rizik za oboljevanje od PD i/ili T2D. Takođe, ciljevi ove studije bili su ispitivanje uticaja kliničkih parodontoloških parametara (inflamacije iz parodoncijuma) ili polimorfizama (-308G/A TNFα, +252A/G LTα, +36A/G TNFR1 i +676T/G TNFR2) na sistemski nivo pomenutih molekula. Ispitanici, materijal i metode: Ispitanici (N=180) su raspoređeni u tri grupe: sistemski zdravi ispitanci bez kliničkih znakova PD (ZK grupa), sistemski zdravi ispitanici sa dijagnostikovanom PD (PD grupa) i ispitanici sa dijagnostikovanim T2D i PD (T2D grupa). Kliničkim pregledom parodoncijuma praćeni su plak indeks Silness-Loe (PI), krvarenja na provokaciju (KNP), dubina sondiranja (DS) i nivo pripojnog epitela (NPE). Uticaj inflamiranog parodoncijuma na sistemski nivo citokina kvantifikovan je PESA i PISA parametrima. Detekcija polimorfizama vršena RFLP-PCR metodom iz DNK izolovanih iz briseva bukalne sluzokože. Koncentracija ispitivanih molekula određivana je ELISA metodom. Pratili smo i uticaj bihejvioralnih faktora na kliničke parametre oboljenja i na sistemski nivo citokina putem regresionih modela. Rezultati: Polimorfizam -308G/A TNFα nije se izdvojio kao faktor rizika za oboljevanje od PD ili T2D. AA genotip (OR=0,173, CI=0,036-0,837, p=0,022) i alel A (OR=0,563, CI=0,334-0,936, p=0,029) ovog polimorfizma pokazao je protektivan efekat za oboljevanje od PD i T2D u odnosu na PD. AG genotip (OR=2,75, CI=1,184-6,380, p=0,019) i alel G (OR=1,824, CI=1,047-3,176, p=0,032) +252A/G LTα polimorfizma izdvojili su se kao nosioci povećanog rizika za oboljevanje od PD...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Influence of polymorphism of proinflammatory cytokines and receptors on serum cytokine level and clinical parameters of chronic periodontitis and Diabetes mellitus type 2.
T1  - Uticaj polimorfizama gena za inflamatorne citokine i njihove receptore na nivo cirkulišućih citokina i kliničke parametre kod pacijenata sa hroničnom parodontopatijom i dijabetes melitusom tipa 2
UR  - https://hdl.handle.net/21.15107/rcub_nardus_6743
ER  - 

