TY  - JOUR
AU  - Kopčalić, Katarina
AU  - Petrović, Nina
AU  - Stanojković, Tatjana P.
AU  - Stanković, Vesna
AU  - Bukumirić, Zoran
AU  - Roganović, Jelena
AU  - Mališić, Emina
AU  - Nikitović, Marina
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2594
AB  - Introduction: Nearly sixty percent of patients with prostate cancer (PCa) undergo radiation therapy (RT). During the course of treatment patients may experience normal tissue reactions. It is a well established fact that genetic and epigenetic mechanisms, such as microRNA (miRNA) level changes might be associated with radiotoxicity, as a response to irradiation. 
Materials and methods: This is the first study that has investigated levels of radiosensory miRNAs in association with acute genitourinary radiotoxicity extracted from peripheral blood mononuclear cells (PBCs), in three points; before RT (BRT), after RT (ART) and on the first control examination (FCONT). We measured levels of miR-21/146a/155 expression by quantitative real-time PCR (qRT-PCR), comparative ΔΔCt method, in fifteen patients with localized prostate cancer, treated with three-dimensional conformal radiotherapy (3DCRT). Nine subjects have experienced acute genitourinary (GU) radiotoxicity whereas six where without GU radiotoxicity. 
Results: Firstly, we detected the highest levels of miR-21 in ART group (p = 0.043) in the patients with acute GU radiotoxicity. Secondly, we found trend towards higher miR-21 levels and significantly higher levels of miR-146a/155 within the patients with acute GU toxicity than in patients without (p = 0.068, p = 0.016, and p = 0.010, respectively). Thirdly, we detected significant change in miR-146a/155 levels within the patients without acute GU radiotoxicity during RT p = 0.042, and p = 0.041, respectively). 
Conclusion: miR-21/146a/155 might be useful potential factors of radiosensitivity and acute genitourinary radiotoxicity in prostate cancer patients. miRNA might have great potential as predictors of various pathological conditions extracted from PBMCs.
PB  - Elsevier GmbH
T2  - Pathology - Research and Practice
T1  - Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study
VL  - 215
IS  - 4
SP  - 626
EP  - 631
DO  - 10.1016/j.prp.2018.12.007
ER  - 

@article{
author = "Kopčalić, Katarina and Petrović, Nina and Stanojković, Tatjana P. and Stanković, Vesna and Bukumirić, Zoran and Roganović, Jelena and Mališić, Emina and Nikitović, Marina",
year = "2019",
abstract = "Introduction: Nearly sixty percent of patients with prostate cancer (PCa) undergo radiation therapy (RT). During the course of treatment patients may experience normal tissue reactions. It is a well established fact that genetic and epigenetic mechanisms, such as microRNA (miRNA) level changes might be associated with radiotoxicity, as a response to irradiation. 
Materials and methods: This is the first study that has investigated levels of radiosensory miRNAs in association with acute genitourinary radiotoxicity extracted from peripheral blood mononuclear cells (PBCs), in three points; before RT (BRT), after RT (ART) and on the first control examination (FCONT). We measured levels of miR-21/146a/155 expression by quantitative real-time PCR (qRT-PCR), comparative ΔΔCt method, in fifteen patients with localized prostate cancer, treated with three-dimensional conformal radiotherapy (3DCRT). Nine subjects have experienced acute genitourinary (GU) radiotoxicity whereas six where without GU radiotoxicity. 
Results: Firstly, we detected the highest levels of miR-21 in ART group (p = 0.043) in the patients with acute GU radiotoxicity. Secondly, we found trend towards higher miR-21 levels and significantly higher levels of miR-146a/155 within the patients with acute GU toxicity than in patients without (p = 0.068, p = 0.016, and p = 0.010, respectively). Thirdly, we detected significant change in miR-146a/155 levels within the patients without acute GU radiotoxicity during RT p = 0.042, and p = 0.041, respectively). 
Conclusion: miR-21/146a/155 might be useful potential factors of radiosensitivity and acute genitourinary radiotoxicity in prostate cancer patients. miRNA might have great potential as predictors of various pathological conditions extracted from PBMCs.",
publisher = "Elsevier GmbH",
journal = "Pathology - Research and Practice",
title = "Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study",
volume = "215",
number = "4",
pages = "626-631",
doi = "10.1016/j.prp.2018.12.007"
}

