TY  - JOUR
AU  - Dragović, Gordana
AU  - Toljić, Boško
AU  - Jevtović, Đorđe
AU  - Lukić, Relja
AU  - de Luka, Silvio R.
AU  - Trbovich, Alexander
AU  - Milašin, Jelena
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3285
AB  - Background: Components of the metabolic syndrome (MetS) play an important role in the accelerated aging process. Relative telomere length (RTL) is a marker of biological aging. The aim of our study was to determine RTL and its possible association with MetS and the components of MetS in HIV-infected patients treated with cART.

Methods: We included 24 HIV-infected men, all Caucasians, with successful cART (<50 HIV-RNA copies/mL) and on stable cART for at least 24 months. The presence of MetS and its components was determined by the criteria prescribed by the International Diabetes Federation. RTL was determined by Real-Time PCR and ΔΔCt method. We performed a multiple linear regression modeling on log-transformed RTL (dependant variable) to evaluate which components of the metabolic syndrome as well as cART duration and cART type, had an impact on RTL.

Results: Eleven (45.8%) patients had and 13 (54.2%) had not MetS. All patients, had an undetectable viral RNA and a relatively good immune status. The mean RTL was 0.62 ± 0.15 and 0.95 ± 0.36 in patients with and without MetS, respectively (p = 0.01). Multiple linear regression model showed no significant association between duration of cART, cART type and RTL (p = 0.2165, p = 0.8628, respectively). The same analysis showed that an increase in number of MetS components was associated with shorter telomere length (β = -0.4982, p = 0.042).

Conclusions: We showed for the first time association between RTL shortening in HIV-infected men with metabolic syndrome. Furthermore, our study also indicated that an increment of metabolic syndrome components is strongly associated with shorter telomere length.
PB  - Elsevier Inc.
T2  - Experimental Gerontology
T1  - Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy
VL  - 147
IS  - May
SP  - 111269
DO  - 10.1016/j.exger.2021.111269
ER  - 

@article{
author = "Dragović, Gordana and Toljić, Boško and Jevtović, Đorđe and Lukić, Relja and de Luka, Silvio R. and Trbovich, Alexander and Milašin, Jelena",
year = "2021",
abstract = "Background: Components of the metabolic syndrome (MetS) play an important role in the accelerated aging process. Relative telomere length (RTL) is a marker of biological aging. The aim of our study was to determine RTL and its possible association with MetS and the components of MetS in HIV-infected patients treated with cART.

Methods: We included 24 HIV-infected men, all Caucasians, with successful cART (<50 HIV-RNA copies/mL) and on stable cART for at least 24 months. The presence of MetS and its components was determined by the criteria prescribed by the International Diabetes Federation. RTL was determined by Real-Time PCR and ΔΔCt method. We performed a multiple linear regression modeling on log-transformed RTL (dependant variable) to evaluate which components of the metabolic syndrome as well as cART duration and cART type, had an impact on RTL.

Results: Eleven (45.8%) patients had and 13 (54.2%) had not MetS. All patients, had an undetectable viral RNA and a relatively good immune status. The mean RTL was 0.62 ± 0.15 and 0.95 ± 0.36 in patients with and without MetS, respectively (p = 0.01). Multiple linear regression model showed no significant association between duration of cART, cART type and RTL (p = 0.2165, p = 0.8628, respectively). The same analysis showed that an increase in number of MetS components was associated with shorter telomere length (β = -0.4982, p = 0.042).

Conclusions: We showed for the first time association between RTL shortening in HIV-infected men with metabolic syndrome. Furthermore, our study also indicated that an increment of metabolic syndrome components is strongly associated with shorter telomere length.",
publisher = "Elsevier Inc.",
journal = "Experimental Gerontology",
title = "Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy",
volume = "147",
number = "May",
pages = "111269",
doi = "10.1016/j.exger.2021.111269"
}

Dragović, G., Toljić, B., Jevtović, Đ., Lukić, R., de Luka, S. R., Trbovich, A.,& Milašin, J.. (2021). Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy. in Experimental Gerontology
Elsevier Inc.., 147(May), 111269.
https://doi.org/10.1016/j.exger.2021.111269

Dragović G, Toljić B, Jevtović Đ, Lukić R, de Luka SR, Trbovich A, Milašin J. Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy. in Experimental Gerontology. 2021;147(May):111269.
doi:10.1016/j.exger.2021.111269 .

Dragović, Gordana, Toljić, Boško, Jevtović, Đorđe, Lukić, Relja, de Luka, Silvio R., Trbovich, Alexander, Milašin, Jelena, "Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy" in Experimental Gerontology, 147, no. May (2021):111269,
https://doi.org/10.1016/j.exger.2021.111269 . .