Nine specimens of well‐differentiated squamous cell carcinoma of the lip vermilion have been analyzed for the pressence of H‐ras oncogene mutations, using the technique of hybridization with synthetic oligonucleotide probes on in vitro amplified tumour DNA. Five specimens harbored mutations: four in codon 12 and one in codon 13. This high incidence (55%) of mutated H‐ras genes suggests that their activation may play an important role in lip tumour development and may be connected to the exposure to chemical and/or physical carcinogens.
Keywords:
H‐ras / lip cancer / oncogene mutations
Source:
Journal of Oral Pathology & Medicine, 1994, 23, 7, 298-301
TY - JOUR
AU - Milašin, Jelena
AU - Pujić, N.
AU - Dedović, Nasta
AU - Nikolić, Ž.
AU - Petrović, V.
AU - Dimitrijević, B.
PY - 1994
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1061
AB - Nine specimens of well‐differentiated squamous cell carcinoma of the lip vermilion have been analyzed for the pressence of H‐ras oncogene mutations, using the technique of hybridization with synthetic oligonucleotide probes on in vitro amplified tumour DNA. Five specimens harbored mutations: four in codon 12 and one in codon 13. This high incidence (55%) of mutated H‐ras genes suggests that their activation may play an important role in lip tumour development and may be connected to the exposure to chemical and/or physical carcinogens.
T2 - Journal of Oral Pathology & Medicine
T1 - High incidence of H‐ras oncogene mutations in squamous cell carcinoma of lip vermilion
VL - 23
IS - 7
SP - 298
EP - 301
DO - 10.1111/j.1600-0714.1994.tb00065.x
ER -
@article{
author = "Milašin, Jelena and Pujić, N. and Dedović, Nasta and Nikolić, Ž. and Petrović, V. and Dimitrijević, B.",
year = "1994",
abstract = "Nine specimens of well‐differentiated squamous cell carcinoma of the lip vermilion have been analyzed for the pressence of H‐ras oncogene mutations, using the technique of hybridization with synthetic oligonucleotide probes on in vitro amplified tumour DNA. Five specimens harbored mutations: four in codon 12 and one in codon 13. This high incidence (55%) of mutated H‐ras genes suggests that their activation may play an important role in lip tumour development and may be connected to the exposure to chemical and/or physical carcinogens.",
journal = "Journal of Oral Pathology & Medicine",
title = "High incidence of H‐ras oncogene mutations in squamous cell carcinoma of lip vermilion",
volume = "23",
number = "7",
pages = "298-301",
doi = "10.1111/j.1600-0714.1994.tb00065.x"
}
Milašin, J., Pujić, N., Dedović, N., Nikolić, Ž., Petrović, V.,& Dimitrijević, B.. (1994). High incidence of H‐ras oncogene mutations in squamous cell carcinoma of lip vermilion. in Journal of Oral Pathology & Medicine, 23(7), 298-301.
https://doi.org/10.1111/j.1600-0714.1994.tb00065.x
Milašin J, Pujić N, Dedović N, Nikolić Ž, Petrović V, Dimitrijević B. High incidence of H‐ras oncogene mutations in squamous cell carcinoma of lip vermilion. in Journal of Oral Pathology & Medicine. 1994;23(7):298-301.
doi:10.1111/j.1600-0714.1994.tb00065.x .
Milašin, Jelena, Pujić, N., Dedović, Nasta, Nikolić, Ž., Petrović, V., Dimitrijević, B., "High incidence of H‐ras oncogene mutations in squamous cell carcinoma of lip vermilion" in Journal of Oral Pathology & Medicine, 23, no. 7 (1994):298-301,
https://doi.org/10.1111/j.1600-0714.1994.tb00065.x . .
