Myelodysplastic syndromes (MDS) are rare disorders in children. Molecular mechanisims underlying MDS in children are not yet completely understood. Considering the role of FMS and TP53 gene mutations in adult MDS patients, we analyzed nnutations of these genes in a cohort of 35 children with MDS. Single-strand conformation polymorphism polymerase chain reaction analysis performed on FMS codon 969 and TP53 exons 5-9 showed no mutations in the analyzed sequences. Our results Suggest that molecular mechanisms of MDS evolution in children are different from those in adults.
Source:
Cancer Genetics & Cytogenetics, 2006, 166, 2, 163-165
TY - JOUR
AU - Jekić, B.
AU - Novaković, I.
AU - Luković, L
AU - Kuzmanović, M
AU - Popović, Branka
AU - Milašin, Jelena
AU - Bunjevacki, G
AU - Damnjanović, Tatjana
AU - Cvjetičanin, S
AU - Bunjevački, Vera
PY - 2006
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1314
AB - Myelodysplastic syndromes (MDS) are rare disorders in children. Molecular mechanisims underlying MDS in children are not yet completely understood. Considering the role of FMS and TP53 gene mutations in adult MDS patients, we analyzed nnutations of these genes in a cohort of 35 children with MDS. Single-strand conformation polymorphism polymerase chain reaction analysis performed on FMS codon 969 and TP53 exons 5-9 showed no mutations in the analyzed sequences. Our results Suggest that molecular mechanisms of MDS evolution in children are different from those in adults.
PB - Elsevier Science Inc, New York
T2 - Cancer Genetics & Cytogenetics
T1 - Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome
VL - 166
IS - 2
SP - 163
EP - 165
DO - 10.1016/j.cancergencyto.2005.11.003
ER -
@article{
author = "Jekić, B. and Novaković, I. and Luković, L and Kuzmanović, M and Popović, Branka and Milašin, Jelena and Bunjevacki, G and Damnjanović, Tatjana and Cvjetičanin, S and Bunjevački, Vera",
year = "2006",
abstract = "Myelodysplastic syndromes (MDS) are rare disorders in children. Molecular mechanisims underlying MDS in children are not yet completely understood. Considering the role of FMS and TP53 gene mutations in adult MDS patients, we analyzed nnutations of these genes in a cohort of 35 children with MDS. Single-strand conformation polymorphism polymerase chain reaction analysis performed on FMS codon 969 and TP53 exons 5-9 showed no mutations in the analyzed sequences. Our results Suggest that molecular mechanisms of MDS evolution in children are different from those in adults.",
publisher = "Elsevier Science Inc, New York",
journal = "Cancer Genetics & Cytogenetics",
title = "Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome",
volume = "166",
number = "2",
pages = "163-165",
doi = "10.1016/j.cancergencyto.2005.11.003"
}
Jekić, B., Novaković, I., Luković, L., Kuzmanović, M., Popović, B., Milašin, J., Bunjevacki, G., Damnjanović, T., Cvjetičanin, S.,& Bunjevački, V.. (2006). Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome. in Cancer Genetics & Cytogenetics
Elsevier Science Inc, New York., 166(2), 163-165.
https://doi.org/10.1016/j.cancergencyto.2005.11.003
Jekić B, Novaković I, Luković L, Kuzmanović M, Popović B, Milašin J, Bunjevacki G, Damnjanović T, Cvjetičanin S, Bunjevački V. Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome. in Cancer Genetics & Cytogenetics. 2006;166(2):163-165.
doi:10.1016/j.cancergencyto.2005.11.003 .
Jekić, B., Novaković, I., Luković, L, Kuzmanović, M, Popović, Branka, Milašin, Jelena, Bunjevacki, G, Damnjanović, Tatjana, Cvjetičanin, S, Bunjevački, Vera, "Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome" in Cancer Genetics & Cytogenetics, 166, no. 2 (2006):163-165,
https://doi.org/10.1016/j.cancergencyto.2005.11.003 . .
