Although myc genes are an important family of oncogenes involved in human carcinogenesis, data concerning its role in head and neck tumors are quite limited. Moreover, information regarding precancerous lesions is almost inexisting. In order to better understand mechanisms of progression of premalignant lesions into malignant and the possible role of c-myc amplification, the status of this oncogene was analyzed in two types of pathological changes known to possess malignant transformation potential oral leukoplakia and chronic laryngitis. In the first type of lesions a high percentage of c-myc activation (33%) was observed pointing to a probable role of myc in leukoplakia malignant transformation, while in the other type of lesion there were no signs of myc amplification.
C-myc spada u red onkogena sa važnom ulogom u humanoj kancerogenezi, međutim malo je podataka u literaturi o promenama ovog gena u malignim i premalignim lezijama glave i vrata. Sa ciljem da se bolje upoznaju mehanizmi evolucije prekanceroznih lezija u prave kancere sa naglaskom na c-myc onkogen, analiziran je njegov status u dva tipa promena za koje se zna da imaju maligni potencijal: oralnim leukoplakijama i hroničnim laringitisima. U prvom tipu lezija ustanovljen je visok stepen (33%) aktivacije myc-onkogena, što bi ukazivalo na značaj ove promene u malignoj transformaciji leukoplakija, dok u drugom nije nađen nijedan uzorak sa ovom promenom.
TY - JOUR
AU - Ninković, Tanja
AU - Dedović, Nasta
AU - Kosanović, Rade
AU - Dimitrijević, Bogomir
AU - Josipović, Obrad
AU - Vukadinović, Miroslav
AU - Milašin, Jelena
PY - 2003
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1174
AB - Although myc genes are an important family of oncogenes involved in human carcinogenesis, data concerning its role in head and neck tumors are quite limited. Moreover, information regarding precancerous lesions is almost inexisting. In order to better understand mechanisms of progression of premalignant lesions into malignant and the possible role of c-myc amplification, the status of this oncogene was analyzed in two types of pathological changes known to possess malignant transformation potential oral leukoplakia and chronic laryngitis. In the first type of lesions a high percentage of c-myc activation (33%) was observed pointing to a probable role of myc in leukoplakia malignant transformation, while in the other type of lesion there were no signs of myc amplification.
AB - C-myc spada u red onkogena sa važnom ulogom u humanoj kancerogenezi, međutim malo je podataka u literaturi o promenama ovog gena u malignim i premalignim lezijama glave i vrata. Sa ciljem da se bolje upoznaju mehanizmi evolucije prekanceroznih lezija u prave kancere sa naglaskom na c-myc onkogen, analiziran je njegov status u dva tipa promena za koje se zna da imaju maligni potencijal: oralnim leukoplakijama i hroničnim laringitisima. U prvom tipu lezija ustanovljen je visok stepen (33%) aktivacije myc-onkogena, što bi ukazivalo na značaj ove promene u malignoj transformaciji leukoplakija, dok u drugom nije nađen nijedan uzorak sa ovom promenom.
PB - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2 - Stomatološki glasnik Srbije
T1 - C-myc amplification in precancerous lesions of oral cavity and larynx
T1 - Amplifikacija c-myc onkogena u prekancerozama usne duplje i larinksa
VL - 50
IS - 3
SP - 117
EP - 119
DO - 10.2298/SGS0303117N
ER -
@article{
author = "Ninković, Tanja and Dedović, Nasta and Kosanović, Rade and Dimitrijević, Bogomir and Josipović, Obrad and Vukadinović, Miroslav and Milašin, Jelena",
year = "2003",
abstract = "Although myc genes are an important family of oncogenes involved in human carcinogenesis, data concerning its role in head and neck tumors are quite limited. Moreover, information regarding precancerous lesions is almost inexisting. In order to better understand mechanisms of progression of premalignant lesions into malignant and the possible role of c-myc amplification, the status of this oncogene was analyzed in two types of pathological changes known to possess malignant transformation potential oral leukoplakia and chronic laryngitis. In the first type of lesions a high percentage of c-myc activation (33%) was observed pointing to a probable role of myc in leukoplakia malignant transformation, while in the other type of lesion there were no signs of myc amplification., C-myc spada u red onkogena sa važnom ulogom u humanoj kancerogenezi, međutim malo je podataka u literaturi o promenama ovog gena u malignim i premalignim lezijama glave i vrata. Sa ciljem da se bolje upoznaju mehanizmi evolucije prekanceroznih lezija u prave kancere sa naglaskom na c-myc onkogen, analiziran je njegov status u dva tipa promena za koje se zna da imaju maligni potencijal: oralnim leukoplakijama i hroničnim laringitisima. U prvom tipu lezija ustanovljen je visok stepen (33%) aktivacije myc-onkogena, što bi ukazivalo na značaj ove promene u malignoj transformaciji leukoplakija, dok u drugom nije nađen nijedan uzorak sa ovom promenom.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "C-myc amplification in precancerous lesions of oral cavity and larynx, Amplifikacija c-myc onkogena u prekancerozama usne duplje i larinksa",
volume = "50",
number = "3",
pages = "117-119",
doi = "10.2298/SGS0303117N"
}
Ninković, T., Dedović, N., Kosanović, R., Dimitrijević, B., Josipović, O., Vukadinović, M.,& Milašin, J.. (2003). C-myc amplification in precancerous lesions of oral cavity and larynx. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 50(3), 117-119.
https://doi.org/10.2298/SGS0303117N
Ninković T, Dedović N, Kosanović R, Dimitrijević B, Josipović O, Vukadinović M, Milašin J. C-myc amplification in precancerous lesions of oral cavity and larynx. in Stomatološki glasnik Srbije. 2003;50(3):117-119.
doi:10.2298/SGS0303117N .
Ninković, Tanja, Dedović, Nasta, Kosanović, Rade, Dimitrijević, Bogomir, Josipović, Obrad, Vukadinović, Miroslav, Milašin, Jelena, "C-myc amplification in precancerous lesions of oral cavity and larynx" in Stomatološki glasnik Srbije, 50, no. 3 (2003):117-119,
https://doi.org/10.2298/SGS0303117N . .
