Craniofacial morphology in males with 46,XX chromosomal constitution

Abstract

The aim of this investigation was to assess the craniofacial morphology of five male individuals with 46,XX chromosomal constitution, and to compare them with normal male individuals (46,XY) and normal female participates (46,XX). The investigation was carried out on the lateral cephalomestic radiographs of five male individuals with sex reverse syndrome (46,XX chromosomal constitution), 62 normal female (46,XX) and 31 normal male (46,XY chromosomal constitution) participants. The following angular variables were measured: SNA, SNB, ANB, SN/SpP, SN/MP and SpP/MP. For each variable the mean value and standard deviation were calculated. The Student t-test was used to compare the result obtained between the group of patients with sex reverse syndrome and group of normal male, as well as of normal female participants. The male individuals with 46, XX chromosomal constitution showed slight bimaxillary retrognathism, and class III sagittal jaw relationship. Due to decreased inclination of the upper jaw to the anterior cranial base, the angle of vertical jaw relationship slightly increased in the group of patients with sex reverse syndrome, compared to normal male and female participants.

Cilj ovog istraživanja bio je da se ispita kraniofacijalna morfologija muškaraca sa 46,XX hromozomskom konstitucijom i uporedi sa morfologijom normalnih žena (46,XX) i muškaraca (46,XY). Istraživanje je sprovedeno na profilnim kefalometrijskim snimcima tri grupe ispitanika. Prvu grupu sačinjavalo je pet muškaraca sa hromozomskom konstitucijom 46,XX. Drugu grupu činila su 62 kefalometrijska snimka normalnih žena sa hromozomskom konstitucijom 46,XX, a treću 31 snimak normalnih muškaraca sa hromozomskom konstitucijom 46,XY. Na kefalometrijskim snimcima su mereni sledeći angularni parametri: SNA, SNB, ANB, SN/SpP, SN/MP i SpP/MP. Za sve analizirane parametre izračunata je prosečna vrednost i standardna devijacija, a t-testom je ispitivano postojanje statistički značajnih razlika između tri analizirane grupe ispitanika. Istraživanjem je utvrđeno da se 46,XX muškarci odlikuju blagim bimaksilarnim retrognatizmom i skeletnim sagitalnim odnosom III klase. Blago povećanje vertikalnog međuviličnog ugla kod 46,XX muškaraca posledica je manje inklinacije gornje vilice u odnosu na osnovnu ravan prednje kranijalne baze.