TY  - JOUR
AU  - Mladenović, Irena
AU  - Supić, Gordana
AU  - Kozomara, Ružica
AU  - Dodić, Slobodan
AU  - Ivković, Nedeljka
AU  - Milićević, Bojana
AU  - Simić, Ivana
AU  - Magić, Zvonko
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2124
AB  - Aims: To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain. Methods: A total of 90 patients with a diagnosis of painful TMD and 92 matched controls were investigated for the presence of TMD, TMD pain, and psychosocial variables by the Research Diagnostic Criteria for TMD. In a prospective cohort study of 40 subjects who underwent extraction of at least one fully impacted mandibular third molar, subjects had 6 months post-surgery follow-up of postoperative pain. DNA extracted from peripheral blood was genotyped for three COMT polymorphisms (rs4680, rs6269, and rs165774) by real-time TaqMan method. The association between COMT polymorphisms and clinical variables was determined by calculating odds ratios (OR) and their 95% confidence intervals (CO. Results: Homozygous AA genotype and heterozygous variant A allele carriers (genotype AG/AA) for rs165774 polymorphism were associated with increased risk of TMD compared to wild type (wt) GG genotype (OR = 9.448, P =.006; OR = 2.088, P =.017, respectively). In addition, AA genotype was associated with increased risk of arthralgia (OR = 4.448, P =.011), myofascial pain (OR = 3.543, P =.035), and chronic TMD pain (OR = 6.173, P =.006), compared to wt genotype. AA genotype for rs6269 polymorphism was related to less postoperative chronic TMD pain (P =.025) and lower postoperative acute pain at the extraction site (P =.030). No associations with depression and somatization were observed. Conclusion: AA genotype of rs165774 could be a significant risk factor for the development of TMD and TMD pain, while AA genotype of rs6269 presents less postoperative chronic TMD pain and acute pain at a dental extraction site.
PB  - Quintessence Publishing Co Inc, Hanover Park
T2  - Journal of Oral & Facial Pain & Headache
T1  - Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain
VL  - 30
IS  - 4
SP  - 302
EP  - 310
DO  - 10.11607/ofph.1688
ER  - 

@article{
author = "Mladenović, Irena and Supić, Gordana and Kozomara, Ružica and Dodić, Slobodan and Ivković, Nedeljka and Milićević, Bojana and Simić, Ivana and Magić, Zvonko",
year = "2016",
abstract = "Aims: To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain. Methods: A total of 90 patients with a diagnosis of painful TMD and 92 matched controls were investigated for the presence of TMD, TMD pain, and psychosocial variables by the Research Diagnostic Criteria for TMD. In a prospective cohort study of 40 subjects who underwent extraction of at least one fully impacted mandibular third molar, subjects had 6 months post-surgery follow-up of postoperative pain. DNA extracted from peripheral blood was genotyped for three COMT polymorphisms (rs4680, rs6269, and rs165774) by real-time TaqMan method. The association between COMT polymorphisms and clinical variables was determined by calculating odds ratios (OR) and their 95% confidence intervals (CO. Results: Homozygous AA genotype and heterozygous variant A allele carriers (genotype AG/AA) for rs165774 polymorphism were associated with increased risk of TMD compared to wild type (wt) GG genotype (OR = 9.448, P =.006; OR = 2.088, P =.017, respectively). In addition, AA genotype was associated with increased risk of arthralgia (OR = 4.448, P =.011), myofascial pain (OR = 3.543, P =.035), and chronic TMD pain (OR = 6.173, P =.006), compared to wt genotype. AA genotype for rs6269 polymorphism was related to less postoperative chronic TMD pain (P =.025) and lower postoperative acute pain at the extraction site (P =.030). No associations with depression and somatization were observed. Conclusion: AA genotype of rs165774 could be a significant risk factor for the development of TMD and TMD pain, while AA genotype of rs6269 presents less postoperative chronic TMD pain and acute pain at a dental extraction site.",
publisher = "Quintessence Publishing Co Inc, Hanover Park",
journal = "Journal of Oral & Facial Pain & Headache",
title = "Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain",
volume = "30",
number = "4",
pages = "302-310",
doi = "10.11607/ofph.1688"
}

Mladenović, I., Supić, G., Kozomara, R., Dodić, S., Ivković, N., Milićević, B., Simić, I.,& Magić, Z.. (2016). Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain. in Journal of Oral & Facial Pain & Headache
Quintessence Publishing Co Inc, Hanover Park., 30(4), 302-310.
https://doi.org/10.11607/ofph.1688

Mladenović I, Supić G, Kozomara R, Dodić S, Ivković N, Milićević B, Simić I, Magić Z. Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain. in Journal of Oral & Facial Pain & Headache. 2016;30(4):302-310.
doi:10.11607/ofph.1688 .

Mladenović, Irena, Supić, Gordana, Kozomara, Ružica, Dodić, Slobodan, Ivković, Nedeljka, Milićević, Bojana, Simić, Ivana, Magić, Zvonko, "Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain" in Journal of Oral & Facial Pain & Headache, 30, no. 4 (2016):302-310,
https://doi.org/10.11607/ofph.1688 . .