TY  - JOUR
AU  - Ćetković, Dejan
AU  - Milić, Marija
AU  - Biočanin, Vladimir
AU  - Brajić, Ivana
AU  - Ćalasan, Dejan
AU  - Radović, Katarina
AU  - Živković, Rade
AU  - Brković, Božidar
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2448
AB  - Bacground/Aim. The efficient dental anesthesia, which is related to the clinically adequate depth, duration and the width of anesthetic field, is an important prerequisite for successful dental treatment. The aim of this study was to investigate and compare the pulpal anesthesia and cardiovascular parameters after the anterior middle superior alveolar (AMSA) nerve block with 4% articaine with epinephrine administered by conventional cartridge-syringe and computer-controlled local anesthetic delivery system (CCLADS). Methods. This controlled double-blind cross-over randomized clinical study included 38 healthy volunteers. Efficacy of pulpal anesthesia after the AMSA nerve block was evaluated by measuring a success rate, onset and duration of pulpal anesthesia, using an electrical pulp tester. The parameters of cardiovascular function (systolic and diastolic blood pressure, heart rate) were monitored noninvasively. Results. Successful pulpal anesthesia of all tested teeth was obtained in 57.9% participants with CCLADS and in 44.7% participants with conventional syringe. The onset time was not significantly different between two investigated groups. The pulpal anesthesia duration was not significantly different neither within nor between investigated groups. The systolic and diastolic blood pressures were significantly decreased in both investigated groups, in comparison with the baseline values. Heart rate significantly decreased within CCLADS from 10th to 30th minute when compared to baseline. Conclusion. The efficacy of pulpal anesthesia and safety of cardiovascular profile of 0.6 mL of articaine with epinephrine (1:100.000) delivered with CCLADS were improved in comparison to the conventional syringe delivery. Significant changes of cardiovascular function were not observed.
AB  - Uvod/Cilj. Efikasna zubna anestezija u pogledu klinički adekvatne dubine, trajanja i širine anestetičkog polja je važan preduslov za uspešno zubno lečenje. Cilj rada bio je ispitivanje i upoređivanje parametra anestezije zubne pulpe i kardiovaskularnih parametra posle gornje prednje i srednje alveolarne (AMSA) sprovodne anestezije postignute 4% artikainom sa epinefrinom, primenom standardne karpulbrizgalice i kompjuterski kontrolisanog sistema za primenu anestetičkog rastvora (CCLADS). Metode. U ovom randomizovanom, prospektivnom, kontrolisanom, dvostruko slepom ukrštenom kliničkom istraživanju učestvovalo je 38 ispitanika. Kvalitet anestezije zubne pulpe posle AMSA anestezije praćen je na osnovu uspešnosti, latentnog perioda i trajanja anestezije zubne pulpe, primenom električnog pulp-testera. Parametri kardiovaskularne funkcije (sistolni i dijastolni krvni pritisak, srčana frekvencija) praćeni su neinvazivno, primenom aparata za monitoring. Rezultati. Uspešna anestezija zubne pulpe svih ispitivanih zuba bila je prisutna kod 57,9% ispitanika posle kod CCLADS i kod 44,7% ispitanika posle primene standardne karpul-brizgalice. Latentni period i trajanje anestezije zubne pulpe nisu se značajno razlikovali između ispitivanih grupa. Sistolni i dijastolni pritisak bili su značajno sniženi u praćenim vremenskim intervalima u odnosu na početne vrednosti. Srčana frekvencija je bila značajno snižena kod CCLADS grupe od 10 do 30 minuta u odnosu na početne vrednosti. Zaključak. Kontrolisanom kompjuterizovanom primenom (CCLADS) 0,6 mL 4% artikaina sa epinefrinom (1:100,000) za AMSA sprovodnu anesteziju, postignut je bolji kvalitet anestezije zubne pulpe u odnosu na primenu artikaina sa epinefrinom standardnom karpul brizgalicom. Nisu uočene bitne promene funkcija kardiovaskularnog sistema.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study
T1  - Efikasnost i sigurnost 4% artikaina sa epinefrinom za gornji prednji i srednji alveolarni nervni blok primenom kompjuterski kontrolisanog sistema i standardnog pristupa za primenu anestetičkog rastvora - prospektivna, randomizovana, kontrolisana, dvosturko slepa, ukrštena klinička studija
VL  - 76
IS  - 10
SP  - 1045
EP  - 1053
DO  - 10.2298/VSP170511013C
ER  - 

