TY  - JOUR
AU  - Lisul, Bogdan
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Tepavčević, Zvezdana
AU  - Koruga, Đuro
AU  - Grga, Đurica
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2424
AB  - PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.
PB  - Springer Heidelberg, Heidelberg
T2  - Journal of Medical & Biological Engineering
T1  - Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins
VL  - 39
IS  - 6
SP  - 874
EP  - 884
DO  - 10.1007/s40846-019-00473-y
ER  - 

@article{
author = "Lisul, Bogdan and Jelovac, Drago and Petrović, Milan and Tepavčević, Zvezdana and Koruga, Đuro and Grga, Đurica",
year = "2019",
abstract = "PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Journal of Medical & Biological Engineering",
title = "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins",
volume = "39",
number = "6",
pages = "874-884",
doi = "10.1007/s40846-019-00473-y"
}

Lisul, B., Jelovac, D., Petrović, M., Tepavčević, Z., Koruga, Đ.,& Grga, Đ.. (2019). Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering
Springer Heidelberg, Heidelberg., 39(6), 874-884.
https://doi.org/10.1007/s40846-019-00473-y

Lisul B, Jelovac D, Petrović M, Tepavčević Z, Koruga Đ, Grga Đ. Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering. 2019;39(6):874-884.
doi:10.1007/s40846-019-00473-y .

Lisul, Bogdan, Jelovac, Drago, Petrović, Milan, Tepavčević, Zvezdana, Koruga, Đuro, Grga, Đurica, "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins" in Journal of Medical & Biological Engineering, 39, no. 6 (2019):874-884,
https://doi.org/10.1007/s40846-019-00473-y . .

TY  - JOUR
AU  - Šarac, Dušan
AU  - Mitrović, Nenad
AU  - Tanasić, Ivan
AU  - Tihaček-Šojić, Ljiljana
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2336
AB  - Deformations in the vicinity of dental implants are affected by their design and if threshold level of 0.3 % is surpassed, bone resorption could occur. The goal of this study is to present a novel experimental approch for the analysis of effect od dental implant geometry on the surrounding structure strain values. A bone block model, with dimensions of 68x25x9 mm, was made from polymethyl-methacrylate. 3D printed block mold also provided a fixture for vertically placed Strauman ø4.0x12 mm. The sample was loaded in a three-point bending setup. The axial force of 600 N was applied on the dental implant. The Digital Image Correlation method was used for strain and displacement measurement. The highest von Mises strain of 0.7 % is located in the area of implant neck. The maximum displacement value in loading direction was 0.466 mm. Surface strain and displacement are correlated with implant geometry. This experimental methodology can be utilized to estimate dental implant load transfer characteristics.
AB  - Dizajn dentalnih implanata utiče na vrednosti deformacija koje nastaju u njihovoj okolini, i ako se pređe granična vrednost od 0.3 %, može doći do resorpcije kosti. Cilj ove studije je da predstavi novi eksperimentalni pristup za analizu uticaja geometrije dentalnih implanata na deformacije okolne strukture. Model kosti, sa dimenzijama od 68h25h9 mm, je napravljen od polimetil-metakrilata. Kalup za model koji je napravljen pomoću tehnike 3D štampe, je takođe služio i kao fiksator položaja za vertikalno postavljeni implant Štrauman ø4.0x12 mm. Uzorak je opterećen na savijanje u tri tačke. Aksijalna sila od 600 N je primenjena na dentalni implant. Za merenje deformacija i pomeraja je korišćena metoda Digitalne korelacije slika. Najveće vrednosti Von Mizesovih deformacija od 0.7 % su izmerene u području vrata implanta. Maksimalne vrednosti pomeraja u pravcu opterećenja su iznosile 0.466 mm. Površinska deformacija i pomeraji su povezani sa geometrijom implanata. Ova eksperimentalna metodologija se može koristiti u cilju određivanja karakteristika prenosa opterećenja dentalnih.
PB  - Univerzitet u Beogradu - Mašinski fakultet, Beograd
T2  - FME Transactions
T1  - Experimental methodology for analysis of influence of dental implant design on load transfer
T1  - Eksperimentalna metodologija za određivanje uticaja dizajna dentalnih implanata na prenos opterećenja
VL  - 46
IS  - 2
SP  - 266
EP  - 271
DO  - 10.5937/fmet1802266S
ER  - 

