Substance P (SP)-induced changes in oxygen consumption of rat subtnandibular, sublingual and parotid gland slices were investigated. SP elicited the concentration-dependent increase of oxygen consumption in all 3 glands. The increase was inhibit able by spamide II, the selective NK1 receptor antagonist, hut not by atropine, the muscarinic receptor antagonist. Respiratory effect of SP required the presence of Ca2+ in the incubation medium and was blocked by ouabain. SP had no significant effect on acetylcholine resting release from all 3 salivary glands. The study indicates that SP activates selective NK1 receptors, which are located only postsynaptically, and produces Ca2+-dependent and oubain-sensitive oxygen consumption in rat major salivary glands.
Keywords:
oxygen consumption / substance P / salivary glands
TY - JOUR
AU - Stojić, Dragica
AU - Kršljak, Elena
PY - 2000
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1110
AB - Substance P (SP)-induced changes in oxygen consumption of rat subtnandibular, sublingual and parotid gland slices were investigated. SP elicited the concentration-dependent increase of oxygen consumption in all 3 glands. The increase was inhibit able by spamide II, the selective NK1 receptor antagonist, hut not by atropine, the muscarinic receptor antagonist. Respiratory effect of SP required the presence of Ca2+ in the incubation medium and was blocked by ouabain. SP had no significant effect on acetylcholine resting release from all 3 salivary glands. The study indicates that SP activates selective NK1 receptors, which are located only postsynaptically, and produces Ca2+-dependent and oubain-sensitive oxygen consumption in rat major salivary glands.
PB - Udruženje stomatologa Balkana
T2 - Balkan Journal of Stomatology
T1 - Substance P-induced oxygen consumption in rat major salivary glands
VL - 4
IS - 1
SP - 9
EP - 11
UR - https://hdl.handle.net/21.15107/rcub_smile_1110
ER -
@article{
author = "Stojić, Dragica and Kršljak, Elena",
year = "2000",
abstract = "Substance P (SP)-induced changes in oxygen consumption of rat subtnandibular, sublingual and parotid gland slices were investigated. SP elicited the concentration-dependent increase of oxygen consumption in all 3 glands. The increase was inhibit able by spamide II, the selective NK1 receptor antagonist, hut not by atropine, the muscarinic receptor antagonist. Respiratory effect of SP required the presence of Ca2+ in the incubation medium and was blocked by ouabain. SP had no significant effect on acetylcholine resting release from all 3 salivary glands. The study indicates that SP activates selective NK1 receptors, which are located only postsynaptically, and produces Ca2+-dependent and oubain-sensitive oxygen consumption in rat major salivary glands.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Stomatology",
title = "Substance P-induced oxygen consumption in rat major salivary glands",
volume = "4",
number = "1",
pages = "9-11",
url = "https://hdl.handle.net/21.15107/rcub_smile_1110"
}
Stojić, D.,& Kršljak, E.. (2000). Substance P-induced oxygen consumption in rat major salivary glands. in Balkan Journal of Stomatology
Udruženje stomatologa Balkana., 4(1), 9-11.
https://hdl.handle.net/21.15107/rcub_smile_1110
Stojić D, Kršljak E. Substance P-induced oxygen consumption in rat major salivary glands. in Balkan Journal of Stomatology. 2000;4(1):9-11.
https://hdl.handle.net/21.15107/rcub_smile_1110 .
Stojić, Dragica, Kršljak, Elena, "Substance P-induced oxygen consumption in rat major salivary glands" in Balkan Journal of Stomatology, 4, no. 1 (2000):9-11,
https://hdl.handle.net/21.15107/rcub_smile_1110 .
