Substance P-induced oxygen consumption in rat major salivary glands
Apstrakt
Substance P (SP)-induced changes in oxygen consumption of rat subtnandibular, sublingual and parotid gland slices were investigated. SP elicited the concentration-dependent increase of oxygen consumption in all 3 glands. The increase was inhibit able by spamide II, the selective NK1 receptor antagonist, hut not by atropine, the muscarinic receptor antagonist. Respiratory effect of SP required the presence of Ca2+ in the incubation medium and was blocked by ouabain. SP had no significant effect on acetylcholine resting release from all 3 salivary glands. The study indicates that SP activates selective NK1 receptors, which are located only postsynaptically, and produces Ca2+-dependent and oubain-sensitive oxygen consumption in rat major salivary glands.
Ključne reči:
oxygen consumption / substance P / salivary glandsIzvor:
Balkan Journal of Stomatology, 2000, 4, 1, 9-11Izdavač:
- Udruženje stomatologa Balkana
Kolekcije
Institucija/grupa
Stomatološki fakultetTY - JOUR AU - Stojić, Dragica AU - Kršljak, Elena PY - 2000 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1110 AB - Substance P (SP)-induced changes in oxygen consumption of rat subtnandibular, sublingual and parotid gland slices were investigated. SP elicited the concentration-dependent increase of oxygen consumption in all 3 glands. The increase was inhibit able by spamide II, the selective NK1 receptor antagonist, hut not by atropine, the muscarinic receptor antagonist. Respiratory effect of SP required the presence of Ca2+ in the incubation medium and was blocked by ouabain. SP had no significant effect on acetylcholine resting release from all 3 salivary glands. The study indicates that SP activates selective NK1 receptors, which are located only postsynaptically, and produces Ca2+-dependent and oubain-sensitive oxygen consumption in rat major salivary glands. PB - Udruženje stomatologa Balkana T2 - Balkan Journal of Stomatology T1 - Substance P-induced oxygen consumption in rat major salivary glands VL - 4 IS - 1 SP - 9 EP - 11 UR - https://hdl.handle.net/21.15107/rcub_smile_1110 ER -
@article{ author = "Stojić, Dragica and Kršljak, Elena", year = "2000", abstract = "Substance P (SP)-induced changes in oxygen consumption of rat subtnandibular, sublingual and parotid gland slices were investigated. SP elicited the concentration-dependent increase of oxygen consumption in all 3 glands. The increase was inhibit able by spamide II, the selective NK1 receptor antagonist, hut not by atropine, the muscarinic receptor antagonist. Respiratory effect of SP required the presence of Ca2+ in the incubation medium and was blocked by ouabain. SP had no significant effect on acetylcholine resting release from all 3 salivary glands. The study indicates that SP activates selective NK1 receptors, which are located only postsynaptically, and produces Ca2+-dependent and oubain-sensitive oxygen consumption in rat major salivary glands.", publisher = "Udruženje stomatologa Balkana", journal = "Balkan Journal of Stomatology", title = "Substance P-induced oxygen consumption in rat major salivary glands", volume = "4", number = "1", pages = "9-11", url = "https://hdl.handle.net/21.15107/rcub_smile_1110" }
Stojić, D.,& Kršljak, E.. (2000). Substance P-induced oxygen consumption in rat major salivary glands. in Balkan Journal of Stomatology Udruženje stomatologa Balkana., 4(1), 9-11. https://hdl.handle.net/21.15107/rcub_smile_1110
Stojić D, Kršljak E. Substance P-induced oxygen consumption in rat major salivary glands. in Balkan Journal of Stomatology. 2000;4(1):9-11. https://hdl.handle.net/21.15107/rcub_smile_1110 .
Stojić, Dragica, Kršljak, Elena, "Substance P-induced oxygen consumption in rat major salivary glands" in Balkan Journal of Stomatology, 4, no. 1 (2000):9-11, https://hdl.handle.net/21.15107/rcub_smile_1110 .