@article{
author = "Šarac, Dušan and Mitrović, Nenad and Tanasić, Ivan and Tihaček-Šojić, Ljiljana",
year = "2018",
abstract = "Deformations in the vicinity of dental implants are affected by their design and if threshold level of 0.3 % is surpassed, bone resorption could occur. The goal of this study is to present a novel experimental approch for the analysis of effect od dental implant geometry on the surrounding structure strain values. A bone block model, with dimensions of 68x25x9 mm, was made from polymethyl-methacrylate. 3D printed block mold also provided a fixture for vertically placed Strauman ø4.0x12 mm. The sample was loaded in a three-point bending setup. The axial force of 600 N was applied on the dental implant. The Digital Image Correlation method was used for strain and displacement measurement. The highest von Mises strain of 0.7 % is located in the area of implant neck. The maximum displacement value in loading direction was 0.466 mm. Surface strain and displacement are correlated with implant geometry. This experimental methodology can be utilized to estimate dental implant load transfer characteristics., Dizajn dentalnih implanata utiče na vrednosti deformacija koje nastaju u njihovoj okolini, i ako se pređe granična vrednost od 0.3 %, može doći do resorpcije kosti. Cilj ove studije je da predstavi novi eksperimentalni pristup za analizu uticaja geometrije dentalnih implanata na deformacije okolne strukture. Model kosti, sa dimenzijama od 68h25h9 mm, je napravljen od polimetil-metakrilata. Kalup za model koji je napravljen pomoću tehnike 3D štampe, je takođe služio i kao fiksator položaja za vertikalno postavljeni implant Štrauman ø4.0x12 mm. Uzorak je opterećen na savijanje u tri tačke. Aksijalna sila od 600 N je primenjena na dentalni implant. Za merenje deformacija i pomeraja je korišćena metoda Digitalne korelacije slika. Najveće vrednosti Von Mizesovih deformacija od 0.7 % su izmerene u području vrata implanta. Maksimalne vrednosti pomeraja u pravcu opterećenja su iznosile 0.466 mm. Površinska deformacija i pomeraji su povezani sa geometrijom implanata. Ova eksperimentalna metodologija se može koristiti u cilju određivanja karakteristika prenosa opterećenja dentalnih.",
publisher = "Univerzitet u Beogradu - Mašinski fakultet, Beograd",
journal = "FME Transactions",
title = "Experimental methodology for analysis of influence of dental implant design on load transfer, Eksperimentalna metodologija za određivanje uticaja dizajna dentalnih implanata na prenos opterećenja",
volume = "46",
number = "2",
pages = "266-271",
doi = "10.5937/fmet1802266S"
}

Šarac, D., Mitrović, N., Tanasić, I.,& Tihaček-Šojić, L.. (2018). Experimental methodology for analysis of influence of dental implant design on load transfer. in FME Transactions
Univerzitet u Beogradu - Mašinski fakultet, Beograd., 46(2), 266-271.
https://doi.org/10.5937/fmet1802266S

Šarac D, Mitrović N, Tanasić I, Tihaček-Šojić L. Experimental methodology for analysis of influence of dental implant design on load transfer. in FME Transactions. 2018;46(2):266-271.
doi:10.5937/fmet1802266S .

Šarac, Dušan, Mitrović, Nenad, Tanasić, Ivan, Tihaček-Šojić, Ljiljana, "Experimental methodology for analysis of influence of dental implant design on load transfer" in FME Transactions, 46, no. 2 (2018):266-271,
https://doi.org/10.5937/fmet1802266S . .

TY  - JOUR
AU  - Grga, Đurica
AU  - Marjanović, Marina
AU  - Hut, Igor
AU  - Dželetović, Bojan
AU  - Koruga, Đuro
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1721
AB  - Emerging technologies and new nanoscale information have potential to transform dental practice by improving all aspects of diagnostics and therapy. Nanocharacterization allows understanding of oral diseases at molecular and cellular levels which eventually can increase the success of prevention and treatment. Opto-magnetic spectroscopy (OMS) is a promising new technique based on light-matter interaction which allows insight into the quantum state of matter. Since biomolecules and tissues are usually paramagnetic or diamagnetic materials it is possible to determine the dynamics of para-and diamagnetism at different teeth structures using that method. The topography of the surface of a sample can be obtained with a very high resolution using atomic force microscopy (AFM), which allows observation of minimal changes up to 10 nm, while magnetic force microscopy (MFM) is used to record the magnetic field gradient and its distribution over the surface of a sample. The aim of this study was to determine the possibility of AFM and MFM for the characterization of dental calculus, and a potential application of OMS for the detection of subgingival dental calculus.
AB  - Inovativne tehnologije i nove informacije na nanonivou imaju potencijal da poboljšaju stomatološku praksu, unapređujući sve aspekte dijagnostike i terapije. Nanokarakterizacija omogućava razumevanje razvoja oboljenja na ćelijskom i molekularnom nivou, što za krajnji rezultat može imati poboljšanje prevencije i uspeha lečenja. Optomagnetna spektroskopija (engl. opto-magnetic spectroscopy - OMS) je nova tehnika koja obećava, a zasnovana je na interakciji svetlosti i materije koja omogućava uvid u kvantno stanje materije. S obzirom na to da biomolekuli i tkiva mogu ispoljavati osobine paramagnetičnosti, odnosno dijamagnetičnosti, ovom metodom moguće je utvrditi dinamiku paramagnetizma i dijamagnetizma na različitim strukturama zuba. Pomoću mikroskopije atomskih sila (engl. atomic force microscopy - AFM) moguće je dobiti topografiju površine uzorka vrlo visoke rezolucije, čime se uočavaju i najmanje promene sve do 10 nm, dok se mikroskopija magnetnih sila (engl. magnetic force microscopy - MFM) koristi za snimanje gradijenta magnetnog polja i njegove raspodele po površini uzorka. Cilj ovog rada bio je da prikaže mogućnosti primene AFM i MFM za karakterizaciju zubnog kamenca, kao i primene OMS za otkrivanje subgingivalnog kalkulusa.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Dental calculus: Nanocharacterization
T1  - Zubni kamenac - karakterizacija na nanonivou
VL  - 59
IS  - 3
SP  - 154
EP  - 159
DO  - 10.2298/SGS1203154G
ER  - 

