TY  - JOUR
AU  - Toljić, Boško
AU  - Milašin, Jelena
AU  - de Luka, Silvio R.
AU  - Dragović, Gordana
AU  - Jevtović, Đorđe
AU  - Maslać, Aleksandar
AU  - Ristić-Đurović, Jasna
AU  - Trbovich, Alexander M.
PY  - 2023
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3281
AB  - We appraised the relationship between the biological and the chrono-
logical age and estimated the rate of biological aging in HIV-infected patients. Two
independent biomarkers, the relative telomere length and iron metabolism parame-
ters, were analyzed in younger (,35) and older (.50) HIV-infected and uninfected
patients (control group). In our control group, telomeres of younger patients were
significantly longer than telomeres of older ones. However, in HIV-infected partici-
pants, the difference in the length of telomeres was lost. By combining the length of
telomeres with serum iron, ferritin, and transferrin iron-binding capacity, a new for-
mula for determination of the aging process was developed. The life expectancy of
the healthy population was related to their biological age, and HIV-infected patients
were biologically older. The effect of antiretroviral HIV drug therapies varied with
respect to the biological aging process.
IMPORTANCE This article is focused on the dynamics of human aging. Moreover, its
interdisciplinary approach is applicable to various systems that are aging.
PB  - American Society for Microbiology
T2  - Microbiology Spectrum
T1  - HIV-Infected Patients as a Model of Aging
VL  - 11
IS  - 3
SP  - e00532-23
DO  - 10.1128/spectrum.00532-23
ER  - 

@article{
author = "Toljić, Boško and Milašin, Jelena and de Luka, Silvio R. and Dragović, Gordana and Jevtović, Đorđe and Maslać, Aleksandar and Ristić-Đurović, Jasna and Trbovich, Alexander M.",
year = "2023",
abstract = "We appraised the relationship between the biological and the chrono-
logical age and estimated the rate of biological aging in HIV-infected patients. Two
independent biomarkers, the relative telomere length and iron metabolism parame-
ters, were analyzed in younger (,35) and older (.50) HIV-infected and uninfected
patients (control group). In our control group, telomeres of younger patients were
significantly longer than telomeres of older ones. However, in HIV-infected partici-
pants, the difference in the length of telomeres was lost. By combining the length of
telomeres with serum iron, ferritin, and transferrin iron-binding capacity, a new for-
mula for determination of the aging process was developed. The life expectancy of
the healthy population was related to their biological age, and HIV-infected patients
were biologically older. The effect of antiretroviral HIV drug therapies varied with
respect to the biological aging process.
IMPORTANCE This article is focused on the dynamics of human aging. Moreover, its
interdisciplinary approach is applicable to various systems that are aging.",
publisher = "American Society for Microbiology",
journal = "Microbiology Spectrum",
title = "HIV-Infected Patients as a Model of Aging",
volume = "11",
number = "3",
pages = "e00532-23",
doi = "10.1128/spectrum.00532-23"
}

Toljić, B., Milašin, J., de Luka, S. R., Dragović, G., Jevtović, Đ., Maslać, A., Ristić-Đurović, J.,& Trbovich, A. M.. (2023). HIV-Infected Patients as a Model of Aging. in Microbiology Spectrum
American Society for Microbiology., 11(3), e00532-23.
https://doi.org/10.1128/spectrum.00532-23

Toljić B, Milašin J, de Luka SR, Dragović G, Jevtović Đ, Maslać A, Ristić-Đurović J, Trbovich AM. HIV-Infected Patients as a Model of Aging. in Microbiology Spectrum. 2023;11(3):e00532-23.
doi:10.1128/spectrum.00532-23 .

Toljić, Boško, Milašin, Jelena, de Luka, Silvio R., Dragović, Gordana, Jevtović, Đorđe, Maslać, Aleksandar, Ristić-Đurović, Jasna, Trbovich, Alexander M., "HIV-Infected Patients as a Model of Aging" in Microbiology Spectrum, 11, no. 3 (2023):e00532-23,
https://doi.org/10.1128/spectrum.00532-23 . .