@article{
author = "Ćetković, Dejan and Milić, Marija and Biočanin, Vladimir and Brajić, Ivana and Ćalasan, Dejan and Radović, Katarina and Živković, Rade and Brković, Božidar",
year = "2019",
abstract = "Bacground/Aim. The efficient dental anesthesia, which is related to the clinically adequate depth, duration and the width of anesthetic field, is an important prerequisite for successful dental treatment. The aim of this study was to investigate and compare the pulpal anesthesia and cardiovascular parameters after the anterior middle superior alveolar (AMSA) nerve block with 4% articaine with epinephrine administered by conventional cartridge-syringe and computer-controlled local anesthetic delivery system (CCLADS). Methods. This controlled double-blind cross-over randomized clinical study included 38 healthy volunteers. Efficacy of pulpal anesthesia after the AMSA nerve block was evaluated by measuring a success rate, onset and duration of pulpal anesthesia, using an electrical pulp tester. The parameters of cardiovascular function (systolic and diastolic blood pressure, heart rate) were monitored noninvasively. Results. Successful pulpal anesthesia of all tested teeth was obtained in 57.9% participants with CCLADS and in 44.7% participants with conventional syringe. The onset time was not significantly different between two investigated groups. The pulpal anesthesia duration was not significantly different neither within nor between investigated groups. The systolic and diastolic blood pressures were significantly decreased in both investigated groups, in comparison with the baseline values. Heart rate significantly decreased within CCLADS from 10th to 30th minute when compared to baseline. Conclusion. The efficacy of pulpal anesthesia and safety of cardiovascular profile of 0.6 mL of articaine with epinephrine (1:100.000) delivered with CCLADS were improved in comparison to the conventional syringe delivery. Significant changes of cardiovascular function were not observed., Uvod/Cilj. Efikasna zubna anestezija u pogledu klinički adekvatne dubine, trajanja i širine anestetičkog polja je važan preduslov za uspešno zubno lečenje. Cilj rada bio je ispitivanje i upoređivanje parametra anestezije zubne pulpe i kardiovaskularnih parametra posle gornje prednje i srednje alveolarne (AMSA) sprovodne anestezije postignute 4% artikainom sa epinefrinom, primenom standardne karpulbrizgalice i kompjuterski kontrolisanog sistema za primenu anestetičkog rastvora (CCLADS). Metode. U ovom randomizovanom, prospektivnom, kontrolisanom, dvostruko slepom ukrštenom kliničkom istraživanju učestvovalo je 38 ispitanika. Kvalitet anestezije zubne pulpe posle AMSA anestezije praćen je na osnovu uspešnosti, latentnog perioda i trajanja anestezije zubne pulpe, primenom električnog pulp-testera. Parametri kardiovaskularne funkcije (sistolni i dijastolni krvni pritisak, srčana frekvencija) praćeni su neinvazivno, primenom aparata za monitoring. Rezultati. Uspešna anestezija zubne pulpe svih ispitivanih zuba bila je prisutna kod 57,9% ispitanika posle kod CCLADS i kod 44,7% ispitanika posle primene standardne karpul-brizgalice. Latentni period i trajanje anestezije zubne pulpe nisu se značajno razlikovali između ispitivanih grupa. Sistolni i dijastolni pritisak bili su značajno sniženi u praćenim vremenskim intervalima u odnosu na početne vrednosti. Srčana frekvencija je bila značajno snižena kod CCLADS grupe od 10 do 30 minuta u odnosu na početne vrednosti. Zaključak. Kontrolisanom kompjuterizovanom primenom (CCLADS) 0,6 mL 4% artikaina sa epinefrinom (1:100,000) za AMSA sprovodnu anesteziju, postignut je bolji kvalitet anestezije zubne pulpe u odnosu na primenu artikaina sa epinefrinom standardnom karpul brizgalicom. Nisu uočene bitne promene funkcija kardiovaskularnog sistema.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study, Efikasnost i sigurnost 4% artikaina sa epinefrinom za gornji prednji i srednji alveolarni nervni blok primenom kompjuterski kontrolisanog sistema i standardnog pristupa za primenu anestetičkog rastvora - prospektivna, randomizovana, kontrolisana, dvosturko slepa, ukrštena klinička studija",
volume = "76",
number = "10",
pages = "1045-1053",
doi = "10.2298/VSP170511013C"
}