Kopčalić, K., Petrović, N., Stanojković, T. P., Stanković, V., Bukumirić, Z., Roganović, J., Mališić, E.,& Nikitović, M.. (2019). Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study. in Pathology - Research and Practice
Elsevier GmbH., 215(4), 626-631.
https://doi.org/10.1016/j.prp.2018.12.007

Kopčalić K, Petrović N, Stanojković TP, Stanković V, Bukumirić Z, Roganović J, Mališić E, Nikitović M. Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study. in Pathology - Research and Practice. 2019;215(4):626-631.
doi:10.1016/j.prp.2018.12.007 .

Kopčalić, Katarina, Petrović, Nina, Stanojković, Tatjana P., Stanković, Vesna, Bukumirić, Zoran, Roganović, Jelena, Mališić, Emina, Nikitović, Marina, "Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study" in Pathology - Research and Practice, 215, no. 4 (2019):626-631,
https://doi.org/10.1016/j.prp.2018.12.007 . .

TY  - JOUR
AU  - Kopcalić, Katarina
AU  - Petrović, Nina
AU  - Stanojković, Tatjana P.
AU  - Stanković, Vesna
AU  - Bukumirić, Zoran
AU  - Roganović, Jelena
AU  - Malisić, Emina
AU  - Nikitović, Marina
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2391
AB  - Introduction: Nearly sixty percent of patients with prostate cancer (PCa) undergo radiation therapy (RT). During the course of treatment patients may experience normal tissue reactions. It is a well established fact that genetic and epigenetic mechanisms, such as microRNA (miRNA) level changes might be associated with radiotoxicity, as a response to irradiation. Materials and methods: This is the first study that has investigated levels of radiosensory miRNAs in association with acute genitourinary radiotoxicity extracted from peripheral blood mononuclear cells (PBCs), in three points; before RT (BRT), after RT (ART) and on the first control examination (FCONT). We measured levels of miR-21/146a/155 expression by quantitative real-time PCR (qRT-PCR), comparative Delta Delta Ct method, in fifteen patients with localized prostate cancer, treated with three-dimensional conformal radiotherapy (3DCRT). Nine subjects have experienced acute genitourinary (GU) radiotoxicity whereas six where without GU radiotoxicity. Results: Firstly, we detected the highest levels of miR-21 in ART group (p = 0.043) in the patients with acute GU radiotoxicity. Secondly, we found trend towards higher miR-21 levels and significantly higher levels of miR-146a/155 within the patients with acute GU toxicity than in patients without (p = 0.068, p = 0.016, and p = 0.010, respectively). Thirdly, we detected significant change in miR-146a/155 levels within the patients without acute GU radiotoxicity during RT p = 0.042, and p = 0.041, respectively). Conclusion: miR-21/146a/155 might be useful potential factors of radiosensitivity and acute genitourinary radiotoxicity in prostate cancer patients. miRNA might have great potential as predictors of various pathological conditions extracted from PBMCs.
PB  - Elsevier Gmbh, Munich
T2  - Pathology Research & Practice
T1  - Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study
VL  - 215
IS  - 4
SP  - 626
EP  - 631
DO  - 10.1016/j.prp.2018.12.007
ER  - 