@phdthesis{
author = "Matić, Sanja D.",
year = "2016",
abstract = "Introduction: Chronic periodontitis (CP) and Type 2 Diabetes (T2D) are two common chronic inflammatory diseases. Although of different origin, they share some pathogenetic mechanisms. CP has been considered as the sixth complication of T2D for 30 years now, but also there is increasing evidence about the influence of inflammation from periodontium on T2D onset and progression. According that both diseases are polygenic and genetic susceptibility for CP or T2D is widely studied, it would be useful to explore if some genetic variations are responsible for cross-susceptibility or bidirectional relationship of mentioned diseases. Tumor Necrosis Factor (TNFα) plays key role in pathogenesis of both diseases and could explain their bidirectional relationship. TNFα is structurally, functionally or genetically related with Lymphotoxin alpha (LTα) and their receptors TNFR1 and TNFR2. Aims: According that Single Nucleotide Polymorphisms (SNPs) on genes for mentioned molecules regulates their expression, function or cleavage, it would be interesting to explore if SNPs of TNFα and its related molecules may be responsible for susceptibility for CP and/or T2D. Further, the aims of this study were to study if serum levels of TNFα, LTα, TNFR1 and TNFR2 are influenced by clinical periodontal parameters (inflammation from periodontium) or SNPs (-308G/A TNFα, +252A/G LTα, +36A/G TNFR1 and +676T/G TNFR2). Subjects, Materials and Methods: This study of association included 180 subjects divided into three groups: systematically health subjects without CP (HC group), systematically health subjects with CP (PD group) and patients with diagnosed CP and T2D (T2D group). Plaque Index (PI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL) were measured at six points of each tooth except third molars. Impact of inflammation from periodontium on circulating levels were measured by Periodontal Epithelial, Surface Area (PESA) and Periodontal Inflamed Surface Area (PISA) parameters. SNPs were detected using Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) from DNA isolated from buccal epithelial cells. Serum concentrations of TNFα, LTα, TNFR1 and TNFR2 were measured by ELISA method. Impact of behavioral characetistic on clinical parameters and serum concentrations of cytokines were measured. Results: -308G/A TNFα SNP did not show risk effect for PD or T2D..., Uvod: Hronična parodontopatija (PD) i tip 2 dijabetesa melitusa (T2D) su hronična, inflamatorna poligena oboljenja, koja dele zajedničke patogenetske mehanizme. Već 30 godina parodontopatija se smatra šestom komplikacijom T2D, ali je sve više dokaza o uticaju inflamacije iz parodoncijuma na pojavu i kliničku sliku dijabetesa. S obzirom da je genska podložnos bitna u nastanku i progresiji oba oboljenja, sve je veće interesovanje da se ispita da li su neke varijacije genoma odgovorne za zajedničku podložnost i dvosmernu povezanost ovih oboljenja. Faktor nekroze tumora (TNFα) igra ključnu ulogu u patogenezi oba oboljenja i objašnjava pomenutu dvosmernu povezanost. Blisko strukturalno, funkcionalno odnosno genski povezani sa TNFα su limfotoksin alfa (LTα), kao i njihovi receptori -TNFR1 i TNFR2. Ciljevi studije: S ozirom da polimorfizmi gena ovih molekula utiču na ekspresiju, funkciju ili oslobađanje solubilnih formi ovih citokina/receptora, zanimljivo je bilo ispitati da li polimorfizam na ovim molekulima mogu uticati na rizik za oboljevanje od PD i/ili T2D. Takođe, ciljevi ove studije bili su ispitivanje uticaja kliničkih parodontoloških parametara (inflamacije iz parodoncijuma) ili polimorfizama (-308G/A TNFα, +252A/G LTα, +36A/G TNFR1 i +676T/G TNFR2) na sistemski nivo pomenutih molekula. Ispitanici, materijal i metode: Ispitanici (N=180) su raspoređeni u tri grupe: sistemski zdravi ispitanci bez kliničkih znakova PD (ZK grupa), sistemski zdravi ispitanici sa dijagnostikovanom PD (PD grupa) i ispitanici sa dijagnostikovanim T2D i PD (T2D grupa). Kliničkim pregledom parodoncijuma praćeni su plak indeks Silness-Loe (PI), krvarenja na provokaciju (KNP), dubina sondiranja (DS) i nivo pripojnog epitela (NPE). Uticaj inflamiranog parodoncijuma na sistemski nivo citokina kvantifikovan je PESA i PISA parametrima. Detekcija polimorfizama vršena RFLP-PCR metodom iz DNK izolovanih iz briseva bukalne sluzokože. Koncentracija ispitivanih molekula određivana je ELISA metodom. Pratili smo i uticaj bihejvioralnih faktora na kliničke parametre oboljenja i na sistemski nivo citokina putem regresionih modela. Rezultati: Polimorfizam -308G/A TNFα nije se izdvojio kao faktor rizika za oboljevanje od PD ili T2D. AA genotip (OR=0,173, CI=0,036-0,837, p=0,022) i alel A (OR=0,563, CI=0,334-0,936, p=0,029) ovog polimorfizma pokazao je protektivan efekat za oboljevanje od PD i T2D u odnosu na PD. AG genotip (OR=2,75, CI=1,184-6,380, p=0,019) i alel G (OR=1,824, CI=1,047-3,176, p=0,032) +252A/G LTα polimorfizma izdvojili su se kao nosioci povećanog rizika za oboljevanje od PD...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Influence of polymorphism of proinflammatory cytokines and receptors on serum cytokine level and clinical parameters of chronic periodontitis and Diabetes mellitus type 2., Uticaj polimorfizama gena za inflamatorne citokine i njihove receptore na nivo cirkulišućih citokina i kliničke parametre kod pacijenata sa hroničnom parodontopatijom i dijabetes melitusom tipa 2",
url = "https://hdl.handle.net/21.15107/rcub_nardus_6743"
}

Matić, S. D.. (2016). Influence of polymorphism of proinflammatory cytokines and receptors on serum cytokine level and clinical parameters of chronic periodontitis and Diabetes mellitus type 2.. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_6743

Matić SD. Influence of polymorphism of proinflammatory cytokines and receptors on serum cytokine level and clinical parameters of chronic periodontitis and Diabetes mellitus type 2.. 2016;.
https://hdl.handle.net/21.15107/rcub_nardus_6743 .

Matić, Sanja D., "Influence of polymorphism of proinflammatory cytokines and receptors on serum cytokine level and clinical parameters of chronic periodontitis and Diabetes mellitus type 2." (2016),
https://hdl.handle.net/21.15107/rcub_nardus_6743 .