Ćetković, D., Milić, M., Biočanin, V., Brajić, I., Ćalasan, D., Radović, K., Živković, R.,& Brković, B.. (2019). Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(10), 1045-1053.
https://doi.org/10.2298/VSP170511013C

Ćetković D, Milić M, Biočanin V, Brajić I, Ćalasan D, Radović K, Živković R, Brković B. Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study. in Vojnosanitetski pregled. 2019;76(10):1045-1053.
doi:10.2298/VSP170511013C .

Ćetković, Dejan, Milić, Marija, Biočanin, Vladimir, Brajić, Ivana, Ćalasan, Dejan, Radović, Katarina, Živković, Rade, Brković, Božidar, "Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study" in Vojnosanitetski pregled, 76, no. 10 (2019):1045-1053,
https://doi.org/10.2298/VSP170511013C . .

TY  - JOUR
AU  - Dožić, Aleksandra
AU  - Cetković, M.
AU  - Marinković, S.
AU  - Mitrović, D.
AU  - Grujicić, M.
AU  - Micović, M.
AU  - Milisavljević, M.
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1889
AB  - Background: Lack of the relevant data in the literature and possible clinical significance of the geniculate ganglion vasculature inspired us to examine the vessels of this ganglion. Materials and methods: Twelve temporal bones were taken during autopsy and microdissected. Four geniculate ganglions were taken as well, serially sectioned and used for haematoxylin-eosin and trichrome staining, and for CD34 immunostaining. Results: The geniculate ganglion was supplied by the petrosal artery, which averaged 1.1 in number, 0.44 mm in the outer diameter, 0.24 mm in the luminal diameter, and 17.1 mm in length. The artery approached the greater petrosal nerve, giving off 1-3 twigs to it with a mean diameter of 24 mu m, and entered the nerve hiatus or a small bone opening close to the ganglion. Before the artery continued to the tympanic segment of the facial nerve, it gave rise to 1 (8.33%), 2 (75.00%) or 3 (16.67%) branches to the geniculate ganglion, which ranged in diameter between 18 mu m and 56 mu m (mean 29 mu m). From the formed superficial network, several twigs penetrated the ganglion and built an intraganglionic plexus. The counting, performed in microscopic fields, each measuring 341.7 mu m x 250.0 mu m in size, contained between 20 and 38 (mean 28.1) ganglion cells, as well as from 87 to 143 microvessels (mean 99.8), so that the neuron/vessel ratio was 1:3.6. Conclusions: This is the first detailed examination of the geniculate ganglion vasculature. The obtained data could be of clinical importance, especially in relation to the Bell's palsy, ganglionitis, geniculate neuralgia, petrous bone imaging, and operations in the same region.
PB  - Via Medica, Gdansk
T2  - Folia Morphologica
T1  - Vascularisation of the geniculate ganglion
VL  - 73
IS  - 4
SP  - 414
EP  - 421
DO  - 10.5603/FM.2014.0063
ER  - 

