TY  - JOUR
AU  - Srebro, Dragana P.
AU  - Vucković, Sonja M.
AU  - Dožić, Ivan
AU  - Dožić, Branko
AU  - Savić-Vujović, Katarina R.
AU  - Milovanović, Aleksandar P.
AU  - Karadžić, Branislav
AU  - Prostran, Milica S.
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2315
AB  - Background: In humans, orofacial pain has a high prevalence and is often difficult to treat. Magnesium is an essential element in biological a system which controls the activity of many ion channels, neurotransmitters and enzymes. Magnesium produces an antinociceptive effect in neuropathic pain, while in inflammatory pain results are not consistent. We examined the effects of magnesium sulfate using the rat orofacial formalin test, a model of trigeminal pain. Methods: Male Wistar rats were injected with 1.5% formalin into the perinasal area, and the total time spent in pain-related behavior (face rubbing) was quantified. We also spectrophotometrically determined the concentration of magnesium and creatine kinase activity in blood serum. Results: Magnesium sulfate administered subcutaneously (0.005-45 mg/kg) produced significant antinociception in the second phase of the orofacial formalin test in rats at physiological serum concentration of magnesium. The effect was not dose-dependent. The maximum antinociceptive effect of magnesium sulfate was about 50% and was achieved at doses of 15 and 45 mg/kg. Magnesium did not affect increase the levels of serum creatine kinase activity. Conclusions: Preemptive systemic administration of magnesium sulfate as the only drug can be used to prevent inflammatory pain in the orofacial region. Its analgesic effect is not associated with magnesium deficiency.
PB  - Polish Acad Sciences Inst Pharmacology, Krakow
T2  - Pharmacological Reports
T1  - Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels
VL  - 70
IS  - 1
SP  - 81
EP  - 86
DO  - 10.1016/j.pharep.2017.08.005
ER  - 

@article{
author = "Srebro, Dragana P. and Vucković, Sonja M. and Dožić, Ivan and Dožić, Branko and Savić-Vujović, Katarina R. and Milovanović, Aleksandar P. and Karadžić, Branislav and Prostran, Milica S.",
year = "2018",
abstract = "Background: In humans, orofacial pain has a high prevalence and is often difficult to treat. Magnesium is an essential element in biological a system which controls the activity of many ion channels, neurotransmitters and enzymes. Magnesium produces an antinociceptive effect in neuropathic pain, while in inflammatory pain results are not consistent. We examined the effects of magnesium sulfate using the rat orofacial formalin test, a model of trigeminal pain. Methods: Male Wistar rats were injected with 1.5% formalin into the perinasal area, and the total time spent in pain-related behavior (face rubbing) was quantified. We also spectrophotometrically determined the concentration of magnesium and creatine kinase activity in blood serum. Results: Magnesium sulfate administered subcutaneously (0.005-45 mg/kg) produced significant antinociception in the second phase of the orofacial formalin test in rats at physiological serum concentration of magnesium. The effect was not dose-dependent. The maximum antinociceptive effect of magnesium sulfate was about 50% and was achieved at doses of 15 and 45 mg/kg. Magnesium did not affect increase the levels of serum creatine kinase activity. Conclusions: Preemptive systemic administration of magnesium sulfate as the only drug can be used to prevent inflammatory pain in the orofacial region. Its analgesic effect is not associated with magnesium deficiency.",
publisher = "Polish Acad Sciences Inst Pharmacology, Krakow",
journal = "Pharmacological Reports",
title = "Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels",
volume = "70",
number = "1",
pages = "81-86",
doi = "10.1016/j.pharep.2017.08.005"
}

Srebro, D. P., Vucković, S. M., Dožić, I., Dožić, B., Savić-Vujović, K. R., Milovanović, A. P., Karadžić, B.,& Prostran, M. S.. (2018). Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels. in Pharmacological Reports
Polish Acad Sciences Inst Pharmacology, Krakow., 70(1), 81-86.
https://doi.org/10.1016/j.pharep.2017.08.005

Srebro DP, Vucković SM, Dožić I, Dožić B, Savić-Vujović KR, Milovanović AP, Karadžić B, Prostran MS. Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels. in Pharmacological Reports. 2018;70(1):81-86.
doi:10.1016/j.pharep.2017.08.005 .

Srebro, Dragana P., Vucković, Sonja M., Dožić, Ivan, Dožić, Branko, Savić-Vujović, Katarina R., Milovanović, Aleksandar P., Karadžić, Branislav, Prostran, Milica S., "Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels" in Pharmacological Reports, 70, no. 1 (2018):81-86,
https://doi.org/10.1016/j.pharep.2017.08.005 . .