Biocompatibility of PMMA-based material implanted in bone tissue

Abstract

The aim of histopathological investigations was to evaluate the effect of PMMA based material on bone tissue of experimental animals. In the femoral bone of laboratory Wistar rats pastes were implanted for canal obturation SEALPEX (Kerr, Romulus, USA), AH-26 (DeTrey, Zurich, Switzerland) and poly methyl metacrylate (PMMA) based material, called SPONGI CEMENT (Tomic, 1981, US PATENT 4296209). As control material sterile wax was used. The rats were sacrificed 60 days after implantation, and the material was prepared by standard histological method and hematoxillin eosine stained. The results of microscopic investigations suggested that implanted PMMA based material was in direct contact with the new completely formed bone. SEALPEX and AH-26 implanted in bone tissue of rats was surrounded with inflamed infiltrate. Implantation of wax produced fibrous tissue capsule around the material. These findings suggest biocompatibility of polymethyl metacrylate material (PMMA).

Cilj ovog rada je bio da se ispita efekt materijala za punjenje kanala na bazi PMMA na koštano tkivo laboratorijskih životinja. U femoralnu kost laboratorijskih pacova Wistar soja implantirane su paste za opturaciju kanala SEALAPEX (Kerr, Romulus, USA), AH-26(DeTrey, Zurich, Switzerland) i SPONGIO CEMENT preparat na bazi polimetilmetakrilat(PMMA)-(Tomić, 1981, US PATENT 4296209). Kao kontrolni materijal korišten je stomatološki roze vosak. Životinje su žrtvovane nakon 60 dana, a materijal je pripreman za patohistološka istraživanja standardnom tehnikom i bojen hematoksilineozinom. Mikroskopski nalaz je pokazao da je Spongio cement u direktnom kontaktu sa zrelom košću. Paste Ah-26 i Sealapex implantirane u koštanom tkivu su okruženi zapaljenskim infiltratom. Roze vosak je okružen kapsulom ožiljnig vezivnog tkiva. Ovaj nalaz ukazuje na biokompatibilnost materijala na bazi polimetil metakrilata(PMMA).