@article{
author = "Dožić, Aleksandra and Cetković, M. and Marinković, S. and Mitrović, D. and Grujicić, M. and Micović, M. and Milisavljević, M.",
year = "2014",
abstract = "Background: Lack of the relevant data in the literature and possible clinical significance of the geniculate ganglion vasculature inspired us to examine the vessels of this ganglion. Materials and methods: Twelve temporal bones were taken during autopsy and microdissected. Four geniculate ganglions were taken as well, serially sectioned and used for haematoxylin-eosin and trichrome staining, and for CD34 immunostaining. Results: The geniculate ganglion was supplied by the petrosal artery, which averaged 1.1 in number, 0.44 mm in the outer diameter, 0.24 mm in the luminal diameter, and 17.1 mm in length. The artery approached the greater petrosal nerve, giving off 1-3 twigs to it with a mean diameter of 24 mu m, and entered the nerve hiatus or a small bone opening close to the ganglion. Before the artery continued to the tympanic segment of the facial nerve, it gave rise to 1 (8.33%), 2 (75.00%) or 3 (16.67%) branches to the geniculate ganglion, which ranged in diameter between 18 mu m and 56 mu m (mean 29 mu m). From the formed superficial network, several twigs penetrated the ganglion and built an intraganglionic plexus. The counting, performed in microscopic fields, each measuring 341.7 mu m x 250.0 mu m in size, contained between 20 and 38 (mean 28.1) ganglion cells, as well as from 87 to 143 microvessels (mean 99.8), so that the neuron/vessel ratio was 1:3.6. Conclusions: This is the first detailed examination of the geniculate ganglion vasculature. The obtained data could be of clinical importance, especially in relation to the Bell's palsy, ganglionitis, geniculate neuralgia, petrous bone imaging, and operations in the same region.",
publisher = "Via Medica, Gdansk",
journal = "Folia Morphologica",
title = "Vascularisation of the geniculate ganglion",
volume = "73",
number = "4",
pages = "414-421",
doi = "10.5603/FM.2014.0063"
}

Dožić, A., Cetković, M., Marinković, S., Mitrović, D., Grujicić, M., Micović, M.,& Milisavljević, M.. (2014). Vascularisation of the geniculate ganglion. in Folia Morphologica
Via Medica, Gdansk., 73(4), 414-421.
https://doi.org/10.5603/FM.2014.0063

Dožić A, Cetković M, Marinković S, Mitrović D, Grujicić M, Micović M, Milisavljević M. Vascularisation of the geniculate ganglion. in Folia Morphologica. 2014;73(4):414-421.
doi:10.5603/FM.2014.0063 .

Dožić, Aleksandra, Cetković, M., Marinković, S., Mitrović, D., Grujicić, M., Micović, M., Milisavljević, M., "Vascularisation of the geniculate ganglion" in Folia Morphologica, 73, no. 4 (2014):414-421,
https://doi.org/10.5603/FM.2014.0063 . .

TY  - JOUR
AU  - Gašić, Jovanka
AU  - Popović, Jelena
AU  - Živković, Slavoljub
AU  - Petrović, Aleksandar
AU  - Barac, Radomir
AU  - Nikolić, Marija
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1764
AB  - To determine whether sodium hypochlorite (NaOCl) with 0.2% chlorhexidine gluconate (CHX) leads to colour change and precipitate formation, and to ultrastructurally analyse the dentine surface after simultaneous irrigation with 0.5% NaOCl and 0.2% CHX. Four tubes in which 5ml of different NaOCl concentrations and 5ml 0,2% CHX were placed, were observed every 15 minutes in the first two hours and after 7 days. Mixture solutions were centrifuged at 800 rpm/4 min. A precipitate is observed under light-microscopy. Thirty-five single-rooted teeth were instrumented using crown-down technique with irrigation: Positive control: distilled water, Negative control: 0,5% NaOCl+15% EDTA, Experimental group: identical to the negative control, then canals were treated with 0.5% NaOCl+0.2% CHX. The longitudinal root sections were observed under scanning-electron-microscopy. The amount of debris was assessed with 5/score-system, and the results were analysed using the Mann-Whitney U test (p  lt  0.001). Change in colour was noticed immediately after the merger and it did not change with time. Mixture solutions showed considerable turbidity, but precipitate was observed only after centrifugation. Statistical analysis showed a significant difference in the dentinal wall purity when comparing the cervical and middle root canal thirds between the experimental and negative control group. The difference was also observed between the cervical and middle thirds compared to the apical third of the root canal within these groups. Interaction between NaOCl and CHX, as well as the creation of precipitates, depends not only on the concentration of NaOCl, but also on the concentration of CHX. Microsc. Res. Tech. 75:10991103, 2012.
PB  - Wiley, Hoboken
T2  - Microscopy Research & Technique
T1  - Ultrastructural analysis of the root canal walls after simultaneous irrigation of different sodium hypochlorite concentration and 0.2% chlorhexidine gluconate
VL  - 75
IS  - 8
SP  - 1099
EP  - 1103
DO  - 10.1002/jemt.22036
ER  - 

