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dc.creatorJapundžić-Žigon, Nina
dc.creatorMilutinović-Smiljanić, Sanja
dc.creatorJovanović, A
dc.date.accessioned2020-07-02T12:06:28Z
dc.date.available2020-07-02T12:06:28Z
dc.date.issued2004
dc.identifier.issn1347-8613
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1220
dc.description.abstractEffects of V-1 (OPC-21268) and V-2 (OPC-31260) vasopressin antagonists on blood pressure (BP) short-term variability were investigated in adult spontaneously hypertensive rats (SHR) under basal conditions and after the stimulation of vasopressin release by hemorrhage. BP was recorded intra-arterially and sampled at 20 Hz to be analyzed on a personal computer. BP time spectra were calculated on 30 stationary overlapping 2048 point-time series. Spectral power was estimated in total (0.00976 - 3 Hz), very low frequency (VLF: 0.00976 - 0.195 Hz), low frequency (LF: 0.195 - 0.605 Hz), and high frequency (HF: 0. 8 - 3 Hz) regions. Under basal conditions a V, antagonist (5 mg/kg, i.v.) decreased BP without affecting BP variability, while combined (V-1 + V-2) blockade or V-2 blockade (1 mg/kg, i.v.) alone did not affect cardiovascular parameters. Mild hemorrhage (5 ml/kg per min) increased HF-BP variability, while moderate (10 ml/kg per min) and massive (15 ml/kg per min) hemorrhage did not affect it. In V-1, but not V-2, antagonist pre-treated SHR HF-BP increased significantly after moderate and massive hemorrhage. V-1 or V-2 antagonist pre-treatment also enhanced VLF-BP variability during massive hemorrhage. Moreover V-1 blockade prevented hemorrhage-induced bradycardia, while V-2 blockade potentiated it. It follows that in adult SHR, vasopressin buffers BP oscillations in HF and VLF frequency domains only in hypovolaemic conditions and that the modulation of the autonomic adjustment of the HR to hemorrhage by vasopressin is preserved.en
dc.publisherJapanese Pharmacological Soc, Kyoto
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of Pharmacological Sciences
dc.subjectblood pressure variabilityen
dc.subjectspectral analysisen
dc.subjectvasopressin antagonisten
dc.subjecthemorrhageen
dc.subjecthypertensionen
dc.titleEffects of nonpeptide and selective V-1 and V-2 antagonists on blood pressure short-term variability in spontaneously hypertensive ratsen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractМилутиновић-Смиљанић, Сања; Јовановић, A; Јапунджић-Жигон, Нина;
dc.citation.volume95
dc.citation.issue1
dc.citation.spage47
dc.citation.epage55
dc.citation.other95(1): 47-55
dc.citation.rankM23
dc.identifier.wos000221675900007
dc.identifier.doi10.1254/jphs.95.47
dc.identifier.pmid15153650
dc.identifier.scopus2-s2.0-3042797830
dc.identifier.fulltexthttps://smile.stomf.bg.ac.rs/bitstream/id/100/1215.pdf
dc.type.versionpublishedVersion


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