@article{
author = "Kopcalić, Katarina and Petrović, Nina and Stanojković, Tatjana P. and Stanković, Vesna and Bukumirić, Zoran and Roganović, Jelena and Malisić, Emina and Nikitović, Marina",
year = "2019",
abstract = "Introduction: Nearly sixty percent of patients with prostate cancer (PCa) undergo radiation therapy (RT). During the course of treatment patients may experience normal tissue reactions. It is a well established fact that genetic and epigenetic mechanisms, such as microRNA (miRNA) level changes might be associated with radiotoxicity, as a response to irradiation. Materials and methods: This is the first study that has investigated levels of radiosensory miRNAs in association with acute genitourinary radiotoxicity extracted from peripheral blood mononuclear cells (PBCs), in three points; before RT (BRT), after RT (ART) and on the first control examination (FCONT). We measured levels of miR-21/146a/155 expression by quantitative real-time PCR (qRT-PCR), comparative Delta Delta Ct method, in fifteen patients with localized prostate cancer, treated with three-dimensional conformal radiotherapy (3DCRT). Nine subjects have experienced acute genitourinary (GU) radiotoxicity whereas six where without GU radiotoxicity. Results: Firstly, we detected the highest levels of miR-21 in ART group (p = 0.043) in the patients with acute GU radiotoxicity. Secondly, we found trend towards higher miR-21 levels and significantly higher levels of miR-146a/155 within the patients with acute GU toxicity than in patients without (p = 0.068, p = 0.016, and p = 0.010, respectively). Thirdly, we detected significant change in miR-146a/155 levels within the patients without acute GU radiotoxicity during RT p = 0.042, and p = 0.041, respectively). Conclusion: miR-21/146a/155 might be useful potential factors of radiosensitivity and acute genitourinary radiotoxicity in prostate cancer patients. miRNA might have great potential as predictors of various pathological conditions extracted from PBMCs.",
publisher = "Elsevier Gmbh, Munich",
journal = "Pathology Research & Practice",
title = "Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study",
volume = "215",
number = "4",
pages = "626-631",
doi = "10.1016/j.prp.2018.12.007"
}

Kopcalić, K., Petrović, N., Stanojković, T. P., Stanković, V., Bukumirić, Z., Roganović, J., Malisić, E.,& Nikitović, M.. (2019). Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study. in Pathology Research & Practice
Elsevier Gmbh, Munich., 215(4), 626-631.
https://doi.org/10.1016/j.prp.2018.12.007

Kopcalić K, Petrović N, Stanojković TP, Stanković V, Bukumirić Z, Roganović J, Malisić E, Nikitović M. Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study. in Pathology Research & Practice. 2019;215(4):626-631.
doi:10.1016/j.prp.2018.12.007 .

Kopcalić, Katarina, Petrović, Nina, Stanojković, Tatjana P., Stanković, Vesna, Bukumirić, Zoran, Roganović, Jelena, Malisić, Emina, Nikitović, Marina, "Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study" in Pathology Research & Practice, 215, no. 4 (2019):626-631,
https://doi.org/10.1016/j.prp.2018.12.007 . .

TY  - JOUR
AU  - Bijelić, Borivoj
AU  - Matić, Ivana Z.
AU  - Besu, Irina
AU  - Janković, Ljiljana
AU  - Juranić, Zorica
AU  - Marusić, Senka
AU  - Andrejević, Slađana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2456
AB  - The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Antibodies against tissue transglutaminase (anti-tTG), deaminated gliadin peptides (DGP), deaminated gliadinanalogous fragments (anti-GAF-3X) and Saccharomyces cerevisiae (ASCA) were determined by ELISA and anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunoflurescence (IIF) in 57 patients with RAS and 60 control subjects. The prevalence of CeD specific antibodies did not differ between RAS patients and controls. However, the concentrations of IgA anti-tTG, IgA anti-GAF-3X antibodies in patients with RAS were significantly higher compared to controls (p = 0.002 and p = 0.04 respectively). Histological changes consistent with CeD were confirmed by duodenal biopsy in one RAS patient with highly positive IgA anti-tTG, anti-GAF-3X and anti-DGP antibodies. Higher prevalence along with higher concentrations of IgG ASCA were found in RAS patients compared to controls (p  lt  0.01). Patients with positive IgG ASCA in the absence of clinical symptoms decided not to pursue any further testing. Dysfunction of oral mucosa and the exposure to various antigens might be a reason for the loss of tolerance resulting in increased production of autoantibodies. It seems likely that antibodies are markers of aberrant immune response, rather than key effectors involved in the pathogenesis of the disease.
PB  - Elsevier Gmbh, Munich
T2  - Immunobiology
T1  - Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis
VL  - 224
IS  - 1
SP  - 75
EP  - 79
DO  - 10.1016/j.imbio.2018.10.006
ER  - 

