TY  - JOUR
AU  - Hadži-Mihailović, Miloš
AU  - Čakić, Saša
AU  - Janković, Saša
AU  - Raybaud, Helene
AU  - Nedeljković, Nenad
AU  - Janković, Ljiljana
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1748
AB  - Purpose: The monoclonal antibody Ki-67 detects a nuclear antigen that is present only in proliferating cells. This is of particular interest for the analysis of the proliferation rates of malignant tumors. The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of expression of Ki-67 in healthy individuals (HI), patients with OLP and patients with squamous cell carcinoma (SCC), and to see for any potential interdependence between Ki-67 expression and different clinical and histopathological parameters in OLP. Methods: Immunohistochemistry for Ki-67 was carried out using an avidin-biotin peroxidase complex method. Results: Ki-67 was more expressed in keratinocytes and lymphocytes of OLP patients compared with HI, but less compared with patients with SCC. Keratinocytes and lymphocytes stained with Ki-67 in OLP patients were significantly higher in males, and in OLP specimens showed less developed civatte bodies (CB) and thickening of the basal membrane (TBM). Conclusion: Ki-67 may not serve as prognostic biomarker in oral cancer development from the initially diagnosed OLP, but it could help selecting patients with higher need of follow up for prevention of malignancy.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Ki-67 expression in oral lichen planus
VL  - 17
IS  - 1
SP  - 132
EP  - 137
UR  - https://hdl.handle.net/21.15107/rcub_smile_1748
ER  - 

@article{
author = "Hadži-Mihailović, Miloš and Čakić, Saša and Janković, Saša and Raybaud, Helene and Nedeljković, Nenad and Janković, Ljiljana",
year = "2012",
abstract = "Purpose: The monoclonal antibody Ki-67 detects a nuclear antigen that is present only in proliferating cells. This is of particular interest for the analysis of the proliferation rates of malignant tumors. The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of expression of Ki-67 in healthy individuals (HI), patients with OLP and patients with squamous cell carcinoma (SCC), and to see for any potential interdependence between Ki-67 expression and different clinical and histopathological parameters in OLP. Methods: Immunohistochemistry for Ki-67 was carried out using an avidin-biotin peroxidase complex method. Results: Ki-67 was more expressed in keratinocytes and lymphocytes of OLP patients compared with HI, but less compared with patients with SCC. Keratinocytes and lymphocytes stained with Ki-67 in OLP patients were significantly higher in males, and in OLP specimens showed less developed civatte bodies (CB) and thickening of the basal membrane (TBM). Conclusion: Ki-67 may not serve as prognostic biomarker in oral cancer development from the initially diagnosed OLP, but it could help selecting patients with higher need of follow up for prevention of malignancy.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Ki-67 expression in oral lichen planus",
volume = "17",
number = "1",
pages = "132-137",
url = "https://hdl.handle.net/21.15107/rcub_smile_1748"
}

Hadži-Mihailović, M., Čakić, S., Janković, S., Raybaud, H., Nedeljković, N.,& Janković, L.. (2012). Ki-67 expression in oral lichen planus. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 17(1), 132-137.
https://hdl.handle.net/21.15107/rcub_smile_1748

Hadži-Mihailović M, Čakić S, Janković S, Raybaud H, Nedeljković N, Janković L. Ki-67 expression in oral lichen planus. in Journal of BUON. 2012;17(1):132-137.
https://hdl.handle.net/21.15107/rcub_smile_1748 .

Hadži-Mihailović, Miloš, Čakić, Saša, Janković, Saša, Raybaud, Helene, Nedeljković, Nenad, Janković, Ljiljana, "Ki-67 expression in oral lichen planus" in Journal of BUON, 17, no. 1 (2012):132-137,
https://hdl.handle.net/21.15107/rcub_smile_1748 .