OBJECTIVE: Acute and chronic actions of lithium on salivation induced by agonists associated with receptor-linked hydrolysis of membrane inositol phospholipids (carbachol and phenylephrine) and by agonist linked to activation of adenylate cyclase (isoproterenol) were investigated. MATERIAL AND METHODS: In anaesthetized rats, submandibular salivation induced by intravenous injection of carbachol, phenylephrine and isoproterenol, was measured and expressed as volume of fluid (mul) elicited per 100 mg wet weight of each gland per minute. The experiments were repeated after acute and chronic treatment of lithium (7 mg kg(-1)). The results were analysed with unpaired t-test. RESULTS: Chronic, but not acute lithium treatment significantly decreases carbachol- and phenylephrine-induced salivation while isoproterenol-induced salivation was not changed neither after acute nor after chronic administration of lithium. CONCLUSION: The results suggest that hyposalivation during chronic lithium ther...apy could be mediated by alterations in the phosphatidylinositol cycle and a consequent lack of inositol after agonist stimulation.
Keywords:
lithium / salivation / acute and chronic treatment
TY - JOUR
AU - Popović, J
AU - Kršljak, Elena
AU - Grbović, L
AU - Stojić, D.
PY - 2005
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1236
AB - OBJECTIVE: Acute and chronic actions of lithium on salivation induced by agonists associated with receptor-linked hydrolysis of membrane inositol phospholipids (carbachol and phenylephrine) and by agonist linked to activation of adenylate cyclase (isoproterenol) were investigated. MATERIAL AND METHODS: In anaesthetized rats, submandibular salivation induced by intravenous injection of carbachol, phenylephrine and isoproterenol, was measured and expressed as volume of fluid (mul) elicited per 100 mg wet weight of each gland per minute. The experiments were repeated after acute and chronic treatment of lithium (7 mg kg(-1)). The results were analysed with unpaired t-test. RESULTS: Chronic, but not acute lithium treatment significantly decreases carbachol- and phenylephrine-induced salivation while isoproterenol-induced salivation was not changed neither after acute nor after chronic administration of lithium. CONCLUSION: The results suggest that hyposalivation during chronic lithium therapy could be mediated by alterations in the phosphatidylinositol cycle and a consequent lack of inositol after agonist stimulation.
PB - Wiley, Hoboken
T2 - Oral Diseases
T1 - The effects of acute and chronic lithium treatment on rat submandibular salivation
VL - 11
IS - 2
SP - 100
EP - 103
DO - 10.1111/j.1601-0825.2004.01066.x
ER -
@article{
author = "Popović, J and Kršljak, Elena and Grbović, L and Stojić, D.",
year = "2005",
abstract = "OBJECTIVE: Acute and chronic actions of lithium on salivation induced by agonists associated with receptor-linked hydrolysis of membrane inositol phospholipids (carbachol and phenylephrine) and by agonist linked to activation of adenylate cyclase (isoproterenol) were investigated. MATERIAL AND METHODS: In anaesthetized rats, submandibular salivation induced by intravenous injection of carbachol, phenylephrine and isoproterenol, was measured and expressed as volume of fluid (mul) elicited per 100 mg wet weight of each gland per minute. The experiments were repeated after acute and chronic treatment of lithium (7 mg kg(-1)). The results were analysed with unpaired t-test. RESULTS: Chronic, but not acute lithium treatment significantly decreases carbachol- and phenylephrine-induced salivation while isoproterenol-induced salivation was not changed neither after acute nor after chronic administration of lithium. CONCLUSION: The results suggest that hyposalivation during chronic lithium therapy could be mediated by alterations in the phosphatidylinositol cycle and a consequent lack of inositol after agonist stimulation.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "The effects of acute and chronic lithium treatment on rat submandibular salivation",
volume = "11",
number = "2",
pages = "100-103",
doi = "10.1111/j.1601-0825.2004.01066.x"
}
Popović, J., Kršljak, E., Grbović, L.,& Stojić, D.. (2005). The effects of acute and chronic lithium treatment on rat submandibular salivation. in Oral Diseases
Wiley, Hoboken., 11(2), 100-103.
https://doi.org/10.1111/j.1601-0825.2004.01066.x
Popović J, Kršljak E, Grbović L, Stojić D. The effects of acute and chronic lithium treatment on rat submandibular salivation. in Oral Diseases. 2005;11(2):100-103.
doi:10.1111/j.1601-0825.2004.01066.x .
Popović, J, Kršljak, Elena, Grbović, L, Stojić, D., "The effects of acute and chronic lithium treatment on rat submandibular salivation" in Oral Diseases, 11, no. 2 (2005):100-103,
https://doi.org/10.1111/j.1601-0825.2004.01066.x . .