@article{
author = "Bijelić, Borivoj and Matić, Ivana Z. and Besu, Irina and Janković, Ljiljana and Juranić, Zorica and Marusić, Senka and Andrejević, Slađana",
year = "2019",
abstract = "The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Antibodies against tissue transglutaminase (anti-tTG), deaminated gliadin peptides (DGP), deaminated gliadinanalogous fragments (anti-GAF-3X) and Saccharomyces cerevisiae (ASCA) were determined by ELISA and anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunoflurescence (IIF) in 57 patients with RAS and 60 control subjects. The prevalence of CeD specific antibodies did not differ between RAS patients and controls. However, the concentrations of IgA anti-tTG, IgA anti-GAF-3X antibodies in patients with RAS were significantly higher compared to controls (p = 0.002 and p = 0.04 respectively). Histological changes consistent with CeD were confirmed by duodenal biopsy in one RAS patient with highly positive IgA anti-tTG, anti-GAF-3X and anti-DGP antibodies. Higher prevalence along with higher concentrations of IgG ASCA were found in RAS patients compared to controls (p  lt  0.01). Patients with positive IgG ASCA in the absence of clinical symptoms decided not to pursue any further testing. Dysfunction of oral mucosa and the exposure to various antigens might be a reason for the loss of tolerance resulting in increased production of autoantibodies. It seems likely that antibodies are markers of aberrant immune response, rather than key effectors involved in the pathogenesis of the disease.",
publisher = "Elsevier Gmbh, Munich",
journal = "Immunobiology",
title = "Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis",
volume = "224",
number = "1",
pages = "75-79",
doi = "10.1016/j.imbio.2018.10.006"
}

Bijelić, B., Matić, I. Z., Besu, I., Janković, L., Juranić, Z., Marusić, S.,& Andrejević, S.. (2019). Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis. in Immunobiology
Elsevier Gmbh, Munich., 224(1), 75-79.
https://doi.org/10.1016/j.imbio.2018.10.006

Bijelić B, Matić IZ, Besu I, Janković L, Juranić Z, Marusić S, Andrejević S. Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis. in Immunobiology. 2019;224(1):75-79.
doi:10.1016/j.imbio.2018.10.006 .

Bijelić, Borivoj, Matić, Ivana Z., Besu, Irina, Janković, Ljiljana, Juranić, Zorica, Marusić, Senka, Andrejević, Slađana, "Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis" in Immunobiology, 224, no. 1 (2019):75-79,
https://doi.org/10.1016/j.imbio.2018.10.006 . .