@article{
author = "Gašić, Jovanka and Popović, Jelena and Živković, Slavoljub and Petrović, Aleksandar and Barac, Radomir and Nikolić, Marija",
year = "2012",
abstract = "To determine whether sodium hypochlorite (NaOCl) with 0.2% chlorhexidine gluconate (CHX) leads to colour change and precipitate formation, and to ultrastructurally analyse the dentine surface after simultaneous irrigation with 0.5% NaOCl and 0.2% CHX. Four tubes in which 5ml of different NaOCl concentrations and 5ml 0,2% CHX were placed, were observed every 15 minutes in the first two hours and after 7 days. Mixture solutions were centrifuged at 800 rpm/4 min. A precipitate is observed under light-microscopy. Thirty-five single-rooted teeth were instrumented using crown-down technique with irrigation: Positive control: distilled water, Negative control: 0,5% NaOCl+15% EDTA, Experimental group: identical to the negative control, then canals were treated with 0.5% NaOCl+0.2% CHX. The longitudinal root sections were observed under scanning-electron-microscopy. The amount of debris was assessed with 5/score-system, and the results were analysed using the Mann-Whitney U test (p  lt  0.001). Change in colour was noticed immediately after the merger and it did not change with time. Mixture solutions showed considerable turbidity, but precipitate was observed only after centrifugation. Statistical analysis showed a significant difference in the dentinal wall purity when comparing the cervical and middle root canal thirds between the experimental and negative control group. The difference was also observed between the cervical and middle thirds compared to the apical third of the root canal within these groups. Interaction between NaOCl and CHX, as well as the creation of precipitates, depends not only on the concentration of NaOCl, but also on the concentration of CHX. Microsc. Res. Tech. 75:10991103, 2012.",
publisher = "Wiley, Hoboken",
journal = "Microscopy Research & Technique",
title = "Ultrastructural analysis of the root canal walls after simultaneous irrigation of different sodium hypochlorite concentration and 0.2% chlorhexidine gluconate",
volume = "75",
number = "8",
pages = "1099-1103",
doi = "10.1002/jemt.22036"
}

Gašić, J., Popović, J., Živković, S., Petrović, A., Barac, R.,& Nikolić, M.. (2012). Ultrastructural analysis of the root canal walls after simultaneous irrigation of different sodium hypochlorite concentration and 0.2% chlorhexidine gluconate. in Microscopy Research & Technique
Wiley, Hoboken., 75(8), 1099-1103.
https://doi.org/10.1002/jemt.22036

Gašić J, Popović J, Živković S, Petrović A, Barac R, Nikolić M. Ultrastructural analysis of the root canal walls after simultaneous irrigation of different sodium hypochlorite concentration and 0.2% chlorhexidine gluconate. in Microscopy Research & Technique. 2012;75(8):1099-1103.
doi:10.1002/jemt.22036 .

Gašić, Jovanka, Popović, Jelena, Živković, Slavoljub, Petrović, Aleksandar, Barac, Radomir, Nikolić, Marija, "Ultrastructural analysis of the root canal walls after simultaneous irrigation of different sodium hypochlorite concentration and 0.2% chlorhexidine gluconate" in Microscopy Research & Technique, 75, no. 8 (2012):1099-1103,
https://doi.org/10.1002/jemt.22036 . .