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dc.creatorPapp, J
dc.creatorRaicević, L
dc.creatorMilašin, Jelena
dc.creatorDimitrijević, B.
dc.creatorRadulović, Siniša
dc.creatorOlah, E
dc.date.accessioned2020-07-02T11:58:56Z
dc.date.available2020-07-02T11:58:56Z
dc.date.issued1999
dc.identifier.issn1021-335X
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1103
dc.description.abstractThe frequency of germline BRCA1 and BRCA2 mutations was tested in Yugoslav breast and breast/ovarian cancer families using combined heteroduplex/single-strand conformation polymorphism analysis for the entire coding region of both genes. Three different recurrent BRCA1 mutations (one 185delAG, one 3447del4 and two 5382insC) were identified in 4 of 12 families (33%), whereas no definite disease-causing alterations of BRCA2 was detected. Genotype analysis revealed a possible common founder effect for each 185delAG and 5382insC. The relatively high frequency of germline BRCA1 mutations determined in this panel of families confirms the important role of BRCA1 in disease predisposition in the Yugoslav population, while the lack of population specific founder and/or unique mutations show the need of further analysis of samples from this yet unexamined region of Europe.en
dc.rightsrestrictedAccess
dc.sourceOncology reports
dc.subjectBRCA1en
dc.subjectBRCA2en
dc.subjectmutation screeningen
dc.titleGermline mutation analysis of BRCA1 and BRCA2 genes in Yugoslav breast/ovarian cancer familiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРадуловић, Синиша; Димитријевић, Б; Раицевић, Л; Папп, Ј; Олах, Е; Милашин, Јелена;
dc.citation.volume6
dc.citation.issue6
dc.citation.spage1435
dc.citation.epage1438
dc.citation.other6(6): 1435-1438
dc.citation.rankM23
dc.identifier.wos000083135500051
dc.identifier.pmid10523726
dc.identifier.scopus2-s2.0-0033227485
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_vinar_2281
dc.type.versionpublishedVersion


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