TY  - JOUR
AU  - Čolić, Miodrag
AU  - Rudolf, Rebeka
AU  - Stamenković, Dragoslav
AU  - Anžel, Ivan
AU  - Vucević, Dragana
AU  - Jenko, Monika
AU  - Lazić, Vojkan
AU  - Lojen, Gorazd
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1553
AB  - Cu-Al-Ni shape memory alloys (SMAs) have been investigated as materials for medical devices, but their biomedical application is still limited. The aim of this work was to compare the microstructure, corrosion and cytotoxicity in vitro of a Cu-Al-Ni SMA. Rapidly solidified (RS) thin ribbons, manufactured via melt spinning, were used for the tests. The control alloy was a permanent mould casting of the same composition, but without shape memory effect. The results show that RS ribbons are significantly more resistant to corrosion compared with the control alloy, as judged by the lesser release of Cu and Ni into the conditioning medium. These results correlate with the finding that RS ribbons were not cytotoxic to L929 mouse fibroblasts and rat thymocytes. In addition, the RS ribbon conditioning medium inhibited cellular proliferation and IL-2 production by activated rat splenocytes to a much lesser extent. The inhibitory effects were almost completely abolished by conditioning the RS ribbons in culture medium for 4 weeks. Microstructural analysis showed that RS ribbons are martensitic, with boron particles as a minor phase. In contrast, the control Cu-Al-Ni alloy had a complex multiphase microstructure. Examination of the alloy surfaces after conditioning by energy dispersive X-ray and Auger electron spectroscopy showed the formation of Cu and Al oxide layers and confirmed that the metals in RS ribbons are less susceptible to oxidation and corrosion compared with the control alloy. In conclusion, these results suggest that rapid solidification significantly improves the corrosion stability and biocompatibility in vitro of Cu-Al-Ni SMA ribbons.
PB  - Elsevier Sci Ltd, Oxford
T2  - Acta Biomaterialia
T1  - Relationship between microstructure, cytotoxicity and corrosion properties of a Cu-Al-Ni shape memory alloy
VL  - 6
IS  - 1
SP  - 308
EP  - 317
DO  - 10.1016/j.actbio.2009.06.027
ER  - 

@article{
author = "Čolić, Miodrag and Rudolf, Rebeka and Stamenković, Dragoslav and Anžel, Ivan and Vucević, Dragana and Jenko, Monika and Lazić, Vojkan and Lojen, Gorazd",
year = "2010",
abstract = "Cu-Al-Ni shape memory alloys (SMAs) have been investigated as materials for medical devices, but their biomedical application is still limited. The aim of this work was to compare the microstructure, corrosion and cytotoxicity in vitro of a Cu-Al-Ni SMA. Rapidly solidified (RS) thin ribbons, manufactured via melt spinning, were used for the tests. The control alloy was a permanent mould casting of the same composition, but without shape memory effect. The results show that RS ribbons are significantly more resistant to corrosion compared with the control alloy, as judged by the lesser release of Cu and Ni into the conditioning medium. These results correlate with the finding that RS ribbons were not cytotoxic to L929 mouse fibroblasts and rat thymocytes. In addition, the RS ribbon conditioning medium inhibited cellular proliferation and IL-2 production by activated rat splenocytes to a much lesser extent. The inhibitory effects were almost completely abolished by conditioning the RS ribbons in culture medium for 4 weeks. Microstructural analysis showed that RS ribbons are martensitic, with boron particles as a minor phase. In contrast, the control Cu-Al-Ni alloy had a complex multiphase microstructure. Examination of the alloy surfaces after conditioning by energy dispersive X-ray and Auger electron spectroscopy showed the formation of Cu and Al oxide layers and confirmed that the metals in RS ribbons are less susceptible to oxidation and corrosion compared with the control alloy. In conclusion, these results suggest that rapid solidification significantly improves the corrosion stability and biocompatibility in vitro of Cu-Al-Ni SMA ribbons.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Acta Biomaterialia",
title = "Relationship between microstructure, cytotoxicity and corrosion properties of a Cu-Al-Ni shape memory alloy",
volume = "6",
number = "1",
pages = "308-317",
doi = "10.1016/j.actbio.2009.06.027"
}

Čolić, M., Rudolf, R., Stamenković, D., Anžel, I., Vucević, D., Jenko, M., Lazić, V.,& Lojen, G.. (2010). Relationship between microstructure, cytotoxicity and corrosion properties of a Cu-Al-Ni shape memory alloy. in Acta Biomaterialia
Elsevier Sci Ltd, Oxford., 6(1), 308-317.
https://doi.org/10.1016/j.actbio.2009.06.027

Čolić M, Rudolf R, Stamenković D, Anžel I, Vucević D, Jenko M, Lazić V, Lojen G. Relationship between microstructure, cytotoxicity and corrosion properties of a Cu-Al-Ni shape memory alloy. in Acta Biomaterialia. 2010;6(1):308-317.
doi:10.1016/j.actbio.2009.06.027 .

Čolić, Miodrag, Rudolf, Rebeka, Stamenković, Dragoslav, Anžel, Ivan, Vucević, Dragana, Jenko, Monika, Lazić, Vojkan, Lojen, Gorazd, "Relationship between microstructure, cytotoxicity and corrosion properties of a Cu-Al-Ni shape memory alloy" in Acta Biomaterialia, 6, no. 1 (2010):308-317,
https://doi.org/10.1016/j.actbio.2009.06.027 . .