@article{
author = "Grga, Đurica and Marjanović, Marina and Hut, Igor and Dželetović, Bojan and Koruga, Đuro",
year = "2012",
abstract = "Emerging technologies and new nanoscale information have potential to transform dental practice by improving all aspects of diagnostics and therapy. Nanocharacterization allows understanding of oral diseases at molecular and cellular levels which eventually can increase the success of prevention and treatment. Opto-magnetic spectroscopy (OMS) is a promising new technique based on light-matter interaction which allows insight into the quantum state of matter. Since biomolecules and tissues are usually paramagnetic or diamagnetic materials it is possible to determine the dynamics of para-and diamagnetism at different teeth structures using that method. The topography of the surface of a sample can be obtained with a very high resolution using atomic force microscopy (AFM), which allows observation of minimal changes up to 10 nm, while magnetic force microscopy (MFM) is used to record the magnetic field gradient and its distribution over the surface of a sample. The aim of this study was to determine the possibility of AFM and MFM for the characterization of dental calculus, and a potential application of OMS for the detection of subgingival dental calculus., Inovativne tehnologije i nove informacije na nanonivou imaju potencijal da poboljšaju stomatološku praksu, unapređujući sve aspekte dijagnostike i terapije. Nanokarakterizacija omogućava razumevanje razvoja oboljenja na ćelijskom i molekularnom nivou, što za krajnji rezultat može imati poboljšanje prevencije i uspeha lečenja. Optomagnetna spektroskopija (engl. opto-magnetic spectroscopy - OMS) je nova tehnika koja obećava, a zasnovana je na interakciji svetlosti i materije koja omogućava uvid u kvantno stanje materije. S obzirom na to da biomolekuli i tkiva mogu ispoljavati osobine paramagnetičnosti, odnosno dijamagnetičnosti, ovom metodom moguće je utvrditi dinamiku paramagnetizma i dijamagnetizma na različitim strukturama zuba. Pomoću mikroskopije atomskih sila (engl. atomic force microscopy - AFM) moguće je dobiti topografiju površine uzorka vrlo visoke rezolucije, čime se uočavaju i najmanje promene sve do 10 nm, dok se mikroskopija magnetnih sila (engl. magnetic force microscopy - MFM) koristi za snimanje gradijenta magnetnog polja i njegove raspodele po površini uzorka. Cilj ovog rada bio je da prikaže mogućnosti primene AFM i MFM za karakterizaciju zubnog kamenca, kao i primene OMS za otkrivanje subgingivalnog kalkulusa.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Dental calculus: Nanocharacterization, Zubni kamenac - karakterizacija na nanonivou",
volume = "59",
number = "3",
pages = "154-159",
doi = "10.2298/SGS1203154G"
}

Grga, Đ., Marjanović, M., Hut, I., Dželetović, B.,& Koruga, Đ.. (2012). Dental calculus: Nanocharacterization. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 59(3), 154-159.
https://doi.org/10.2298/SGS1203154G

Grga Đ, Marjanović M, Hut I, Dželetović B, Koruga Đ. Dental calculus: Nanocharacterization. in Stomatološki glasnik Srbije. 2012;59(3):154-159.
doi:10.2298/SGS1203154G .

Grga, Đurica, Marjanović, Marina, Hut, Igor, Dželetović, Bojan, Koruga, Đuro, "Dental calculus: Nanocharacterization" in Stomatološki glasnik Srbije, 59, no. 3 (2012):154-159,
https://doi.org/10.2298/SGS1203154G . .