TY  - THES
AU  - Bijelić, Borivoj
PY  - 2017
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=5603
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:17132/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49850383
UR  - http://nardus.mpn.gov.rs/123456789/9250
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1023
AB  - Humoral immunity as a part of an adaptive immune response is primary represented by B lymphocytes which differentiate into plasma cells, able to secrete antibodies, which are basic efector mechanism of humoral immunity. Alterations in antibody production has been observed in patients with different immune-inflammatory conditions including recurrent oral ulcerations (ROU), gluten sensitive enteropathy (GSE) and inflammatory bowel disease (IBD). Recurrent oral ulcerations represents an inflammatory disease characterized by appearance of repeated episodes of solitary or multiple painfully ulcerations of oral mucosa, affecting about 20% of the general population. Precise etiology of recurrent oral ulcerations is still unknown but it is proven that numerous etiological factors like heritage, stress, trauma, hypersensitivity to the food components, nutritional deficiency and hormonal imbalance, have important role in their occurrence. Gluten sensitive enteropathy or celiac disease (CeD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. GSE can be presented with classical gastrointestinal symptoms but also as an atypical, silent and latent form with a wide spectrum of non-gastrointestinal symptoms. In recent years, antibodies against native gliadin (GL), tissue transglutaminase (tTG), deaminated gliadin peptides (DGP) and deaminated gliadin analogous fragments (GAF) play a key role in early diagnosis. Inflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases with primary intestinal involvement. IBD patients may exhibit a wide range of non-intestinal signs and symptoms, among which ROU is classified as well. Serologic markers for UC and CD are antineutrophil cytoplasmic antibodies (ANCA) and antibodies against Saccharomyces cerevisiae (ASCA) respectively. Modifications in oral tolerance, mucosal immunity and in epithelial barrier functionality observed in GSE, IBC and food allergens hypersensitivity, could also influence occurrence of ROU...
AB  - Humoralni imunitet predstavlja deo adaptivnog imunskog odgovora i sačinjavaju ga prevashodno B limfociti, čijom aktivacijom nastaju plazmociti, sposobni da produkuju antitela koja ujedno predstavljaju osnovni efektorski mehanizam humoralnog imuniteta. Poremećaj u produkciji antitela uočen je kod pacijenata sa različitim imuno-inflamatornim stanjima, u koja se svrstavaju i rekurentne oralne ulceracije (ROU), gluten senzitivna enteropatija (GSE) i inflamatorne bolesti creva (IBC). Rekurentne oralne ulceracije predstavljaju inflamantorno oboljenje koje se karakteriše pojavom ponavljanih epizoda solitarnih ili multiplih, bolnih ulceracija oralne sluzokože. One se javljaju u oko 20% opšte populacije. Precizna etiologija rekurentnih oralnih ulceracija je i dalje nepoznata, ali je dokazano da brojni etiološki faktori u koje se svrstavaju nasleđe, stres, trauma, preosetljivost na komponente hrane, nutritivni deficit i hormonski disbalans imaju značajnu ulogu u njihovom nastanku. Gluten senzitivna enteropatija ili celijačna bolest (CD) je imuno-posredovano oboljenje koje se javlja kod genetski predisponiranih osoba, izazvano unosom glutena, proteina koji se nalazi u mnogim žitaricama. Klinički se ispoljava klasičnim gastrointestinalnim simptomima, ali se može javiti i kao atipična, pritajena ili latentna forma kada je postavljanje dijagnoze GSE značajno otežano. Poslednjih godina, značajnu ulogu u dijagnostici imaju i antitela specifična za GSE kao što su antitela na nativni glijadin (GL), antitela specifična za tkivnu transglutaminazu (tTG), antitela specifična za deaminirane glijadinske peptide (DGP) i antitela specifična za fuzione peptide, glijadinske analoge (GAF-3X). Inflamatorne bolesti creva su imunski-posredovana, hronična, recidivirajuća oboljenja predstavljena kroz dve osnovne kliničke forme: Kronovu bolest (KB) i ulcerozni kolitis (UK). Pacijenti oboleli od IBC mogu imati širok spektar vancrevnih simptoma među koje se svrstavaju i oralne ulceracije. Kao pomoćni markeri u dijagnostici IBC koriste se antitela specifična za Saccharomyces cervisiae (ASCA) i antitela specifična za citoplazmatske antigene neutrofilnih leukocita (ANCA)...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Specificity of humoral immune responses in patients with recurrent oral ulcerations
T1  - Specifičnosti humoralne imunosti kod obolelih od rekurentnih oralnih ulceracija
UR  - https://hdl.handle.net/21.15107/rcub_nardus_9250
ER  - 

