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dc.creatorJekić, B.
dc.creatorNovaković, I.
dc.creatorLuković, L
dc.creatorKuzmanović, M
dc.creatorPopović, Branka
dc.creatorPastar, I
dc.creatorMilašin, Jelena
dc.creatorBunjevacki, G
dc.creatorBunjevački, Vera
dc.date.accessioned2020-07-02T12:06:43Z
dc.date.available2020-07-02T12:06:43Z
dc.date.issued2004
dc.identifier.issn0165-4608
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1224
dc.description.abstractIn children, myelodysplastic syndromes (MDS) represent less then 10% of all hematological malignancies; consequently, molecular genetic studies dealing with this group of patients are scarce. We have analyzed 35 archival bone marrow samples of children with MDS for the presence of mutations in the first and second exons of the NRAS and KRAS2 genes. Mutations were detected with single-strand conformation polymorphism analysis in three patients. One patient harbored a mutation in the second exon of NRAS and two patients in the second exon of KRAS2. Sequencing was performed in two samples and novel mutations were found in both. One patient had a missense mutation in codon 45 of NRAS; the other had a silent mutation in codon 53 and a missense mutation in codon 55 of KRAS2.en
dc.publisherElsevier Science Inc, New York
dc.rightsrestrictedAccess
dc.sourceCancer Genetics & Cytogenetics
dc.titleLow frequency of NRAS and KRAS2 gene mutations in childhood myelodysplastic syndromesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБуњевачки, Вера; Милашин, Јелена; Поповић, Бранка; Буњевацки, Г; Пастар, И; Кузмановић, М; Луковић, Л; Новаковић, И; Јекић, Б;
dc.citation.volume154
dc.citation.issue2
dc.citation.spage180
dc.citation.epage182
dc.citation.other154(2): 180-182
dc.citation.rankM23
dc.identifier.wos000224907000015
dc.identifier.doi10.1016/j.cancergencyto.2004.02.025
dc.identifier.pmid15474158
dc.identifier.scopus2-s2.0-5144234239
dc.type.versionpublishedVersion


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