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dc.creatorIgnjatović, N
dc.creatorNinkov, P
dc.creatorAjduković, Z
dc.creatorKonstantinović, Vitomir
dc.creatorUskoković, D
dc.date.accessioned2020-07-02T12:08:12Z
dc.date.available2020-07-02T12:08:12Z
dc.date.issued2005
dc.identifier.issn0255-5476
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1247
dc.description.abstractComposite biomaterials, like calciumphosphate/bioresorbable polymer, offer excellent potential for reconstruction and reparation of bone tissue defects induced by different sources. In this paper synthesis of calciumphosphate/poly-DL-lactide-co-glycolide (BCP/DLPLG) composite biomaterial formed as filler and blocks was studied. BCP/DLPLG composite biomaterial was produced in the form of spherical granules of BCP covered by a DLPLG layer, average diameter of 150-250 mu m. By cold and hot pressing of granules at up to 10000 kg/cm(2), blocks with fine distribution of phases and porosity up to 3% were obtained. Characterization was performed by wide-angle X-ray structural analysis (WAXS), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), infrared spectroscopy (IR), and mechanical properties by defining the compressive strength. In vitro citotoxicity research was carried out on cellular cultures of fibroblasts of human (MRC5) and mouse (L929). In vivo research was performed in two steps. Reparatory ability of BCP/DLPLG in mice was examined in the first step, and then bone tissue reconstruction possibilities on 10 patients in the next step. In vitro tests showed very good fibroblast adhesion and non-citotoxicity of the composite. A material is considered non-cytotoxic if the cell survival is above 50%, and in our case it was 90%. In vivo research on mice indicated high level of reparatory ability of this composite with formation of new bone and vascular tissue six weeks after reparation. Application of this composite for healing infrabone defects of patients showed a high level of osseous regeneration.en
dc.publisherTrans Tech Publications Ltd, Durnten-Zurich
dc.rightsrestrictedAccess
dc.sourceCurrent Research in Advanced Materials & Processes
dc.subjectbone repairen
dc.subjectcalcium phosphateen
dc.subjectcompositeen
dc.subjectcytotoxicityen
dc.subjectin vitroen
dc.subjectin vivoen
dc.titleBiphasic calcium phosphate/poly-(DL-lactide-co-glycolide) biocomposite as filler and blocks for reparation of bone tissueen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКонстантиновић, Витомир; Нинков, П; Aјдуковић, З; Игњатовић, Н; Ускоковић, Д;
dc.citation.volume494
dc.citation.spage519
dc.citation.epage524
dc.citation.other494: 519-524
dc.citation.rankM23
dc.identifier.wos000230985800085
dc.identifier.doi10.4028/www.scientific.net/MSF.494.519
dc.identifier.rcubconv_2693
dc.type.versionpublishedVersion


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