@phdthesis{
author = "Bijelić, Borivoj",
year = "2017",
abstract = "Humoral immunity as a part of an adaptive immune response is primary represented by B lymphocytes which differentiate into plasma cells, able to secrete antibodies, which are basic efector mechanism of humoral immunity. Alterations in antibody production has been observed in patients with different immune-inflammatory conditions including recurrent oral ulcerations (ROU), gluten sensitive enteropathy (GSE) and inflammatory bowel disease (IBD). Recurrent oral ulcerations represents an inflammatory disease characterized by appearance of repeated episodes of solitary or multiple painfully ulcerations of oral mucosa, affecting about 20% of the general population. Precise etiology of recurrent oral ulcerations is still unknown but it is proven that numerous etiological factors like heritage, stress, trauma, hypersensitivity to the food components, nutritional deficiency and hormonal imbalance, have important role in their occurrence. Gluten sensitive enteropathy or celiac disease (CeD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. GSE can be presented with classical gastrointestinal symptoms but also as an atypical, silent and latent form with a wide spectrum of non-gastrointestinal symptoms. In recent years, antibodies against native gliadin (GL), tissue transglutaminase (tTG), deaminated gliadin peptides (DGP) and deaminated gliadin analogous fragments (GAF) play a key role in early diagnosis. Inflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases with primary intestinal involvement. IBD patients may exhibit a wide range of non-intestinal signs and symptoms, among which ROU is classified as well. Serologic markers for UC and CD are antineutrophil cytoplasmic antibodies (ANCA) and antibodies against Saccharomyces cerevisiae (ASCA) respectively. Modifications in oral tolerance, mucosal immunity and in epithelial barrier functionality observed in GSE, IBC and food allergens hypersensitivity, could also influence occurrence of ROU..., Humoralni imunitet predstavlja deo adaptivnog imunskog odgovora i sačinjavaju ga prevashodno B limfociti, čijom aktivacijom nastaju plazmociti, sposobni da produkuju antitela koja ujedno predstavljaju osnovni efektorski mehanizam humoralnog imuniteta. Poremećaj u produkciji antitela uočen je kod pacijenata sa različitim imuno-inflamatornim stanjima, u koja se svrstavaju i rekurentne oralne ulceracije (ROU), gluten senzitivna enteropatija (GSE) i inflamatorne bolesti creva (IBC). Rekurentne oralne ulceracije predstavljaju inflamantorno oboljenje koje se karakteriše pojavom ponavljanih epizoda solitarnih ili multiplih, bolnih ulceracija oralne sluzokože. One se javljaju u oko 20% opšte populacije. Precizna etiologija rekurentnih oralnih ulceracija je i dalje nepoznata, ali je dokazano da brojni etiološki faktori u koje se svrstavaju nasleđe, stres, trauma, preosetljivost na komponente hrane, nutritivni deficit i hormonski disbalans imaju značajnu ulogu u njihovom nastanku. Gluten senzitivna enteropatija ili celijačna bolest (CD) je imuno-posredovano oboljenje koje se javlja kod genetski predisponiranih osoba, izazvano unosom glutena, proteina koji se nalazi u mnogim žitaricama. Klinički se ispoljava klasičnim gastrointestinalnim simptomima, ali se može javiti i kao atipična, pritajena ili latentna forma kada je postavljanje dijagnoze GSE značajno otežano. Poslednjih godina, značajnu ulogu u dijagnostici imaju i antitela specifična za GSE kao što su antitela na nativni glijadin (GL), antitela specifična za tkivnu transglutaminazu (tTG), antitela specifična za deaminirane glijadinske peptide (DGP) i antitela specifična za fuzione peptide, glijadinske analoge (GAF-3X). Inflamatorne bolesti creva su imunski-posredovana, hronična, recidivirajuća oboljenja predstavljena kroz dve osnovne kliničke forme: Kronovu bolest (KB) i ulcerozni kolitis (UK). Pacijenti oboleli od IBC mogu imati širok spektar vancrevnih simptoma među koje se svrstavaju i oralne ulceracije. Kao pomoćni markeri u dijagnostici IBC koriste se antitela specifična za Saccharomyces cervisiae (ASCA) i antitela specifična za citoplazmatske antigene neutrofilnih leukocita (ANCA)...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Specificity of humoral immune responses in patients with recurrent oral ulcerations, Specifičnosti humoralne imunosti kod obolelih od rekurentnih oralnih ulceracija",
url = "https://hdl.handle.net/21.15107/rcub_nardus_9250"
}

Bijelić, B.. (2017). Specificity of humoral immune responses in patients with recurrent oral ulcerations. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_9250

Bijelić B. Specificity of humoral immune responses in patients with recurrent oral ulcerations. 2017;.
https://hdl.handle.net/21.15107/rcub_nardus_9250 .

Bijelić, Borivoj, "Specificity of humoral immune responses in patients with recurrent oral ulcerations" (2017),
https://hdl.handle.net/21.15107/rcub_nardus_9250 .

TY  - JOUR
AU  - Besu, Irina
AU  - Janković, Ljiljana
AU  - Konić-Ristić, Aleksandra
AU  - Rasković, Sanvila
AU  - Besu, Valeri
AU  - Đurić, Milanko
AU  - Čakić, Saša
AU  - Magdu, Ileana Ursu
AU  - Juranić, Zorica
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1817
AB  - Background Recurrent aphthous ulcerations (RAU), or recurrent aphthous stomatitis, is recognized as one of the most common oral mucosal diseases worldwide. It was noted some connection between immunity to cow's milk proteins (CMP) and oral diseases. The goal of this study was to determine the prevalence of the increased levels of serum antibodies to specific cow's milk proteins (SCMP), constituents of cheese or of whey, by enzyme-linked immunosorbent assay (ELISA) test, in subjects who have RAU. Methods Fifty subjects with RAU and 50 healthy people, as controls (C), were included in this research. Levels of serum IgA, IgG, and IgE antibodies to SCMP were determined by ELISA. The statistical analysis of data was performed by Wilcoxon rank sum test with continuity correction. Results The levels of serum anti-SCMP IgA, IgG, and IgE antibodies were significantly higher in subjects with RAU in comparison with controls (P  lt  0.005). Conclusions These results indicate the strong association between high levels of serum anti-SCMP IgA, IgG, and IgE antibodies, especially to caseins: a-, beta-, and ?-casein from cow's milk and clinical manifestations of RAU. Serum immunity to the whey proteins in subjects with RAU was not in so high percentage expressed.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Oral Pathology & Medicine
T1  - The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers
VL  - 42
IS  - 1
SP  - 82
EP  - 88
DO  - 10.1111/j.1600-0714.2012.01204.x
ER  - 

@article{
author = "Besu, Irina and Janković, Ljiljana and Konić-Ristić, Aleksandra and Rasković, Sanvila and Besu, Valeri and Đurić, Milanko and Čakić, Saša and Magdu, Ileana Ursu and Juranić, Zorica",
year = "2013",
abstract = "Background Recurrent aphthous ulcerations (RAU), or recurrent aphthous stomatitis, is recognized as one of the most common oral mucosal diseases worldwide. It was noted some connection between immunity to cow's milk proteins (CMP) and oral diseases. The goal of this study was to determine the prevalence of the increased levels of serum antibodies to specific cow's milk proteins (SCMP), constituents of cheese or of whey, by enzyme-linked immunosorbent assay (ELISA) test, in subjects who have RAU. Methods Fifty subjects with RAU and 50 healthy people, as controls (C), were included in this research. Levels of serum IgA, IgG, and IgE antibodies to SCMP were determined by ELISA. The statistical analysis of data was performed by Wilcoxon rank sum test with continuity correction. Results The levels of serum anti-SCMP IgA, IgG, and IgE antibodies were significantly higher in subjects with RAU in comparison with controls (P  lt  0.005). Conclusions These results indicate the strong association between high levels of serum anti-SCMP IgA, IgG, and IgE antibodies, especially to caseins: a-, beta-, and ?-casein from cow's milk and clinical manifestations of RAU. Serum immunity to the whey proteins in subjects with RAU was not in so high percentage expressed.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Oral Pathology & Medicine",
title = "The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers",
volume = "42",
number = "1",
pages = "82-88",
doi = "10.1111/j.1600-0714.2012.01204.x"
}

Besu, I., Janković, L., Konić-Ristić, A., Rasković, S., Besu, V., Đurić, M., Čakić, S., Magdu, I. U.,& Juranić, Z.. (2013). The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers. in Journal of Oral Pathology & Medicine
Wiley-Blackwell, Hoboken., 42(1), 82-88.
https://doi.org/10.1111/j.1600-0714.2012.01204.x

Besu I, Janković L, Konić-Ristić A, Rasković S, Besu V, Đurić M, Čakić S, Magdu IU, Juranić Z. The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers. in Journal of Oral Pathology & Medicine. 2013;42(1):82-88.
doi:10.1111/j.1600-0714.2012.01204.x .

Besu, Irina, Janković, Ljiljana, Konić-Ristić, Aleksandra, Rasković, Sanvila, Besu, Valeri, Đurić, Milanko, Čakić, Saša, Magdu, Ileana Ursu, Juranić, Zorica, "The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers" in Journal of Oral Pathology & Medicine, 42, no. 1 (2013):82-88,
https://doi.org/10.1111/j.1600-0714.2012.01204.x . .